Incidental Mutation 'R2150:Nek9'
ID 234216
Institutional Source Beutler Lab
Gene Symbol Nek9
Ensembl Gene ENSMUSG00000034290
Gene Name NIMA (never in mitosis gene a)-related expressed kinase 9
Synonyms C130021H08Rik
MMRRC Submission 040153-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R2150 (G1)
Quality Score 225
Status Validated
Chromosome 12
Chromosomal Location 85346288-85386136 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 85376677 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tryptophan to Arginine at position 235 (W235R)
Ref Sequence ENSEMBL: ENSMUSP00000049056 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000040992]
AlphaFold Q8K1R7
Predicted Effect probably damaging
Transcript: ENSMUST00000040992
AA Change: W235R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000049056
Gene: ENSMUSG00000034290
AA Change: W235R

DomainStartEndE-ValueType
low complexity region 19 49 N/A INTRINSIC
S_TKc 52 308 1.07e-73 SMART
Pfam:RCC1 389 441 1.2e-9 PFAM
Pfam:RCC1_2 428 457 1.5e-8 PFAM
Pfam:RCC1 444 495 3.6e-13 PFAM
Pfam:RCC1_2 482 511 3.6e-11 PFAM
Pfam:RCC1 499 547 7.6e-14 PFAM
Pfam:RCC1 615 665 4.2e-8 PFAM
Pfam:RCC1_2 652 681 4.4e-7 PFAM
low complexity region 752 767 N/A INTRINSIC
low complexity region 889 900 N/A INTRINSIC
low complexity region 910 927 N/A INTRINSIC
Meta Mutation Damage Score 0.9753 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.6%
Validation Efficiency 98% (59/60)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. The encoded protein is activated in mitosis and, in turn, activates other family members during mitosis. This protein also mediates cellular processes that are essential for interphase progression. [provided by RefSeq, Jul 2016]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933402J07Rik C T 8: 88,312,691 (GRCm39) Q159* probably null Het
Abca12 C A 1: 71,302,647 (GRCm39) V2191L probably benign Het
Adam34 A G 8: 44,105,538 (GRCm39) Y36H probably benign Het
Adprm A G 11: 66,929,055 (GRCm39) V312A probably benign Het
Anapc2 T C 2: 25,162,682 (GRCm39) L52P probably benign Het
Anxa2 TCCC TCC 9: 69,397,036 (GRCm39) probably null Het
Apoc4 T A 7: 19,412,560 (GRCm39) T62S probably damaging Het
Arfgef1 C T 1: 10,270,103 (GRCm39) A349T probably benign Het
Arhgap32 A G 9: 32,027,436 (GRCm39) E2G possibly damaging Het
Atg4c C A 4: 99,109,463 (GRCm39) N143K possibly damaging Het
C1qtnf12 A G 4: 156,050,922 (GRCm39) N297S probably benign Het
Cadps2 G T 6: 23,838,998 (GRCm39) probably benign Het
Ccdc63 C G 5: 122,265,628 (GRCm39) A71P possibly damaging Het
Cdca2 T C 14: 67,952,258 (GRCm39) K38E probably damaging Het
Cyp2j11 G A 4: 96,204,595 (GRCm39) T317I probably damaging Het
Dab2 T C 15: 6,446,398 (GRCm39) V5A probably benign Het
Dennd3 A T 15: 73,426,909 (GRCm39) H762L probably benign Het
Disp1 A G 1: 182,869,936 (GRCm39) F828S probably damaging Het
Dnah2 T C 11: 69,406,587 (GRCm39) M552V probably benign Het
Dock2 A G 11: 34,179,472 (GRCm39) probably null Het
Dsel A T 1: 111,787,987 (GRCm39) N849K probably benign Het
Fah A T 7: 84,244,042 (GRCm39) I239N probably damaging Het
