Mutagenetix > Incidental Mutation

Incidental Mutation 'R2174:Nav2'

237696

Institutional Source

Beutler Lab

Gene Symbol

Nav2

Ensembl Gene

ENSMUSG00000052512

Gene Name

neuron navigator 2

Synonyms

Rainb1, Unc53H2, 5330421F07Rik, POMFIL2, HELAD1, RAINB2

MMRRC Submission

040176-MU

Accession Numbers

Essential gene?

Possibly essential (E-score: 0.571) question?

Stock #

R2174 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

48608796-49259838 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 49102411 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Lysine at position 342 (M342K)

Ref Sequence

ENSEMBL: ENSMUSP00000139309 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000064395] [ENSMUST00000183659] [ENSMUST00000184124] [ENSMUST00000184945]

AlphaFold

E9Q842

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000064383

SMART Domains

Protein: ENSMUSP00000066835
Gene: ENSMUSG00000052512

Domain	Start	End	E-Value	Type
Blast:CH	18	79	2e-35	BLAST
PDB:2YRN\|A	18	80	3e-33	PDB
SCOP:d1dxxa1	29	81	4e-15	SMART
low complexity region	94	102	N/A	INTRINSIC
low complexity region	189	202	N/A	INTRINSIC
low complexity region	229	240	N/A	INTRINSIC
low complexity region	304	316	N/A	INTRINSIC
coiled coil region	378	408	N/A	INTRINSIC
low complexity region	472	483	N/A	INTRINSIC
low complexity region	505	517	N/A	INTRINSIC
low complexity region	532	554	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000064395
AA Change: M403K

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000067448
Gene: ENSMUSG00000052512
AA Change: M403K

Domain	Start	End	E-Value	Type
CH	84	187	1.58e-13	SMART
low complexity region	202	210	N/A	INTRINSIC
low complexity region	297	310	N/A	INTRINSIC
low complexity region	337	348	N/A	INTRINSIC
low complexity region	412	424	N/A	INTRINSIC
coiled coil region	486	516	N/A	INTRINSIC
low complexity region	580	591	N/A	INTRINSIC
low complexity region	613	625	N/A	INTRINSIC
low complexity region	640	662	N/A	INTRINSIC
low complexity region	846	857	N/A	INTRINSIC
low complexity region	920	944	N/A	INTRINSIC
low complexity region	947	967	N/A	INTRINSIC
low complexity region	990	1004	N/A	INTRINSIC
low complexity region	1062	1074	N/A	INTRINSIC
low complexity region	1343	1360	N/A	INTRINSIC
low complexity region	1368	1385	N/A	INTRINSIC
low complexity region	1417	1432	N/A	INTRINSIC
low complexity region	1454	1466	N/A	INTRINSIC
low complexity region	1526	1540	N/A	INTRINSIC
low complexity region	1614	1628	N/A	INTRINSIC
coiled coil region	1630	1717	N/A	INTRINSIC
low complexity region	1789	1800	N/A	INTRINSIC
coiled coil region	1841	1909	N/A	INTRINSIC
AAA	2093	2247	1.69e-5	SMART
low complexity region	2404	2430	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000183659
AA Change: M342K

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000139309
Gene: ENSMUSG00000052512
AA Change: M342K

