Incidental Mutation 'R1992:Ttc28'
| ID |
223600 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Ttc28
|
| Ensembl Gene |
ENSMUSG00000033209 |
| Gene Name |
tetratricopeptide repeat domain 28 |
| Synonyms |
TPRBK, 2310015L07Rik |
| MMRRC Submission |
040003-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R1992 (G1)
|
| Quality Score |
100 |
|
Status
|
Not validated
|
| Chromosome |
5 |
| Chromosomal Location |
111027669-111437646 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 111424188 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Leucine
at position 1485
(S1485L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000136116
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000040111]
[ENSMUST00000156290]
|
| AlphaFold |
Q80XJ3 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000040111
AA Change: S1485L
PolyPhen 2
Score 0.365 (Sensitivity: 0.90; Specificity: 0.89)
|
| SMART Domains |
Protein: ENSMUSP00000136116
Gene: ENSMUSG00000033209
AA Change: S1485L
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
4 |
28 |
N/A |
INTRINSIC |
|
TPR
|
52 |
85 |
2.84e1 |
SMART |
|
TPR
|
86 |
119 |
5.03e-1 |
SMART |
|
TPR
|
120 |
153 |
2.11e-3 |
SMART |
|
TPR
|
268 |
301 |
8.51e0 |
SMART |
|
TPR
|
339 |
372 |
1.78e-1 |
SMART |
|
TPR
|
379 |
412 |
2.82e-4 |
SMART |
|
TPR
|
419 |
452 |
9.98e-5 |
SMART |
|
TPR
|
459 |
492 |
1.88e0 |
SMART |
|
TPR
|
499 |
532 |
1.11e1 |
SMART |
|
TPR
|
539 |
572 |
2.93e-2 |
SMART |
|
TPR
|
579 |
612 |
1.21e-3 |
SMART |
|
TPR
|
619 |
652 |
4.91e-4 |
SMART |
|
TPR
|
659 |
692 |
7.56e-5 |
SMART |
|
TPR
|
699 |
732 |
8.29e0 |
SMART |
|
TPR
|
739 |
772 |
1.63e0 |
SMART |
|
TPR
|
779 |
812 |
1.24e0 |
SMART |
|
TPR
|
819 |
852 |
7.98e-4 |
SMART |
|
TPR
|
859 |
892 |
8.74e0 |
SMART |
|
TPR
|
902 |
935 |
5.43e-6 |
SMART |
|
TPR
|
942 |
975 |
4.09e-1 |
SMART |
|
TPR
|
982 |
1015 |
9.98e-5 |
SMART |
|
TPR
|
1022 |
1055 |
7.12e-1 |
SMART |
|
TPR
|
1062 |
1095 |
5.69e0 |
SMART |
|
TPR
|
1102 |
1135 |
3.14e-2 |
SMART |
|
TPR
|
1142 |
1175 |
2.84e1 |
SMART |
|
low complexity region
|
1259 |
1277 |
N/A |
INTRINSIC |
|
Pfam:CHAT
|
1415 |
1738 |
7.3e-77 |
PFAM |
|
low complexity region
|
1972 |
1990 |
N/A |
INTRINSIC |
|
low complexity region
|
2014 |
2031 |
N/A |
INTRINSIC |
|
low complexity region
|
2033 |
2045 |
N/A |
INTRINSIC |
|
low complexity region
|
2155 |
2171 |
N/A |
INTRINSIC |
|
low complexity region
|
2283 |
2293 |
N/A |
INTRINSIC |
|
low complexity region
|
2327 |
2352 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000156290
AA Change: S1454L
PolyPhen 2
Score 0.085 (Sensitivity: 0.93; Specificity: 0.85)
|
| SMART Domains |
Protein: ENSMUSP00000137609
Gene: ENSMUSG00000033209
AA Change: S1454L
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
4 |
28 |
N/A |
INTRINSIC |
|
TPR
|
52 |
85 |
2.84e1 |
SMART |
|
TPR
|
86 |
119 |
5.03e-1 |
SMART |
|
TPR
|
120 |
153 |
2.11e-3 |
SMART |
|
TPR
|
268 |
301 |
8.51e0 |
SMART |
|
TPR
|
308 |
341 |
1.78e-1 |
SMART |
|
TPR
|
348 |
381 |
2.82e-4 |
SMART |
|
TPR
|
388 |
421 |
9.98e-5 |
SMART |
|
TPR
|
428 |
461 |
1.88e0 |
SMART |
|
TPR
|
468 |
501 |
1.11e1 |
SMART |
|
TPR
|
508 |
541 |
2.93e-2 |
SMART |
|
TPR
|
548 |
