Mutagenetix > Incidental Mutation

Incidental Mutation 'R1992:Adgrl2'

223579

Institutional Source

Beutler Lab

Gene Symbol

Adgrl2

Ensembl Gene

ENSMUSG00000028184

Gene Name

adhesion G protein-coupled receptor L2

Synonyms

Lphn2, Lphh1, Lec1

MMRRC Submission

040003-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R1992 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

148521219-148696191 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 148522880 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Threonine at position 217 (I217T)

Ref Sequence

ENSEMBL: ENSMUSP00000132116 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000106128] [ENSMUST00000168352] [ENSMUST00000195988] [ENSMUST00000196526] [ENSMUST00000197567] [ENSMUST00000199059] [ENSMUST00000199238] [ENSMUST00000198779] [ENSMUST00000199750] [ENSMUST00000200543] [ENSMUST00000200154]

AlphaFold

Q8JZZ7

Predicted Effect

possibly damaging
Transcript: ENSMUST00000106128
AA Change: I1465T

PolyPhen 2 Score 0.474 (Sensitivity: 0.89; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000101734
Gene: ENSMUSG00000028184
AA Change: I1465T

Domain	Start	End	E-Value	Type
signal peptide	1	25	N/A	INTRINSIC
Pfam:Gal_Lectin	49	129	2.5e-26	PFAM
OLF	142	398	5.22e-140	SMART
HormR	469	534	3.14e-20	SMART
Pfam:GAIN	537	764	1.3e-58	PFAM
GPS	788	840	3.47e-25	SMART
Pfam:7tm_2	848	1108	4.6e-69	PFAM
Pfam:Latrophilin	1128	1487	6.4e-181	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000168352
AA Change: I217T

PolyPhen 2 Score 0.895 (Sensitivity: 0.82; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000132116
Gene: ENSMUSG00000028184
AA Change: I217T

Domain	Start	End	E-Value	Type
Pfam:Latrophilin	1	239	2.5e-122	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000195988
AA Change: I1413T

PolyPhen 2 Score 0.456 (Sensitivity: 0.89; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000143444
Gene: ENSMUSG00000028184
AA Change: I1413T

Domain	Start	End	E-Value	Type
signal peptide	1	25	N/A	INTRINSIC
Pfam:Gal_Lectin	49	129	3.3e-23	PFAM
OLF	142	398	3.3e-142	SMART
HormR	469	534	2e-22	SMART
GPS	788	840	2.1e-27	SMART
Pfam:7tm_2	848	1099	8.1e-66	PFAM
Pfam:Latrophilin	1119	1189	2.2e-28	PFAM
Pfam:Latrophilin	1184	1435	5.5e-123	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000196526

SMART Domains

Protein: ENSMUSP00000143788
Gene: ENSMUSG00000028184

Domain	Start	End	E-Value	Type
signal peptide	1	25	N/A	INTRINSIC
Pfam:Gal_Lectin	49	129	8.7e-24	PFAM
OLF	138	394	3.4e-142	SMART
HormR	465	530	2e-22	SMART
Pfam:GAIN	533	747	1.1e-54	PFAM
GPS	771	823	2.2e-27	SMART
Pfam:7tm_2	831	1067	6.5e-68	PFAM
Pfam:Latrophilin	1087	1158	9.9e-36	PFAM
low complexity region	1163	1173	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000197348

Predicted Effect

possibly damaging
Transcript: ENSMUST00000197567
AA Change: I1465T

PolyPhen 2 Score 0.611 (Sensitivity: 0.87; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000143626
Gene: ENSMUSG00000028184
AA Change: I1465T

Domain	Start	End	E-Value	Type
signal peptide	1	25	N/A	INTRINSIC
Pfam:Gal_Lectin	49	129	1.9e-26	PFAM
OLF	142	398	5.22e-140	SMART
HormR	469	534	3.14e-20	SMART
Pfam:GAIN	537	764	1.1e-58	PFAM
GPS	788	840	3.47e-25	SMART
Pfam:7tm_2	848	1108	6.4e-69	PFAM
Pfam:Latrophilin	1128	1487	2.8e-181	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000197925

Predicted Effect

possibly damaging
Transcript: ENSMUST00000199059
AA Change: I1445T

PolyPhen 2 Score 0.474 (Sensitivity: 0.89; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000143150
Gene: ENSMUSG00000028184
AA Change: I1445T

