Incidental Mutation 'R2072:Or4c35'
ID 227197
Institutional Source Beutler Lab
Gene Symbol Or4c35
Ensembl Gene ENSMUSG00000042894
Gene Name olfactory receptor family 4 subfamily C member 35
Synonyms GA_x6K02T2Q125-51409740-51410672, Olfr1260, MOR232-2
MMRRC Submission 040077-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.150) question?
Stock # R2072 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 89808124-89809056 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 89808557 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Lysine at position 145 (T145K)
Ref Sequence ENSEMBL: ENSMUSP00000151110 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000061830] [ENSMUST00000111512] [ENSMUST00000144710] [ENSMUST00000214630] [ENSMUST00000216678]
AlphaFold Q8VGN9
Predicted Effect probably benign
Transcript: ENSMUST00000061830
AA Change: T145K

PolyPhen 2 Score 0.026 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000053523
Gene: ENSMUSG00000042894
AA Change: T145K

DomainStartEndE-ValueType
Pfam:7tm_4 29 303 2.7e-45 PFAM
Pfam:7tm_1 39 285 1.7e-15 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000111512
AA Change: T145K

PolyPhen 2 Score 0.026 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000107137
Gene: ENSMUSG00000042894
AA Change: T145K

DomainStartEndE-ValueType
Pfam:7tm_1 39 285 7.4e-27 PFAM
Pfam:7tm_4 137 278 2.4e-38 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000141685
Predicted Effect noncoding transcript
Transcript: ENSMUST00000144613
Predicted Effect probably benign
Transcript: ENSMUST00000144710
AA Change: T145K

PolyPhen 2 Score 0.026 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000119512
Gene: ENSMUSG00000042894
AA Change: T145K

DomainStartEndE-ValueType
Pfam:7tm_1 39 121 4.2e-14 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213162
Predicted Effect probably benign
Transcript: ENSMUST00000214630
AA Change: T145K