581 |
1.21e-3 |
SMART |
|
TPR
|
588 |
621 |
4.91e-4 |
SMART |
|
TPR
|
628 |
661 |
7.56e-5 |
SMART |
|
TPR
|
668 |
701 |
8.29e0 |
SMART |
|
TPR
|
708 |
741 |
1.63e0 |
SMART |
|
TPR
|
748 |
781 |
1.24e0 |
SMART |
|
TPR
|
788 |
821 |
7.98e-4 |
SMART |
|
TPR
|
828 |
861 |
8.74e0 |
SMART |
|
TPR
|
871 |
904 |
5.43e-6 |
SMART |
|
TPR
|
911 |
944 |
4.09e-1 |
SMART |
|
TPR
|
951 |
984 |
9.98e-5 |
SMART |
|
TPR
|
991 |
1024 |
7.12e-1 |
SMART |
|
TPR
|
1031 |
1064 |
5.69e0 |
SMART |
|
TPR
|
1071 |
1104 |
3.14e-2 |
SMART |
|
TPR
|
1111 |
1144 |
2.84e1 |
SMART |
|
low complexity region
|
1228 |
1246 |
N/A |
INTRINSIC |
|
Pfam:CHAT
|
1384 |
1707 |
1.1e-76 |
PFAM |
|
low complexity region
|
1941 |
1959 |
N/A |
INTRINSIC |
|
low complexity region
|
1983 |
2000 |
N/A |
INTRINSIC |
|
low complexity region
|
2002 |
2014 |
N/A |
INTRINSIC |
|
low complexity region
|
2124 |
2140 |
N/A |
INTRINSIC |
|
low complexity region
|
2252 |
2262 |
N/A |
INTRINSIC |
|
low complexity region
|
2296 |
2321 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000183861
|
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.4%
- 20x: 92.5%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 123 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2310009B15Rik |
T |
C |
1: 138,781,380 (GRCm39) |
T90A |
probably damaging |
Het |
| A930011G23Rik |
T |
C |
5: 99,381,784 (GRCm39) |
D326G |
possibly damaging |
Het |
| Abcc2 |
A |
T |
19: 43,795,581 (GRCm39) |
I446F |
probably damaging |
Het |
| Adam34l |
T |
C |
8: 44,080,176 (GRCm39) |
K16R |
probably benign |
Het |
| Adamts14 |
A |
G |
10: 61,034,439 (GRCm39) |
Y1150H |
probably benign |
Het |
| Adgrl2 |
A |
G |
3: 148,522,880 (GRCm39) |
I217T |
possibly damaging |
Het |
| Afap1l1 |
A |
T |
18: 61,874,842 (GRCm39) |
Y446* |
probably null |
Het |
| Aimp2 |
G |
A |
5: 143,843,548 (GRCm39) |
A14V |
probably damaging |
Het |
| Akap8 |
G |
A |
17: 32,535,586 (GRCm39) |
H143Y |
probably damaging |
Het |
| Aldh2 |
A |
T |
5: 121,714,026 (GRCm39) |
V207E |
possibly damaging |
Het |
| Aoc1l2 |
T |
A |
6: 48,907,703 (GRCm39) |
H234Q |
probably damaging |
Het |
| Armc3 |
T |
C |
2: 19,297,953 (GRCm39) |
Y575H |
probably damaging |
Het |
| Arpp21 |
T |
C |
9: 111,986,861 (GRCm39) |
E230G |
probably damaging |
Het |
| Arrdc3 |
G |
A |
13: 81,031,808 (GRCm39) |
D14N |
probably damaging |
Het |
| Atn1 |
A |
G |
6: 124,722,291 (GRCm39) |
|
probably benign |
Het |
| Atxn7l1 |
G |
A |
12: 33,408,743 (GRCm39) |
D302N |
probably damaging |
Het |
| Bbs1 |
T |
A |
19: 4,941,736 (GRCm39) |
H518L |
probably benign |
Het |
| Bltp1 |
A |
T |
3: 37,054,181 (GRCm39) |
H3100L |
probably benign |
Het |
| Bmpr1a |
C |
A |
14: 34,147,050 (GRCm39) |
G241C |
probably damaging |
Het |
| Cacna1b |
G |
A |
2: 24,622,318 (GRCm39) |
P222L |
probably damaging |
Het |
| Calcrl |
T |
C |
2: 84,200,855 (GRCm39) |
Y63C |
probably damaging |
Het |
| Cand2 |
A |
G |
6: 115,762,093 (GRCm39) |
H173R |
possibly damaging |
Het |
| Cap2 |
T |
A |
13: 46,791,357 (GRCm39) |
Y175N |
possibly damaging |
Het |
| Card14 |
A |
T |
11: 119,212,647 (GRCm39) |
|
probably null |
Het |
| Cd3d |
T |
A |
9: 44,896,299 (GRCm39) |
Y29* |
probably null |