Domain	Start	End	E-Value	Type
low complexity region	2	11	N/A	INTRINSIC
CH	23	126	6.19e-16	SMART
low complexity region	141	149	N/A	INTRINSIC
low complexity region	236	249	N/A	INTRINSIC
low complexity region	276	287	N/A	INTRINSIC
low complexity region	351	363	N/A	INTRINSIC
coiled coil region	425	455	N/A	INTRINSIC
low complexity region	519	530	N/A	INTRINSIC
low complexity region	552	564	N/A	INTRINSIC
low complexity region	579	601	N/A	INTRINSIC
low complexity region	785	796	N/A	INTRINSIC
low complexity region	859	883	N/A	INTRINSIC
low complexity region	886	906	N/A	INTRINSIC
low complexity region	929	943	N/A	INTRINSIC
low complexity region	1001	1013	N/A	INTRINSIC
low complexity region	1282	1299	N/A	INTRINSIC
low complexity region	1307	1324	N/A	INTRINSIC
low complexity region	1356	1371	N/A	INTRINSIC
low complexity region	1393	1405	N/A	INTRINSIC
low complexity region	1465	1479	N/A	INTRINSIC
low complexity region	1553	1567	N/A	INTRINSIC
coiled coil region	1569	1656	N/A	INTRINSIC
low complexity region	1728	1739	N/A	INTRINSIC
coiled coil region	1780	1848	N/A	INTRINSIC
AAA	2032	2186	1.69e-5	SMART
low complexity region	2343	2369	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000184124

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000184155

Predicted Effect

probably damaging
Transcript: ENSMUST00000184945
AA Change: M403K

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000139045
Gene: ENSMUSG00000052512
AA Change: M403K

Domain	Start	End	E-Value	Type
CH	84	187	1.58e-13	SMART
low complexity region	202	210	N/A	INTRINSIC
low complexity region	297	310	N/A	INTRINSIC
low complexity region	337	348	N/A	INTRINSIC
low complexity region	412	424	N/A	INTRINSIC
coiled coil region	486	516	N/A	INTRINSIC
low complexity region	580	591	N/A	INTRINSIC
low complexity region	613	625	N/A	INTRINSIC
low complexity region	640	662	N/A	INTRINSIC
low complexity region	846	857	N/A	INTRINSIC
low complexity region	920	944	N/A	INTRINSIC
low complexity region	947	967	N/A	INTRINSIC
low complexity region	990	1004	N/A	INTRINSIC
low complexity region	1062	1074	N/A	INTRINSIC
low complexity region	1343	1360	N/A	INTRINSIC
low complexity region	1368	1385	N/A	INTRINSIC
low complexity region	1417	1432	N/A	INTRINSIC
low complexity region	1454	1466	N/A	INTRINSIC
low complexity region	1526	1540	N/A	INTRINSIC
low complexity region	1614	1628	N/A	INTRINSIC
coiled coil region	1630	1717	N/A	INTRINSIC
low complexity region	1789	1800	N/A	INTRINSIC
coiled coil region	1841	1909	N/A	INTRINSIC
AAA	2093	2247	1.69e-5	SMART
low complexity region	2404	2430	N/A	INTRINSIC

