Incidental Mutation 'R2426:Or6c207'
ID 250234
Institutional Source Beutler Lab
Gene Symbol Or6c207
Ensembl Gene ENSMUSG00000062914
Gene Name olfactory receptor family 6 subfamily C member 207
Synonyms Olfr777, MOR114-9, GA_x6K02T2PULF-10955551-10954616
MMRRC Submission 040388-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.079) question?
Stock # R2426 (G1)
Quality Score 225
Status Not validated
Chromosome 10
Chromosomal Location 129104255-129105190 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 129105135 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Arginine at position 19 (Q19R)
Ref Sequence ENSEMBL: ENSMUSP00000145475 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080313] [ENSMUST00000204573] [ENSMUST00000213512]
AlphaFold Q8VFH3
Predicted Effect probably benign
Transcript: ENSMUST00000080313
AA Change: Q19R

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000079191
Gene: ENSMUSG00000062914
AA Change: Q19R

DomainStartEndE-ValueType
Pfam:7tm_4 28 307 1.4e-42 PFAM
Pfam:7tm_1 38 287 1.5e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000204573
AA Change: Q19R

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000145475
Gene: ENSMUSG00000062914
AA Change: Q19R

DomainStartEndE-ValueType
Pfam:7tm_4 28 307 1.4e-42 PFAM
Pfam:7tm_1 38 287 1.5e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213512
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 93.8%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 67 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca14 G T 7: 119,882,446 (GRCm39) V1203L probably benign Het
Adamtsl1 G A 4: 86,075,025 (GRCm39) V131I probably benign Het
Adgra3 A T 5: 50,166,791 (GRCm39) M187K possibly damaging Het
Agbl1 T C 7: 76,071,650 (GRCm39) V324A probably damaging Het
Ahnak A T 19: 8,980,215 (GRCm39) I500F possibly damaging Het
Aldh1l1 A G 6: 90,575,266 (GRCm39) D851G probably damaging Het
Amot T C X: 144,259,287 (GRCm39) K460E probably damaging Het
Arhgef3 G T 14: 27,106,138 (GRCm39) E161* probably null Het
Atg9b A T 5: 24,591,992 (GRCm39) I669N probably damaging Het
Ccdc83 A G 7: 89,877,639 (GRCm39) Y268H probably damaging Het
Cep170 A G 1: 176,602,201 (GRCm39) S302P probably benign Het
Cyp4a31 T A 4: 115,428,213 (GRCm39) M303K probably damaging Het
Cyp4v3 T A 8: 45,770,813 (GRCm39) Y231F probably benign Het
Defa39 T G 8: 22,192,653 (GRCm39) K114N possibly damaging Het
Dock3 A T 9: 106,791,740 (GRCm39) L1411Q possibly damaging Het
Dsg1a T A 18: 20,469,861 (GRCm39) I629N probably damaging Het
Dst A T 1: 34,231,893 (GRCm39) H2837L probably benign Het
Fam114a2 G A 11: 57,383,906 (GRCm39) P343L probably benign Het
Fbrs A G 7: 127,086,511 (GRCm39) probably null Het
Fbxl13 A C 5: 21,727,135 (GRCm39) D620E probably damaging Het
Frmd4a T A 2: 4,534,673 (GRCm39) S164T probably damaging Het
Gdi2 T G 13: 3,612,034 (GRCm39) S330A probably benign Het
Gm5878 A T 6: 85,095,613 (GRCm39) M70K probably benign Het
H2-Q6 G T 17: 35,643,913 (GRCm39) A21S probably benign Het
Hfm1 A T 5: 106,995,519 (GRCm39) probably null Het
Hnmt C T 2: 23,909,167 (GRCm39) C82Y probably benign Het
Il1rl1 C A 1: 40,485,779 (GRCm39) A310D probably damaging Het
Ints1 A T 5: 139,757,569 (GRCm39) probably null Het
Kcne4 C A 1: 78,795,688 (GRCm39) A112E possibly damaging Het
Krt32 T C 11: 99,977,192 (GRCm39) K236R possibly damaging Het
Maml2 T C 9: 13,617,794 (GRCm39) L380P probably damaging Het
Meis1 A T 11: 18,938,356 (GRCm39) D218E possibly damaging Het
Mon1b G A 8: 114,365,752 (GRCm39) G360D probably damaging Het
Mpp4 A G 1: 59,169,216 (GRCm39) S383P probably damaging Het
