Incidental Mutation 'R2880:Vmn2r65'
ID 260277
Institutional Source Beutler Lab
Gene Symbol Vmn2r65
Ensembl Gene ENSMUSG00000066372
Gene Name vomeronasal 2, receptor 65
Synonyms ENSMUSG00000070600
MMRRC Submission 040468-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.071) question?
Stock # R2880 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 84589377-84613217 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 84613094 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Serine at position 42 (C42S)
Ref Sequence ENSEMBL: ENSMUSP00000036551 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000044583]
AlphaFold G3X931
Predicted Effect probably damaging
Transcript: ENSMUST00000044583
AA Change: C42S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000036551
Gene: ENSMUSG00000066372
AA Change: C42S

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
Pfam:ANF_receptor 73 435 5.6e-41 PFAM
Pfam:NCD3G 501 553 1.3e-21 PFAM
Pfam:7tm_3 584 821 2.3e-53 PFAM
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.5%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ano4 C T 10: 88,948,661 (GRCm39) E150K probably damaging Het
Blnk T C 19: 40,950,899 (GRCm39) Y84C probably damaging Het
Brinp3 G A 1: 146,777,740 (GRCm39) R729H probably damaging Het
Bsn C T 9: 107,990,266 (GRCm39) A1829T possibly damaging Het
Cd300c A T 11: 114,850,616 (GRCm39) N62K probably benign Het
Chd3 T C 11: 69,242,946 (GRCm39) D1425G probably damaging Het
Ewsr1 C A 11: 5,028,523 (GRCm39) probably benign Het
Gm4076 G A 13: 85,275,357 (GRCm39) noncoding transcript Het
Gm9637 A G 14: 19,401,978 (GRCm38) noncoding transcript Het
Greb1l A T 18: 10,547,288 (GRCm39) N1502I possibly damaging Het
H13 A G 2: 152,537,481 (GRCm39) M309V probably damaging Het
Lmf2 A G 15: 89,235,856 (GRCm39) S683P possibly damaging Het
Lrit1 T A 14: 36,779,394 (GRCm39) L109Q probably damaging Het
Maml2 A T 9: 13,531,893 (GRCm39) probably null Het
Map3k14 C A 11: 103,111,858 (GRCm39) R941L probably damaging Het
Megf6 A G 4: 154,337,006 (GRCm39) K262E probably damaging Het
Mtnr1b T G 9: 15,774,102 (GRCm39) Y319S probably damaging Het
Myh8 A G 11: 67,188,090 (GRCm39) K954R probably damaging Het
Myof T C 19: 37,911,473 (GRCm39) D1486G probably benign Het
Nbea A G 3: 55,554,779 (GRCm39) V2623A probably benign Het
Pak1 T A 7: 97,554,018 (GRCm39) Y463N probably damaging Het
Pex5l T A 3: 33,047,152 (GRCm39) probably null Het
Rasa4 T C 5: 136,120,625 (GRCm39) V87A probably damaging Het
Rnf112 G A 11: 61,341,293 (GRCm39) H431Y possibly damaging Het
Slc25a30 A G 14: 76,007,651 (GRCm39) V118A probably benign Het
Slc4a7 T A 14: 14,773,277 (GRCm38) I872K probably damaging Het
Slc5a11 GGTGC G 7: 122,838,595 (GRCm39) probably null Het
Sycp1 T C 3: 102,726,214 (GRCm39) E970G probably damaging Het
Tex15 T A 8: 34,064,935 (GRCm39) L1455* probably null Het
Tgfb2 T A 1: 186,436,752 (GRCm39) T74S probably damaging Het
