Incidental Mutation 'R2127:Pappa'
| ID |
227595 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Pappa
|
| Ensembl Gene |
ENSMUSG00000028370 |
| Gene Name |
pregnancy-associated plasma protein A |
| Synonyms |
PAPP-A, PAG1, 8430414N03Rik, IGFBP-4ase |
| MMRRC Submission |
040130-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R2127 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
4 |
| Chromosomal Location |
65042411-65275746 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 65215494 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Leucine to Methionine
at position 1134
(L1134M)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000081545
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000084501]
|
| AlphaFold |
Q8R4K8 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000084501
AA Change: L1134M
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000081545
Gene: ENSMUSG00000028370
AA Change: L1134M
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
|
low complexity region
|
24 |
66 |
N/A |
INTRINSIC |
|
low complexity region
|
69 |
87 |
N/A |
INTRINSIC |
|
LamGL
|
114 |
263 |
1.55e-54 |
SMART |
|
NL
|
396 |
438 |
4.15e-8 |
SMART |
|
NL
|
441 |
471 |
6.73e-1 |
SMART |
|
Pfam:Peptidase_M43
|
500 |
657 |
2.5e-10 |
PFAM |
|
Blast:FN3
|
669 |
929 |
1e-165 |
BLAST |
|
CCP
|
1212 |
1277 |
1.39e-9 |
SMART |
|
CCP
|
1282 |
1339 |
1.08e-6 |
SMART |
|
CCP
|
1343 |
1407 |
1.64e-6 |
SMART |
|
CCP
|
1412 |
1468 |
8.06e-6 |
SMART |
|
NL
|
1544 |
1581 |
3.24e-10 |
SMART |
|
low complexity region
|
1584 |
1591 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.6467 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.7%
- 10x: 97.5%
- 20x: 95.9%
|
| Validation Efficiency |
98% (93/95) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null mutants are smaller than normal with delayed ossification, but are otherwise normal and fertile. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 93 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930449I24Rik |
T |
A |
5: 146,441,752 (GRCm39) |
S300T |
possibly damaging |
Het |
| A2ml1 |
A |
C |
6: 128,535,400 (GRCm39) |
V770G |
probably damaging |
Het |
| Abca6 |
A |
G |
11: 110,110,475 (GRCm39) |
I558T |
probably benign |
Het |
| Abhd17c |
C |
A |
7: 83,759,870 (GRCm39) |
G295W |
probably damaging |
Het |
| Actn3 |
G |
A |
19: 4,921,703 (GRCm39) |
A159V |
probably damaging |
Het |
| Adgrv1 |
A |
T |
13: 81,705,199 (GRCm39) |
F1537Y |
probably damaging |
Het |
| Agbl1 |
G |
T |
7: 76,069,628 (GRCm39) |
V373F |
possibly damaging |
Het |
| Aldh1a1 |
A |
T |
19: 20,620,279 (GRCm39) |
E485D |
probably benign |
Het |
| Amdhd2 |
A |
G |
17: 24,377,282 (GRCm39) |
|
probably null |
Het |
| Armc3 |
A |
G |
2: 19,206,622 (GRCm39) |
D15G |
probably damaging |
Het |
| Atp2b2 |
A |
G |
6: 113,737,611 (GRCm39) |
L921P |
probably damaging |
Het |
| Btbd16 |
A |
G |
7: 130,386,038 (GRCm39) |
N88S |
probably benign |
Het |
| Capn10 |
T |
A |
1: 92,865,756 (GRCm39) |
C77* |
probably null |
Het |
| Caskin1 |
T |
C |
17: 24,715,970 (GRCm39) |
|
probably null |
Het |
| Catsper4 |
T |
C |
4: 133,941,117 (GRCm39) |
D254G |
probably benign |
Het |
| Catsperg1 |
T |
C |
7: 28,884,465 (GRCm39) |
D958G |
probably damaging |
Het |
| Ccar2 |
T |
G |
14: 70,377,100 (GRCm39) |
K787Q |
probably benign |
Het |
| Ccdc191 |
C |
T |
16: 43,728,998 (GRCm39) |
T244I |
probably benign |
Het |
| Cd33 |
A |
T |
7: 43,179,699 (GRCm39) |
L243Q |
possibly damaging |
Het |
| Cdc37 |
T |
C |
9: 21,061,143 (GRCm39) |
Y4C |
probably damaging |
Het |
| Cenpe |
T |
G |
3: 134,945,541 (GRCm39) |
N1018K |
probably benign |
Het |
