Incidental Mutation 'R1990:Or5p66'
ID 224916
Institutional Source Beutler Lab
Gene Symbol Or5p66
Ensembl Gene ENSMUSG00000109884
Gene Name olfactory receptor family 5 subfamily P member 66
Synonyms Olfr490, GA_x6K02T2PBJ9-10617173-10616229, MOR204-17
Accession Numbers
Essential gene? Probably non essential (E-score: 0.164) question?
Stock # R1990 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 107885387-107886331 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) C to A at 107885566 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glycine to Stop codon at position 256 (G256*)
Ref Sequence ENSEMBL: ENSMUSP00000147922 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000210114] [ENSMUST00000211345]
AlphaFold Q8VFD2
Predicted Effect probably null
Transcript: ENSMUST00000074550
AA Change: G256*
SMART Domains Protein: ENSMUSP00000074137
Gene: ENSMUSG00000093808
AA Change: G256*

DomainStartEndE-ValueType
Pfam:7tm_4 34 311 4e-53 PFAM
Pfam:7tm_1 44 293 5e-23 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000210114
AA Change: G256*
Predicted Effect probably null
Transcript: ENSMUST00000211345
AA Change: G256*
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.7%
  • 20x: 93.5%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 97 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110002E22Rik C T 3: 137,771,419 (GRCm39) R203* probably null Het
Acp6 T C 3: 97,083,054 (GRCm39) L355P probably damaging Het
Aebp2 T C 6: 140,579,464 (GRCm39) S234P probably damaging Het
Anapc7 A G 5: 122,577,567 (GRCm39) D374G probably benign Het
Apob A T 12: 8,051,039 (GRCm39) I1088F probably damaging Het
Arid4b T C 13: 14,307,021 (GRCm39) V92A probably damaging Het
Armc3 T C 2: 19,297,953 (GRCm39) Y575H probably damaging Het
Asxl2 G T 12: 3,534,558 (GRCm39) G252* probably null Het
Atl1 A T 12: 70,010,102 (GRCm39) K556M probably damaging Het
AU018091 A G 7: 3,212,104 (GRCm39) V206A probably benign Het
Bcas1 A T 2: 170,212,397 (GRCm39) D383E possibly damaging Het
Bmx A G X: 163,015,192 (GRCm39) W257R probably benign Het
Bpifb6 T C 2: 153,747,270 (GRCm39) probably null Het
Cacna1b G A 2: 24,622,318 (GRCm39) P222L probably damaging Het
Cand1 A G 10: 119,045,972 (GRCm39) S978P probably damaging Het
Cap2 T A 13: 46,791,357 (GRCm39) Y175N possibly damaging Het
Caps2 G A 10: 112,036,591 (GRCm39) A384T probably benign Het
Catsperg2 A T 7: 29,420,470 (GRCm39) Y223* probably null Het
Cd81 G T 7: 142,620,938 (GRCm39) G206* probably null Het
Cd84 A G 1: 171,700,317 (GRCm39) T145A possibly damaging Het
Cdkn2aip G T 8: 48,165,211 (GRCm39) N167K probably benign Het
Ceacam14 T A 7: 17,549,290 (GRCm39) L227* probably null Het
Ceacam5 A T 7: 17,491,805 (GRCm39) D725V probably damaging Het
Cldn34a A T X: 151,346,841 (GRCm39) H171L probably benign Het
Col18a1 T C 10: 76,916,988 (GRCm39) I114V unknown Het
Cp A G 3: 20,033,177 (GRCm39) D667G probably damaging Het
Cr2 G A 1: 194,836,458 (GRCm39) P1278S possibly damaging Het
Crat A G 2: 30,295,060 (GRCm39) Y452H possibly damaging Het