Zbtb12 T A 17: 35,114,455 (GRCm39) I80N probably damaging Het
Other mutations in Vmn2r65
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00942:Vmn2r65 APN 7 84,592,761 (GRCm39) missense probably damaging 0.99
IGL01104:Vmn2r65 APN 7 84,589,996 (GRCm39) missense possibly damaging 0.93
IGL01154:Vmn2r65 APN 7 84,592,729 (GRCm39) missense probably benign 0.00
IGL01453:Vmn2r65 APN 7 84,589,708 (GRCm39) missense probably damaging 1.00
IGL01675:Vmn2r65 APN 7 84,596,587 (GRCm39) missense probably benign 0.00
IGL01748:Vmn2r65 APN 7 84,589,507 (GRCm39) missense probably damaging 1.00
IGL01997:Vmn2r65 APN 7 84,589,978 (GRCm39) missense probably damaging 1.00
IGL02527:Vmn2r65 APN 7 84,595,724 (GRCm39) missense possibly damaging 0.82
IGL02617:Vmn2r65 APN 7 84,589,549 (GRCm39) missense probably damaging 1.00
IGL02676:Vmn2r65 APN 7 84,589,381 (GRCm39) missense possibly damaging 0.86
IGL03084:Vmn2r65 APN 7 84,592,354 (GRCm39) missense probably damaging 1.00
A4554:Vmn2r65 UTSW 7 84,595,791 (GRCm39) missense probably damaging 0.96
PIT4651001:Vmn2r65 UTSW 7 84,595,461 (GRCm39) missense probably benign 0.12
R0322:Vmn2r65 UTSW 7 84,595,756 (GRCm39) missense probably benign 0.01
R0453:Vmn2r65 UTSW 7 84,595,442 (GRCm39) missense probably benign 0.03
R0862:Vmn2r65 UTSW 7 84,592,853 (GRCm39) missense probably benign 0.00
R1392:Vmn2r65 UTSW 7 84,596,624 (GRCm39) missense probably benign 0.14
R1392:Vmn2r65 UTSW 7 84,596,624 (GRCm39) missense probably benign 0.14
R1508:Vmn2r65 UTSW 7 84,589,886 (GRCm39) missense probably benign 0.00
R1687:Vmn2r65 UTSW 7 84,590,026 (GRCm39) missense probably benign 0.02
R1876:Vmn2r65 UTSW 7 84,595,505 (GRCm39) missense probably damaging 1.00
R2136:Vmn2r65 UTSW 7 84,592,781 (GRCm39) missense probably damaging 0.96
R2259:Vmn2r65 UTSW 7 84,590,119 (GRCm39) missense possibly damaging 0.86
R2338:Vmn2r65 UTSW 7 84,590,051 (GRCm39) missense possibly damaging 0.86
R3410:Vmn2r65 UTSW 7 84,595,896 (GRCm39) missense probably benign 0.00
R3411:Vmn2r65 UTSW 7 84,595,896 (GRCm39) missense probably benign 0.00
R3770:Vmn2r65 UTSW 7 84,589,623 (GRCm39) missense probably damaging 1.00
R3800:Vmn2r65 UTSW 7 84,589,738 (GRCm39) missense possibly damaging 0.93
R3850:Vmn2r65 UTSW 7 84,595,859 (GRCm39) missense probably benign 0.00
R4105:Vmn2r65 UTSW 7 84,595,691 (GRCm39) missense probably benign 0.03
R4568:Vmn2r65 UTSW 7 84,596,677 (GRCm39) missense probably damaging 1.00
R4677:Vmn2r65 UTSW 7 84,613,082 (GRCm39) missense possibly damaging 0.55
R4768:Vmn2r65 UTSW 7 84,596,602 (GRCm39) missense probably damaging 1.00
R4778:Vmn2r65 UTSW 7 84,592,801 (GRCm39) missense possibly damaging 0.47
R5057:Vmn2r65 UTSW 7 84,589,819 (GRCm39) missense probably damaging 1.00
R5279:Vmn2r65 UTSW 7 84,589,849 (GRCm39) missense probably damaging 1.00
R5280:Vmn2r65 UTSW 7 84,595,542 (GRCm39) missense probably damaging 0.99
R5394:Vmn2r65 UTSW 7 84,595,862 (GRCm39) missense probably benign 0.04
