Incidental Mutation 'R1990:Trim46'
ID 224850
Institutional Source Beutler Lab
Gene Symbol Trim46
Ensembl Gene ENSMUSG00000042766
Gene Name tripartite motif-containing 46
Synonyms TRIFIC
Accession Numbers
Essential gene? Possibly essential (E-score: 0.695) question?
Stock # R1990 (G1)
Quality Score 225
Status Not validated
Chromosome 3
Chromosomal Location 89141484-89153616 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 89145008 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Asparagine at position 489 (Y489N)
Ref Sequence ENSEMBL: ENSMUSP00000088442 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000041022] [ENSMUST00000041142] [ENSMUST00000090924] [ENSMUST00000107464] [ENSMUST00000143637]
AlphaFold Q7TNM2
Predicted Effect probably damaging
Transcript: ENSMUST00000041022
AA Change: Y502N

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000036053
Gene: ENSMUSG00000042766
AA Change: Y502N

DomainStartEndE-ValueType
RING 33 133 1.92e-6 SMART
BBOX 222 263 9.59e-7 SMART
Blast:BBC 271 395 3e-13 BLAST
FN3 430 515 2.03e-2 SMART
low complexity region 561 571 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000041142
SMART Domains Protein: ENSMUSP00000041963
Gene: ENSMUSG00000042784

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
low complexity region 30 46 N/A INTRINSIC
internal_repeat_2 48 106 4.93e-6 PROSPERO
internal_repeat_1 79 151 3.46e-38 PROSPERO
low complexity region 153 181 N/A INTRINSIC
internal_repeat_1 183 254 3.46e-38 PROSPERO
internal_repeat_2 192 259 4.93e-6 PROSPERO
low complexity region 277 292 N/A INTRINSIC
low complexity region 296 307 N/A INTRINSIC
low complexity region 370 381 N/A INTRINSIC
low complexity region 382 400 N/A INTRINSIC
SEA 412 528 6.2e-43 SMART
low complexity region 537 552 N/A INTRINSIC
Blast:SEA 557 624 2e-36 BLAST
Predicted Effect probably damaging
Transcript: ENSMUST00000090924
AA Change: Y489N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000088442
Gene: ENSMUSG00000042766
AA Change: Y489N

DomainStartEndE-ValueType
RING 20 120 1.92e-6 SMART
BBOX 209 250 9.59e-7 SMART
Blast:BBC 258 382 8e-13 BLAST
FN3 417 502 2.03e-2 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000107464
AA Change: Y479N

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000103088
Gene: ENSMUSG00000042766
AA Change: Y479N

DomainStartEndE-ValueType
RING 10 110 1.92e-6 SMART
BBOX 199 240 9.59e-7 SMART
Blast:BBC 248 372 2e-13 BLAST
FN3 407 492 2.03e-2 SMART
low complexity region 538 548 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000139206
Predicted Effect noncoding transcript
Transcript: ENSMUST00000139419
Predicted Effect probably benign
Transcript: ENSMUST00000143637
SMART Domains Protein: ENSMUSP00000119270
Gene: ENSMUSG00000042766