| Crocc |
G |
A |
4: 140,744,407 (GRCm39) |
R1830C |
probably damaging |
Het |
| Csmd1 |
T |
C |
8: 15,967,392 (GRCm39) |
D3157G |
probably damaging |
Het |
| Dhx57 |
C |
T |
17: 80,580,477 (GRCm39) |
V492M |
probably damaging |
Het |
| Dnah2 |
A |
T |
11: 69,349,011 (GRCm39) |
I2486N |
probably benign |
Het |
| Dnhd1 |
C |
T |
7: 105,342,928 (GRCm39) |
T1424I |
possibly damaging |
Het |
| Dsc3 |
C |
T |
18: 20,101,411 (GRCm39) |
A661T |
probably benign |
Het |
| F930015N05Rik |
A |
G |
11: 64,326,229 (GRCm39) |
|
probably benign |
Het |
| Fbxo34 |
C |
A |
14: 47,767,563 (GRCm39) |
R308S |
probably damaging |
Het |
| Gm10608 |
CAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGA |
CAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGA |
9: 118,989,784 (GRCm39) |
|
probably benign |
Het |
| Gm11595 |
A |
T |
11: 99,663,327 (GRCm39) |
C118S |
unknown |
Het |
| Gm9742 |
A |
T |
13: 8,085,011 (GRCm39) |
|
noncoding transcript |
Het |
| Gmeb2 |
G |
A |
2: 180,900,842 (GRCm39) |
A185V |
probably benign |
Het |
| Gpr15 |
A |
G |
16: 58,538,618 (GRCm39) |
V157A |
possibly damaging |
Het |
| Gpr3 |
C |
T |
4: 132,937,932 (GRCm39) |
A247T |
probably damaging |
Het |
| Grin2b |
A |
C |
6: 135,755,698 (GRCm39) |
S539A |
probably benign |
Het |
| Hmbs |
T |
C |
9: 44,252,004 (GRCm39) |
T92A |
probably benign |
Het |
| Inpp4a |
A |
G |
1: 37,406,000 (GRCm39) |
M173V |
probably benign |
Het |
| Irx4 |
T |
A |
13: 73,413,595 (GRCm39) |
S22T |
probably benign |
Het |
| Jph3 |
C |
T |
8: 122,511,881 (GRCm39) |
A623V |
probably benign |
Het |
| Kif1b |
G |
A |
4: 149,272,097 (GRCm39) |
S1568L |
possibly damaging |
Het |
| Ksr1 |
G |
A |
11: 78,924,139 (GRCm39) |
S361L |
probably damaging |
Het |
| Lyst |
T |
G |
13: 13,809,847 (GRCm39) |
Y506D |
probably damaging |
Het |
| Mctp1 |
A |
G |
13: 76,972,941 (GRCm39) |
D648G |
probably damaging |
Het |
| Megf8 |
T |
C |
7: 25,064,007 (GRCm39) |
S2788P |
possibly damaging |
Het |
| Mfsd2b |
T |
A |
12: 4,917,659 (GRCm39) |
Y129F |
probably benign |
Het |
| Mindy4 |
T |
C |
6: 55,195,250 (GRCm39) |
S155P |
probably benign |
Het |
| Mospd4 |
A |
G |
18: 46,598,731 (GRCm39) |
|
noncoding transcript |
Het |
| Myo18b |
A |
T |
5: 112,978,944 (GRCm39) |
L1223Q |
probably damaging |
Het |
| Nckipsd |
A |
G |
9: 108,688,932 (GRCm39) |
T156A |
probably benign |
Het |
| Ndst1 |
G |
A |
18: 60,824,280 (GRCm39) |
T799I |
probably benign |
Het |
| Npffr2 |
A |
T |
5: 89,715,924 (GRCm39) |
I84F |
probably damaging |
Het |
| Nphp3 |
G |
A |
9: 103,885,442 (GRCm39) |
V167M |
probably damaging |
Het |
| Nup107 |
C |
A |
10: 117,610,380 (GRCm39) |
R354L |
possibly damaging |
Het |
| Olfml2a |
T |
C |
2: 38,831,699 (GRCm39) |
C93R |
probably damaging |
Het |
| Or12e10 |
A |
G |
2: 87,640,685 (GRCm39) |
I174V |
probably benign |
Het |
| Or1e25 |
C |
G |
11: 73,493,631 (GRCm39) |
S75C |
possibly damaging |
Het |
| Or5l14 |
A |
T |
2: 87,793,176 (GRCm39) |
V20D |
probably benign |
Het |
| Plscr4 |
T |
G |
9: 92,370,683 (GRCm39) |
F217V |
possibly damaging |
Het |
| Pnpla8 |
T |
A |
12: 44,354,840 (GRCm39) |
Y667N |
probably benign |
Het |
| Polg |
A |
G |
7: 79,114,676 (GRCm39) |
L95P |
probably damaging |
Het |
| Psg20 |
T |
G |
7: 18,416,643 (GRCm39) |
I158L |
probably damaging |
Het |
| Pwwp2a |
A |
G |
11: 43,596,145 (GRCm39) |
S437G |
probably benign |
Het |
| Rdx |
A |
G |
9: 51,981,032 (GRCm39) |
M305V |
possibly damaging |
Het |
| Rinl |
A |
G |
7: 28,496,168 (GRCm39) |
E383G |
probably damaging |
Het |
| Ror1 |
A |
G |
4: 100,299,290 (GRCm39) |
M888V |
probably benign |
Het |
| Rps12 |
A |
T |
10: 23,662,776 (GRCm39) |
I22K |