R5487:Vmn2r65 UTSW 7 84,595,529 (GRCm39) missense possibly damaging 0.76
R5580:Vmn2r65 UTSW 7 84,596,802 (GRCm39) missense probably damaging 0.99
R5638:Vmn2r65 UTSW 7 84,590,047 (GRCm39) missense probably damaging 1.00
R5673:Vmn2r65 UTSW 7 84,596,615 (GRCm39) missense probably benign 0.23
R5688:Vmn2r65 UTSW 7 84,589,900 (GRCm39) missense probably benign 0.00
R5935:Vmn2r65 UTSW 7 84,592,869 (GRCm39) missense probably benign 0.00
R6354:Vmn2r65 UTSW 7 84,589,574 (GRCm39) missense probably benign 0.35
R6372:Vmn2r65 UTSW 7 84,589,861 (GRCm39) missense probably damaging 1.00
R6924:Vmn2r65 UTSW 7 84,613,198 (GRCm39) missense probably benign 0.20
R7021:Vmn2r65 UTSW 7 84,596,587 (GRCm39) missense probably benign 0.00
R7195:Vmn2r65 UTSW 7 84,592,347 (GRCm39) critical splice donor site probably null
R7422:Vmn2r65 UTSW 7 84,595,569 (GRCm39) missense probably damaging 0.99
R7654:Vmn2r65 UTSW 7 84,590,261 (GRCm39) missense probably damaging 1.00
R7686:Vmn2r65 UTSW 7 84,589,744 (GRCm39) missense probably damaging 0.99
R7691:Vmn2r65 UTSW 7 84,592,851 (GRCm39) missense probably benign 0.30
R7798:Vmn2r65 UTSW 7 84,596,192 (GRCm39) missense probably damaging 1.00
R7798:Vmn2r65 UTSW 7 84,595,530 (GRCm39) missense probably benign 0.00
R8103:Vmn2r65 UTSW 7 84,595,919 (GRCm39) missense probably damaging 1.00
R8272:Vmn2r65 UTSW 7 84,596,817 (GRCm39) missense probably benign 0.02
R8303:Vmn2r65 UTSW 7 84,589,391 (GRCm39) nonsense probably null
R8354:Vmn2r65 UTSW 7 84,589,402 (GRCm39) missense possibly damaging 0.73
R8454:Vmn2r65 UTSW 7 84,589,402 (GRCm39) missense possibly damaging 0.73
R8489:Vmn2r65 UTSW 7 84,589,964 (GRCm39) missense possibly damaging 0.85
R8554:Vmn2r65 UTSW 7 84,595,960 (GRCm39) missense probably benign 0.00
R8680:Vmn2r65 UTSW 7 84,589,388 (GRCm39) missense probably benign 0.00
R8731:Vmn2r65 UTSW 7 84,589,447 (GRCm39) nonsense probably null
R8839:Vmn2r65 UTSW 7 84,595,489 (GRCm39) nonsense probably null
R8847:Vmn2r65 UTSW 7 84,590,212 (GRCm39) missense probably damaging 1.00
R8916:Vmn2r65 UTSW 7 84,595,665 (GRCm39) missense probably benign 0.21
R9254:Vmn2r65 UTSW 7 84,596,650 (GRCm39) missense probably damaging 0.99
R9379:Vmn2r65 UTSW 7 84,596,650 (GRCm39) missense probably damaging 0.99
R9392:Vmn2r65 UTSW 7 84,589,718 (GRCm39) missense possibly damaging 0.95
R9563:Vmn2r65 UTSW 7 84,589,880 (GRCm39) nonsense probably null
R9686:Vmn2r65 UTSW 7 84,590,084 (GRCm39) missense probably benign 0.45
X0067:Vmn2r65 UTSW 7 84,590,113 (GRCm39) missense probably benign 0.04
Z1088:Vmn2r65 UTSW 7 84,592,473 (GRCm39) critical splice acceptor site probably null
Z1177:Vmn2r65 UTSW 7 84,590,234 (GRCm39) missense probably damaging 0.97
Predicted Primers PCR Primer
(F):5'- GGGTGAACAAAATGCCTAATCC -3'
(R):5'- TACTGCACTTGACTCAGGCTC -3'

Sequencing Primer
(F):5'- CAAAATGCCTAATCCAGAAATAGGG -3'
(R):5'- CTTGACTCAGGCTCAAGGCATAG -3'
Posted On 2015-01-23