Mutagenetix > Incidental Mutation

Incidental Mutation 'R1993:Naip2'

223982

Institutional Source

Beutler Lab

Gene Symbol

Naip2

Ensembl Gene

ENSMUSG00000078945

Gene Name

NLR family, apoptosis inhibitory protein 2

Synonyms

Naip-rs6, Birc1b, Naip2

MMRRC Submission

040004-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.069) question?

Stock #

R1993 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

100280571-100338600 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 100298515 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Serine at position 507 (N507S)

Ref Sequence

ENSEMBL: ENSMUSP00000113890 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000067975] [ENSMUST00000117913] [ENSMUST00000167986]

AlphaFold

Q9QUK4

Predicted Effect

probably benign
Transcript: ENSMUST00000067975
AA Change: N507S

PolyPhen 2 Score 0.032 (Sensitivity: 0.95; Specificity: 0.82)

SMART Domains

Protein: ENSMUSP00000070827
Gene: ENSMUSG00000078945
AA Change: N507S

Domain	Start	End	E-Value	Type
BIR	58	129	7.95e-18	SMART
BIR	157	229	5.31e-37	SMART
BIR	276	347	4.22e-31	SMART
Pfam:NACHT	508	662	1.9e-36	PFAM
low complexity region	954	964	N/A	INTRINSIC
low complexity region	1116	1126	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000117913
AA Change: N507S

PolyPhen 2 Score 0.032 (Sensitivity: 0.95; Specificity: 0.82)

SMART Domains

Protein: ENSMUSP00000113890
Gene: ENSMUSG00000078945
AA Change: N507S

Domain	Start	End	E-Value	Type
BIR	58	129	7.95e-18	SMART
BIR	157	229	5.31e-37	SMART
BIR	276	347	4.22e-31	SMART
Pfam:NACHT	508	662	1.9e-36	PFAM
low complexity region	954	964	N/A	INTRINSIC
low complexity region	1116	1126	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000167986
AA Change: N507S

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)

SMART Domains

Protein: ENSMUSP00000125852
Gene: ENSMUSG00000078945
AA Change: N507S

Domain	Start	End	E-Value	Type
BIR	58	129	7.95e-18	SMART
BIR	157	229	5.31e-37	SMART
BIR	276	347	4.22e-31	SMART
Pfam:NACHT	508	662	8.6e-35	PFAM
low complexity region	954	964	N/A	INTRINSIC
low complexity region	1116	1126	N/A	INTRINSIC

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 97.0%
20x: 94.3%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This copy of the gene is full length; additional copies with truncations and internal deletions are also present in this region of chromosome 5q13. It is thought that this gene is a modifier of spinal muscular atrophy caused by mutations in a neighboring gene, SMN1. The protein encoded by this gene contains regions of homology to two baculovirus inhibitor of apoptosis proteins, and it is able to suppress apoptosis induced by various signals. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Nov 2016]