Het |
| Cd4 |
A |
G |
6: 124,844,651 (GRCm39) |
V378A |
possibly damaging |
Het |
| Cluh |
A |
T |
11: 74,550,828 (GRCm39) |
H318L |
probably damaging |
Het |
| Clvs1 |
T |
A |
4: 9,281,899 (GRCm39) |
D114E |
probably benign |
Het |
| Cnot4 |
T |
A |
6: 35,000,344 (GRCm39) |
T548S |
probably benign |
Het |
| Col18a1 |
T |
C |
10: 76,916,988 (GRCm39) |
I114V |
unknown |
Het |
| Cr2 |
G |
A |
1: 194,836,458 (GRCm39) |
P1278S |
possibly damaging |
Het |
| Crebbp |
A |
T |
16: 3,946,561 (GRCm39) |
|
probably null |
Het |
| Dnah7a |
T |
G |
1: 53,621,835 (GRCm39) |
K1097Q |
possibly damaging |
Het |
| Doc2a |
T |
A |
7: 126,450,979 (GRCm39) |
|
probably null |
Het |
| Dpp10 |
A |
T |
1: 123,832,833 (GRCm39) |
V48E |
probably null |
Het |
| Dsg2 |
A |
G |
18: 20,734,530 (GRCm39) |
K836R |
probably damaging |
Het |
| Egr2 |
T |
C |
10: 67,375,857 (GRCm39) |
V164A |
probably damaging |
Het |
| Erbin |
A |
T |
13: 103,970,221 (GRCm39) |
S1132T |
probably benign |
Het |
| Espn |
T |
A |
4: 152,213,012 (GRCm39) |
|
probably null |
Het |
| Fam83b |
A |
G |
9: 76,399,304 (GRCm39) |
S600P |
probably benign |
Het |
| Fanca |
A |
T |
8: 124,024,551 (GRCm39) |
N425K |
possibly damaging |
Het |
| Flot2 |
C |
T |
11: 77,949,445 (GRCm39) |
L294F |
probably damaging |
Het |
| Frs2 |
A |
G |
10: 116,910,459 (GRCm39) |
V301A |
probably benign |
Het |
| Fv1 |
T |
A |
4: 147,953,618 (GRCm39) |
N61K |
possibly damaging |
Het |
| Fxr2 |
A |
G |
11: 69,540,659 (GRCm39) |
E339G |
possibly damaging |
Het |
| Gck |
T |
C |
11: 5,856,515 (GRCm39) |
Y214C |
probably damaging |
Het |
| Golga3 |
C |
G |
5: 110,340,839 (GRCm39) |
T551R |
probably damaging |
Het |
| Gorab |
A |
G |
1: 163,224,625 (GRCm39) |
S59P |
probably damaging |
Het |
| Gsdme |
C |
T |
6: 50,185,102 (GRCm39) |
V451M |
probably damaging |
Het |
| H2-T13 |
A |
C |
17: 36,391,938 (GRCm39) |
I216S |
probably damaging |
Het |
| Herc4 |
T |
A |
10: 63,081,743 (GRCm39) |
V22E |
possibly damaging |
Het |
| Hjurp |
GT |
GTT |
1: 88,194,246 (GRCm39) |
|
probably null |
Het |
| Hoxa2 |
A |
T |
6: 52,141,576 (GRCm39) |
S17T |
probably damaging |
Het |
| Hs3st5 |
A |
G |
10: 36,708,882 (GRCm39) |
Y139C |
probably damaging |
Het |
| Ism1 |
G |
A |
2: 139,587,937 (GRCm39) |
V221I |
probably benign |
Het |
| Kalrn |
T |
G |
16: 33,796,108 (GRCm39) |
L1222F |
probably damaging |
Het |
| Katnip |
A |
G |
7: 125,419,261 (GRCm39) |
N476S |
probably benign |
Het |
| Kdm4c |
A |
G |
4: 74,261,631 (GRCm39) |
D602G |
possibly damaging |
Het |
| Ktn1 |
A |
G |
14: 47,932,978 (GRCm39) |
K711E |
probably damaging |
Het |
| Lce1k |
A |
T |
3: 92,714,125 (GRCm39) |
C20S |
unknown |
Het |
| Macf1 |
A |
G |
4: 123,350,488 (GRCm39) |
S3792P |
probably damaging |
Het |
| Maml3 |
C |
T |
3: 51,598,178 (GRCm39) |
M189I |
probably benign |
Het |
| Mcc |
C |
A |
18: 44,624,382 (GRCm39) |
E213* |
probably null |
Het |
| Mep1a |
T |
G |
17: 43,813,573 (GRCm39) |
I13L |
probably benign |
Het |
| Mkrn2 |
G |
T |
6: 115,586,562 (GRCm39) |
C16F |
probably damaging |
Het |
| Mlh1 |
C |
T |
9: 111,057,631 (GRCm39) |
A727T |
probably damaging |
Het |
| Muc21 |
A |
T |
17: 35,929,600 (GRCm39) |
S1529T |
