Incidental Mutation 'R3161:Sult2a4'
ID 258161
Institutional Source Beutler Lab
Gene Symbol Sult2a4
Ensembl Gene ENSMUSG00000074377
Gene Name sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 4
Synonyms Gm5584
MMRRC Submission 040612-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.063) question?
Stock # R3161 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 13643602-13723516 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 13723396 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 40 (T40A)
Ref Sequence ENSEMBL: ENSMUSP00000130490 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000108520] [ENSMUST00000165167]
AlphaFold L7N245
Predicted Effect probably benign
Transcript: ENSMUST00000108520
AA Change: T41A

PolyPhen 2 Score 0.166 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000104160
Gene: ENSMUSG00000074377
AA Change: T41A

DomainStartEndE-ValueType
Pfam:Sulfotransfer_3 5 205 1.5e-10 PFAM
Pfam:Sulfotransfer_1 34 278 1.2e-82 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000165167
AA Change: T40A

PolyPhen 2 Score 0.166 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000130490
Gene: ENSMUSG00000074377
AA Change: T40A

DomainStartEndE-ValueType
Pfam:Sulfotransfer_1 33 277 1.3e-82 PFAM
Meta Mutation Damage Score 0.4446 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.1%
  • 20x: 94.3%
Validation Efficiency 98% (54/55)
MGI Phenotype FUNCTION: This is one of seven sulfotransferase family 2A genes in a chromosome 7 A1 cluster. [provided by RefSeq, May 2010]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
0610040J01Rik T C 5: 64,053,833 (GRCm39) probably benign Het
1700066M21Rik T A 1: 57,422,234 (GRCm39) N203K probably benign Het
Adcy9 A G 16: 4,129,452 (GRCm39) L715P probably damaging Het
Adgrl2 G A 3: 148,523,187 (GRCm39) L1354F probably damaging Het
Amer2 A G 14: 60,616,000 (GRCm39) D65G probably damaging Het
Aox1 G T 1: 58,343,597 (GRCm39) V427L possibly damaging Het
Atad2b C A 12: 4,989,689 (GRCm39) N133K possibly damaging Het
Bptf A T 11: 106,965,302 (GRCm39) D1182E probably damaging Het
Camk1g T C 1: 193,042,115 (GRCm39) T45A possibly damaging Het
Caps2 C A 10: 112,018,391 (GRCm39) Y180* probably null Het
Cfap54 T A 10: 92,881,140 (GRCm39) K349N probably damaging Het
Chct1 A G 11: 85,064,110 (GRCm39) S84G probably damaging Het
Ciz1 A G 2: 32,260,075 (GRCm39) D207G probably benign Het
Copa T A 1: 171,918,800 (GRCm39) C127S probably damaging Het
Crabp2 A T 3: 87,859,484 (GRCm39) K45* probably null Het
Daam1 C A 12: 71,993,872 (GRCm39) T425K unknown Het
Dapk2 T G 9: 66,161,893 (GRCm39) V267G probably damaging Het
Disp1 T C 1: 182,868,806 (GRCm39) K1205E probably benign Het
Dlg4 G C 11: 69,908,051 (GRCm39) R4T probably damaging Het
Fbf1 A G 11: 116,039,046 (GRCm39) I743T probably damaging Het
Fen1 A G 19: 10,177,655 (GRCm39) L263P probably damaging Het
G6pc2 A G 2: 69,050,456 (GRCm39) N27S probably damaging Het
Garnl3 A T 2: 32,924,723 (GRCm39) N246K probably damaging Het
Gm7337 A C 5: 87,999,416 (GRCm39) noncoding transcript Het
Gpr152 A G 19: 4,192,713 (GRCm39) T85A probably benign Het
Hnrnpu T C 1: 178,158,690 (GRCm39) probably benign Het