Allele List at MGI

Other mutations in this stock

Total: 104 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcb1b	T	G	5: 8,871,322 (GRCm39)	I292S	possibly damaging	Het
Abcc4	T	C	14: 118,763,694 (GRCm39)	N1047S	probably benign	Het
Abcc8	G	T	7: 45,766,847 (GRCm39)		probably null	Het
Akap9	T	A	5: 4,088,520 (GRCm39)		probably null	Het
Alox5	T	A	6: 116,392,424 (GRCm39)	I366F	probably damaging	Het
Amn	A	G	12: 111,242,526 (GRCm39)	N447S	probably damaging	Het
Ankrd22	A	T	19: 34,143,174 (GRCm39)	M1K	probably null	Het
Asic1	G	T	15: 99,569,765 (GRCm39)	G29C	probably damaging	Het
Atxn7l1	A	G	12: 33,395,976 (GRCm39)	N235S	probably benign	Het
AY358078	T	A	14: 52,063,519 (GRCm39)	D388E	probably damaging	Het
Bod1l	A	G	5: 41,974,679 (GRCm39)	S2212P	probably damaging	Het
Cacna1e	T	A	1: 154,353,563 (GRCm39)	Q423L	probably damaging	Het
Calu	T	C	6: 29,366,974 (GRCm39)	I62T	possibly damaging	Het
Cars2	A	G	8: 11,564,515 (GRCm39)	V75A	probably benign	Het
Catsperb	T	A	12: 101,569,026 (GRCm39)	N899K	possibly damaging	Het
Ccdc50	T	A	16: 27,228,089 (GRCm39)	C86*	probably null	Het
Cdh5	G	T	8: 104,864,447 (GRCm39)	L469F	probably damaging	Het
Clrn3	A	T	7: 135,115,848 (GRCm39)	D167E	probably benign	Het
Csmd1	A	T	8: 16,396,698 (GRCm39)	C411S	probably damaging	Het
Dchs1	A	T	7: 105,411,755 (GRCm39)	S1454T	probably benign	Het
Ddx20	G	A	3: 105,586,660 (GRCm39)	Q562*	probably null	Het
Dgkg	T	G	16: 22,419,344 (GRCm39)	Y52S	probably damaging	Het
Dhx58	T	C	11: 100,594,316 (GRCm39)		probably null	Het
Dpp6	A	T	5: 27,604,004 (GRCm39)	I145L	probably benign	Het
Efna2	A	T	10: 80,022,711 (GRCm39)	Y85F	possibly damaging	Het
Eif3a	C	T	19: 60,769,954 (GRCm39)	V127I	probably benign	Het
Exph5	A	T	9: 53,284,935 (GRCm39)	H672L	possibly damaging	Het
Fam131b	T	C	6: 42,297,818 (GRCm39)	T112A	possibly damaging	Het
Fcgr1	A	T	3: 96,193,184 (GRCm39)	V271E	probably damaging	Het
Fgfr4	A	G	13: 55,313,715 (GRCm39)	D508G	probably damaging	Het
Fndc3b	A	G	3: 27,473,549 (GRCm39)	M1172T	probably benign	Het
Fryl	G	T	5: 73,265,836 (GRCm39)	T495K	probably damaging	Het
Garin5b	A	T	7: 4,761,017 (GRCm39)	V565E	probably damaging	Het
Gm5134	A	T	10: 75,802,227 (GRCm39)	I93F	probably damaging	Het
Gpbar1	G	A	1: 74,318,603 (GRCm39)	G282D	possibly damaging	Het
Gria2	G	A	3: 80,709,664 (GRCm39)	L10F	probably benign	Het
Grm7	T	C	6: 111,184,769 (GRCm39)	Y367H	probably benign	Het
H1f9	T	A	11: 94,858,858 (GRCm39)	V51E	probably damaging	Het
Hivep1	G	A	13: 42,310,969 (GRCm39)	A1070T	probably benign	Het
Il33	A	G	19: 29,934,304 (GRCm39)	D155G	possibly damaging	Het
Kdm6b	T	C	11: 69,297,129 (GRCm39)	S408G	probably null	Het
Kntc1	A	G	5: 123,948,874 (GRCm39)		probably null	Het
Kntc1	G	A	5: 123,897,162 (GRCm39)		probably null	Het
Ltbp2	T	G	12: 84,855,220 (GRCm39)		probably null	Het
Mapk8ip3	G	T	17: 25,133,562 (GRCm39)	L83I	probably damaging	Het
Meltf	C	A	16: 31,711,440 (GRCm39)	Y554*	probably null	Het
Mov10	A	C	3: 104,706,735 (GRCm39)	F725C	probably damaging	Het
Ms4a6d	A	C	19: 11,567,523 (GRCm39)	L18R	probably damaging	Het
Nodal	A	G	10: 61,254,113 (GRCm39)	Q12R	probably benign	Het
Npy6r	T	C	18: 44,409,575 (GRCm39)	L332P	probably damaging	Het
Nrxn3	A	G	12: 89,227,181 (GRCm39)	K272R	possibly damaging	Het