probably benign |
Het |
| Naa16 |
T |
C |
14: 79,593,931 (GRCm39) |
Y344C |
probably damaging |
Het |
| Nebl |
T |
A |
2: 17,457,321 (GRCm39) |
I80F |
probably damaging |
Het |
| Nlrc4 |
T |
A |
17: 74,752,628 (GRCm39) |
Y585F |
probably benign |
Het |
| Nrcam |
A |
G |
12: 44,587,753 (GRCm39) |
K149R |
probably damaging |
Het |
| Nufip1 |
T |
A |
14: 76,372,287 (GRCm39) |
I467N |
probably damaging |
Het |
| Nup133 |
A |
G |
8: 124,632,960 (GRCm39) |
I1057T |
possibly damaging |
Het |
| Obscn |
A |
T |
11: 58,886,653 (GRCm39) |
|
probably benign |
Het |
| Or10ag52 |
T |
A |
2: 87,043,588 (GRCm39) |
C117* |
probably null |
Het |
| Or5k1 |
A |
G |
16: 58,617,309 (GRCm39) |
V300A |
probably benign |
Het |
| Or5k14 |
A |
C |
16: 58,692,874 (GRCm39) |
I213R |
probably benign |
Het |
| Pi4k2a |
A |
T |
19: 42,104,377 (GRCm39) |
I380F |
probably damaging |
Het |
| Piezo2 |
A |
T |
18: 63,207,733 (GRCm39) |
L1426Q |
probably null |
Het |
| Pik3cg |
A |
T |
12: 32,254,024 (GRCm39) |
D654E |
possibly damaging |
Het |
| Poli |
G |
T |
18: 70,642,058 (GRCm39) |
P714Q |
probably damaging |
Het |
| Polr3f |
A |
G |
2: 144,378,230 (GRCm39) |
N201D |
probably benign |
Het |
| Prorp |
A |
G |
12: 55,384,991 (GRCm39) |
D89G |
probably damaging |
Het |
| Ptprz1 |
A |
T |
6: 22,959,747 (GRCm39) |
K81N |
probably benign |
Het |
| Rbm19 |
T |
C |
5: 120,271,948 (GRCm39) |
|
probably null |
Het |
| Sec24a |
C |
T |
11: 51,627,190 (GRCm39) |
V241I |
probably benign |
Het |
| Sgk3 |
A |
G |
1: 9,950,567 (GRCm39) |
T160A |
possibly damaging |
Het |
| Slc1a4 |
A |
G |
11: 20,254,375 (GRCm39) |
I497T |
probably benign |
Het |
| Slc26a9 |
A |
T |
1: 131,690,532 (GRCm39) |
D512V |
probably damaging |
Het |
| Slc43a3 |
C |
T |
2: 84,788,084 (GRCm39) |
R489C |
probably damaging |
Het |
| Slc5a12 |
T |
A |
2: 110,452,089 (GRCm39) |
F327L |
probably benign |
Het |
| Slitrk3 |
A |
G |
3: 72,957,104 (GRCm39) |
V556A |
possibly damaging |
Het |
| Spata6l |
A |
G |
19: 28,926,024 (GRCm39) |
F130L |
probably damaging |
Het |
| Spib |
T |
C |
7: 44,178,281 (GRCm39) |
E180G |
probably benign |
Het |
| Spint2 |
T |
A |
7: 28,958,833 (GRCm39) |
N128Y |
probably damaging |
Het |
| Spx |
G |
A |
6: 142,364,245 (GRCm39) |
G102E |
probably benign |
Het |
| Spz1 |
T |
A |
13: 92,712,166 (GRCm39) |
E103D |
possibly damaging |
Het |
| Sstr2 |
T |
C |
11: 113,515,495 (GRCm39) |
I138T |
probably benign |
Het |
| Sytl3 |
T |
A |
17: 7,000,448 (GRCm39) |
I206N |
possibly damaging |
Het |
| Tcaf2 |
T |
C |
6: 42,606,791 (GRCm39) |
T388A |
probably benign |
Het |
| Tdpoz8 |
G |
T |
3: 92,981,344 (GRCm39) |
A121S |
probably benign |
Het |
| Thap12 |
T |
C |
7: 98,365,572 (GRCm39) |
V580A |
possibly damaging |
Het |
| Tlr5 |
T |
A |
1: 182,801,912 (GRCm39) |
D405E |
probably damaging |
Het |
| Tnxb |
T |
C |
17: 34,890,878 (GRCm39) |
V407A |
probably damaging |
Het |
| Tpx2 |
T |
A |
2: 152,732,544 (GRCm39) |
M606K |
probably benign |
Het |
| Trim43a |
T |
G |
9: 88,466,312 (GRCm39) |
L211R |
probably damaging |
Het |
| Trim46 |
A |
T |
3: 89,145,008 (GRCm39) |
Y489N |
probably damaging |
Het |
| Ttll8 |
T |
C |
15: 88,798,654 (GRCm39) |
T694A |
