Incidental Mutation 'R2201:Zscan29'
ID 238637
Institutional Source Beutler Lab
Gene Symbol Zscan29
Ensembl Gene ENSMUSG00000050619
Gene Name zinc finger SCAN domains 29
Synonyms Zfp690
MMRRC Submission 040203-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.159) question?
Stock # R2201 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 120988754-121001606 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 120999883 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Glycine at position 106 (V106G)
Ref Sequence ENSEMBL: ENSMUSP00000125987 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000039541] [ENSMUST00000079024] [ENSMUST00000110657] [ENSMUST00000110658] [ENSMUST00000110661] [ENSMUST00000163766] [ENSMUST00000186659] [ENSMUST00000146243]
AlphaFold E9Q5B4
Predicted Effect probably benign
Transcript: ENSMUST00000039541
SMART Domains Protein: ENSMUSP00000044049
Gene: ENSMUSG00000027263

DomainStartEndE-ValueType
Pfam:Spc97_Spc98 4 573 2.8e-111 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000079024
AA Change: V106G

PolyPhen 2 Score 0.280 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000078033
Gene: ENSMUSG00000050619
AA Change: V106G

DomainStartEndE-ValueType
SCAN 13 125 5.83e-70 SMART
Pfam:Myb_DNA-bind_4 238 323 3e-21 PFAM
Pfam:Myb_DNA-bind_4 399 484 4.1e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000110657
SMART Domains Protein: ENSMUSP00000106285
Gene: ENSMUSG00000027263

DomainStartEndE-ValueType
Pfam:Spc97_Spc98 4 572 3.1e-115 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000110658
SMART Domains Protein: ENSMUSP00000106286
Gene: ENSMUSG00000027263

DomainStartEndE-ValueType
Pfam:Spc97_Spc98 4 572 4.1e-115 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000110661
AA Change: V106G

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000106289
Gene: ENSMUSG00000050619
AA Change: V106G

DomainStartEndE-ValueType
SCAN 13 125 5.83e-70 SMART
Pfam:Myb_DNA-bind_4 238 323 5.4e-21 PFAM
Pfam:Myb_DNA-bind_4 399 484 7.4e-22 PFAM
low complexity region 518 532 N/A INTRINSIC
ZnF_C2H2 665 687 2.99e-4 SMART
ZnF_C2H2 693 715 2.75e-3 SMART
ZnF_C2H2 721 743 8.02e-5 SMART
ZnF_C2H2 749 771 1.13e-4 SMART
ZnF_C2H2 777 799 1.18e-2 SMART
ZnF_C2H2 805 827 1.33e-1 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000130929
Predicted Effect probably damaging
Transcript: ENSMUST00000163766
AA Change: V106G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000125987
Gene: ENSMUSG00000050619
AA Change: V106G

DomainStartEndE-ValueType
SCAN 13 125 5.83e-70 SMART
Pfam:Myb_DNA-bind_4 238 323 5.9e-21 PFAM
Pfam:Myb_DNA-bind_4 434 519 1.3e-21 PFAM
low complexity region 553 567 N/A INTRINSIC
ZnF_C2H2 700 722 2.99e-4 SMART
ZnF_C2H2 728 750 2.75e-3 SMART
ZnF_C2H2 756 778 8.02e-5 SMART
ZnF_C2H2 784 806 1.13e-4 SMART
ZnF_C2H2 812 834 1.18e-2 SMART
ZnF_C2H2 840 862 1.33e-1 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156370
Predicted Effect noncoding transcript
Transcript: ENSMUST00000133773
Predicted Effect noncoding transcript
Transcript: ENSMUST00000144123
Predicted Effect noncoding transcript
Transcript: ENSMUST00000138601
Predicted Effect noncoding transcript
Transcript: ENSMUST00000144076
Predicted Effect noncoding transcript
Transcript: ENSMUST00000135555
Predicted Effect noncoding transcript
Transcript: ENSMUST00000154633
Predicted Effect probably benign
Transcript: ENSMUST00000186659
SMART Domains Protein: ENSMUSP00000140417
Gene: ENSMUSG00000027263

DomainStartEndE-ValueType
Pfam:Spc97_Spc98 4 572 4.1e-115 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000146243
SMART Domains Protein: ENSMUSP00000120997
Gene: ENSMUSG00000050619

