Incidental Mutation 'R2368:Vstm5'
ID 246402
Institutional Source Beutler Lab
Gene Symbol Vstm5
Ensembl Gene ENSMUSG00000031937
Gene Name V-set and transmembrane domain containing 5
Synonyms 2200002K05Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.077) question?
Stock # R2368 (G1)
Quality Score 225
Status Not validated
Chromosome 9
Chromosomal Location 15150341-15170712 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 15169027 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Leucine at position 166 (M166L)
Ref Sequence ENSEMBL: ENSMUSP00000034413 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034411] [ENSMUST00000034413] [ENSMUST00000213788]
AlphaFold Q9D806
Predicted Effect probably benign
Transcript: ENSMUST00000034411
SMART Domains Protein: ENSMUSP00000034411
Gene: ENSMUSG00000031935

DomainStartEndE-ValueType
low complexity region 51 82 N/A INTRINSIC
Pfam:Med17 123 452 8.5e-13 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000034413
AA Change: M166L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000034413
Gene: ENSMUSG00000031937
AA Change: M166L

DomainStartEndE-ValueType
signal peptide 1 27 N/A INTRINSIC
IG 39 138 2e-3 SMART
transmembrane domain 147 169 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000213788
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.3%
  • 20x: 95.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 18 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arid2 A G 15: 96,247,893 (GRCm39) K102E possibly damaging Het
Bsn G A 9: 107,988,229 (GRCm39) Q2508* probably null Het
Cc2d2a A G 5: 43,861,230 (GRCm39) T549A probably benign Het
Lyst A T 13: 13,871,248 (GRCm39) S2662C probably damaging Het
Nek9 A G 12: 85,376,661 (GRCm39) V240A possibly damaging Het
Nol4l T C 2: 153,259,959 (GRCm39) D165G probably damaging Het
Or10ak12 A G 4: 118,667,019 (GRCm39) V14A probably benign Het
Or14j5 A T 17: 38,161,509 (GRCm39) M9L probably benign Het
Or5p69 A G 7: 107,967,576 (GRCm39) Y293C probably damaging Het
Or8h8 A T 2: 86,753,451 (GRCm39) Y142N probably benign Het
Plin5 T C 17: 56,422,588 (GRCm39) E116G probably damaging Het
Slc35d2 C T 13: 64,277,119 (GRCm39) M1I probably null Het
Srgap1 A T 10: 121,665,194 (GRCm39) S493T probably benign Het
Syt9 T A 7: 107,035,906 (GRCm39) Y308N probably damaging Het
Ttc23l CT CTTGGATT 15: 10,537,648 (GRCm39) probably benign Het
Ttc23l G A 15: 10,537,652 (GRCm39) S206L probably benign Het
Vmn2r74 C T 7: 85,610,522 (GRCm39) D57N probably benign Het
Zbtb12 T C 17: 35,114,674 (GRCm39) L153P possibly damaging Het
Other mutations in Vstm5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01597:Vstm5 APN 9 15,168,675 (GRCm39) missense probably damaging 1.00
IGL01781:Vstm5 APN 9 15,168,968 (GRCm39) missense probably damaging 1.00
IGL02940:Vstm5 APN 9 15,168,962 (GRCm39) missense probably damaging 1.00
R1155:Vstm5 UTSW 9 15,168,849 (GRCm39) missense probably damaging 1.00
R1721:Vstm5 UTSW 9 15,168,663 (GRCm39) missense probably benign 0.13
R3160:Vstm5 UTSW 9 15,168,594 (GRCm39) missense probably benign 0.02
R3161:Vstm5 UTSW 9 15,168,594 (GRCm39) missense probably benign 0.02
R3162:Vstm5 UTSW 9 15,168,594 (GRCm39) missense probably benign 0.02
R4612:Vstm5 UTSW 9 15,168,789 (GRCm39) missense probably benign 0.22
R4692:Vstm5 UTSW 9 15,168,718 (GRCm39) missense probably damaging 0.99
R4950:Vstm5 UTSW 9 15,169,090 (GRCm39) splice site probably null
R5088:Vstm5 UTSW 9 15,168,601 (GRCm39) missense possibly damaging 0.87
R6351:Vstm5 UTSW 9 15,168,829 (GRCm39) missense probably damaging 1.00
R7063:Vstm5 UTSW 9 15,150,549 (GRCm39) start gained probably benign
R7720:Vstm5 UTSW 9 15,150,652 (GRCm39) missense probably benign 0.08
R9300:Vstm5 UTSW 9 15,168,585 (GRCm39) missense probably damaging 1.00
R9491:Vstm5 UTSW 9 15,168,586 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- GTCACTGTCACAGAGCATCC -3'
(R):5'- AAGAGGTTGAAAATCTGTCACCC -3'

Sequencing Primer
(F):5'- TGTGTCTGGTAAGAGAGCCCC -3'
(R):5'- GTTGAAAATCTGTCACCCAGTGG -3'
Posted On 2014-10-30