probably benign |
Het |
| Txnl1 |
T |
C |
18: 63,812,585 (GRCm39) |
T70A |
probably benign |
Het |
| Ube3a |
C |
T |
7: 58,953,535 (GRCm39) |
A823V |
probably damaging |
Het |
| Ubqln5 |
C |
A |
7: 103,778,741 (GRCm39) |
V28F |
probably damaging |
Het |
| Ulk1 |
T |
A |
5: 110,935,017 (GRCm39) |
Q972L |
probably damaging |
Het |
| Unc93b1 |
T |
C |
19: 3,994,062 (GRCm39) |
Y398H |
probably benign |
Het |
| Usp1 |
A |
G |
4: 98,822,531 (GRCm39) |
D615G |
probably benign |
Het |
| Utp15 |
A |
G |
13: 98,387,420 (GRCm39) |
C385R |
probably benign |
Het |
| Vmn2r91 |
T |
A |
17: 18,356,142 (GRCm39) |
V603D |
probably damaging |
Het |
| Whamm |
C |
T |
7: 81,241,519 (GRCm39) |
R277* |
probably null |
Het |
| Wnt8a |
A |
G |
18: 34,677,937 (GRCm39) |
D115G |
probably damaging |
Het |
| Yjefn3 |
A |
T |
8: 70,341,645 (GRCm39) |
|
probably null |
Het |
| Ywhab |
A |
T |
2: 163,853,807 (GRCm39) |
I95F |
probably damaging |
Het |
| Zfp143 |
C |
T |
7: 109,660,489 (GRCm39) |
|
probably benign |
Het |
| Zfp607b |
C |
G |
7: 27,401,949 (GRCm39) |
T135R |
possibly damaging |
Het |
| Zfp970 |
A |
G |
2: 177,166,663 (GRCm39) |
Q79R |
possibly damaging |
Het |
|
| Other mutations in Ttc28 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00516:Ttc28
|
APN |
5 |
111,373,554 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00963:Ttc28
|
APN |
5 |
111,434,255 (GRCm39) |
nonsense |
probably null |
|
|
IGL00969:Ttc28
|
APN |
5 |
111,373,606 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01366:Ttc28
|
APN |
5 |
111,233,037 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01528:Ttc28
|
APN |
5 |
111,249,826 (GRCm39) |
splice site |
probably benign |
|
|
IGL01558:Ttc28
|
APN |
5 |
111,431,828 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01973:Ttc28
|
APN |
5 |
111,372,101 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
IGL02040:Ttc28
|
APN |
5 |
111,040,802 (GRCm39) |
nonsense |
probably null |
|
|
IGL02432:Ttc28
|
APN |
5 |
111,371,101 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02531:Ttc28
|
APN |
5 |
111,373,716 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02819:Ttc28
|
APN |
5 |
111,414,449 (GRCm39) |
missense |
probably benign |
|
|
IGL02830:Ttc28
|
APN |
5 |
111,434,105 (GRCm39) |
missense |
probably benign |
0.10 |
|
IGL02893:Ttc28
|
APN |
5 |
111,433,251 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
IGL03387:Ttc28
|
APN |
5 |
111,381,208 (GRCm39) |
missense |
probably benign |
0.07 |
|
PIT4131001:Ttc28
|
UTSW |
5 |
111,040,719 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0142:Ttc28
|
UTSW |
5 |
111,425,323 (GRCm39) |
missense |
probably benign |
0.40 |
|
R0166:Ttc28
|
UTSW |
5 |
111,373,500 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0328:Ttc28
|
UTSW |
5 |
111,431,933 (GRCm39) |
splice site |
probably benign |
|
|
R0582:Ttc28
|
UTSW |
5 |
111,331,162 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0744:Ttc28
|
UTSW |
5 |
111,378,947 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0811:Ttc28
|
UTSW |
5 |
111,383,366 (GRCm39) |
missense |
probably benign |
0.24 |
|
R0812:Ttc28
|
UTSW |
5 |
111,383,366 (GRCm39) |
missense |
probably benign |