Domain	Start	End	E-Value	Type
signal peptide	1	25	N/A	INTRINSIC
Pfam:Gal_Lectin	49	129	3.4e-23	PFAM
OLF	142	398	3.3e-142	SMART
HormR	469	534	2e-22	SMART
GPS	788	840	2.1e-27	SMART
Pfam:7tm_2	848	1099	8.3e-66	PFAM
Pfam:Latrophilin	1119	1467	7.1e-174	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000199238
AA Change: I1456T

PolyPhen 2 Score 0.611 (Sensitivity: 0.87; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000142405
Gene: ENSMUSG00000028184
AA Change: I1456T

Domain	Start	End	E-Value	Type
signal peptide	1	25	N/A	INTRINSIC
Pfam:Gal_Lectin	49	129	3.4e-23	PFAM
OLF	142	398	3.3e-142	SMART
HormR	469	534	2e-22	SMART
GPS	788	840	2.1e-27	SMART
Pfam:7tm_2	848	1099	8.4e-66	PFAM
Pfam:Latrophilin	1119	1478	1.6e-187	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000198779
AA Change: I1430T

PolyPhen 2 Score 0.017 (Sensitivity: 0.95; Specificity: 0.80)

SMART Domains

Protein: ENSMUSP00000142347
Gene: ENSMUSG00000028184
AA Change: I1430T

Domain	Start	End	E-Value	Type
signal peptide	1	25	N/A	INTRINSIC
Pfam:Gal_Lectin	49	129	3.4e-23	PFAM
OLF	142	398	3.3e-142	SMART
HormR	469	534	2e-22	SMART
GPS	788	840	2.1e-27	SMART
Pfam:7tm_2	848	1084	1.8e-66	PFAM
Pfam:Latrophilin	1104	1452	7e-174	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000199750
AA Change: I1319T

PolyPhen 2 Score 0.032 (Sensitivity: 0.95; Specificity: 0.82)

SMART Domains

Protein: ENSMUSP00000143320
Gene: ENSMUSG00000028184
AA Change: I1319T

Domain	Start	End	E-Value	Type
signal peptide	1	25	N/A	INTRINSIC
Pfam:Gal_Lectin	49	129	3.1e-23	PFAM
OLF	142	398	3.3e-142	SMART
HormR	403	468	1.9e-22	SMART
GPS	709	761	2.1e-27	SMART
Pfam:7tm_2	769	1005	1.6e-66	PFAM
Pfam:Latrophilin	1025	1095	2e-28	PFAM
Pfam:Latrophilin	1090	1341	4.9e-123	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000200543
AA Change: I1381T

PolyPhen 2 Score 0.305 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000142336
Gene: ENSMUSG00000028184
AA Change: I1381T

Domain	Start	End	E-Value	Type
signal peptide	1	25	N/A	INTRINSIC
Pfam:Gal_Lectin	49	129	3.2e-23	PFAM
OLF	138	394	3.3e-142	SMART
HormR	465	530	2e-22	SMART
GPS	771	823	2.1e-27	SMART
Pfam:7tm_2	831	1067	1.7e-66	PFAM
Pfam:Latrophilin	1087	1157	2.1e-28	PFAM
Pfam:Latrophilin	1152	1403	5.3e-123	PFAM

Predicted Effect

unknown
Transcript: ENSMUST00000198139
AA Change: I448T

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000200023

Predicted Effect

probably benign
Transcript: ENSMUST00000200154

SMART Domains

Protein: ENSMUSP00000142865
Gene: ENSMUSG00000028184

Domain	Start	End	E-Value	Type
signal peptide	1	25	N/A	INTRINSIC
Pfam:Gal_Lectin	49	129	2.5e-23	PFAM
OLF	138	394	3.3e-142	SMART
HormR	465	530	2e-22	SMART
GPS	771	823	2.1e-27	SMART
Pfam:7tm_2	831	1067	1.2e-66	PFAM
Pfam:Latrophilin	1087	1123	2.2e-4	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000200216