Meta Mutation Damage Score

0.2241

Coding Region Coverage

1x: 99.2%
3x: 98.7%
10x: 97.5%
20x: 95.7%

Validation Efficiency

99% (73/74)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the neuron navigator gene family, which may play a role in cellular growth and migration. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
PHENOTYPE: Homozygous null mice display impaired olfaction and hearing, increased latency in a hot plate test, degeneration of the optic nerve, decreased exploration in new environments, and weight loss. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 72 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1600014C10Rik	T	C	7: 37,894,252 (GRCm39)	I95T	possibly damaging	Het
Adarb1	A	G	10: 77,131,632 (GRCm39)	I619T	probably benign	Het
Aldh2	T	C	5: 121,710,731 (GRCm39)		probably benign	Het
Antxrl	T	A	14: 33,782,357 (GRCm39)	L180Q	probably damaging	Het
Asnsd1	A	T	1: 53,386,760 (GRCm39)	I289N	probably benign	Het
Asxl3	T	G	18: 22,586,701 (GRCm39)	S164A	possibly damaging	Het
Cacnb2	C	T	2: 14,963,578 (GRCm39)	T108I	probably benign	Het
Capn2	A	T	1: 182,307,290 (GRCm39)	I516N	probably benign	Het
Ccdc59	A	T	10: 105,677,388 (GRCm39)	K9M	possibly damaging	Het
Cenpo	T	C	12: 4,267,318 (GRCm39)	K73R	probably benign	Het
Cfap20dc	T	C	14: 8,558,109 (GRCm38)	I159V	probably benign	Het
Clasp1	A	G	1: 118,487,825 (GRCm39)	H823R	probably damaging	Het
Col6a4	T	C	9: 105,937,331 (GRCm39)	D1395G	probably damaging	Het
Ddx60	A	G	8: 62,409,175 (GRCm39)	I404V	probably damaging	Het
Ddx60	G	T	8: 62,470,234 (GRCm39)	M1407I	probably benign	Het
Dennd3	A	T	15: 73,427,154 (GRCm39)	R844W	probably damaging	Het
Depdc1b	A	T	13: 108,498,787 (GRCm39)	K157*	probably null	Het
Dnai7	T	C	6: 145,120,896 (GRCm39)	H641R	probably damaging	Het
Dnajc1	T	C	2: 18,312,762 (GRCm39)	D196G	probably damaging	Het
Fanca	A	G	8: 123,998,009 (GRCm39)	W1226R	probably benign	Het
Fbxl13	A	G	5: 21,787,046 (GRCm39)	V297A	possibly damaging	Het
Fnta	A	T	8: 26,503,498 (GRCm39)	F96I	possibly damaging	Het
Fzd3	T	C	14: 65,449,680 (GRCm39)		probably benign	Het
Gckr	T	C	5: 31,484,353 (GRCm39)	V597A	possibly damaging	Het
Gm43302	T	C	5: 105,422,216 (GRCm39)	K496R	probably benign	Het
Gm5283	A	G	3: 17,285,005 (GRCm39)		noncoding transcript	Het
Gm6741	A	G	17: 91,544,332 (GRCm39)	I32V	probably benign	Het
Gnptab	T	A	10: 88,269,906 (GRCm39)	F870I	probably damaging	Het
Gpx8	G	A	13: 113,182,140 (GRCm39)	P98S	probably benign	Het
Grm2	T	C	9: 106,524,994 (GRCm39)	I574V	probably benign	Het
Gtf3c5	T	C	2: 28,457,787 (GRCm39)	D468G	probably benign	Het