0.24 |
|
R0828:Ttc28
|
UTSW |
5 |
111,371,312 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0833:Ttc28
|
UTSW |
5 |
111,378,947 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1013:Ttc28
|
UTSW |
5 |
111,424,831 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1168:Ttc28
|
UTSW |
5 |
111,378,977 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1194:Ttc28
|
UTSW |
5 |
111,373,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1195:Ttc28
|
UTSW |
5 |
111,373,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1195:Ttc28
|
UTSW |
5 |
111,373,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1195:Ttc28
|
UTSW |
5 |
111,373,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1196:Ttc28
|
UTSW |
5 |
111,373,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1205:Ttc28
|
UTSW |
5 |
111,433,635 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1386:Ttc28
|
UTSW |
5 |
111,373,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1467:Ttc28
|
UTSW |
5 |
111,433,254 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1467:Ttc28
|
UTSW |
5 |
111,433,254 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1537:Ttc28
|
UTSW |
5 |
111,433,184 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1539:Ttc28
|
UTSW |
5 |
111,248,677 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R1558:Ttc28
|
UTSW |
5 |
111,373,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1560:Ttc28
|
UTSW |
5 |
111,373,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1561:Ttc28
|
UTSW |
5 |
111,373,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1566:Ttc28
|
UTSW |
5 |
111,373,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1768:Ttc28
|
UTSW |
5 |
111,425,034 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R1775:Ttc28
|
UTSW |
5 |
111,424,677 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1909:Ttc28
|
UTSW |
5 |
111,431,920 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1911:Ttc28
|
UTSW |
5 |
111,428,616 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R1970:Ttc28
|
UTSW |
5 |
111,383,501 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1990:Ttc28
|
UTSW |
5 |
111,424,188 (GRCm39) |
missense |
probably benign |
0.37 |
|
R2066:Ttc28
|
UTSW |
5 |
111,373,799 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2112:Ttc28
|
UTSW |
5 |
111,424,139 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2158:Ttc28
|
UTSW |
5 |
111,325,483 (GRCm39) |
intron |
probably benign |
|
|
R2192:Ttc28
|
UTSW |
5 |
111,371,362 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2267:Ttc28
|
UTSW |
5 |
111,373,869 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R2384:Ttc28
|
UTSW |
5 |
111,424,074 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R2989:Ttc28
|
UTSW |
5 |
111,371,881 (GRCm39) |
missense |
probably benign |
0.29 |
|
R3881:Ttc28
|
UTSW |
5 |
111,331,106 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3919:Ttc28
|
UTSW |
5 |
111,433,245 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R4455:Ttc28
|
UTSW |
5 |
111,371,924 (GRCm39) |
frame shift |
probably null |
|
|
R4456:Ttc28
|
UTSW |
5 |
111,371,924 (GRCm39) |
frame shift |
probably null |
|
|
R4522:Ttc28