Neb A G 2: 52,059,065 (GRCm39) probably null Het
Nlgn2 A T 11: 69,717,912 (GRCm39) I431N probably damaging Het
Nr2e1 A G 10: 42,439,481 (GRCm39) L134P probably damaging Het
Opcml G A 9: 28,814,663 (GRCm39) probably null Het
Or2t29 A T 11: 58,433,920 (GRCm39) Y127* probably null Het
Or7c19 T C 8: 85,957,693 (GRCm39) S190P probably damaging Het
Pate2 A T 9: 35,581,776 (GRCm39) probably null Het
Pgr G A 9: 8,900,718 (GRCm39) V84M probably damaging Het
Pigu A T 2: 155,141,002 (GRCm39) V296D probably damaging Het
Plcb2 G A 2: 118,546,130 (GRCm39) T555M probably damaging Het
Pld5 T G 1: 175,791,542 (GRCm39) D426A probably benign Het
Prdm2 G T 4: 142,838,320 (GRCm39) C1679* probably null Het
Psme2b A T 11: 48,836,890 (GRCm39) V19D probably benign Het
Ptpn9 A T 9: 56,934,712 (GRCm39) N159Y possibly damaging Het
Sanbr T A 11: 23,526,801 (GRCm39) R190W probably damaging Het
Sdc3 A T 4: 130,546,114 (GRCm39) T64S unknown Het
Serping1 T G 2: 84,600,563 (GRCm39) S260R probably damaging Het
Slc20a1 T C 2: 129,050,150 (GRCm39) F436S probably benign Het
Sntb1 A T 15: 55,769,575 (GRCm39) I138N probably damaging Het
Sorcs3 A T 19: 48,711,364 (GRCm39) Y643F probably damaging Het
Spink1 G T 18: 43,868,287 (GRCm39) S23* probably null Het
Stag1 T C 9: 100,727,169 (GRCm39) probably null Het
Tnfaip8l1 G A 17: 56,479,030 (GRCm39) V107I probably benign Het
Tnik A G 3: 28,700,830 (GRCm39) S907G probably damaging Het
Ttf1 T A 2: 28,957,197 (GRCm39) M489K probably damaging Het
Ugcg C T 4: 59,207,798 (GRCm39) P46S probably benign Het
Usp54 G A 14: 20,615,008 (GRCm39) A811V probably benign Het
Xirp2 A G 2: 67,344,815 (GRCm39) N2352S probably benign Het
Zan T C 5: 137,387,254 (GRCm39) Y4933C unknown Het
Zbtb8a A G 4: 129,254,012 (GRCm39) S161P probably benign Het
Zkscan5 A T 5: 145,157,750 (GRCm39) I751L probably benign Het
Zscan4d A G 7: 10,899,022 (GRCm39) F85S probably damaging Het
Zzef1 A G 11: 72,806,091 (GRCm39) M2647V probably benign Het
Other mutations in Or6c207
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01302:Or6c207 APN 10 129,104,392 (GRCm39) missense probably benign 0.18
IGL01782:Or6c207 APN 10 129,104,908 (GRCm39) missense probably benign 0.00
R0554:Or6c207 UTSW 10 129,104,368 (GRCm39) missense probably benign 0.00
R0594:Or6c207 UTSW 10 129,105,021 (GRCm39) missense possibly damaging 0.95
R1792:Or6c207 UTSW 10 129,105,112 (GRCm39) missense probably benign 0.20
R2357:Or6c207 UTSW 10 129,104,642 (GRCm39) missense probably benign 0.31
R3757:Or6c207 UTSW 10 129,104,934 (GRCm39) missense probably damaging 0.99
R3758:Or6c207 UTSW 10 129,104,934 (GRCm39) missense probably damaging 0.99
R3962:Or6c207 UTSW 10 129,104,535 (GRCm39) missense probably damaging 1.00
R4600:Or6c207 UTSW 10 129,104,274 (GRCm39) missense probably benign 0.01
R4603:Or6c207 UTSW 10 129,104,274 (GRCm39) missense probably benign 0.01
R4611:Or6c207 UTSW 10 129,104,274 (GRCm39) missense probably benign 0.01
R5113:Or6c207 UTSW 10 129,104,535 (GRCm39) missense probably damaging 0.98
R6415:Or6c207 UTSW 10 129,104,890 (GRCm39) missense probably benign 0.01
R7540:Or6c207 UTSW 10 129,105,003 (GRCm39) missense probably benign 0.31
R7909:Or6c207 UTSW 10 129,105,136 (GRCm39) missense probably benign 0.00
R8170:Or6c207 UTSW 10 129,104,917 (GRCm39) missense possibly damaging 0.80
R9079:Or6c207 UTSW 10 129,104,466 (GRCm39) missense possibly damaging 0.90
Predicted Primers PCR Primer
(F):5'- GTCACCTGTTGAGATGTTGTATAAG -3'
(R):5'- GCCCTTATGTTTGCCAACCG -3'

Sequencing Primer
(F):5'- TGTATAAGTATCTGGGAATGCAAGC -3'
(R):5'- CTACTCCTGGACAGATATCTC -3'
Posted On 2014-11-12