Obox2	G	T	7: 15,131,174 (GRCm39)	K93N	probably benign	Het
Or10j27	C	T	1: 172,958,418 (GRCm39)	R122H	possibly damaging	Het
Or51a6	G	T	7: 102,603,953 (GRCm39)	P285Q	probably damaging	Het
Or5b112	A	G	19: 13,319,178 (GRCm39)	T19A	possibly damaging	Het
Or5w13	C	T	2: 87,523,777 (GRCm39)	V150M	probably benign	Het
Pcdh12	T	A	18: 38,415,196 (GRCm39)	D643V	possibly damaging	Het
Pcsk2	A	G	2: 143,529,539 (GRCm39)	D112G	probably benign	Het
Pms1	A	G	1: 53,234,174 (GRCm39)	S781P	probably benign	Het
Prtg	A	G	9: 72,752,178 (GRCm39)	D188G	probably benign	Het
Psg21	A	T	7: 18,388,695 (GRCm39)	N132K	probably benign	Het
Psip1	A	G	4: 83,400,769 (GRCm39)	V25A	probably damaging	Het
Psmd13	T	A	7: 140,478,107 (GRCm39)	I319N	probably damaging	Het
Ptges2	A	G	2: 32,290,104 (GRCm39)	T173A	probably benign	Het
Ptprm	G	A	17: 67,054,155 (GRCm39)	R975W	probably damaging	Het
Rdh1	A	G	10: 127,601,214 (GRCm39)	D254G	probably benign	Het
Rnf138	T	G	18: 21,157,540 (GRCm39)	N212K	probably damaging	Het
Serpine2	A	G	1: 79,799,159 (GRCm39)	S32P	probably damaging	Het
Serpini1	G	T	3: 75,521,971 (GRCm39)	W154L	probably damaging	Het
Sf3a1	C	A	11: 4,129,177 (GRCm39)	Q713K	possibly damaging	Het
Sgo2b	A	T	8: 64,379,867 (GRCm39)	H988Q	probably benign	Het
Sin3a	T	C	9: 57,008,483 (GRCm39)	F468L	probably damaging	Het
Slamf6	A	T	1: 171,761,776 (GRCm39)	I66F	possibly damaging	Het
Slc22a28	A	T	19: 8,094,488 (GRCm39)	C178S	possibly damaging	Het
Slc35a1	A	C	4: 34,675,181 (GRCm39)	V119G	probably damaging	Het
Slc39a12	A	T	2: 14,439,030 (GRCm39)	H428L	probably damaging	Het
Speer2	A	G	16: 69,654,965 (GRCm39)	S167P	probably benign	Het
Sphkap	G	A	1: 83,255,236 (GRCm39)	R838*	probably null	Het
Spsb2	T	C	6: 124,786,329 (GRCm39)		probably null	Het
Stam2	A	T	2: 52,593,168 (GRCm39)	Y341*	probably null	Het
Sv2b	G	A	7: 74,856,089 (GRCm39)	A67V	probably benign	Het
Svep1	A	G	4: 58,064,170 (GRCm39)		probably null	Het
Syt15	A	T	14: 33,944,969 (GRCm39)	Q172L	probably benign	Het
T	G	A	17: 8,660,634 (GRCm39)	S415N	probably benign	Het
Tep1	A	G	14: 51,061,641 (GRCm39)	F2625S	possibly damaging	Het
Tex14	T	C	11: 87,427,581 (GRCm39)	V11A	possibly damaging	Het
Tiam2	A	T	17: 3,465,401 (GRCm39)	R377*	probably null	Het
Tirap	A	G	9: 35,102,312 (GRCm39)		probably null	Het
Tm4sf20	T	C	1: 82,737,938 (GRCm39)	T118A	probably benign	Het
Trank1	A	T	9: 111,207,900 (GRCm39)	Q1715L	probably benign	Het
Trpm2	C	T	10: 77,783,823 (GRCm39)	V217M	probably damaging	Het
Ubap1l	G	A	9: 65,279,078 (GRCm39)	E126K	possibly damaging	Het
Urgcp	G	T	11: 5,666,526 (GRCm39)	P604Q	probably damaging	Het
Vmn1r63	A	G	7: 5,806,254 (GRCm39)	V126A	probably benign	Het
Vmn2r90	T	C	17: 17,933,525 (GRCm39)	C362R	probably damaging	Het
Vmn2r96	A	G	17: 18,804,138 (GRCm39)	I271V	probably damaging	Het
Vps13a	A	T	19: 16,699,822 (GRCm39)	I740K	probably benign	Het
Vps13c	A	G	9: 67,883,138 (GRCm39)	T3562A	probably damaging	Het
Wdr91	T	A	6: 34,869,297 (GRCm39)	H409L	probably damaging	Het
Wnt7a	T	A	6: 91,342,938 (GRCm39)	T315S	possibly damaging	Het
Zfp616	A	G	11: 73,975,795 (GRCm39)	H688R	probably benign	Het
Zfp763	A	T	17: 33,237,413 (GRCm39)	H577Q	probably damaging	Het
Zfp808	G	A	13: 62,320,721 (GRCm39)	S650N	probably benign	Het
Zfp977	A	T	7: 42,229,409 (GRCm39)	M372K	probably benign	Het