DomainStartEndE-ValueType
RING 33 133 1.92e-6 SMART
BBOX 222 263 9.59e-7 SMART
Blast:BBC 270 391 4e-11 BLAST
Meta Mutation Damage Score 0.9495 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.7%
  • 20x: 93.5%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 97 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110002E22Rik C T 3: 137,771,419 (GRCm39) R203* probably null Het
Acp6 T C 3: 97,083,054 (GRCm39) L355P probably damaging Het
Aebp2 T C 6: 140,579,464 (GRCm39) S234P probably damaging Het
Anapc7 A G 5: 122,577,567 (GRCm39) D374G probably benign Het
Apob A T 12: 8,051,039 (GRCm39) I1088F probably damaging Het
Arid4b T C 13: 14,307,021 (GRCm39) V92A probably damaging Het
Armc3 T C 2: 19,297,953 (GRCm39) Y575H probably damaging Het
Asxl2 G T 12: 3,534,558 (GRCm39) G252* probably null Het
Atl1 A T 12: 70,010,102 (GRCm39) K556M probably damaging Het
AU018091 A G 7: 3,212,104 (GRCm39) V206A probably benign Het
Bcas1 A T 2: 170,212,397 (GRCm39) D383E possibly damaging Het
Bmx A G X: 163,015,192 (GRCm39) W257R probably benign Het
Bpifb6 T C 2: 153,747,270 (GRCm39) probably null Het
Cacna1b G A 2: 24,622,318 (GRCm39) P222L probably damaging Het
Cand1 A G 10: 119,045,972 (GRCm39) S978P probably damaging Het
Cap2 T A 13: 46,791,357 (GRCm39) Y175N possibly damaging Het
Caps2 G A 10: 112,036,591 (GRCm39) A384T probably benign Het
Catsperg2 A T 7: 29,420,470 (GRCm39) Y223* probably null Het
Cd81 G T 7: 142,620,938 (GRCm39) G206* probably null Het
Cd84 A G 1: 171,700,317 (GRCm39) T145A possibly damaging Het
Cdkn2aip G T 8: 48,165,211 (GRCm39) N167K probably benign Het
Ceacam14 T A 7: 17,549,290 (GRCm39) L227* probably null Het
Ceacam5 A T 7: 17,491,805 (GRCm39) D725V probably damaging Het
Cldn34a A T X: 151,346,841 (GRCm39) H171L probably benign Het
Col18a1 T C 10: 76,916,988 (GRCm39) I114V unknown Het
Cp A G 3: 20,033,177 (GRCm39) D667G probably damaging Het
Cr2 G A 1: 194,836,458 (GRCm39) P1278S possibly damaging Het
Crat A G 2: 30,295,060 (GRCm39) Y452H possibly damaging Het
Cyp4f13 T A 17: 33,144,542 (GRCm39) H318L probably damaging Het
Dab1 C T 4: 104,588,948 (GRCm39) A524V probably benign Het
Dmbt1 A G 7: 130,660,018 (GRCm39) N527S probably damaging Het
Fcgbpl1 A T 7: 27,853,785 (GRCm39) D1583V probably damaging Het
Fgb G T 3: 82,951,560 (GRCm39) Y256* probably null Het
Frmd3 T A 4: 74,105,676 (GRCm39) S441T probably damaging Het
Glp1r T A 17: 31,149,722 (GRCm39) C329S possibly damaging Het
Gm14190 G T 11: 99,581,431 (GRCm39) Q46K unknown Het
Golt1b T A 6: 142,338,080 (GRCm39) F17Y probably damaging Het
Gsdmc A G 15: 63,673,748 (GRCm39) I179T probably benign Het
Gsdmc2 T A 15: 63,700,086 (GRCm39) M229L probably benign Het
Gulp1 A C 1: 44,805,274 (GRCm39) N121T possibly damaging Het
Ift122 T A 6: 115,901,328 (GRCm39) F1037I probably damaging Het
Ildr1 A T 16: 36,536,568 (GRCm39) Y199F probably damaging Het
Ints2 T A 11: 86,139,760 (GRCm39) H278L possibly damaging Het
Invs T C 4: 48,392,599 (GRCm39) V271A possibly damaging Het
Kcnj2 T C 11: 110,963,709 (GRCm39) I367T probably benign Het
Kif21b T C 1: 136,089,508 (GRCm39) S1115P probably damaging Het
Lce1k A T 3: 92,714,125 (GRCm39) C20S unknown Het
Lcmt2 C A 2: 120,970,762 (GRCm39) R107L probably benign Het
Letm1 A AG 5: 33,926,859 (GRCm39) probably null Het
Lrrc9 A C 12: 72,544,635 (GRCm39) R71S probably damaging Het
Mcc C A 18: 44,624,382 (GRCm39) E213* probably null Het
Mis18bp1 T C 12: 65,205,468 (GRCm39) T235A probably benign Het
Mta2 C T 19: 8,919,696 (GRCm39) probably benign Het
Nebl T A 2: 17,457,321 (GRCm39) I80F probably damaging Het
Nek10 A G 14: 14,860,764 (GRCm38) T467A probably benign Het
Nexn A T 3: 151,958,576 (GRCm39) F106I probably damaging Het
Nrdc T A 4: 108,896,972 (GRCm39) Y282* probably null Het
Nxf3 G A X: 134,976,583 (GRCm39) P380S possibly damaging Het
Oma1 C T 4: 103,178,971 (GRCm39) T208I probably damaging Het
Or1a1 T C 11: 74,086,989 (GRCm39) V220A probably damaging Het
Or4c31 A G 2: 88,291,686 (GRCm39) M1V probably null Het
Or4d10c C A 19: 12,065,620 (GRCm39) V179F probably damaging Het
Or4p21 A G 2: 88,277,033 (GRCm39) L83P probably damaging Het
Or51a42 A T 7: 103,708,335 (GRCm39) I158N possibly damaging Het
Or52l1 A T 7: 104,830,221 (GRCm39) C115S probably damaging Het