Hectd3	A	T	4: 116,856,898 (GRCm39)	M482L	probably benign	Het
Ier5	G	T	1: 154,974,599 (GRCm39)	P193H	possibly damaging	Het
Inpp4a	A	G	1: 37,435,211 (GRCm39)	N827S	probably damaging	Het
Kif13a	A	G	13: 46,922,652 (GRCm39)	L387P	probably damaging	Het
Map3k1	G	C	13: 111,889,016 (GRCm39)	H1314D	possibly damaging	Het
Mbl2	G	A	19: 30,211,412 (GRCm39)	C11Y	possibly damaging	Het
Msr1	A	G	8: 40,084,381 (GRCm39)	L58P	probably damaging	Het
Mtmr10	T	A	7: 63,986,512 (GRCm39)	F530Y	possibly damaging	Het
Myo7b	A	G	18: 32,116,610 (GRCm39)	L999P	probably damaging	Het
Myoz3	T	C	18: 60,723,296 (GRCm39)	E8G	probably benign	Het
Naip6	C	A	13: 100,435,495 (GRCm39)	M1009I	probably benign	Het
Ndufaf6	T	C	4: 11,070,228 (GRCm39)	H131R	probably benign	Het
Nlrp4a	T	C	7: 26,148,849 (GRCm39)	L152P	probably damaging	Het
Or9s23	A	G	1: 92,501,379 (GRCm39)	N162S	probably benign	Het
Pan3	T	C	5: 147,387,463 (GRCm39)	I144T	possibly damaging	Het
Prkdc	A	T	16: 15,552,786 (GRCm39)	Q2074L	probably benign	Het
Pthlh	G	A	6: 147,158,510 (GRCm39)	T150I	probably benign	Het
Ptprq	A	T	10: 107,541,414 (GRCm39)	Y371N	probably damaging	Het
Rfwd3	A	G	8: 112,009,975 (GRCm39)	S377P	probably damaging	Het
Rpl31-ps17	C	T	12: 54,748,397 (GRCm39)		noncoding transcript	Het
Sap130	T	C	18: 31,810,532 (GRCm39)		probably null	Het
Sap25	T	G	5: 137,640,891 (GRCm39)	M229R	possibly damaging	Het
Scaper	A	T	9: 55,766,321 (GRCm39)	V479E	probably null	Het
Scn3a	T	A	2: 65,337,550 (GRCm39)	D649V	probably damaging	Het
Slco1a7	A	T	6: 141,673,319 (GRCm39)	Y406*	probably null	Het
Smc1b	A	G	15: 85,006,052 (GRCm39)		probably benign	Het
Sowahb	T	C	5: 93,192,284 (GRCm39)	E145G	possibly damaging	Het
Stxbp5	T	A	10: 9,711,590 (GRCm39)	I277F	possibly damaging	Het
Tanc1	T	C	2: 59,674,177 (GRCm39)	S1754P	possibly damaging	Het
Tanc2	A	G	11: 105,801,135 (GRCm39)	D1117G	probably benign	Het
Tbc1d31	A	G	15: 57,815,137 (GRCm39)	M605V	possibly damaging	Het
Tekt3	A	T	11: 62,985,514 (GRCm39)	D440V	possibly damaging	Het
Tmem67	C	T	4: 12,063,730 (GRCm39)	W477*	probably null	Het
Tra2a	T	C	6: 49,227,861 (GRCm39)		probably benign	Het
Trappc12	A	G	12: 28,797,380 (GRCm39)	F51L	possibly damaging	Het
Trrap	C	A	5: 144,758,665 (GRCm39)	P2183Q	probably benign	Het
Ubn2	T	A	6: 38,447,076 (GRCm39)		probably null	Het
Unc5d	A	T	8: 29,184,568 (GRCm39)	V644E	probably damaging	Het
Xpo4	A	G	14: 57,827,547 (GRCm39)	L883P	probably damaging	Het
Zbbx	T	G	3: 74,959,721 (GRCm39)	D616A	possibly damaging	Het
Zfp943	T	A	17: 22,211,804 (GRCm39)	C297S	probably damaging	Het