Other mutations in Naip2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00515:Naip2	APN	13	100,291,395 (GRCm39)	missense	probably benign	0.00
IGL00676:Naip2	APN	13	100,289,140 (GRCm39)	missense	probably damaging	1.00
IGL00870:Naip2	APN	13	100,288,568 (GRCm39)	splice site	probably benign
IGL00908:Naip2	APN	13	100,297,157 (GRCm39)	missense	probably benign	0.01
IGL00916:Naip2	APN	13	100,297,939 (GRCm39)	missense	probably damaging	0.97
IGL00949:Naip2	APN	13	100,298,099 (GRCm39)	missense	probably damaging	1.00
IGL01010:Naip2	APN	13	100,291,446 (GRCm39)	missense	probably damaging	0.99
IGL01642:Naip2	APN	13	100,297,445 (GRCm39)	missense	probably damaging	0.97
IGL01884:Naip2	APN	13	100,325,329 (GRCm39)	splice site	probably benign
IGL01917:Naip2	APN	13	100,298,591 (GRCm39)	missense	probably benign	0.00
IGL02015:Naip2	APN	13	100,298,115 (GRCm39)	missense	possibly damaging	0.57
IGL02315:Naip2	APN	13	100,297,744 (GRCm39)	missense	probably damaging	1.00
IGL02328:Naip2	APN	13	100,297,877 (GRCm39)	missense	probably damaging	1.00
IGL02735:Naip2	APN	13	100,296,722 (GRCm39)	missense	probably damaging	0.99
IGL02738:Naip2	APN	13	100,325,685 (GRCm39)	missense	probably benign	0.01
IGL02887:Naip2	APN	13	100,298,020 (GRCm39)	missense	possibly damaging	0.90
IGL02894:Naip2	APN	13	100,320,297 (GRCm39)	missense	probably benign
IGL02894:Naip2	APN	13	100,297,505 (GRCm39)	missense	probably damaging	1.00
IGL02974:Naip2	APN	13	100,298,186 (GRCm39)	missense	probably damaging	1.00
IGL03024:Naip2	APN	13	100,325,862 (GRCm39)	missense	possibly damaging	0.50
IGL03056:Naip2	APN	13	100,298,795 (GRCm39)	missense	possibly damaging	0.90
IGL03281:Naip2	APN	13	100,298,128 (GRCm39)	missense	probably damaging	0.99
R0131:Naip2	UTSW	13	100,320,296 (GRCm39)	missense	probably benign	0.01
R0131:Naip2	UTSW	13	100,320,296 (GRCm39)	missense	probably benign	0.01
R0132:Naip2	UTSW	13	100,320,296 (GRCm39)	missense	probably benign	0.01
R0310:Naip2	UTSW	13	100,285,350 (GRCm39)	missense	probably damaging	1.00
R0367:Naip2	UTSW	13	100,298,290 (GRCm39)	missense	probably benign	0.01
R0368:Naip2	UTSW	13	100,298,290 (GRCm39)	missense	probably benign	0.01
R0422:Naip2	UTSW	13	100,297,621 (GRCm39)	missense	probably benign	0.10
R0441:Naip2	UTSW	13	100,298,290 (GRCm39)	missense	probably benign	0.01
R0445:Naip2	UTSW	13	100,298,395 (GRCm39)	missense	possibly damaging	0.91
R0446:Naip2	UTSW	13	100,298,290 (GRCm39)	missense	probably benign	0.01
R0464:Naip2	UTSW	13	100,298,290 (GRCm39)	missense	probably benign	0.01
