Incidental Mutation 'R2474:Zw10'
ID 253283
Institutional Source Beutler Lab
Gene Symbol Zw10
Ensembl Gene ENSMUSG00000032264
Gene Name zw10 kinetochore protein
Synonyms MmZw10, 6330566F14Rik
MMRRC Submission 040405-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.968) question?
Stock # R2474 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 48966913-48990075 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 48978105 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 351 (I351N)
Ref Sequence ENSEMBL: ENSMUSP00000034803 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034803]
AlphaFold O54692
Predicted Effect probably damaging
Transcript: ENSMUST00000034803
AA Change: I351N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000034803
Gene: ENSMUSG00000032264
AA Change: I351N

DomainStartEndE-ValueType
Pfam:Zw10 9 621 2.1e-249 PFAM
Predicted Effect unknown
Transcript: ENSMUST00000213787
AA Change: I33N
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215706
Meta Mutation Damage Score 0.7382 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 94.9%
Validation Efficiency 100% (32/32)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. This protein is an essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. [provided by RefSeq, Aug 2011]
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrl4 A G 3: 151,248,361 (GRCm39) T678A probably benign Het
Asb7 A T 7: 66,328,901 (GRCm39) N46K probably damaging Het
Atxn7l2 A C 3: 108,111,293 (GRCm39) S414R probably damaging Het
Bckdk C A 7: 127,504,590 (GRCm39) R105S probably damaging Het
Cxcl13 C T 5: 96,107,816 (GRCm39) Q91* probably null Het
Dchs1 T C 7: 105,404,281 (GRCm39) N2754D probably benign Het
Dchs1 A T 7: 105,422,045 (GRCm39) V125E probably damaging Het
Enpep G C 3: 129,077,807 (GRCm39) S603R possibly damaging Het
Greb1 T C 12: 16,764,954 (GRCm39) N393S possibly damaging Het
Hfm1 A T 5: 107,020,282 (GRCm39) V1048D possibly damaging Het
Ilvbl T C 10: 78,412,558 (GRCm39) V93A probably damaging Het
Itpkb A G 1: 180,161,716 (GRCm39) D614G probably damaging Het
Klk14 G A 7: 43,341,501 (GRCm39) C51Y probably damaging Het
Lgi3 G A 14: 70,770,689 (GRCm39) probably null Het
Mpeg1 G A 19: 12,439,613 (GRCm39) C357Y probably damaging Het
Nedd1 A G 10: 92,555,465 (GRCm39) F7L probably damaging Het
Or8g26 A G 9: 39,095,846 (GRCm39) D121G probably damaging Het
Or8k35 C A 2: 86,424,957 (GRCm39) V72F probably benign Het
Parp8 A T 13: 117,029,577 (GRCm39) C510S possibly damaging Het
Phb1 T C 11: 95,562,248 (GRCm39) F42L possibly damaging Het
Pik3r1 A T 13: 101,839,284 (GRCm39) Y189* probably null Het
Rps5 T A 7: 12,660,488 (GRCm39) probably null Het
Secisbp2l C T 2: 125,582,657 (GRCm39) G933D possibly damaging Het
Senp3 T A 11: 69,564,923 (GRCm39) N516Y probably damaging Het
Tfap2b A T 1: 19,284,599 (GRCm39) H169L possibly damaging Het
Tmem260 A G 14: 48,733,781 (GRCm39) D226G probably null Het
Ttc6 G T 12: 57,622,713 (GRCm39) R37S probably benign Het
Vmn2r84 A T 10: 130,222,392 (GRCm39) D609E possibly damaging Het
Vmn2r99 A T 17: 19,598,891 (GRCm39) M192L probably benign Het
Zfp746 T C 6: 48,041,703 (GRCm39) D341G probably damaging Het
Zfp941 A T 7: 140,391,384 (GRCm39) H658Q probably damaging Het
Other mutations in Zw10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01778:Zw10 APN 9 48,980,915 (GRCm39) missense probably benign
IGL02111:Zw10 APN 9 48,980,054 (GRCm39) missense probably damaging 0.98
IGL02673:Zw10 APN 9 48,988,893 (GRCm39) splice site probably null
PIT4382001:Zw10 UTSW 9 48,982,944 (GRCm39) missense probably benign 0.15
R0402:Zw10 UTSW 9 48,980,023 (GRCm39) missense probably benign 0.00
R0736:Zw10 UTSW 9 48,975,432 (GRCm39) missense probably benign 0.00
R1830:Zw10 UTSW 9 48,981,041 (GRCm39) missense probably damaging 1.00
R1966:Zw10 UTSW 9 48,980,133 (GRCm39) missense probably damaging 1.00
R2231:Zw10 UTSW 9 48,975,421 (GRCm39) missense possibly damaging 0.79
R2849:Zw10 UTSW 9 48,968,941 (GRCm39) critical splice acceptor site probably null
R3162:Zw10 UTSW 9 48,988,860 (GRCm39) missense probably damaging 0.98
R3162:Zw10 UTSW 9 48,988,860 (GRCm39) missense probably damaging 0.98
R4893:Zw10 UTSW 9 48,985,325 (GRCm39) missense possibly damaging 0.58
R4927:Zw10 UTSW 9 48,979,983 (GRCm39) missense probably damaging 1.00
R5070:Zw10 UTSW 9 48,988,759 (GRCm39) nonsense probably null
R5214:Zw10 UTSW 9 48,975,463 (GRCm39) missense possibly damaging 0.91
R5637:Zw10 UTSW 9 48,968,950 (GRCm39) missense probably damaging 1.00
R5983:Zw10 UTSW 9 48,988,745 (GRCm39) splice site probably null
R6368:Zw10 UTSW 9 48,984,535 (GRCm39) missense probably damaging 1.00
R6605:Zw10 UTSW 9 48,980,926 (GRCm39) missense probably benign 0.00
R7221:Zw10 UTSW 9 48,981,012 (GRCm39) missense probably benign 0.00
R7292:Zw10 UTSW 9 48,972,491 (GRCm39) missense probably benign 0.00
R7938:Zw10 UTSW 9 48,982,933 (GRCm39) missense probably benign 0.04
R8120:Zw10 UTSW 9 48,985,413 (GRCm39) missense probably benign 0.26
R8376:Zw10 UTSW 9 48,988,783 (GRCm39) missense possibly damaging 0.85
R8471:Zw10 UTSW 9 48,982,914 (GRCm39) missense probably damaging 0.99
R8480:Zw10 UTSW 9 48,986,299 (GRCm39) missense probably benign 0.01
R8735:Zw10 UTSW 9 48,988,861 (GRCm39) missense probably damaging 0.99
R9699:Zw10 UTSW 9 48,966,942 (GRCm39) start gained probably benign
RF007:Zw10 UTSW 9 48,972,220 (GRCm39) missense possibly damaging 0.81
Z1177:Zw10 UTSW 9 48,985,396 (GRCm39) missense probably benign 0.12
Predicted Primers PCR Primer
(F):5'- TGGAAACCTGTTCTGCCTACC -3'
(R):5'- CTTCATCAAAGAGGCAGGAAGC -3'

Sequencing Primer
(F):5'- GTTCTGCCTACCATCTTAAAACTGAG -3'
(R):5'- CCAGTTTAGCCTTGAACTCATAGGG -3'
Posted On 2014-12-04