Incidental Mutation 'R3161:Camk1g'
ID 258145
Institutional Source Beutler Lab
Gene Symbol Camk1g
Ensembl Gene ENSMUSG00000016179
Gene Name calcium/calmodulin-dependent protein kinase I gamma
Synonyms CLICK-III, CaMKIgamma
MMRRC Submission 040612-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.101) question?
Stock # R3161 (G1)
Quality Score 225
Status Validated
Chromosome 1
Chromosomal Location 193028654-193052606 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 193042115 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 45 (T45A)
Ref Sequence ENSEMBL: ENSMUSP00000128143 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000016323] [ENSMUST00000169907]
AlphaFold Q91VB2
Predicted Effect probably benign
Transcript: ENSMUST00000016323
AA Change: T45A

PolyPhen 2 Score 0.434 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000016323
Gene: ENSMUSG00000016179
AA Change: T45A

DomainStartEndE-ValueType
S_TKc 23 277 9.53e-112 SMART
low complexity region 376 389 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000163202
SMART Domains Protein: ENSMUSP00000131451
Gene: ENSMUSG00000016179

DomainStartEndE-ValueType
S_TKc 2 238 5.19e-72 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000165718
Predicted Effect possibly damaging
Transcript: ENSMUST00000169907
AA Change: T45A

PolyPhen 2 Score 0.657 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000128143
Gene: ENSMUSG00000016179
AA Change: T45A