R0466:Naip2	UTSW	13	100,298,290 (GRCm39)	missense	probably benign	0.01
R0467:Naip2	UTSW	13	100,298,290 (GRCm39)	missense	probably benign	0.01
R0486:Naip2	UTSW	13	100,298,290 (GRCm39)	missense	probably benign	0.01
R0533:Naip2	UTSW	13	100,298,290 (GRCm39)	missense	probably benign	0.01
R0853:Naip2	UTSW	13	100,298,362 (GRCm39)	missense	probably benign
R0853:Naip2	UTSW	13	100,298,368 (GRCm39)	missense	probably benign	0.00
R0855:Naip2	UTSW	13	100,298,368 (GRCm39)	missense	probably benign	0.00
R0855:Naip2	UTSW	13	100,298,362 (GRCm39)	missense	probably benign
R0904:Naip2	UTSW	13	100,298,368 (GRCm39)	missense	probably benign	0.00
R0904:Naip2	UTSW	13	100,298,362 (GRCm39)	missense	probably benign
R0906:Naip2	UTSW	13	100,298,368 (GRCm39)	missense	probably benign	0.00
R0906:Naip2	UTSW	13	100,298,362 (GRCm39)	missense	probably benign
R0908:Naip2	UTSW	13	100,298,368 (GRCm39)	missense	probably benign	0.00
R0908:Naip2	UTSW	13	100,298,362 (GRCm39)	missense	probably benign
R0959:Naip2	UTSW	13	100,291,419 (GRCm39)	missense	probably benign	0.03
R0959:Naip2	UTSW	13	100,291,386 (GRCm39)	missense	probably benign	0.01
R0962:Naip2	UTSW	13	100,315,893 (GRCm39)	missense	probably damaging	1.00
R1024:Naip2	UTSW	13	100,298,368 (GRCm39)	missense	probably benign	0.00
R1024:Naip2	UTSW	13	100,298,362 (GRCm39)	missense	probably benign
R1186:Naip2	UTSW	13	100,298,545 (GRCm39)	frame shift	probably null
R1186:Naip2	UTSW	13	100,298,489 (GRCm39)	missense	possibly damaging	0.63
R1217:Naip2	UTSW	13	100,298,368 (GRCm39)	missense	probably benign	0.00
R1217:Naip2	UTSW	13	100,298,362 (GRCm39)	missense	probably benign
R1340:Naip2	UTSW	13	100,325,630 (GRCm39)	missense	possibly damaging	0.80
R1342:Naip2	UTSW	13	100,298,368 (GRCm39)	missense	probably benign	0.00
R1342:Naip2	UTSW	13	100,298,362 (GRCm39)	missense	probably benign
R1404:Naip2	UTSW	13	100,298,362 (GRCm39)	missense	probably benign
R1423:Naip2	UTSW	13	100,291,355 (GRCm39)	intron	probably benign
R1423:Naip2	UTSW	13	100,298,368 (GRCm39)	missense	probably benign	0.00
R1423:Naip2	UTSW	13	100,291,386 (GRCm39)	missense	probably benign	0.01
R1423:Naip2	UTSW	13	100,291,380 (GRCm39)	missense	possibly damaging	0.59
R1426:Naip2	UTSW	13	100,298,368 (GRCm39)	missense	probably benign	0.00
R1426:Naip2	UTSW	13	100,298,362 (GRCm39)	missense	probably benign
R1472:Naip2	UTSW	13	100,298,368 (GRCm39)	missense	probably benign	0.00
R1575:Naip2	UTSW	13	100,291,537 (GRCm39)	intron	probably benign
R1575:Naip2	UTSW	13	100,291,529 (GRCm39)	missense	probably benign	0.00
R1576:Naip2	UTSW	13	100,291,529 (GRCm39)	missense	probably benign	0.00