Predicted Effect

probably benign
Transcript: ENSMUST00000200456

Coding Region Coverage

1x: 99.1%
3x: 98.4%
10x: 96.4%
20x: 92.5%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors. The encoded protein participates in the regulation of exocytosis. The proprotein is thought to be further cleaved within a cysteine-rich G-protein-coupled receptor proteolysis site into two chains that are non-covalently bound at the cell membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
PHENOTYPE: Homozygous null mice die prenatally at fetal stages. Heterozygous mice exhibit decreased locomotor activity in an open field test. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 123 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2310009B15Rik	T	C	1: 138,781,380 (GRCm39)	T90A	probably damaging	Het
A930011G23Rik	T	C	5: 99,381,784 (GRCm39)	D326G	possibly damaging	Het
Abcc2	A	T	19: 43,795,581 (GRCm39)	I446F	probably damaging	Het
Adam34l	T	C	8: 44,080,176 (GRCm39)	K16R	probably benign	Het
Adamts14	A	G	10: 61,034,439 (GRCm39)	Y1150H	probably benign	Het
Afap1l1	A	T	18: 61,874,842 (GRCm39)	Y446*	probably null	Het
Aimp2	G	A	5: 143,843,548 (GRCm39)	A14V	probably damaging	Het
Akap8	G	A	17: 32,535,586 (GRCm39)	H143Y	probably damaging	Het
Aldh2	A	T	5: 121,714,026 (GRCm39)	V207E	possibly damaging	Het
Aoc1l2	T	A	6: 48,907,703 (GRCm39)	H234Q	probably damaging	Het
Armc3	T	C	2: 19,297,953 (GRCm39)	Y575H	probably damaging	Het
Arpp21	T	C	9: 111,986,861 (GRCm39)	E230G	probably damaging	Het
Arrdc3	G	A	13: 81,031,808 (GRCm39)	D14N	probably damaging	Het
Atn1	A	G	6: 124,722,291 (GRCm39)		probably benign	Het
Atxn7l1	G	A	12: 33,408,743 (GRCm39)	D302N	probably damaging	Het
Bbs1	T	A	19: 4,941,736 (GRCm39)	H518L	probably benign	Het
Bltp1	A	T	3: 37,054,181 (GRCm39)	H3100L	probably benign	Het
Bmpr1a	C	A	14: 34,147,050 (GRCm39)	G241C	probably damaging	Het
Cacna1b	G	A	2: 24,622,318 (GRCm39)	P222L	probably damaging	Het
Calcrl	T	C	2: 84,200,855 (GRCm39)	Y63C	probably damaging	Het
Cand2	A	G	6: 115,762,093 (GRCm39)	H173R	possibly damaging	Het
Cap2	T	A	13: 46,791,357 (GRCm39)	Y175N	possibly damaging	Het
Card14	A	T	11: 119,212,647 (GRCm39)		probably null	Het
Cd3d	T	A	9: 44,896,299 (GRCm39)	Y29*	probably null	Het
Cd4	A	G	6: 124,844,651 (GRCm39)	V378A	possibly damaging	Het
Cluh	A	T	11: 74,550,828 (GRCm39)	H318L	probably damaging	Het
Clvs1	T	A	4: 9,281,899 (GRCm39)	D114E	probably benign	Het
Cnot4	T	A	6: 35,000,344 (GRCm39)	T548S	probably benign	Het
Col18a1	T	C	10: 76,916,988 (GRCm39)	I114V	unknown	Het
Cr2	G	A	1: 194,836,458 (GRCm39)	P1278S	possibly damaging	Het
Crebbp	A	T	16: 3,946,561 (GRCm39)		probably null	Het
Dnah7a	T	G	1: 53,621,835 (GRCm39)	K1097Q	possibly damaging	Het
Doc2a	T	A	7: 126,450,979 (GRCm39)		probably null	Het