possibly damaging |
Het |
| Rtca |
C |
A |
3: 116,291,323 (GRCm39) |
R219L |
possibly damaging |
Het |
| Ryr2 |
G |
A |
13: 11,727,081 (GRCm39) |
P2427S |
probably damaging |
Het |
| Slc10a6 |
A |
G |
5: 103,756,922 (GRCm39) |
Y281H |
probably benign |
Het |
| Slc39a11 |
A |
G |
11: 113,260,629 (GRCm39) |
S176P |
probably benign |
Het |
| Slfn10-ps |
A |
G |
11: 82,921,168 (GRCm39) |
|
noncoding transcript |
Het |
| Spef2 |
T |
C |
15: 9,729,747 (GRCm39) |
T124A |
possibly damaging |
Het |
| Sult2a4 |
G |
T |
7: 13,649,185 (GRCm39) |
P207Q |
probably damaging |
Het |
| Tas1r3 |
G |
A |
4: 155,944,927 (GRCm39) |
R765C |
probably damaging |
Het |
| Tcstv1a |
T |
C |
13: 120,355,282 (GRCm39) |
T117A |
probably damaging |
Het |
| Tha1 |
A |
G |
11: 117,760,600 (GRCm39) |
V208A |
probably damaging |
Het |
| Tmbim4 |
T |
A |
10: 120,060,658 (GRCm39) |
I215N |
probably damaging |
Het |
| Tmem202 |
T |
A |
9: 59,427,483 (GRCm39) |
I122F |
probably benign |
Het |
| Tomm70a |
T |
C |
16: 56,942,234 (GRCm39) |
S4P |
unknown |
Het |
| Tpcn2 |
A |
G |
7: 144,827,712 (GRCm39) |
|
probably benign |
Het |
| Trim36 |
A |
T |
18: 46,345,404 (GRCm39) |
F10I |
probably benign |
Het |
| Usp30 |
A |
G |
5: 114,249,224 (GRCm39) |
E176G |
probably damaging |
Het |
| Usp8 |
T |
G |
2: 126,579,495 (GRCm39) |
|
probably null |
Het |
| Vmn1r32 |
T |
A |
6: 66,530,533 (GRCm39) |
Y81F |
probably benign |
Het |
| Vps36 |
G |
T |
8: 22,708,305 (GRCm39) |
|
probably null |
Het |
| Wdr87-ps |
T |
C |
7: 29,236,565 (GRCm39) |
|
noncoding transcript |
Het |
| Wnt3 |
A |
G |
11: 103,703,474 (GRCm39) |
H319R |
possibly damaging |
Het |
| Zfp319 |
A |
T |
8: 96,050,391 (GRCm39) |
|
probably benign |
Het |
| Zfp408 |
T |
C |
2: 91,475,519 (GRCm39) |
E545G |
probably damaging |
Het |
| Zfp799 |
C |
T |
17: 33,038,472 (GRCm39) |
R598Q |
possibly damaging |
Het |
| Zfp831 |
T |
C |
2: 174,489,917 (GRCm39) |
V1228A |
probably benign |
Het |
| Zfp938 |
T |
C |
10: 82,061,876 (GRCm39) |
D248G |
probably benign |
Het |
|
| Other mutations in Pappa |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01096:Pappa
|
APN |
4 |
65,107,553 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01340:Pappa
|
APN |
4 |
65,242,109 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
IGL01482:Pappa
|
APN |
4 |
65,074,271 (GRCm39) |
missense |
probably benign |
0.18 |
|
IGL01485:Pappa
|
APN |
4 |
65,107,536 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL01759:Pappa
|
APN |
4 |
65,123,395 (GRCm39) |
splice site |
probably null |
|
|
IGL01860:Pappa
|
APN |
4 |
65,123,329 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
IGL01990:Pappa
|
APN |
4 |
65,074,924 (GRCm39) |
splice site |
probably benign |
|
|
IGL02089:Pappa
|
APN |
4 |
65,074,361 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
IGL02153:Pappa
|
APN |
4 |
65,215,674 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02184:Pappa
|
APN |
4 |
65,258,928 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL02324:Pappa
|
APN |
4 |
65,115,045 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02542:Pappa
|
APN |
4 |
65,094,518 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02556:Pappa
|
APN |
4 |
65,074,863 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
IGL02698:Pappa
|
APN |
4 |
65,099,257 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02903:Pappa
|
APN |
4 |
65,180,217 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02974:Pappa
|
APN |
4 |
65,123,172 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03107:Pappa
|
APN |
4 |
65,122,940 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03376:Pappa
|
APN |
4 |