PolyPhen 2 Score 0.040 (Sensitivity: 0.94; Specificity: 0.83)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216744
Predicted Effect probably benign
Transcript: ENSMUST00000216678
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.3%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 76 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
0610040J01Rik G C 5: 64,056,080 (GRCm39) R272P possibly damaging Het
Ablim3 A T 18: 61,990,159 (GRCm39) D83E possibly damaging Het
Aco1 G A 4: 40,183,605 (GRCm39) G508S probably damaging Het
Adamts13 C A 2: 26,895,437 (GRCm39) T1176N probably benign Het
Adgre5 T C 8: 84,454,433 (GRCm39) T357A probably benign Het
Akap8l C T 17: 32,551,457 (GRCm39) R511H probably damaging Het
Ankrd33 T C 15: 101,017,517 (GRCm39) V310A probably benign Het
Armh3 A T 19: 45,953,820 (GRCm39) I188K probably damaging Het
Bnipl C T 3: 95,151,522 (GRCm39) G232E probably damaging Het
Btbd17 A T 11: 114,682,778 (GRCm39) probably null Het
Cacna1s G A 1: 136,007,242 (GRCm39) V173I probably benign Het
Ccdc122 T C 14: 77,306,391 (GRCm39) probably null Het
Ces1a T A 8: 93,774,703 (GRCm39) N12Y probably benign Het
Chrdl1 T C X: 142,086,414 (GRCm39) I231V probably benign Het
Ciita C T 16: 10,336,217 (GRCm39) T958I probably benign Het
Cnot1 G T 8: 96,466,461 (GRCm39) T1592K possibly damaging Het
Dcaf15 T C 8: 84,828,370 (GRCm39) D240G probably damaging Het
Dlgap1 C T 17: 70,969,765 (GRCm39) R524C probably damaging Het
Dmd G C X: 83,356,089 (GRCm39) A2257P probably benign Het
Dsg1c A G 18: 20,408,309 (GRCm39) M453V probably benign Het
Ednrb G T 14: 104,054,535 (GRCm39) N432K probably benign Het
Fcgbp G A 7: 27,819,814 (GRCm39) G2514S probably damaging Het
Fez1 A G 9: 36,779,241 (GRCm39) K306R probably benign Het
Fmo4 A G 1: 162,637,456 (GRCm39) V12A probably benign Het
Fpgt T C 3: 154,793,511 (GRCm39) Y172C probably damaging Het
Fsip2 T A 2: 82,839,159 (GRCm39) F6976I possibly damaging Het
Galnt12 C T 4: 47,108,477 (GRCm39) R205* probably null Het
Grik5 A T 7: 24,714,738 (GRCm39) M752K possibly damaging Het
Herc2 A G 7: 55,876,712 (GRCm39) N4516S probably damaging Het
Ifrd2 A T 9: 107,469,744 (GRCm39) D439V probably damaging Het
Igsf3 A G 3: 101,346,831 (GRCm39) T609A probably benign Het
Kif5a T C 10: 127,081,238 (GRCm39) D232G probably damaging Het
Lgi2 A G 5: 52,695,847 (GRCm39) S371P probably damaging Het
Marchf3 A T 18: 56,944,925 (GRCm39) V56E possibly damaging Het
Mib2 T C 4: 155,744,158 (GRCm39) D168G probably damaging Het
Nhs T A X: 160,625,717 (GRCm39) H544L probably damaging Het
Nlrp2 A G 7: 5,328,005 (GRCm39) S683P probably damaging Het
Onecut3 T G 10: 80,330,848 (GRCm39) L3V unknown Het
Or12j2 T C 7: 139,916,566 (GRCm39) S264P possibly damaging Het
Or5b102 A T 19: 13,041,044 (GRCm39) M90L probably benign Het
Otogl C T 10: 107,616,904 (GRCm39) C1791Y probably damaging Het
Paip1 T C 13: 119,566,798 (GRCm39) V128A possibly damaging Het
Pcnx2 A T 8: 126,488,481 (GRCm39) C1688S possibly damaging Het
Pdzd2 A G 15: 12,385,905 (GRCm39) L955P probably damaging Het
Phlpp2 T C 8: 110,655,124 (GRCm39) S605P possibly damaging Het
Pkhd1l1 G T 15: 44,422,035 (GRCm39) A3102S probably damaging Het
Plxnb2 G T 15: 89,042,654 (GRCm39) R1545S probably damaging Het
Ppp4c T C 7: 126,386,520 (GRCm39) probably null Het
Prune1 C T 3: 95,162,719 (GRCm39) R318Q probably benign Het
Psg27 T C 7: 18,294,342 (GRCm39) D355G probably damaging Het
Psg27 A G 7: 18,298,934 (GRCm39) L129P probably benign Het
Psmc6 A G 14: 45,567,323 (GRCm39) K7E possibly damaging Het
Reln A T 5: 22,124,175 (GRCm39) V2777E probably damaging Het
Rigi A T 4: 40,224,069 (GRCm39) probably null Het
Scn11a G T 9: 119,640,274 (GRCm39) A207E possibly damaging Het