Ighv1-81 C G 12: 115,883,949 (GRCm39) E101Q probably benign Het
Ipo9 T C 1: 135,337,214 (GRCm39) T174A probably benign Het
Myo9a C T 9: 59,739,598 (GRCm39) probably benign Het
Nup155 G T 15: 8,177,867 (GRCm39) R1083S possibly damaging Het
Or11g24 T A 14: 50,662,488 (GRCm39) C171S probably damaging Het
Or5an1c T C 19: 12,218,860 (GRCm39) H55R probably benign Het
Or6d13 C T 6: 116,517,807 (GRCm39) A131V probably damaging Het
Or7a35 C A 10: 78,853,438 (GRCm39) T94N probably benign Het
Phyh T A 2: 4,942,482 (GRCm39) probably benign Het
Pkp4 G T 2: 59,138,449 (GRCm39) R233M probably damaging Het
Plcb1 A T 2: 135,177,402 (GRCm39) Q578L probably benign Het
Ppil3 A T 1: 58,473,573 (GRCm39) N92K probably benign Het
Prokr1 C T 6: 87,565,413 (GRCm39) R144H probably damaging Het
Psap T C 10: 60,113,575 (GRCm39) L4P possibly damaging Het
Rai14 T C 15: 10,633,250 (GRCm39) T47A possibly damaging Het
Rps2 G T 17: 24,939,952 (GRCm39) A129S probably benign Het
Tacr2 A G 10: 62,101,024 (GRCm39) D378G probably benign Het
Topaz1 T C 9: 122,578,446 (GRCm39) I452T probably benign Het
Ttn A G 2: 76,663,581 (GRCm39) probably benign Het
Vmn2r115 T A 17: 23,575,998 (GRCm39) M532K possibly damaging Het
Vmn2r117 A G 17: 23,679,352 (GRCm39) L624P probably damaging Het
Vstm5 T G 9: 15,168,594 (GRCm39) S53A probably benign Het
Wipf1 C T 2: 73,265,293 (GRCm39) E437K probably damaging Het
Wls G T 3: 159,603,073 (GRCm39) C162F probably damaging Het
Yeats2 T C 16: 20,012,395 (GRCm39) V531A probably damaging Het
Zfp868 A G 8: 70,064,736 (GRCm39) S200P probably benign Het
Other mutations in Sult2a4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00557:Sult2a4 APN 7 13,718,870 (GRCm39) missense probably damaging 1.00
IGL00835:Sult2a4 APN 7 13,643,714 (GRCm39) missense probably benign 0.01
IGL02078:Sult2a4 APN 7 13,723,469 (GRCm39) missense probably benign 0.02
IGL02409:Sult2a4 APN 7 13,718,844 (GRCm39) nonsense probably null
IGL02970:Sult2a4 APN 7 13,643,831 (GRCm39) splice site probably benign
IGL03201:Sult2a4 APN 7 13,665,692 (GRCm39) missense probably damaging 0.97
R0827:Sult2a4 UTSW 7 13,718,886 (GRCm39) missense probably benign 0.03
R1484:Sult2a4 UTSW 7 13,643,726 (GRCm39) missense probably benign
R1523:Sult2a4 UTSW 7 13,643,785 (GRCm39) nonsense probably null
R1613:Sult2a4 UTSW 7 13,723,420 (GRCm39) missense probably damaging 0.98
R2127:Sult2a4 UTSW 7 13,649,185 (GRCm39) missense probably damaging 0.99
R2372:Sult2a4 UTSW 7 13,649,225 (GRCm39) missense probably benign 0.15
R5181:Sult2a4 UTSW 7 13,722,316 (GRCm39) missense probably benign 0.04
R7124:Sult2a4 UTSW 7 13,722,320 (GRCm39) nonsense probably null
R7983:Sult2a4 UTSW 7 13,649,152 (GRCm39) missense probably damaging 1.00
R8214:Sult2a4 UTSW 7 13,723,401 (GRCm39) missense probably benign 0.10
R9508:Sult2a4 UTSW 7 13,723,437 (GRCm39) missense probably benign 0.01
X0028:Sult2a4 UTSW 7 13,722,166 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGCACAATCATTGTTCTGGTG -3'
(R):5'- TGCTATAAGCTGAATAGGTGTCCTG -3'

Sequencing Primer
(F):5'- CACAATCATTGTTCTGGTGCCATAG -3'
(R):5'- CTGGGCTGGAATTCTAACAGCATC -3'
Posted On 2015-01-23