Cyp4f13 T A 17: 33,144,542 (GRCm39) H318L probably damaging Het
Dab1 C T 4: 104,588,948 (GRCm39) A524V probably benign Het
Dmbt1 A G 7: 130,660,018 (GRCm39) N527S probably damaging Het
Fcgbpl1 A T 7: 27,853,785 (GRCm39) D1583V probably damaging Het
Fgb G T 3: 82,951,560 (GRCm39) Y256* probably null Het
Frmd3 T A 4: 74,105,676 (GRCm39) S441T probably damaging Het
Glp1r T A 17: 31,149,722 (GRCm39) C329S possibly damaging Het
Gm14190 G T 11: 99,581,431 (GRCm39) Q46K unknown Het
Golt1b T A 6: 142,338,080 (GRCm39) F17Y probably damaging Het
Gsdmc A G 15: 63,673,748 (GRCm39) I179T probably benign Het
Gsdmc2 T A 15: 63,700,086 (GRCm39) M229L probably benign Het
Gulp1 A C 1: 44,805,274 (GRCm39) N121T possibly damaging Het
Ift122 T A 6: 115,901,328 (GRCm39) F1037I probably damaging Het
Ildr1 A T 16: 36,536,568 (GRCm39) Y199F probably damaging Het
Ints2 T A 11: 86,139,760 (GRCm39) H278L possibly damaging Het
Invs T C 4: 48,392,599 (GRCm39) V271A possibly damaging Het
Kcnj2 T C 11: 110,963,709 (GRCm39) I367T probably benign Het
Kif21b T C 1: 136,089,508 (GRCm39) S1115P probably damaging Het
Lce1k A T 3: 92,714,125 (GRCm39) C20S unknown Het
Lcmt2 C A 2: 120,970,762 (GRCm39) R107L probably benign Het
Letm1 A AG 5: 33,926,859 (GRCm39) probably null Het
Lrrc9 A C 12: 72,544,635 (GRCm39) R71S probably damaging Het
Mcc C A 18: 44,624,382 (GRCm39) E213* probably null Het
Mis18bp1 T C 12: 65,205,468 (GRCm39) T235A probably benign Het
Mta2 C T 19: 8,919,696 (GRCm39) probably benign Het
Nebl T A 2: 17,457,321 (GRCm39) I80F probably damaging Het
Nek10 A G 14: 14,860,764 (GRCm38) T467A probably benign Het
Nexn A T 3: 151,958,576 (GRCm39) F106I probably damaging Het
Nrdc T A 4: 108,896,972 (GRCm39) Y282* probably null Het
Nxf3 G A X: 134,976,583 (GRCm39) P380S possibly damaging Het
Oma1 C T 4: 103,178,971 (GRCm39) T208I probably damaging Het
Or1a1 T C 11: 74,086,989 (GRCm39) V220A probably damaging Het
Or4c31 A G 2: 88,291,686 (GRCm39) M1V probably null Het
Or4d10c C A 19: 12,065,620 (GRCm39) V179F probably damaging Het
Or4p21 A G 2: 88,277,033 (GRCm39) L83P probably damaging Het
Or51a42 A T 7: 103,708,335 (GRCm39) I158N possibly damaging Het
Or52l1 A T 7: 104,830,221 (GRCm39) C115S probably damaging Het
Or5p70 A G 7: 107,995,041 (GRCm39) Y238C probably benign Het
Panx2 A T 15: 88,953,941 (GRCm39) Y632F possibly damaging Het
Pdia4 T C 6: 47,773,589 (GRCm39) T587A probably benign Het
Piezo2 A T 18: 63,207,733 (GRCm39) L1426Q probably null Het
Pigk T A 3: 152,450,131 (GRCm39) Y212N probably damaging Het
Pramel22 T A 4: 143,380,838 (GRCm39) Y395F probably damaging Het
Prl3b1 C T 13: 27,429,775 (GRCm39) T71I possibly damaging Het
Rab3gap1 A G 1: 127,870,166 (GRCm39) E929G possibly damaging Het
Rabl3 T C 16: 37,384,079 (GRCm39) I162T probably benign Het
Rasgrf2 T A 13: 92,172,473 (GRCm39) T188S probably damaging Het
Slc12a2 A G 18: 58,043,358 (GRCm39) I601V possibly damaging Het
Slc25a42 A T 8: 70,644,519 (GRCm39) I60N probably benign Het
Slc2a3 C T 6: 122,713,694 (GRCm39) G173S probably damaging Het