R1576:Naip2	UTSW	13	100,291,537 (GRCm39)	intron	probably benign
R1599:Naip2	UTSW	13	100,298,489 (GRCm39)	missense	possibly damaging	0.63
R1640:Naip2	UTSW	13	100,298,489 (GRCm39)	missense	possibly damaging	0.63
R1641:Naip2	UTSW	13	100,298,489 (GRCm39)	missense	possibly damaging	0.63
R1642:Naip2	UTSW	13	100,298,489 (GRCm39)	missense	possibly damaging	0.63
R1643:Naip2	UTSW	13	100,298,489 (GRCm39)	missense	possibly damaging	0.63
R1644:Naip2	UTSW	13	100,319,437 (GRCm39)	missense	possibly damaging	0.83
R1681:Naip2	UTSW	13	100,298,368 (GRCm39)	missense	probably benign	0.00
R1681:Naip2	UTSW	13	100,298,362 (GRCm39)	missense	probably benign
R1891:Naip2	UTSW	13	100,291,395 (GRCm39)	missense	probably benign	0.00
R1913:Naip2	UTSW	13	100,288,665 (GRCm39)	critical splice acceptor site	probably null
R1937:Naip2	UTSW	13	100,298,368 (GRCm39)	missense	probably benign	0.00
R1937:Naip2	UTSW	13	100,298,362 (GRCm39)	missense	probably benign
R2001:Naip2	UTSW	13	100,281,096 (GRCm39)	missense	probably damaging	1.00
R2055:Naip2	UTSW	13	100,315,880 (GRCm39)	missense	probably benign	0.07
R2198:Naip2	UTSW	13	100,289,100 (GRCm39)	missense	probably damaging	1.00
R2906:Naip2	UTSW	13	100,298,504 (GRCm39)	missense	probably damaging	1.00
R2931:Naip2	UTSW	13	100,291,529 (GRCm39)	missense	probably benign	0.00
R3014:Naip2	UTSW	13	100,298,290 (GRCm39)	missense	probably benign	0.01
R3016:Naip2	UTSW	13	100,298,290 (GRCm39)	missense	probably benign	0.01
R3037:Naip2	UTSW	13	100,291,457 (GRCm39)	missense	probably benign	0.08
R3414:Naip2	UTSW	13	100,325,771 (GRCm39)	nonsense	probably null
R3437:Naip2	UTSW	13	100,291,419 (GRCm39)	missense	probably benign	0.03
R3713:Naip2	UTSW	13	100,298,410 (GRCm39)	missense	probably damaging	1.00
R3806:Naip2	UTSW	13	100,289,142 (GRCm39)	missense	possibly damaging	0.92
R3847:Naip2	UTSW	13	100,315,940 (GRCm39)	missense	probably damaging	1.00
R3847:Naip2	UTSW	13	100,315,941 (GRCm39)	missense	probably damaging	1.00
R3848:Naip2	UTSW	13	100,315,940 (GRCm39)	missense	probably damaging	1.00
R3848:Naip2	UTSW	13	100,315,941 (GRCm39)	missense	probably damaging	1.00
R3849:Naip2	UTSW	13	100,315,940 (GRCm39)	missense	probably damaging	1.00
R3849:Naip2	UTSW	13	100,315,941 (GRCm39)	missense	probably damaging	1.00
R3850:Naip2	UTSW	13	100,315,940 (GRCm39)	missense	probably damaging	1.00
R3850:Naip2	UTSW	13	100,315,941 (GRCm39)	missense	probably damaging	1.00
R3891:Naip2	UTSW	13	100,297,606 (GRCm39)	missense	probably damaging	0.99
R4419:Naip2	UTSW	13	100,297,133 (GRCm39)	missense	probably benign	0.03