DomainStartEndE-ValueType
SCAN 13 118 4.23e-58 SMART
Meta Mutation Damage Score 0.5449 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.9%
Validation Efficiency 98% (59/60)
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2ml1 A T 6: 128,524,268 (GRCm39) N1121K probably null Het
Actr10 A G 12: 71,006,795 (GRCm39) N351D probably damaging Het
Adcy7 G A 8: 89,044,606 (GRCm39) A500T probably damaging Het
Ankrd35 T C 3: 96,586,564 (GRCm39) I80T possibly damaging Het
Arap2 G A 5: 62,864,028 (GRCm39) T532I probably damaging Het
Bag3 AAAGG AAAGGAAGG 7: 128,147,493 (GRCm39) probably null Het
Cc2d2a T C 5: 43,841,375 (GRCm39) probably benign Het
Cep85l A T 10: 53,224,827 (GRCm39) M254K probably benign Het
Clic4 A G 4: 134,950,850 (GRCm39) S114P probably damaging Het
Ctsj T C 13: 61,150,363 (GRCm39) Y213C probably damaging Het
Ddx28 A G 8: 106,737,206 (GRCm39) V284A probably damaging Het
Dnase2b T A 3: 146,290,443 (GRCm39) D176V probably damaging Het
Dsg2 T A 18: 20,729,111 (GRCm39) N663K probably damaging Het
Dst T A 1: 34,235,002 (GRCm39) S3694T possibly damaging Het
Emilin1 T C 5: 31,073,036 (GRCm39) S158P probably benign Het
Eng T C 2: 32,563,752 (GRCm39) probably benign Het
Entrep2 T A 7: 64,409,141 (GRCm39) M418L probably benign Het
Fdxr C A 11: 115,161,208 (GRCm39) V223L probably benign Het
Fhip1b T C 7: 105,037,398 (GRCm39) N395S probably damaging Het
Frem2 T A 3: 53,423,994 (GRCm39) M3148L probably benign Het
Hip1 A T 5: 135,460,584 (GRCm39) D114E probably benign Het
Itga9 T C 9: 118,706,183 (GRCm39) probably benign Het
Kcnt2 T A 1: 140,437,179 (GRCm39) N487K probably damaging Het
Krt6a A G 15: 101,601,606 (GRCm39) F172L probably benign Het
Megf8 C T 7: 25,040,170 (GRCm39) R1034W probably damaging Het
Muc6 C T 7: 141,236,075 (GRCm39) D451N probably damaging Het
Myo5a A G 9: 75,125,225 (GRCm39) T1838A possibly damaging Het
N4bp2l2 A T 5: 150,585,073 (GRCm39) D302E probably damaging Het
Nbeal2 T A 9: 110,459,318 (GRCm39) I1930F probably benign Het
Nhsl3 A G 4: 129,116,432 (GRCm39) V732A probably benign Het
Npas4 A T 19: 5,037,392 (GRCm39) Y301N probably benign Het
Nt5m A G 11: 59,766,741 (GRCm39) K211E probably benign Het
Pfn4 A G 12: 4,824,382 (GRCm39) probably null Het
Pfpl A C 19: 12,407,843 (GRCm39) D698A probably benign Het
Pias1 G T 9: 62,859,137 (GRCm39) H124N possibly damaging Het
Pja2 A T 17: 64,618,162 (GRCm39) probably benign Het
Polr3e T C 7: 120,531,465 (GRCm39) Y185H probably benign Het
Pomc T C 12: 4,010,275 (GRCm39) L172S probably benign Het
Rapgef4 A G 2: 71,875,533 (GRCm39) T129A probably damaging Het
Reep1 T C 6: 71,750,278 (GRCm39) S97P probably damaging Het
Rttn T A 18: 89,029,067 (GRCm39) I595N possibly damaging Het
Sap30 T C 8: 57,938,506 (GRCm39) probably null Het
Slc1a7 T C 4: 107,850,203 (GRCm39) Y105H probably damaging Het
Slc5a5 C T 8: 71,345,102 (GRCm39) M68I probably damaging Het
Stab2 T A 10: 86,776,503 (GRCm39) Y791F probably benign Het
Tdrd1 C A 19: 56,847,094 (GRCm39) H912N probably benign Het
Tdrd1 C A 19: 56,847,093 (GRCm39) S911R probably benign Het
Tgm7 A T 2: 120,929,062 (GRCm39) F278Y probably damaging Het
Tln2 T C 9: 67,283,039 (GRCm39) T310A probably damaging Het
Tmem256 T C 11: 69,730,271 (GRCm39) I93T probably benign Het
Trpm2 G A 10: 77,756,305 (GRCm39) Q1172* probably null Het
Ttll8 A G 15: 88,818,156 (GRCm39) V173A possibly damaging Het
Ubr5 T C 15: 38,002,543 (GRCm39) S1497G possibly damaging Het