65,115,071 (GRCm39) |
missense |
probably benign |
0.01 |
|
caer
|
UTSW |
4 |
65,043,128 (GRCm39) |
missense |
probably damaging |
0.98 |
|
Maennel
|
UTSW |
4 |
65,232,824 (GRCm39) |
missense |
probably benign |
0.05 |
|
maennelein
|
UTSW |
4 |
65,233,033 (GRCm39) |
splice site |
probably null |
|
|
mama
|
UTSW |
4 |
65,123,104 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
Revisitation
|
UTSW |
4 |
65,212,705 (GRCm39) |
missense |
probably damaging |
0.96 |
|
Sesquester
|
UTSW |
4 |
65,074,612 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
untersuchen
|
UTSW |
4 |
65,215,494 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02980:Pappa
|
UTSW |
4 |
65,226,011 (GRCm39) |
missense |
probably benign |
0.25 |
|
PIT4498001:Pappa
|
UTSW |
4 |
65,234,469 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0077:Pappa
|
UTSW |
4 |
65,226,049 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0390:Pappa
|
UTSW |
4 |
65,269,850 (GRCm39) |
splice site |
probably null |
|
|
R0458:Pappa
|
UTSW |
4 |
65,074,119 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0883:Pappa
|
UTSW |
4 |
65,107,552 (GRCm39) |
nonsense |
probably null |
|
|
R0946:Pappa
|
UTSW |
4 |
65,233,029 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1228:Pappa
|
UTSW |
4 |
65,258,926 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1327:Pappa
|
UTSW |
4 |
65,269,840 (GRCm39) |
splice site |
probably benign |
|
|
R1489:Pappa
|
UTSW |
4 |
65,099,185 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R1619:Pappa
|
UTSW |
4 |
65,094,466 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1856:Pappa
|
UTSW |
4 |
65,258,980 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2047:Pappa
|
UTSW |
4 |
65,149,378 (GRCm39) |
splice site |
probably benign |
|
|
R2102:Pappa
|
UTSW |
4 |
65,234,465 (GRCm39) |
nonsense |
probably null |
|
|
R2143:Pappa
|
UTSW |
4 |
65,099,186 (GRCm39) |
nonsense |
probably null |
|
|
R2144:Pappa
|
UTSW |
4 |
65,099,186 (GRCm39) |
nonsense |
probably null |
|
|
R2166:Pappa
|
UTSW |
4 |
65,074,682 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2167:Pappa
|
UTSW |
4 |
65,074,682 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2168:Pappa
|
UTSW |
4 |
65,074,682 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2178:Pappa
|
UTSW |
4 |
65,269,924 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2504:Pappa
|
UTSW |
4 |
65,099,126 (GRCm39) |
nonsense |
probably null |
|
|
R4043:Pappa
|
UTSW |
4 |
65,232,824 (GRCm39) |
missense |
probably benign |
0.05 |
|
R4289:Pappa
|
UTSW |
4 |
65,074,100 (GRCm39) |
missense |
probably benign |
0.19 |
|
R4415:Pappa
|
UTSW |
4 |
65,223,532 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4529:Pappa
|
UTSW |
4 |
65,149,419 (GRCm39) |
missense |
probably benign |
|
|
R4620:Pappa
|
UTSW |
4 |
65,245,265 (GRCm39) |
missense |
probably benign |
0.43 |
|
R4657:Pappa
|
UTSW |
4 |
65,233,033 (GRCm39) |
splice site |
probably null |
|
|
R4658:Pappa
|
UTSW |
4 |
65,233,033 (GRCm39) |
splice site |
probably null |
|
|
R5074:Pappa
|
UTSW |
4 |
65,123,365 (GRCm39) |
missense |
probably benign |
0.15 |
|
R5200:Pappa
|
UTSW |
4 |
65,074,076 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5420:Pappa
|
UTSW |
4 |
65,254,017 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5469:Pappa
|
UTSW |
4 |
65,123,389 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5651:Pappa
|
UTSW |
4 |
65,074,589 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5725:Pappa
|
UTSW |
4 |
65,107,647 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5941:Pappa
|
UTSW |
4 |
65,232,830 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R6002:Pappa