Flt4 T C 11: 49,536,824 (GRCm39) Y1265H probably benign Het
Ghdc T C 11: 100,660,018 (GRCm39) E243G probably benign Het
Glb1 T C 9: 114,279,716 (GRCm39) Y375H probably damaging Het
Gm6619 A G 6: 131,466,021 (GRCm39) I40V probably benign Het
Gpld1 T C 13: 25,146,630 (GRCm39) V225A probably benign Het
Hectd4 T C 5: 121,391,921 (GRCm39) probably benign Het
Igdcc4 A G 9: 65,032,617 (GRCm39) I542V possibly damaging Het
Igsf9b T C 9: 27,245,633 (GRCm39) L1200P probably damaging Het
Itgb7 C T 15: 102,130,553 (GRCm39) V378M probably damaging Het
Krt84 T C 15: 101,438,019 (GRCm39) E312G possibly damaging Het
Man2a2 A G 7: 80,017,532 (GRCm39) W250R probably damaging Het
Mcam T C 9: 44,047,932 (GRCm39) V59A probably damaging Het
Mfrp T C 9: 44,015,015 (GRCm39) L314P probably benign Het
Mgat5 T C 1: 127,396,987 (GRCm39) V578A probably damaging Het
Mycbp2 G A 14: 103,393,358 (GRCm39) H3068Y probably damaging Het
Myh1 A C 11: 67,113,234 (GRCm39) D1873A probably benign Het
Or9g19 T C 2: 85,600,342 (GRCm39) S66P probably damaging Het
Parvb A G 15: 84,116,369 (GRCm39) K33E possibly damaging Het
Pecr T C 1: 72,316,517 (GRCm39) R63G possibly damaging Het
Pkhd1l1 T G 15: 44,363,378 (GRCm39) probably null Het
Plekha5 T C 6: 140,516,129 (GRCm39) V270A probably damaging Het
Prr14l T C 5: 32,988,046 (GRCm39) D483G probably benign Het
Rimkla T A 4: 119,331,779 (GRCm39) M140L possibly damaging Het
Senp1 C T 15: 97,956,196 (GRCm39) V408I possibly damaging Het
Stambpl1 T A 19: 34,204,104 (GRCm39) Y65N probably damaging Het
Tada2a T C 11: 83,970,455 (GRCm39) D432G probably damaging Het
Themis T A 10: 28,544,723 (GRCm39) I23N probably damaging Het
Thnsl1 T C 2: 21,217,344 (GRCm39) I366T probably benign Het
Tmem131 C A 1: 36,851,690 (GRCm39) V938L probably benign Het
Tmem178b A T 6: 40,184,435 (GRCm39) Q111L probably damaging Het
Vmn1r195 C G 13: 22,462,934 (GRCm39) L135V possibly damaging Het
Vmn2r-ps36 C T 7: 7,431,539 (GRCm39) noncoding transcript Het
Zfp956 G A 6: 47,940,805 (GRCm39) R388H probably damaging Het
Zfr2 T G 10: 81,077,950 (GRCm39) V259G probably benign Het
Other mutations in Nek9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01431:Nek9 APN 12 85,361,361 (GRCm39) missense probably benign 0.23
IGL01595:Nek9 APN 12 85,361,194 (GRCm39) missense probably damaging 1.00
IGL01603:Nek9 APN 12 85,352,379 (GRCm39) missense probably damaging 1.00
IGL01893:Nek9 APN 12 85,383,174 (GRCm39) missense probably damaging 1.00
IGL02017:Nek9 APN 12 85,376,697 (GRCm39) missense probably damaging 1.00
IGL02197:Nek9 APN 12 85,354,704 (GRCm39) missense probably null
IGL02207:Nek9 APN 12 85,350,257 (GRCm39) nonsense probably null
IGL02749:Nek9 APN 12 85,352,281 (GRCm39) missense probably benign 0.02
IGL02756:Nek9 APN 12 85,358,110 (GRCm39) critical splice donor site probably null
IGL03343:Nek9 APN 12 85,350,383 (GRCm39) missense probably damaging 1.00
Rose_colored UTSW 12 85,350,311 (GRCm39) missense probably damaging 1.00
R0048:Nek9 UTSW 12 85,348,673 (GRCm39) missense probably benign 0.17
R0331:Nek9 UTSW 12 85,374,149 (GRCm39) splice site probably benign
R0499:Nek9 UTSW 12 85,348,657 (GRCm39) missense probably benign 0.09