Ubr7 G A 12: 102,727,764 (GRCm39) probably null Het
Vmn1r37 T A 6: 66,708,878 (GRCm39) M1K probably null Het
Vmn2r14 A G 5: 109,366,698 (GRCm39) probably null Het
Vmn2r72 T C 7: 85,387,444 (GRCm39) I707V probably benign Het
Vps8 A G 16: 21,395,507 (GRCm39) R1266G probably damaging Het
Wdr87-ps T A 7: 29,235,950 (GRCm39) noncoding transcript Het
Zfhx4 A G 3: 5,307,349 (GRCm39) N192D probably damaging Het
Zfp638 G C 6: 83,906,500 (GRCm39) D222H probably damaging Het
Other mutations in Zscan29
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01935:Zscan29 APN 2 121,000,538 (GRCm39) missense probably damaging 1.00
IGL01938:Zscan29 APN 2 120,996,690 (GRCm39) missense probably benign 0.16
IGL02220:Zscan29 APN 2 120,997,170 (GRCm39) missense probably damaging 0.99
IGL02370:Zscan29 APN 2 120,994,314 (GRCm39) missense probably benign 0.00
IGL02585:Zscan29 APN 2 120,994,357 (GRCm39) nonsense probably null
R0284:Zscan29 UTSW 2 120,997,214 (GRCm39) unclassified probably benign
R0842:Zscan29 UTSW 2 120,991,960 (GRCm39) missense possibly damaging 0.84
R1245:Zscan29 UTSW 2 120,996,984 (GRCm39) missense probably damaging 1.00
R1586:Zscan29 UTSW 2 120,991,641 (GRCm39) missense probably damaging 1.00
R1654:Zscan29 UTSW 2 120,995,260 (GRCm39) missense probably benign 0.06
R1958:Zscan29 UTSW 2 121,000,289 (GRCm39) critical splice donor site probably null
R2073:Zscan29 UTSW 2 120,991,336 (GRCm39) nonsense probably null
R2085:Zscan29 UTSW 2 121,000,427 (GRCm39) nonsense probably null
R2145:Zscan29 UTSW 2 121,000,587 (GRCm39) missense probably damaging 1.00
R2875:Zscan29 UTSW 2 120,994,581 (GRCm39) missense probably damaging 1.00
R2876:Zscan29 UTSW 2 120,994,581 (GRCm39) missense probably damaging 1.00
R3861:Zscan29 UTSW 2 120,991,212 (GRCm39) missense probably benign 0.01
R4244:Zscan29 UTSW 2 120,995,275 (GRCm39) splice site probably null
R4245:Zscan29 UTSW 2 120,995,275 (GRCm39) splice site probably null
R4447:Zscan29 UTSW 2 121,000,367 (GRCm39) splice site probably null
R4662:Zscan29 UTSW 2 120,997,096 (GRCm39) missense probably benign 0.26
R4757:Zscan29 UTSW 2 120,991,392 (GRCm39) missense possibly damaging 0.92
R4777:Zscan29 UTSW 2 120,999,805 (GRCm39) missense probably damaging 0.96
R4905:Zscan29 UTSW 2 120,991,864 (GRCm39) missense possibly damaging 0.53
R4970:Zscan29 UTSW 2 120,999,676 (GRCm39) splice site probably null
R5860:Zscan29 UTSW 2 120,994,518 (GRCm39) missense probably damaging 1.00
R5861:Zscan29 UTSW 2 120,994,518 (GRCm39) missense probably damaging 1.00
R5862:Zscan29 UTSW 2 120,994,518 (GRCm39) missense probably damaging 1.00
R5916:Zscan29 UTSW 2 120,994,518 (GRCm39) missense probably damaging 1.00
R5917:Zscan29 UTSW 2 120,994,518 (GRCm39) missense probably damaging 1.00
R5918:Zscan29 UTSW 2 120,994,518 (GRCm39) missense probably damaging 1.00
R6335:Zscan29 UTSW 2 120,991,917 (GRCm39) missense possibly damaging 0.49
R7214:Zscan29 UTSW 2 120,999,761 (GRCm39) nonsense probably null
R7326:Zscan29 UTSW 2 120,991,469 (GRCm39) missense probably damaging 1.00
R7997:Zscan29 UTSW 2 120,991,221 (GRCm39) missense probably benign 0.01
R8787:Zscan29 UTSW 2 120,996,876 (GRCm39) missense probably damaging 1.00
RF001:Zscan29 UTSW 2 120,994,477 (GRCm39) missense possibly damaging 0.95
Predicted Primers PCR Primer
(F):5'- CTCACCGCTCCTTTGAAAAG -3'
(R):5'- GGGAAGTTTCTTTTCCAGCTGC -3'

Sequencing Primer
(F):5'- AAAAGGTCTGAGATTCTCCTTTGG -3'
(R):5'- CCAGCTGCTATTTGGGTTTC -3'
Posted On 2014-10-02