|
UTSW |
5 |
111,428,038 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4548:Ttc28
|
UTSW |
5 |
111,419,090 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R4591:Ttc28
|
UTSW |
5 |
111,371,147 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4633:Ttc28
|
UTSW |
5 |
111,371,867 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4700:Ttc28
|
UTSW |
5 |
111,424,909 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4714:Ttc28
|
UTSW |
5 |
111,433,095 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R4790:Ttc28
|
UTSW |
5 |
111,372,083 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4803:Ttc28
|
UTSW |
5 |
111,425,329 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R4840:Ttc28
|
UTSW |
5 |
111,433,947 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4969:Ttc28
|
UTSW |
5 |
111,424,121 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5019:Ttc28
|
UTSW |
5 |
111,249,930 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R5130:Ttc28
|
UTSW |
5 |
111,040,722 (GRCm39) |
missense |
probably benign |
|
|
R5150:Ttc28
|
UTSW |
5 |
111,373,555 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5214:Ttc28
|
UTSW |
5 |
111,325,489 (GRCm39) |
intron |
probably benign |
|
|
R5254:Ttc28
|
UTSW |
5 |
111,419,104 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5518:Ttc28
|
UTSW |
5 |
111,373,794 (GRCm39) |
missense |
probably benign |
0.17 |
|
R5851:Ttc28
|
UTSW |
5 |
111,383,335 (GRCm39) |
splice site |
probably benign |
|
|
R5931:Ttc28
|
UTSW |
5 |
111,232,975 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R6011:Ttc28
|
UTSW |
5 |
111,434,309 (GRCm39) |
missense |
probably benign |
|
|
R6176:Ttc28
|
UTSW |
5 |
111,371,851 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6221:Ttc28
|
UTSW |
5 |
111,419,114 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6398:Ttc28
|
UTSW |
5 |
111,424,142 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6717:Ttc28
|
UTSW |
5 |
111,433,302 (GRCm39) |
missense |
probably benign |
|
|
R6770:Ttc28
|
UTSW |
5 |
111,434,006 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6901:Ttc28
|
UTSW |
5 |
111,424,891 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R7038:Ttc28
|
UTSW |
5 |
111,414,445 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7073:Ttc28
|
UTSW |
5 |
111,371,282 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R7101:Ttc28
|
UTSW |
5 |
111,232,958 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7135:Ttc28
|
UTSW |
5 |
111,427,873 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7350:Ttc28
|
UTSW |
5 |
111,373,903 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7454:Ttc28
|
UTSW |
5 |
111,433,350 (GRCm39) |
missense |
probably benign |
0.19 |
|
R7461:Ttc28
|
UTSW |
5 |
111,371,995 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7596:Ttc28
|
UTSW |
5 |
111,427,990 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7613:Ttc28
|
UTSW |
5 |
111,371,995 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7625:Ttc28
|
UTSW |
5 |
111,433,085 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R7648:Ttc28
|
UTSW |
5 |
111,331,258 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R7735:Ttc28