Dpp10	A	T	1: 123,832,833 (GRCm39)	V48E	probably null	Het
Dsg2	A	G	18: 20,734,530 (GRCm39)	K836R	probably damaging	Het
Egr2	T	C	10: 67,375,857 (GRCm39)	V164A	probably damaging	Het
Erbin	A	T	13: 103,970,221 (GRCm39)	S1132T	probably benign	Het
Espn	T	A	4: 152,213,012 (GRCm39)		probably null	Het
Fam83b	A	G	9: 76,399,304 (GRCm39)	S600P	probably benign	Het
Fanca	A	T	8: 124,024,551 (GRCm39)	N425K	possibly damaging	Het
Flot2	C	T	11: 77,949,445 (GRCm39)	L294F	probably damaging	Het
Frs2	A	G	10: 116,910,459 (GRCm39)	V301A	probably benign	Het
Fv1	T	A	4: 147,953,618 (GRCm39)	N61K	possibly damaging	Het
Fxr2	A	G	11: 69,540,659 (GRCm39)	E339G	possibly damaging	Het
Gck	T	C	11: 5,856,515 (GRCm39)	Y214C	probably damaging	Het
Golga3	C	G	5: 110,340,839 (GRCm39)	T551R	probably damaging	Het
Gorab	A	G	1: 163,224,625 (GRCm39)	S59P	probably damaging	Het
Gsdme	C	T	6: 50,185,102 (GRCm39)	V451M	probably damaging	Het
H2-T13	A	C	17: 36,391,938 (GRCm39)	I216S	probably damaging	Het
Herc4	T	A	10: 63,081,743 (GRCm39)	V22E	possibly damaging	Het
Hjurp	GT	GTT	1: 88,194,246 (GRCm39)		probably null	Het
Hoxa2	A	T	6: 52,141,576 (GRCm39)	S17T	probably damaging	Het
Hs3st5	A	G	10: 36,708,882 (GRCm39)	Y139C	probably damaging	Het
Ism1	G	A	2: 139,587,937 (GRCm39)	V221I	probably benign	Het
Kalrn	T	G	16: 33,796,108 (GRCm39)	L1222F	probably damaging	Het
Katnip	A	G	7: 125,419,261 (GRCm39)	N476S	probably benign	Het
Kdm4c	A	G	4: 74,261,631 (GRCm39)	D602G	possibly damaging	Het
Ktn1	A	G	14: 47,932,978 (GRCm39)	K711E	probably damaging	Het
Lce1k	A	T	3: 92,714,125 (GRCm39)	C20S	unknown	Het
Macf1	A	G	4: 123,350,488 (GRCm39)	S3792P	probably damaging	Het
Maml3	C	T	3: 51,598,178 (GRCm39)	M189I	probably benign	Het
Mcc	C	A	18: 44,624,382 (GRCm39)	E213*	probably null	Het
Mep1a	T	G	17: 43,813,573 (GRCm39)	I13L	probably benign	Het
Mkrn2	G	T	6: 115,586,562 (GRCm39)	C16F	probably damaging	Het
Mlh1	C	T	9: 111,057,631 (GRCm39)	A727T	probably damaging	Het
Muc21	A	T	17: 35,929,600 (GRCm39)	S1529T	probably benign	Het
Naa16	T	C	14: 79,593,931 (GRCm39)	Y344C	probably damaging	Het
Nebl	T	A	2: 17,457,321 (GRCm39)	I80F	probably damaging	Het
Nlrc4	T	A	17: 74,752,628 (GRCm39)	Y585F	probably benign	Het
Nrcam	A	G	12: 44,587,753 (GRCm39)	K149R	probably damaging	Het
Nufip1	T	A	14: 76,372,287 (GRCm39)	I467N	probably damaging	Het
Nup133	A	G	8: 124,632,960 (GRCm39)	I1057T	possibly damaging	Het
Obscn	A	T	11: 58,886,653 (GRCm39)		probably benign	Het
Or10ag52	T	A	2: 87,043,588 (GRCm39)	C117*	probably null	Het
Or5k1	A	G	16: 58,617,309 (GRCm39)	V300A	probably benign	Het
Or5k14	A	C	16: 58,692,874 (GRCm39)	I213R	probably benign	Het
Pi4k2a	A	T	19: 42,104,377 (GRCm39)	I380F	probably damaging	Het
Piezo2	A	T	18: 63,207,733 (GRCm39)	L1426Q	probably null	Het