R4456:Naip2	UTSW	13	100,291,419 (GRCm39)	missense	probably benign	0.03
R4458:Naip2	UTSW	13	100,291,419 (GRCm39)	missense	probably benign	0.03
R4689:Naip2	UTSW	13	100,285,320 (GRCm39)	missense	probably damaging	1.00
R4797:Naip2	UTSW	13	100,298,243 (GRCm39)	missense	probably damaging	1.00
R4852:Naip2	UTSW	13	100,298,044 (GRCm39)	missense	probably benign
R4922:Naip2	UTSW	13	100,291,468 (GRCm39)	missense	probably benign
R5135:Naip2	UTSW	13	100,315,948 (GRCm39)	missense	probably damaging	0.98
R5185:Naip2	UTSW	13	100,325,859 (GRCm39)	missense	probably damaging	1.00
R5265:Naip2	UTSW	13	100,289,068 (GRCm39)	missense	probably damaging	1.00
R5451:Naip2	UTSW	13	100,325,368 (GRCm39)	missense	probably benign	0.12
R5521:Naip2	UTSW	13	100,291,422 (GRCm39)	missense	probably damaging	1.00
R5737:Naip2	UTSW	13	100,298,362 (GRCm39)	missense	probably benign	0.38
R6244:Naip2	UTSW	13	100,288,645 (GRCm39)	missense	probably damaging	1.00
R6478:Naip2	UTSW	13	100,298,549 (GRCm39)	missense	probably benign
R6480:Naip2	UTSW	13	100,298,549 (GRCm39)	missense	probably benign
R6481:Naip2	UTSW	13	100,298,549 (GRCm39)	missense	probably benign
R6490:Naip2	UTSW	13	100,297,193 (GRCm39)	missense	probably benign
R6653:Naip2	UTSW	13	100,288,644 (GRCm39)	missense	probably benign	0.00
R6653:Naip2	UTSW	13	100,298,352 (GRCm39)	missense	probably benign
R6768:Naip2	UTSW	13	100,314,832 (GRCm39)	nonsense	probably null
R6791:Naip2	UTSW	13	100,291,468 (GRCm39)	missense	probably benign
R6793:Naip2	UTSW	13	100,291,468 (GRCm39)	missense	probably benign
R6890:Naip2	UTSW	13	100,298,549 (GRCm39)	missense	probably benign
R7036:Naip2	UTSW	13	100,291,529 (GRCm39)	missense	probably benign	0.00
R7213:Naip2	UTSW	13	100,323,991 (GRCm39)	missense	probably damaging	1.00
R7342:Naip2	UTSW	13	100,325,864 (GRCm39)	missense	probably benign	0.09
R7445:Naip2	UTSW	13	100,298,290 (GRCm39)	missense	probably benign	0.01
R7572:Naip2	UTSW	13	100,291,468 (GRCm39)	missense	probably benign
R7699:Naip2	UTSW	13	100,296,877 (GRCm39)	missense	probably benign	0.00
R7840:Naip2	UTSW	13	100,280,917 (GRCm39)	missense	probably benign	0.14
R7874:Naip2	UTSW	13	100,291,468 (GRCm39)	missense	probably benign
R7874:Naip2	UTSW	13	100,291,459 (GRCm39)	missense	probably benign	0.00
R8038:Naip2	UTSW	13	100,298,570 (GRCm39)	missense	probably benign	0.00
R8065:Naip2	UTSW	13	100,325,730 (GRCm39)	missense	probably damaging	1.00
R8094:Naip2	UTSW	13	100,298,290 (GRCm39)	missense	probably benign	0.01
R8166:Naip2	UTSW	13	100,298,515 (GRCm39)	missense	probably benign	0.03