|
UTSW |
5 |
111,414,544 (GRCm39) |
splice site |
probably null |
|
|
R8030:Ttc28
|
UTSW |
5 |
111,433,922 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R8205:Ttc28
|
UTSW |
5 |
111,373,596 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8246:Ttc28
|
UTSW |
5 |
111,381,207 (GRCm39) |
missense |
probably benign |
0.33 |
|
R8247:Ttc28
|
UTSW |
5 |
111,381,207 (GRCm39) |
missense |
probably benign |
0.33 |
|
R8269:Ttc28
|
UTSW |
5 |
111,425,325 (GRCm39) |
missense |
probably benign |
0.09 |
|
R8292:Ttc28
|
UTSW |
5 |
111,371,123 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8346:Ttc28
|
UTSW |
5 |
111,381,207 (GRCm39) |
missense |
probably benign |
0.33 |
|
R8356:Ttc28
|
UTSW |
5 |
111,381,207 (GRCm39) |
missense |
probably benign |
0.33 |
|
R8423:Ttc28
|
UTSW |
5 |
111,381,207 (GRCm39) |
missense |
probably benign |
0.33 |
|
R8424:Ttc28
|
UTSW |
5 |
111,381,207 (GRCm39) |
missense |
probably benign |
0.33 |
|
R8426:Ttc28
|
UTSW |
5 |
111,381,207 (GRCm39) |
missense |
probably benign |
0.33 |
|
R8441:Ttc28
|
UTSW |
5 |
111,325,507 (GRCm39) |
nonsense |
probably null |
|
|
R8494:Ttc28
|
UTSW |
5 |
111,383,506 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8508:Ttc28
|
UTSW |
5 |
111,381,207 (GRCm39) |
missense |
probably benign |
0.33 |
|
R8510:Ttc28
|
UTSW |
5 |
111,381,207 (GRCm39) |
missense |
probably benign |
0.33 |
|
R8729:Ttc28
|
UTSW |
5 |
111,383,509 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8845:Ttc28
|
UTSW |
5 |
111,372,041 (GRCm39) |
missense |
probably benign |
0.11 |
|
R9003:Ttc28
|
UTSW |
5 |
111,424,896 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9185:Ttc28
|
UTSW |
5 |
111,371,342 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9187:Ttc28
|
UTSW |
5 |
111,249,902 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9245:Ttc28
|
UTSW |
5 |
111,325,525 (GRCm39) |
missense |
unknown |
|
|
R9251:Ttc28
|
UTSW |
5 |
111,040,698 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R9372:Ttc28
|
UTSW |
5 |
111,331,073 (GRCm39) |
missense |
probably benign |
0.25 |
|
R9466:Ttc28
|
UTSW |
5 |
111,330,895 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9563:Ttc28
|
UTSW |
5 |
111,371,092 (GRCm39) |
missense |
probably benign |
0.22 |
|
R9606:Ttc28
|
UTSW |
5 |
111,433,140 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9691:Ttc28
|
UTSW |
5 |
111,431,879 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9709:Ttc28
|
UTSW |
5 |
111,433,637 (GRCm39) |
missense |
probably damaging |
0.97 |
|
V8831:Ttc28
|
UTSW |
5 |
111,248,578 (GRCm39) |
missense |
probably benign |
0.11 |
|
Z1088:Ttc28
|
UTSW |
5 |
111,434,181 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1176:Ttc28
|
UTSW |
5 |
111,414,432 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
Z1177:Ttc28
|
UTSW |
5 |
111,433,605 (GRCm39) |
missense |
probably benign |
0.10 |
|
Z1177:Ttc28
|
UTSW |
5 |
111,426,452 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- AACACTTGTACAGGGCAGCAC -3'
(R):5'- TCCTGCCTCTTGACAAAGTTG -3'
Sequencing Primer
(F):5'- TGCCGTGACAGTTAGCCAG -3'
(R):5'- CTGCCTCTTGACAAAGTTGTAATTC -3'
|
| Posted On |
2014-08-25 |
Incidental Mutation