Incidental Mutation 'R2761:Krt31'
ID 254060
Institutional Source Beutler Lab
Gene Symbol Krt31
Ensembl Gene ENSMUSG00000048981
Gene Name keratin 31
Synonyms Kha1, Ha1, MKHA-1, Krt1-1
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R2761 (G1)
Quality Score 225
Status Not validated
Chromosome 11
Chromosomal Location 99937472-99941377 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 99938691 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 301 (T301A)
Ref Sequence ENSEMBL: ENSMUSP00000007318 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000007318]
AlphaFold Q61765
Predicted Effect probably benign
Transcript: ENSMUST00000007318
AA Change: T301A

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000007318
Gene: ENSMUSG00000048981
AA Change: T301A

DomainStartEndE-ValueType
low complexity region 11 26 N/A INTRINSIC
Filament 55 366 2.14e-153 SMART
low complexity region 384 411 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000136820
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.4%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 13 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110002E22Rik T C 3: 137,773,541 (GRCm39) V910A probably damaging Het
1700123K08Rik T C 5: 138,562,436 (GRCm39) T102A possibly damaging Het
Acoxl T C 2: 127,719,733 (GRCm39) Y165H probably benign Het
Alg11 C A 8: 22,558,095 (GRCm39) A469E probably benign Het
Cdh1 T A 8: 107,380,481 (GRCm39) I208N possibly damaging Het
Col11a2 A G 17: 34,270,000 (GRCm39) I477V probably damaging Het
Cpa2 A G 6: 30,554,193 (GRCm39) D271G probably damaging Het
Dzank1 T C 2: 144,355,369 (GRCm39) M109V probably benign Het
Hdac3 A T 18: 38,078,779 (GRCm39) S111T probably benign Het
Kremen1 GGG GGGTGG 11: 5,151,792 (GRCm39) probably benign Het
Rad21 T A 15: 51,846,039 (GRCm39) K10N probably damaging Het
Snap47 T C 11: 59,328,885 (GRCm39) D139G probably benign Het
Tango6 C A 8: 107,425,664 (GRCm39) T408N possibly damaging Het
Other mutations in Krt31
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02313:Krt31 APN 11 99,939,222 (GRCm39) missense probably damaging 1.00
IGL02433:Krt31 APN 11 99,939,221 (GRCm39) missense probably damaging 1.00
R0393:Krt31 UTSW 11 99,941,079 (GRCm39) missense probably damaging 1.00
R0667:Krt31 UTSW 11 99,938,951 (GRCm39) missense probably benign 0.02
R1224:Krt31 UTSW 11 99,940,690 (GRCm39) critical splice donor site probably null
R1544:Krt31 UTSW 11 99,938,699 (GRCm39) missense possibly damaging 0.48
R1891:Krt31 UTSW 11 99,938,634 (GRCm39) missense probably damaging 0.98
R1940:Krt31 UTSW 11 99,939,069 (GRCm39) missense probably benign 0.03
R1987:Krt31 UTSW 11 99,940,406 (GRCm39) missense probably benign 0.00
R2870:Krt31 UTSW 11 99,938,699 (GRCm39) missense possibly damaging 0.82
R2870:Krt31 UTSW 11 99,938,699 (GRCm39) missense possibly damaging 0.82
R3980:Krt31 UTSW 11 99,939,030 (GRCm39) missense probably damaging 0.96
R4809:Krt31 UTSW 11 99,940,748 (GRCm39) missense possibly damaging 0.89
R4822:Krt31 UTSW 11 99,938,610 (GRCm39) missense possibly damaging 0.63
R4931:Krt31 UTSW 11 99,940,983 (GRCm39) missense probably benign 0.05
R6146:Krt31 UTSW 11 99,939,056 (GRCm39) missense probably benign 0.21
R6722:Krt31 UTSW 11 99,939,254 (GRCm39) missense probably damaging 1.00
R6811:Krt31 UTSW 11 99,939,242 (GRCm39) missense probably damaging 1.00
R6996:Krt31 UTSW 11 99,938,558 (GRCm39) missense probably benign 0.19
R7300:Krt31 UTSW 11 99,938,612 (GRCm39) missense probably damaging 0.96
R7548:Krt31 UTSW 11 99,940,346 (GRCm39) missense probably damaging 0.98
R8375:Krt31 UTSW 11 99,938,603 (GRCm39) missense probably benign 0.10
X0028:Krt31 UTSW 11 99,938,534 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGGCCCCTATACGTGTTGATC -3'
(R):5'- TAGTGTCCAGACTGCTGCTGAG -3'

Sequencing Primer
(F):5'- ATACGTGTTGATCTCACACTCCAG -3'
(R):5'- AGAGTCACTGGGGTGTCC -3'
Posted On 2014-12-04