Pik3cg	A	T	12: 32,254,024 (GRCm39)	D654E	possibly damaging	Het
Poli	G	T	18: 70,642,058 (GRCm39)	P714Q	probably damaging	Het
Polr3f	A	G	2: 144,378,230 (GRCm39)	N201D	probably benign	Het
Prorp	A	G	12: 55,384,991 (GRCm39)	D89G	probably damaging	Het
Ptprz1	A	T	6: 22,959,747 (GRCm39)	K81N	probably benign	Het
Rbm19	T	C	5: 120,271,948 (GRCm39)		probably null	Het
Sec24a	C	T	11: 51,627,190 (GRCm39)	V241I	probably benign	Het
Sgk3	A	G	1: 9,950,567 (GRCm39)	T160A	possibly damaging	Het
Slc1a4	A	G	11: 20,254,375 (GRCm39)	I497T	probably benign	Het
Slc26a9	A	T	1: 131,690,532 (GRCm39)	D512V	probably damaging	Het
Slc43a3	C	T	2: 84,788,084 (GRCm39)	R489C	probably damaging	Het
Slc5a12	T	A	2: 110,452,089 (GRCm39)	F327L	probably benign	Het
Slitrk3	A	G	3: 72,957,104 (GRCm39)	V556A	possibly damaging	Het
Spata6l	A	G	19: 28,926,024 (GRCm39)	F130L	probably damaging	Het
Spib	T	C	7: 44,178,281 (GRCm39)	E180G	probably benign	Het
Spint2	T	A	7: 28,958,833 (GRCm39)	N128Y	probably damaging	Het
Spx	G	A	6: 142,364,245 (GRCm39)	G102E	probably benign	Het
Spz1	T	A	13: 92,712,166 (GRCm39)	E103D	possibly damaging	Het
Sstr2	T	C	11: 113,515,495 (GRCm39)	I138T	probably benign	Het
Sytl3	T	A	17: 7,000,448 (GRCm39)	I206N	possibly damaging	Het
Tcaf2	T	C	6: 42,606,791 (GRCm39)	T388A	probably benign	Het
Tdpoz8	G	T	3: 92,981,344 (GRCm39)	A121S	probably benign	Het
Thap12	T	C	7: 98,365,572 (GRCm39)	V580A	possibly damaging	Het
Tlr5	T	A	1: 182,801,912 (GRCm39)	D405E	probably damaging	Het
Tnxb	T	C	17: 34,890,878 (GRCm39)	V407A	probably damaging	Het
Tpx2	T	A	2: 152,732,544 (GRCm39)	M606K	probably benign	Het
Trim43a	T	G	9: 88,466,312 (GRCm39)	L211R	probably damaging	Het
Trim46	A	T	3: 89,145,008 (GRCm39)	Y489N	probably damaging	Het
Ttc28	C	T	5: 111,424,188 (GRCm39)	S1485L	probably benign	Het
Ttll8	T	C	15: 88,798,654 (GRCm39)	T694A	probably benign	Het
Txnl1	T	C	18: 63,812,585 (GRCm39)	T70A	probably benign	Het
Ube3a	C	T	7: 58,953,535 (GRCm39)	A823V	probably damaging	Het
Ubqln5	C	A	7: 103,778,741 (GRCm39)	V28F	probably damaging	Het
Ulk1	T	A	5: 110,935,017 (GRCm39)	Q972L	probably damaging	Het
Unc93b1	T	C	19: 3,994,062 (GRCm39)	Y398H	probably benign	Het
Usp1	A	G	4: 98,822,531 (GRCm39)	D615G	probably benign	Het
Utp15	A	G	13: 98,387,420 (GRCm39)	C385R	probably benign	Het
Vmn2r91	T	A	17: 18,356,142 (GRCm39)	V603D	probably damaging	Het
Whamm	C	T	7: 81,241,519 (GRCm39)	R277*	probably null	Het
Wnt8a	A	G	18: 34,677,937 (GRCm39)	D115G	probably damaging	Het
Yjefn3	A	T	8: 70,341,645 (GRCm39)		probably null	Het
Ywhab	A	T	2: 163,853,807 (GRCm39)	I95F	probably damaging	Het
Zfp143	C	T	7: 109,660,489 (GRCm39)		probably benign	Het
Zfp607b	C	G	7: 27,401,949 (GRCm39)	T135R	possibly damaging	Het
Zfp970	A	G	2: 177,166,663 (GRCm39)	Q79R	possibly damaging	Het