R1484:Nek9 UTSW 12 85,348,622 (GRCm39) missense probably damaging 1.00
R1760:Nek9 UTSW 12 85,357,184 (GRCm39) missense probably benign 0.00
R1760:Nek9 UTSW 12 85,352,364 (GRCm39) missense possibly damaging 0.71
R1883:Nek9 UTSW 12 85,379,330 (GRCm39) missense probably damaging 1.00
R1884:Nek9 UTSW 12 85,379,330 (GRCm39) missense probably damaging 1.00
R1999:Nek9 UTSW 12 85,376,677 (GRCm39) missense probably damaging 1.00
R2046:Nek9 UTSW 12 85,367,481 (GRCm39) splice site probably benign
R2096:Nek9 UTSW 12 85,361,322 (GRCm39) missense probably benign 0.00
R2368:Nek9 UTSW 12 85,376,661 (GRCm39) missense possibly damaging 0.89
R2570:Nek9 UTSW 12 85,379,320 (GRCm39) nonsense probably null
R4381:Nek9 UTSW 12 85,376,632 (GRCm39) missense probably damaging 1.00
R4570:Nek9 UTSW 12 85,367,508 (GRCm39) missense probably damaging 1.00
R4661:Nek9 UTSW 12 85,367,666 (GRCm39) missense possibly damaging 0.78
R4669:Nek9 UTSW 12 85,360,978 (GRCm39) missense probably benign 0.00
R4993:Nek9 UTSW 12 85,357,194 (GRCm39) missense probably damaging 1.00
R5071:Nek9 UTSW 12 85,374,233 (GRCm39) missense possibly damaging 0.70
R5090:Nek9 UTSW 12 85,376,616 (GRCm39) critical splice donor site probably null
R5248:Nek9 UTSW 12 85,355,751 (GRCm39) missense probably damaging 1.00
R5521:Nek9 UTSW 12 85,374,219 (GRCm39) missense probably benign 0.09
R5734:Nek9 UTSW 12 85,350,289 (GRCm39) missense probably benign
R6039:Nek9 UTSW 12 85,359,859 (GRCm39) missense probably benign 0.08
R6039:Nek9 UTSW 12 85,359,859 (GRCm39) missense probably benign 0.08
R6269:Nek9 UTSW 12 85,379,103 (GRCm39) splice site probably null
R6353:Nek9 UTSW 12 85,348,603 (GRCm39) missense probably damaging 0.96
R6406:Nek9 UTSW 12 85,385,946 (GRCm39) missense probably damaging 0.97
R6744:Nek9 UTSW 12 85,376,703 (GRCm39) missense probably benign 0.09
R6922:Nek9 UTSW 12 85,350,311 (GRCm39) missense probably damaging 1.00
R7603:Nek9 UTSW 12 85,350,288 (GRCm39) missense probably benign 0.00
R7686:Nek9 UTSW 12 85,350,433 (GRCm39) missense probably benign 0.01
R7905:Nek9 UTSW 12 85,352,370 (GRCm39) missense probably damaging 1.00
R7964:Nek9 UTSW 12 85,385,787 (GRCm39) missense probably benign 0.02
R8165:Nek9 UTSW 12 85,350,417 (GRCm39) missense probably benign 0.01
R8330:Nek9 UTSW 12 85,376,727 (GRCm39) missense probably damaging 1.00
R8802:Nek9 UTSW 12 85,374,192 (GRCm39) missense probably benign 0.19
R8859:Nek9 UTSW 12 85,353,120 (GRCm39) missense probably damaging 1.00
R8997:Nek9 UTSW 12 85,367,565 (GRCm39) missense probably benign 0.00
R9055:Nek9 UTSW 12 85,348,616 (GRCm39) missense probably damaging 0.99
R9261:Nek9 UTSW 12 85,359,841 (GRCm39) missense probably damaging 1.00
R9661:Nek9 UTSW 12 85,361,253 (GRCm39) missense possibly damaging 0.96
X0052:Nek9 UTSW 12 85,368,801 (GRCm39) critical splice donor site probably null
Z1177:Nek9 UTSW 12 85,380,819 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- TACTACAGGTGATTTCTGTTCAGG -3'
(R):5'- CACTTGAGACCTTGAGTTGGC -3'

Sequencing Primer
(F):5'- TGTTCAGGAAATCAGAATTTTAGGAG -3'
(R):5'- GCAACCTGCTAATAAGTGTTTCCTG -3'
Posted On 2014-10-01