|
UTSW |
4 |
65,215,645 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6252:Pappa
|
UTSW |
4 |
65,107,649 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6303:Pappa
|
UTSW |
4 |
65,122,891 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6322:Pappa
|
UTSW |
4 |
65,232,896 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6431:Pappa
|
UTSW |
4 |
65,074,701 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6462:Pappa
|
UTSW |
4 |
65,043,128 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6484:Pappa
|
UTSW |
4 |
65,232,896 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6537:Pappa
|
UTSW |
4 |
65,215,519 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6578:Pappa
|
UTSW |
4 |
65,074,374 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R6704:Pappa
|
UTSW |
4 |
65,123,161 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6789:Pappa
|
UTSW |
4 |
65,099,278 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7023:Pappa
|
UTSW |
4 |
65,269,955 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7139:Pappa
|
UTSW |
4 |
65,107,687 (GRCm39) |
missense |
probably benign |
0.30 |
|
R7158:Pappa
|
UTSW |
4 |
65,123,104 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7165:Pappa
|
UTSW |
4 |
65,180,110 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7196:Pappa
|
UTSW |
4 |
65,242,128 (GRCm39) |
splice site |
probably null |
|
|
R7410:Pappa
|
UTSW |
4 |
65,253,956 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7457:Pappa
|
UTSW |
4 |
65,107,503 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7506:Pappa
|
UTSW |
4 |
65,149,419 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7546:Pappa
|
UTSW |
4 |
65,074,352 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R7975:Pappa
|
UTSW |
4 |
65,212,705 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8111:Pappa
|
UTSW |
4 |
65,180,229 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8260:Pappa
|
UTSW |
4 |
65,234,419 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8347:Pappa
|
UTSW |
4 |
65,245,302 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8520:Pappa
|
UTSW |
4 |
65,254,001 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8812:Pappa
|
UTSW |
4 |
65,123,166 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R8815:Pappa
|
UTSW |
4 |
65,099,347 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9008:Pappa
|
UTSW |
4 |
65,074,426 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9162:Pappa
|
UTSW |
4 |
65,123,040 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9170:Pappa
|
UTSW |
4 |
65,258,962 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9205:Pappa
|
UTSW |
4 |
65,074,612 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R9336:Pappa
|
UTSW |
4 |
65,042,918 (GRCm39) |
missense |
unknown |
|
|
R9389:Pappa
|
UTSW |
4 |
65,099,125 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9781:Pappa
|
UTSW |
4 |
65,043,104 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
RF006:Pappa
|
UTSW |
4 |
65,242,110 (GRCm39) |
missense |
probably benign |
0.00 |
|
RF020:Pappa
|
UTSW |
4 |
65,123,282 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
X0058:Pappa
|
UTSW |
4 |
65,074,469 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0060:Pappa
|
UTSW |
4 |
65,043,178 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1177:Pappa
|
UTSW |
4 |
65,225,995 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- AAGTCCCTGTAGCAACGTGG -3'
(R):5'- GGTTGCTTACCTCTGCTCAG -3'
Sequencing Primer
(F):5'- CCATAGATGAGGGTGGCCATTTG -3'
(R):5'- AGGGCTGTAGGTCTCTCCTC -3'
|
| Posted On |
2014-09-17 |
Incidental Mutation