Slc46a3 G A 5: 147,823,404 (GRCm39) T146M probably damaging Het
Specc1 C A 11: 61,920,120 (GRCm39) P7T possibly damaging Het
Sptbn4 T C 7: 27,123,235 (GRCm39) D229G probably benign Het
Sspo T C 6: 48,427,984 (GRCm39) I154T probably benign Het
Stx5a T C 19: 8,726,254 (GRCm39) probably null Het
Stxbp6 A T 12: 44,902,640 (GRCm39) C210* probably null Het
Tagap1 C T 17: 7,224,285 (GRCm39) R137Q probably benign Het
Tbc1d9 A G 8: 83,997,932 (GRCm39) Y1163C probably damaging Het
Tex14 T G 11: 87,440,296 (GRCm39) L1367R probably damaging Het
Tnnt3 C T 7: 142,065,262 (GRCm39) R131C possibly damaging Het
Tpx2 T A 2: 152,732,544 (GRCm39) M606K probably benign Het
Trim46 A T 3: 89,145,008 (GRCm39) Y489N probably damaging Het
Ttc28 C T 5: 111,424,188 (GRCm39) S1485L probably benign Het
Txnl1 T C 18: 63,812,585 (GRCm39) T70A probably benign Het
Unc80 T C 1: 66,731,708 (GRCm39) L3053P probably damaging Het
Wars1 G T 12: 108,854,359 (GRCm39) N18K possibly damaging Het
Wnt8a A G 18: 34,677,937 (GRCm39) D115G probably damaging Het
Xndc1 T A 7: 101,722,398 (GRCm39) V21E probably damaging Het
Zfp493 T A 13: 67,934,388 (GRCm39) C114S probably damaging Het
Other mutations in Or5p66
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0395:Or5p66 UTSW 7 107,885,478 (GRCm39) missense probably benign 0.00
R0634:Or5p66 UTSW 7 107,885,503 (GRCm39) missense probably benign 0.00
R0940:Or5p66 UTSW 7 107,886,264 (GRCm39) missense probably benign 0.01
R1991:Or5p66 UTSW 7 107,885,566 (GRCm39) nonsense probably null
R2860:Or5p66 UTSW 7 107,886,169 (GRCm39) missense probably damaging 0.98
R2861:Or5p66 UTSW 7 107,886,169 (GRCm39) missense probably damaging 0.98
R3712:Or5p66 UTSW 7 107,885,663 (GRCm39) nonsense probably null
R4735:Or5p66 UTSW 7 107,885,520 (GRCm39) missense probably benign
R4895:Or5p66 UTSW 7 107,885,802 (GRCm39) missense probably damaging 0.97
R4976:Or5p66 UTSW 7 107,885,818 (GRCm39) missense probably damaging 1.00
R5686:Or5p66 UTSW 7 107,885,949 (GRCm39) missense probably damaging 1.00
R5719:Or5p66 UTSW 7 107,885,599 (GRCm39) missense probably damaging 0.97
R5883:Or5p66 UTSW 7 107,885,451 (GRCm39) missense probably damaging 1.00
R5911:Or5p66 UTSW 7 107,885,605 (GRCm39) missense probably damaging 1.00
R6452:Or5p66 UTSW 7 107,886,100 (GRCm39) missense probably damaging 1.00
R7018:Or5p66 UTSW 7 107,885,551 (GRCm39) missense probably benign 0.34
R7233:Or5p66 UTSW 7 107,885,923 (GRCm39) missense probably benign 0.36
R8085:Or5p66 UTSW 7 107,885,620 (GRCm39) missense probably benign 0.01
R8166:Or5p66 UTSW 7 107,885,904 (GRCm39) missense probably benign 0.06
R8919:Or5p66 UTSW 7 107,886,289 (GRCm39) missense probably damaging 1.00
R9209:Or5p66 UTSW 7 107,885,526 (GRCm39) missense probably benign 0.06
R9612:Or5p66 UTSW 7 107,885,487 (GRCm39) missense probably benign
R9789:Or5p66 UTSW 7 107,885,898 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- ATTTACTACCAAACTCAAAGCCTGG -3'
(R):5'- AGCTCTCGTGTTCTGATGTCAG -3'

Sequencing Primer
(F):5'- TGGATCATAACATGTATCCCCC -3'
(R):5'- CTCGTGTTCTGATGTCAGTGTCTTTG -3'
Posted On 2014-08-25