DomainStartEndE-ValueType
S_TKc 23 277 9.53e-112 SMART
Meta Mutation Damage Score 0.1663 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.1%
  • 20x: 94.3%
Validation Efficiency 98% (54/55)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein similar to calcium/calmodulin dependent protein kinase, however, its exact function is not known. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired dendritogenesis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
0610040J01Rik T C 5: 64,053,833 (GRCm39) probably benign Het
1700066M21Rik T A 1: 57,422,234 (GRCm39) N203K probably benign Het
Adcy9 A G 16: 4,129,452 (GRCm39) L715P probably damaging Het
Adgrl2 G A 3: 148,523,187 (GRCm39) L1354F probably damaging Het
Amer2 A G 14: 60,616,000 (GRCm39) D65G probably damaging Het
Aox1 G T 1: 58,343,597 (GRCm39) V427L possibly damaging Het
Atad2b C A 12: 4,989,689 (GRCm39) N133K possibly damaging Het
Bptf A T 11: 106,965,302 (GRCm39) D1182E probably damaging Het
Caps2 C A 10: 112,018,391 (GRCm39) Y180* probably null Het
Cfap54 T A 10: 92,881,140 (GRCm39) K349N probably damaging Het
Chct1 A G 11: 85,064,110 (GRCm39) S84G probably damaging Het
Ciz1 A G 2: 32,260,075 (GRCm39) D207G probably benign Het
Copa T A 1: 171,918,800 (GRCm39) C127S probably damaging Het
Crabp2 A T 3: 87,859,484 (GRCm39) K45* probably null Het
Daam1 C A 12: 71,993,872 (GRCm39) T425K unknown Het
Dapk2 T G 9: 66,161,893 (GRCm39) V267G probably damaging Het
Disp1 T C 1: 182,868,806 (GRCm39) K1205E probably benign Het
Dlg4 G C 11: 69,908,051 (GRCm39) R4T probably damaging Het
Fbf1 A G 11: 116,039,046 (GRCm39) I743T probably damaging Het
Fen1 A G 19: 10,177,655 (GRCm39) L263P probably damaging Het
G6pc2 A G 2: 69,050,456 (GRCm39) N27S probably damaging Het
Garnl3 A T 2: 32,924,723 (GRCm39) N246K probably damaging Het
Gm7337 A C 5: 87,999,416 (GRCm39) noncoding transcript Het
Gpr152 A G 19: 4,192,713 (GRCm39) T85A probably benign Het
Hnrnpu T C 1: 178,158,690 (GRCm39) probably benign Het
Ighv1-81 C G 12: 115,883,949 (GRCm39) E101Q probably benign Het
Ipo9 T C 1: 135,337,214 (GRCm39) T174A probably benign Het
Myo9a C T 9: 59,739,598 (GRCm39) probably benign Het
Nup155 G T 15: 8,177,867 (GRCm39) R1083S possibly damaging Het
Or11g24 T A 14: 50,662,488 (GRCm39) C171S probably damaging Het
Or5an1c T C 19: 12,218,860 (GRCm39) H55R probably benign Het
Or6d13 C T 6: 116,517,807 (GRCm39) A131V probably damaging Het
Or7a35 C A 10: 78,853,438 (GRCm39) T94N probably benign Het
Phyh T A 2: 4,942,482 (GRCm39) probably benign Het
Pkp4 G T 2: 59,138,449 (GRCm39) R233M probably damaging Het
Plcb1 A T 2: 135,177,402 (GRCm39) Q578L probably benign Het
Ppil3 A T 1: 58,473,573 (GRCm39) N92K probably benign Het
Prokr1 C T 6: 87,565,413 (GRCm39) R144H probably damaging Het
Psap T C 10: 60,113,575 (GRCm39) L4P possibly damaging Het
Rai14 T C 15: 10,633,250 (GRCm39) T47A possibly damaging Het
Rps2 G T 17: 24,939,952 (GRCm39) A129S probably benign Het
Sult2a4 T C 7: 13,723,396 (GRCm39) T40A probably benign Het
Tacr2 A G 10: 62,101,024 (GRCm39) D378G probably benign Het
Topaz1 T C 9: 122,578,446 (GRCm39) I452T probably benign Het
Ttn A G 2: 76,663,581 (GRCm39) probably benign Het
Vmn2r115 T A 17: 23,575,998 (GRCm39) M532K possibly damaging Het
Vmn2r117 A G 17: 23,679,352 (GRCm39) L624P probably damaging Het
Vstm5 T G 9: 15,168,594 (GRCm39) S53A probably benign Het
Wipf1 C T 2: 73,265,293 (GRCm39) E437K probably damaging Het
Wls G T 3: 159,603,073 (GRCm39) C162F probably damaging Het
Yeats2 T C 16: 20,012,395 (GRCm39) V531A probably damaging Het
Zfp868 A G 8: 70,064,736 (GRCm39) S200P probably benign Het
Other mutations in Camk1g
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00433:Camk1g APN 1 193,029,657 (GRCm39) unclassified probably benign
IGL02637:Camk1g APN 1 193,030,696 (GRCm39) missense probably benign 0.38
G1patch:Camk1g UTSW 1 193,032,628 (GRCm39) missense possibly damaging 0.80
I2288:Camk1g UTSW 1 193,033,414 (GRCm39) splice site probably benign
R0375:Camk1g UTSW 1 193,038,709 (GRCm39) splice site probably benign
R0433:Camk1g UTSW 1 193,036,366 (GRCm39) missense probably damaging 0.99
R0967:Camk1g UTSW 1 193,032,604 (GRCm39) missense probably damaging 1.00
R1161:Camk1g UTSW 1 193,030,662 (GRCm39) missense probably benign
R1227:Camk1g UTSW 1 193,029,741 (GRCm39) missense possibly damaging 0.73
R1469:Camk1g UTSW 1 193,044,399 (GRCm39) missense possibly damaging 0.89
R1469:Camk1g UTSW 1 193,044,399 (GRCm39) missense possibly damaging 0.89
R1641:Camk1g UTSW 1 193,038,665 (GRCm39) missense probably benign 0.25
R3109:Camk1g UTSW 1 193,037,301 (GRCm39) missense probably damaging 1.00
R3160:Camk1g UTSW 1 193,042,115 (GRCm39) missense possibly damaging 0.66
R3162:Camk1g UTSW 1 193,042,115 (GRCm39) missense possibly damaging 0.66
R3162:Camk1g UTSW 1 193,042,115 (GRCm39) missense possibly damaging 0.66
R4638:Camk1g UTSW 1 193,038,667 (GRCm39) missense probably damaging 1.00
R4642:Camk1g UTSW 1 193,038,667 (GRCm39) missense probably damaging 1.00
R4644:Camk1g UTSW 1 193,038,667 (GRCm39) missense probably damaging 1.00
R4756:Camk1g UTSW 1 193,044,393 (GRCm39) missense probably benign 0.03
R4781:Camk1g UTSW 1 193,038,652 (GRCm39) missense probably benign 0.00
R4987:Camk1g UTSW 1 193,030,783 (GRCm39) missense probably damaging 0.99
R5224:Camk1g UTSW 1 193,037,342 (GRCm39) missense probably damaging 1.00
R5407:Camk1g UTSW 1 193,029,680 (GRCm39) splice site probably null
R5932:Camk1g UTSW 1 193,036,347 (GRCm39) missense probably benign 0.25
R6725:Camk1g UTSW 1 193,032,628 (GRCm39) missense possibly damaging 0.80
R7071:Camk1g UTSW 1 193,042,117 (GRCm39) missense probably benign 0.10
R7808:Camk1g UTSW 1 193,032,593 (GRCm39) missense possibly damaging 0.51
R7908:Camk1g UTSW 1 193,042,082 (GRCm39) missense probably damaging 1.00
R8135:Camk1g UTSW 1 193,036,335 (GRCm39) missense possibly damaging 0.79
R8355:Camk1g UTSW 1 193,033,355 (GRCm39) missense probably damaging 1.00
R8737:Camk1g UTSW 1 193,030,794 (GRCm39) critical splice acceptor site probably null
R8811:Camk1g UTSW 1 193,044,408 (GRCm39) missense probably damaging 1.00
R9506:Camk1g UTSW 1 193,030,363 (GRCm39) critical splice donor site probably null
R9680:Camk1g UTSW 1 193,030,483 (GRCm39) missense probably benign 0.00
R9688:Camk1g UTSW 1 193,031,029 (GRCm39) missense probably damaging 1.00
Z1176:Camk1g UTSW 1 193,044,408 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GCACAATACCCACAGCTGTG -3'
(R):5'- AGCACACTGGTATGTCAGATAG -3'

Sequencing Primer
(F):5'- CTGTGGAAATCAAGCTCATTTGCC -3'
(R):5'- CACTGGTATGTCAGATAGGCAGTG -3'
Posted On 2015-01-23