Other mutations in Nav2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01097:Nav2	APN	7	49,220,942 (GRCm39)	missense	probably damaging	1.00
IGL01150:Nav2	APN	7	49,102,269 (GRCm39)	missense	probably benign	0.17
IGL01649:Nav2	APN	7	49,225,477 (GRCm39)	missense	probably damaging	1.00
IGL01662:Nav2	APN	7	49,220,957 (GRCm39)	missense	probably damaging	1.00
IGL02297:Nav2	APN	7	49,243,977 (GRCm39)	missense	probably damaging	0.98
IGL02313:Nav2	APN	7	49,208,521 (GRCm39)	missense	probably damaging	0.99
IGL02441:Nav2	APN	7	49,102,260 (GRCm39)	missense	probably damaging	1.00
IGL02472:Nav2	APN	7	49,195,789 (GRCm39)	missense	probably damaging	1.00
IGL02477:Nav2	APN	7	49,232,623 (GRCm39)	missense	probably damaging	0.99
IGL02725:Nav2	APN	7	49,214,843 (GRCm39)	missense	probably damaging	1.00
IGL02944:Nav2	APN	7	49,070,004 (GRCm39)	missense	probably damaging	0.99
IGL02953:Nav2	APN	7	49,198,171 (GRCm39)	missense	probably damaging	1.00
IGL03105:Nav2	APN	7	49,114,627 (GRCm39)	missense	probably damaging	1.00
IGL03234:Nav2	APN	7	49,111,756 (GRCm39)	missense	possibly damaging	0.94
IGL03274:Nav2	APN	7	49,011,847 (GRCm39)	missense	probably damaging	1.00
IGL03294:Nav2	APN	7	49,141,205 (GRCm39)	nonsense	probably null
R0006:Nav2	UTSW	7	49,102,978 (GRCm39)	missense	possibly damaging	0.50
R0070:Nav2	UTSW	7	49,220,462 (GRCm39)	missense	probably damaging	1.00
R0113:Nav2	UTSW	7	49,185,701 (GRCm39)	missense	probably damaging	1.00
R0306:Nav2	UTSW	7	49,195,651 (GRCm39)	missense	probably benign	0.01
R0346:Nav2	UTSW	7	49,254,333 (GRCm39)	missense	probably benign	0.11
R0539:Nav2	UTSW	7	49,111,686 (GRCm39)	missense	probably damaging	1.00
R0669:Nav2	UTSW	7	49,058,431 (GRCm39)	missense	probably damaging	1.00
R0785:Nav2	UTSW	7	49,070,081 (GRCm39)	missense	probably benign	0.06
R0970:Nav2	UTSW	7	49,233,901 (GRCm39)	missense	probably damaging	1.00
R1162:Nav2	UTSW	7	49,185,788 (GRCm39)	splice site	probably benign
R1274:Nav2	UTSW	7	49,254,178 (GRCm39)	nonsense	probably null
R1463:Nav2	UTSW	7	49,185,710 (GRCm39)	missense	probably damaging	1.00
R1464:Nav2	UTSW	7	49,011,952 (GRCm39)	missense	probably damaging	1.00
R1464:Nav2	UTSW	7	49,011,952 (GRCm39)	missense	probably damaging	1.00
R1536:Nav2	UTSW	7	49,195,682 (GRCm39)	missense	probably damaging	1.00
R1612:Nav2	UTSW	7	49,220,959 (GRCm39)	missense	probably damaging	1.00
R1638:Nav2	UTSW	7	49,102,213 (GRCm39)	missense	probably benign
R1731:Nav2	UTSW	7	49,197,922 (GRCm39)	missense	probably damaging	1.00
R1734:Nav2	UTSW	7	49,225,468 (GRCm39)	missense	probably damaging	1.00
R1865:Nav2	UTSW	7	49,197,943 (GRCm39)	missense	possibly damaging	0.95
R1945:Nav2	UTSW	7	49,114,620 (GRCm39)	missense	probably damaging	1.00
R1997:Nav2	UTSW	7	49,198,219 (GRCm39)	missense	probably benign	0.16
R2061:Nav2	UTSW	7	49,248,645 (GRCm39)	splice site	probably benign