Slc5a5 C T 8: 71,345,083 (GRCm39) G75R possibly damaging Het
Smarcd2 A T 11: 106,156,133 (GRCm39) L42* probably null Het
Smg1 T C 7: 117,762,389 (GRCm39) probably benign Het
Smurf2 T A 11: 106,732,595 (GRCm39) Q335L probably benign Het
Sspo A T 6: 48,450,451 (GRCm39) H2580L probably benign Het
Stk3 T C 15: 34,959,195 (GRCm39) M256V possibly damaging Het
Syt1 A G 10: 108,419,833 (GRCm39) I276T probably damaging Het
Syt10 C T 15: 89,674,979 (GRCm39) D456N probably damaging Het
Taar9 A T 10: 23,984,877 (GRCm39) C186S probably damaging Het
Tnrc6b C T 15: 80,767,166 (GRCm39) P977L possibly damaging Het
Trp53bp2 A G 1: 182,286,432 (GRCm39) T1091A probably benign Het
Ttn G T 2: 76,768,120 (GRCm39) T2947N probably damaging Het
Ube2q1 T C 3: 89,686,878 (GRCm39) probably null Het
Ube3c A G 5: 29,840,638 (GRCm39) E671G probably benign Het
Upf3a A G 8: 13,835,850 (GRCm39) K56R possibly damaging Het
Vmn2r15 A T 5: 109,434,619 (GRCm39) M695K possibly damaging Het
Vmn2r3 A T 3: 64,182,493 (GRCm39) M402K possibly damaging Het
Zfp354b T A 11: 50,813,279 (GRCm39) R549* probably null Het
Zfp37 A T 4: 62,109,945 (GRCm39) M411K probably damaging Het
Zfp747 T A 7: 126,973,142 (GRCm39) T343S possibly damaging Het
Zfp853 T A 5: 143,275,137 (GRCm39) Q161L unknown Het
Other mutations in Or4c35
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01548:Or4c35 APN 2 89,808,883 (GRCm39) missense possibly damaging 0.69
IGL01657:Or4c35 APN 2 89,808,221 (GRCm39) missense probably damaging 1.00
IGL01942:Or4c35 APN 2 89,808,322 (GRCm39) missense probably benign 0.03
IGL02139:Or4c35 APN 2 89,808,773 (GRCm39) missense possibly damaging 0.80
IGL02926:Or4c35 APN 2 89,808,506 (GRCm39) missense probably damaging 1.00
IGL03110:Or4c35 APN 2 89,808,493 (GRCm39) missense probably damaging 1.00
IGL03368:Or4c35 APN 2 89,808,133 (GRCm39) missense probably benign
R0046:Or4c35 UTSW 2 89,808,851 (GRCm39) missense probably damaging 1.00
R0046:Or4c35 UTSW 2 89,808,851 (GRCm39) missense probably damaging 1.00
R0087:Or4c35 UTSW 2 89,808,475 (GRCm39) missense probably damaging 1.00
R0599:Or4c35 UTSW 2 89,808,545 (GRCm39) missense probably benign 0.01
R1208:Or4c35 UTSW 2 89,808,836 (GRCm39) missense probably damaging 0.99
R1208:Or4c35 UTSW 2 89,808,836 (GRCm39) missense probably damaging 0.99
R1424:Or4c35 UTSW 2 89,808,415 (GRCm39) nonsense probably null
R1503:Or4c35 UTSW 2 89,808,872 (GRCm39) missense probably damaging 0.99
R1708:Or4c35 UTSW 2 89,808,382 (GRCm39) missense probably benign 0.00
R1863:Or4c35 UTSW 2 89,808,754 (GRCm39) missense probably benign 0.02
R1866:Or4c35 UTSW 2 89,808,671 (GRCm39) missense probably damaging 1.00
R2219:Or4c35 UTSW 2 89,808,256 (GRCm39) missense possibly damaging 0.62
R4606:Or4c35 UTSW 2 89,808,350 (GRCm39) missense possibly damaging 0.79
R4674:Or4c35 UTSW 2 89,808,250 (GRCm39) missense possibly damaging 0.52
R4825:Or4c35 UTSW 2 89,808,497 (GRCm39) missense probably damaging 1.00
R5822:Or4c35 UTSW 2 89,808,787 (GRCm39) missense probably damaging 1.00
R6487:Or4c35 UTSW 2 89,808,182 (GRCm39) missense probably benign 0.31
R6706:Or4c35 UTSW 2 89,808,929 (GRCm39) missense probably damaging 0.96
R7961:Or4c35 UTSW 2 89,808,131 (GRCm39) missense probably benign
R8812:Or4c35 UTSW 2 89,808,715 (GRCm39) missense possibly damaging 0.94
R9504:Or4c35 UTSW 2 89,808,497 (GRCm39) missense probably damaging 1.00
R9618:Or4c35 UTSW 2 89,808,343 (GRCm39) missense probably benign 0.00
X0050:Or4c35 UTSW 2 89,808,360 (GRCm39) missense possibly damaging 0.94
Predicted Primers PCR Primer
(F):5'- TAGATGGCTGCTGCTCTTCC -3'
(R):5'- CTGTTGGCAGCAACAAAGAGTC -3'

Sequencing Primer
(F):5'- TGGCCCCCAAAATGATATTTGAC -3'
(R):5'- CCAAAGATGTGGTTGTCAGTGCAG -3'
Posted On 2014-09-17