Other mutations in Adgrl2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00426:Adgrl2	APN	3	148,571,244 (GRCm39)	missense	probably damaging	0.99
IGL00572:Adgrl2	APN	3	148,532,134 (GRCm39)	missense	probably damaging	1.00
IGL01624:Adgrl2	APN	3	148,542,163 (GRCm39)	missense	probably damaging	1.00
IGL01796:Adgrl2	APN	3	148,564,611 (GRCm39)	missense	probably damaging	1.00
IGL02380:Adgrl2	APN	3	148,534,125 (GRCm39)	nonsense	probably null
IGL02468:Adgrl2	APN	3	148,596,116 (GRCm39)	missense	probably damaging	1.00
IGL02708:Adgrl2	APN	3	148,532,161 (GRCm39)	missense	probably damaging	0.96
IGL02869:Adgrl2	APN	3	148,596,241 (GRCm39)	missense	probably damaging	1.00
IGL03248:Adgrl2	APN	3	148,523,036 (GRCm39)	missense	probably damaging	1.00
IGL03343:Adgrl2	APN	3	148,565,016 (GRCm39)	missense	probably damaging	0.98
P0157:Adgrl2	UTSW	3	148,564,699 (GRCm39)	missense	probably damaging	1.00
PIT4382001:Adgrl2	UTSW	3	148,522,934 (GRCm39)	missense
PIT4544001:Adgrl2	UTSW	3	148,596,157 (GRCm39)	missense	probably damaging	1.00
R0165:Adgrl2	UTSW	3	148,558,499 (GRCm39)	splice site	probably benign
R0242:Adgrl2	UTSW	3	148,544,821 (GRCm39)	splice site	probably null
R0242:Adgrl2	UTSW	3	148,544,821 (GRCm39)	splice site	probably null
R0344:Adgrl2	UTSW	3	148,571,231 (GRCm39)	splice site	probably null
R0488:Adgrl2	UTSW	3	148,552,541 (GRCm39)	missense	probably damaging	1.00
R0542:Adgrl2	UTSW	3	148,564,854 (GRCm39)	missense	probably damaging	1.00
R0630:Adgrl2	UTSW	3	148,544,880 (GRCm39)	missense	probably damaging	0.98
R0674:Adgrl2	UTSW	3	148,543,315 (GRCm39)	missense	possibly damaging	0.91
R1401:Adgrl2	UTSW	3	148,528,617 (GRCm39)	missense	probably damaging	0.99
R1543:Adgrl2	UTSW	3	148,564,909 (GRCm39)	missense	probably damaging	1.00
R1575:Adgrl2	UTSW	3	148,558,398 (GRCm39)	missense	probably benign	0.17
R1645:Adgrl2	UTSW	3	148,571,244 (GRCm39)	missense	probably damaging	1.00
R1780:Adgrl2	UTSW	3	148,558,229 (GRCm39)	missense	probably damaging	1.00
R2014:Adgrl2	UTSW	3	148,532,111 (GRCm39)	missense	probably damaging	1.00
R2130:Adgrl2	UTSW	3	148,596,124 (GRCm39)	missense	probably damaging	0.99
R2131:Adgrl2	UTSW	3	148,596,124 (GRCm39)	missense	probably damaging	0.99
R2400:Adgrl2	UTSW	3	148,557,570 (GRCm39)	missense	probably damaging	1.00
R2997:Adgrl2	UTSW	3	148,523,285 (GRCm39)	missense	probably damaging	1.00
R3161:Adgrl2	UTSW	3	148,523,187 (GRCm39)	missense	probably damaging	1.00
R3416:Adgrl2	UTSW	3	148,564,965 (GRCm39)	missense	probably damaging	1.00
R3417:Adgrl2	UTSW	3	148,564,965 (GRCm39)	missense	probably damaging	1.00
R3551:Adgrl2	UTSW	3	148,564,599 (GRCm39)	missense	probably damaging	1.00
R3760:Adgrl2	UTSW	3	148,522,871 (GRCm39)	missense	probably damaging	1.00
R4355:Adgrl2	UTSW	3	148,544,788 (GRCm39)	missense	probably damaging	1.00
R4850:Adgrl2	UTSW	3	148,564,656 (GRCm39)	missense	probably damaging	1.00
R4911:Adgrl2	UTSW	3	148,596,099 (GRCm39)	missense	probably damaging	0.99