R8378:Naip2	UTSW	13	100,298,290 (GRCm39)	missense	probably benign	0.01
R8669:Naip2	UTSW	13	100,325,477 (GRCm39)	missense	probably benign	0.05
R8691:Naip2	UTSW	13	100,297,676 (GRCm39)	missense	probably damaging	1.00
R8716:Naip2	UTSW	13	100,280,914 (GRCm39)	missense	probably benign
R8720:Naip2	UTSW	13	100,298,630 (GRCm39)	missense	probably benign	0.04
R8888:Naip2	UTSW	13	100,325,644 (GRCm39)	missense	probably benign	0.01
R8895:Naip2	UTSW	13	100,325,644 (GRCm39)	missense	probably benign	0.01
R9031:Naip2	UTSW	13	100,314,776 (GRCm39)	missense	possibly damaging	0.55
R9072:Naip2	UTSW	13	100,291,468 (GRCm39)	missense	probably benign
R9072:Naip2	UTSW	13	100,291,459 (GRCm39)	missense	probably benign	0.00
R9074:Naip2	UTSW	13	100,291,468 (GRCm39)	missense	probably benign
R9074:Naip2	UTSW	13	100,291,459 (GRCm39)	missense	probably benign	0.00
R9077:Naip2	UTSW	13	100,291,468 (GRCm39)	missense	probably benign
R9077:Naip2	UTSW	13	100,291,459 (GRCm39)	missense	probably benign	0.00
R9176:Naip2	UTSW	13	100,298,707 (GRCm39)	missense	probably damaging	1.00
R9219:Naip2	UTSW	13	100,297,213 (GRCm39)	missense	probably benign	0.06
R9358:Naip2	UTSW	13	100,298,080 (GRCm39)	missense	probably damaging	1.00
R9371:Naip2	UTSW	13	100,298,354 (GRCm39)	nonsense	probably null
R9414:Naip2	UTSW	13	100,298,243 (GRCm39)	missense	probably damaging	1.00
R9415:Naip2	UTSW	13	100,298,243 (GRCm39)	missense	probably damaging	1.00
R9416:Naip2	UTSW	13	100,298,243 (GRCm39)	missense	probably damaging	1.00
R9708:Naip2	UTSW	13	100,298,087 (GRCm39)	missense	probably damaging	0.99
V5622:Naip2	UTSW	13	100,291,537 (GRCm39)	intron	probably benign
V5622:Naip2	UTSW	13	100,291,529 (GRCm39)	missense	probably benign	0.00
V5622:Naip2	UTSW	13	100,291,529 (GRCm39)	missense	probably benign	0.00
X0063:Naip2	UTSW	13	100,298,266 (GRCm39)	missense	probably damaging	1.00
Y5405:Naip2	UTSW	13	100,291,468 (GRCm39)	missense	probably benign
Z1088:Naip2	UTSW	13	100,298,417 (GRCm39)	missense	probably benign
Z1176:Naip2	UTSW	13	100,298,417 (GRCm39)	missense	probably benign
Z1176:Naip2	UTSW	13	100,298,101 (GRCm39)	missense	probably benign	0.02
Z1177:Naip2	UTSW	13	100,298,417 (GRCm39)	missense	probably benign
Z1177:Naip2	UTSW	13	100,289,137 (GRCm39)	missense	possibly damaging	0.65
Z1177:Naip2	UTSW	13	100,299,373 (GRCm39)	missense	probably benign	0.01

Predicted Primers

PCR Primer
(F):5'- GATGCTGCTCAGACACACTTC -3'
(R):5'- AGCAGCTGAGAGACACCTAC -3'

Sequencing Primer
(F):5'- CCCTAGGAGTTGGGCACAGATG -3'
(R):5'- TACACCAAAGCTACTTTCCGC -3'

Posted On

2014-08-25