R2117:Nav2	UTSW	7	49,114,328 (GRCm39)	missense	probably benign	0.00
R2182:Nav2	UTSW	7	49,247,002 (GRCm39)	missense	probably benign	0.38
R2251:Nav2	UTSW	7	49,103,025 (GRCm39)	missense	probably damaging	1.00
R2283:Nav2	UTSW	7	49,141,152 (GRCm39)	missense	probably damaging	1.00
R2343:Nav2	UTSW	7	49,248,565 (GRCm39)	missense	possibly damaging	0.82
R2472:Nav2	UTSW	7	49,058,632 (GRCm39)	missense	probably benign
R2568:Nav2	UTSW	7	49,247,312 (GRCm39)	missense	probably damaging	1.00
R2656:Nav2	UTSW	7	49,195,690 (GRCm39)	missense	probably damaging	1.00
R2964:Nav2	UTSW	7	49,206,780 (GRCm39)	missense	probably damaging	1.00
R2966:Nav2	UTSW	7	49,206,780 (GRCm39)	missense	probably damaging	1.00
R3817:Nav2	UTSW	7	49,114,310 (GRCm39)	missense	probably benign	0.00
R3834:Nav2	UTSW	7	49,195,606 (GRCm39)	missense	possibly damaging	0.91
R4207:Nav2	UTSW	7	49,246,979 (GRCm39)	missense	probably damaging	1.00
R4207:Nav2	UTSW	7	49,222,046 (GRCm39)	splice site	probably null
R4411:Nav2	UTSW	7	49,047,857 (GRCm39)	missense	probably benign	0.37
R4413:Nav2	UTSW	7	49,047,857 (GRCm39)	missense	probably benign	0.37
R4440:Nav2	UTSW	7	49,225,011 (GRCm39)	splice site	probably benign
R4440:Nav2	UTSW	7	49,201,785 (GRCm39)	missense	possibly damaging	0.86
R4454:Nav2	UTSW	7	49,198,292 (GRCm39)	splice site	probably null
R4729:Nav2	UTSW	7	49,102,567 (GRCm39)	missense	probably benign	0.17
R4801:Nav2	UTSW	7	49,195,600 (GRCm39)	missense	possibly damaging	0.94
R4802:Nav2	UTSW	7	49,195,600 (GRCm39)	missense	possibly damaging	0.94
R4824:Nav2	UTSW	7	49,058,749 (GRCm39)	intron	probably benign
R4887:Nav2	UTSW	7	49,198,182 (GRCm39)	nonsense	probably null
R4908:Nav2	UTSW	7	49,254,258 (GRCm39)	missense	probably damaging	1.00
R4952:Nav2	UTSW	7	48,954,288 (GRCm39)	intron	probably benign
R4965:Nav2	UTSW	7	49,202,625 (GRCm39)	nonsense	probably null
R5169:Nav2	UTSW	7	49,198,231 (GRCm39)	nonsense	probably null
R5224:Nav2	UTSW	7	49,201,473 (GRCm39)	missense	probably benign	0.00
R5249:Nav2	UTSW	7	49,185,661 (GRCm39)	missense	probably damaging	1.00
R5285:Nav2	UTSW	7	49,197,982 (GRCm39)	missense	probably damaging	1.00
R5314:Nav2	UTSW	7	49,058,440 (GRCm39)	small deletion	probably benign
R5320:Nav2	UTSW	7	49,141,121 (GRCm39)	missense	probably benign	0.00
R5377:Nav2	UTSW	7	49,238,908 (GRCm39)	missense	probably benign	0.02
R5471:Nav2	UTSW	7	49,197,917 (GRCm39)	missense	probably damaging	1.00
R5754:Nav2	UTSW	7	49,206,794 (GRCm39)	missense	probably damaging	1.00
R5832:Nav2	UTSW	7	49,197,817 (GRCm39)	splice site	probably null
R5884:Nav2	UTSW	7	49,246,917 (GRCm39)	nonsense	probably null
R5921:Nav2	UTSW	7	48,954,324 (GRCm39)	intron	probably benign
R6180:Nav2	UTSW	7	49,107,915 (GRCm39)	missense	probably benign	0.39
R6208:Nav2	UTSW	7	49,213,851 (GRCm39)	missense	probably damaging	0.99
R6373:Nav2	UTSW	7	49,102,923 (GRCm39)	missense	probably damaging	1.00