Or5p66 C A 7: 107,885,566 (GRCm39) G256* probably null Het
Or5p70 A G 7: 107,995,041 (GRCm39) Y238C probably benign Het
Panx2 A T 15: 88,953,941 (GRCm39) Y632F possibly damaging Het
Pdia4 T C 6: 47,773,589 (GRCm39) T587A probably benign Het
Piezo2 A T 18: 63,207,733 (GRCm39) L1426Q probably null Het
Pigk T A 3: 152,450,131 (GRCm39) Y212N probably damaging Het
Pramel22 T A 4: 143,380,838 (GRCm39) Y395F probably damaging Het
Prl3b1 C T 13: 27,429,775 (GRCm39) T71I possibly damaging Het
Rab3gap1 A G 1: 127,870,166 (GRCm39) E929G possibly damaging Het
Rabl3 T C 16: 37,384,079 (GRCm39) I162T probably benign Het
Rasgrf2 T A 13: 92,172,473 (GRCm39) T188S probably damaging Het
Slc12a2 A G 18: 58,043,358 (GRCm39) I601V possibly damaging Het
Slc25a42 A T 8: 70,644,519 (GRCm39) I60N probably benign Het
Slc2a3 C T 6: 122,713,694 (GRCm39) G173S probably damaging Het
Slc46a3 G A 5: 147,823,404 (GRCm39) T146M probably damaging Het
Specc1 C A 11: 61,920,120 (GRCm39) P7T possibly damaging Het
Sptbn4 T C 7: 27,123,235 (GRCm39) D229G probably benign Het
Sspo T C 6: 48,427,984 (GRCm39) I154T probably benign Het
Stx5a T C 19: 8,726,254 (GRCm39) probably null Het
Stxbp6 A T 12: 44,902,640 (GRCm39) C210* probably null Het
Tagap1 C T 17: 7,224,285 (GRCm39) R137Q probably benign Het
Tbc1d9 A G 8: 83,997,932 (GRCm39) Y1163C probably damaging Het
Tex14 T G 11: 87,440,296 (GRCm39) L1367R probably damaging Het
Tnnt3 C T 7: 142,065,262 (GRCm39) R131C possibly damaging Het
Tpx2 T A 2: 152,732,544 (GRCm39) M606K probably benign Het
Ttc28 C T 5: 111,424,188 (GRCm39) S1485L probably benign Het
Txnl1 T C 18: 63,812,585 (GRCm39) T70A probably benign Het
Unc80 T C 1: 66,731,708 (GRCm39) L3053P probably damaging Het
Wars1 G T 12: 108,854,359 (GRCm39) N18K possibly damaging Het
Wnt8a A G 18: 34,677,937 (GRCm39) D115G probably damaging Het
Xndc1 T A 7: 101,722,398 (GRCm39) V21E probably damaging Het
Zfp493 T A 13: 67,934,388 (GRCm39) C114S probably damaging Het
Other mutations in Trim46
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00945:Trim46 APN 3 89,151,725 (GRCm39) unclassified probably benign
IGL02082:Trim46 APN 3 89,146,307 (GRCm39) missense probably benign 0.03
IGL02405:Trim46 APN 3 89,149,792 (GRCm39) missense probably benign 0.09
hippocampus UTSW 3 89,153,020 (GRCm39) critical splice donor site probably null
R0107:Trim46 UTSW 3 89,143,640 (GRCm39) missense probably damaging 1.00
R0295:Trim46 UTSW 3 89,152,420 (GRCm39) unclassified probably benign
R0330:Trim46 UTSW 3 89,143,820 (GRCm39) missense probably damaging 1.00
R1303:Trim46 UTSW 3 89,149,515 (GRCm39) missense probably benign 0.03
R1436:Trim46 UTSW 3 89,150,968 (GRCm39) missense probably damaging 1.00
R1458:Trim46 UTSW 3 89,142,375 (GRCm39) splice site probably null
R1991:Trim46 UTSW 3 89,145,008 (GRCm39) missense probably damaging 1.00
R1992:Trim46 UTSW 3 89,145,008 (GRCm39) missense probably damaging 1.00
R2102:Trim46 UTSW 3 89,142,504 (GRCm39) missense probably damaging 1.00
R3729:Trim46 UTSW 3 89,142,256 (GRCm39) missense probably benign
R3730:Trim46 UTSW 3 89,142,256 (GRCm39) missense probably benign
R4603:Trim46 UTSW 3 89,150,958 (GRCm39) missense probably benign 0.11
R6648:Trim46 UTSW 3 89,142,549 (GRCm39) missense possibly damaging 0.88
R6962:Trim46 UTSW 3 89,146,303 (GRCm39) missense probably damaging 1.00
R7761:Trim46 UTSW 3 89,149,565 (GRCm39) missense probably damaging 1.00
R7905:Trim46 UTSW 3 89,151,633 (GRCm39) missense probably damaging 1.00
R8228:Trim46 UTSW 3 89,142,255 (GRCm39) missense probably benign
R8307:Trim46 UTSW 3 89,151,223 (GRCm39) missense probably benign 0.12
R8509:Trim46 UTSW 3 89,153,020 (GRCm39) critical splice donor site probably null
R8958:Trim46 UTSW 3 89,143,760 (GRCm39) missense probably damaging 1.00
R8992:Trim46 UTSW 3 89,143,692 (GRCm39) missense probably damaging 1.00
R9208:Trim46 UTSW 3 89,142,466 (GRCm39) missense possibly damaging 0.73
R9786:Trim46 UTSW 3 89,142,399 (GRCm39) missense probably damaging 1.00
X0021:Trim46 UTSW 3 89,151,016 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ATTGAGCTGAGTACCTGGGC -3'
(R):5'- ACCCAGTGCCTAGAAAGTTCC -3'

Sequencing Primer
(F):5'- TGAGTACCTGGGCCATCC -3'
(R):5'- TCTTCCAACAGTGCCCGAG -3'
Posted On 2014-08-25