R6450:Nav2	UTSW	7	49,244,114 (GRCm39)	missense	probably damaging	1.00
R6522:Nav2	UTSW	7	49,247,281 (GRCm39)	missense	probably damaging	1.00
R6626:Nav2	UTSW	7	49,244,100 (GRCm39)	missense	probably damaging	1.00
R6695:Nav2	UTSW	7	49,114,652 (GRCm39)	missense	probably benign	0.04
R6705:Nav2	UTSW	7	49,201,664 (GRCm39)	missense	probably damaging	1.00
R6842:Nav2	UTSW	7	49,107,917 (GRCm39)	missense	possibly damaging	0.91
R6847:Nav2	UTSW	7	49,141,204 (GRCm39)	missense	probably benign	0.14
R7287:Nav2	UTSW	7	49,070,076 (GRCm39)	missense	probably benign	0.01
R7312:Nav2	UTSW	7	49,111,672 (GRCm39)	missense	possibly damaging	0.55
R7315:Nav2	UTSW	7	49,198,037 (GRCm39)	missense	possibly damaging	0.61
R7337:Nav2	UTSW	7	49,201,521 (GRCm39)	missense	possibly damaging	0.56
R7366:Nav2	UTSW	7	49,203,951 (GRCm39)	splice site	probably null
R7451:Nav2	UTSW	7	49,202,577 (GRCm39)	splice site	probably null
R7545:Nav2	UTSW	7	49,232,605 (GRCm39)	missense	probably damaging	1.00
R7706:Nav2	UTSW	7	49,244,067 (GRCm39)	missense	probably benign	0.35
R7730:Nav2	UTSW	7	49,222,145 (GRCm39)	missense	probably damaging	1.00
R7812:Nav2	UTSW	7	49,246,921 (GRCm39)	missense	probably benign	0.13
R8097:Nav2	UTSW	7	49,237,525 (GRCm39)	missense	probably damaging	1.00
R8110:Nav2	UTSW	7	49,201,698 (GRCm39)	nonsense	probably null
R8119:Nav2	UTSW	7	49,103,232 (GRCm39)	missense	probably damaging	0.99
R8298:Nav2	UTSW	7	49,204,009 (GRCm39)	critical splice donor site	probably null
R8306:Nav2	UTSW	7	49,195,765 (GRCm39)	missense	probably benign	0.33
R8331:Nav2	UTSW	7	49,102,371 (GRCm39)	missense	probably benign
R8402:Nav2	UTSW	7	49,103,185 (GRCm39)	missense	probably benign	0.43
R8421:Nav2	UTSW	7	49,102,269 (GRCm39)	missense	probably benign
R8478:Nav2	UTSW	7	49,111,733 (GRCm39)	missense	probably damaging	0.99
R8724:Nav2	UTSW	7	49,141,184 (GRCm39)	missense	possibly damaging	0.82
R8753:Nav2	UTSW	7	49,102,320 (GRCm39)	missense	probably benign
R8835:Nav2	UTSW	7	49,248,551 (GRCm39)	missense	possibly damaging	0.83
R8933:Nav2	UTSW	7	49,111,705 (GRCm39)	missense	probably damaging	1.00
R8957:Nav2	UTSW	7	49,220,964 (GRCm39)	missense	probably damaging	1.00
R9069:Nav2	UTSW	7	49,208,561 (GRCm39)	missense	probably damaging	0.99
R9095:Nav2	UTSW	7	49,254,293 (GRCm39)	missense	probably damaging	1.00
R9223:Nav2	UTSW	7	49,202,599 (GRCm39)	missense	probably damaging	1.00
R9261:Nav2	UTSW	7	49,246,904 (GRCm39)	missense	probably damaging	1.00
X0023:Nav2	UTSW	7	49,197,647 (GRCm39)	missense	possibly damaging	0.47
Z1177:Nav2	UTSW	7	49,243,971 (GRCm39)	missense	probably benign	0.01
Z1177:Nav2	UTSW	7	49,102,509 (GRCm39)	missense	possibly damaging	0.47

Predicted Primers

PCR Primer
(F):5'- AAAATGTCCCTGCGCCCTTG -3'
(R):5'- GCCCTTGAGTGCAATCTTGG -3'

Sequencing Primer
(F):5'- TTGGAGAACAGCCCTTCCGTC -3'
(R):5'- AGTGCAATCTTGGGGCTGC -3'

Posted On

2014-10-02