R4945:Adgrl2	UTSW	3	148,528,672 (GRCm39)	missense	probably damaging	0.99
R5313:Adgrl2	UTSW	3	148,529,349 (GRCm39)	missense	probably damaging	1.00
R5339:Adgrl2	UTSW	3	148,523,480 (GRCm39)	missense	probably benign	0.01
R5540:Adgrl2	UTSW	3	148,543,198 (GRCm39)	critical splice donor site	probably null
R5583:Adgrl2	UTSW	3	148,564,800 (GRCm39)	missense	probably damaging	1.00
R5890:Adgrl2	UTSW	3	148,564,811 (GRCm39)	missense	probably damaging	1.00
R6170:Adgrl2	UTSW	3	148,528,645 (GRCm39)	missense	probably damaging	1.00
R6197:Adgrl2	UTSW	3	148,564,578 (GRCm39)	missense	probably damaging	1.00
R6284:Adgrl2	UTSW	3	148,532,143 (GRCm39)	missense	probably damaging	1.00
R6877:Adgrl2	UTSW	3	148,522,922 (GRCm39)	missense	probably damaging	1.00
R7048:Adgrl2	UTSW	3	148,552,565 (GRCm39)	missense	probably damaging	1.00
R7205:Adgrl2	UTSW	3	148,564,585 (GRCm39)	missense	probably damaging	1.00
R7326:Adgrl2	UTSW	3	148,552,506 (GRCm39)	missense	probably benign	0.00
R7348:Adgrl2	UTSW	3	148,523,402 (GRCm39)	missense
R7382:Adgrl2	UTSW	3	148,522,919 (GRCm39)	missense
R7486:Adgrl2	UTSW	3	148,523,330 (GRCm39)	missense
R7498:Adgrl2	UTSW	3	148,564,852 (GRCm39)	nonsense	probably null
R7644:Adgrl2	UTSW	3	148,544,789 (GRCm39)	missense	probably damaging	1.00
R7690:Adgrl2	UTSW	3	148,522,934 (GRCm39)	missense
R7742:Adgrl2	UTSW	3	148,542,064 (GRCm39)	missense	probably damaging	1.00
R7745:Adgrl2	UTSW	3	148,542,094 (GRCm39)	missense	probably damaging	1.00
R8291:Adgrl2	UTSW	3	148,556,554 (GRCm39)	missense	possibly damaging	0.93
R8326:Adgrl2	UTSW	3	148,533,190 (GRCm39)	missense
R8343:Adgrl2	UTSW	3	148,552,542 (GRCm39)	missense	probably damaging	1.00
R8344:Adgrl2	UTSW	3	148,565,161 (GRCm39)	missense	probably damaging	0.98
R8487:Adgrl2	UTSW	3	148,565,122 (GRCm39)	missense	probably benign	0.06
R8748:Adgrl2	UTSW	3	148,532,026 (GRCm39)	missense
R8769:Adgrl2	UTSW	3	148,522,917 (GRCm39)	missense
R8804:Adgrl2	UTSW	3	148,552,652 (GRCm39)	missense	probably damaging	1.00
R8911:Adgrl2	UTSW	3	148,558,163 (GRCm39)	intron	probably benign
R8943:Adgrl2	UTSW	3	148,534,119 (GRCm39)	missense	probably damaging	1.00
R8977:Adgrl2	UTSW	3	148,660,223 (GRCm39)	missense	probably null
R9030:Adgrl2	UTSW	3	148,544,761 (GRCm39)	missense	possibly damaging	0.74
R9105:Adgrl2	UTSW	3	148,543,289 (GRCm39)	missense	possibly damaging	0.82
R9427:Adgrl2	UTSW	3	148,526,068 (GRCm39)	missense
R9471:Adgrl2	UTSW	3	148,558,365 (GRCm39)	missense	probably benign
R9646:Adgrl2	UTSW	3	148,544,926 (GRCm39)	missense	probably damaging	0.96
R9742:Adgrl2	UTSW	3	148,541,986 (GRCm39)	critical splice donor site	probably null
RF007:Adgrl2	UTSW	3	148,544,884 (GRCm39)	missense	probably damaging	1.00
X0009:Adgrl2	UTSW	3	148,558,290 (GRCm39)	missense	probably damaging	1.00
X0019:Adgrl2	UTSW	3	148,571,230 (GRCm39)	splice site	probably null

Predicted Primers

PCR Primer
(F):5'- CCGTTTTACTACAAGTGGAGAAC -3'
(R):5'- TGTACACGAGCATGCCCAAC -3'

Sequencing Primer
(F):5'- CCAACAGAGCCGAGTCTTCTG -3'
(R):5'- GAGCATGCCCAACCTAAGAG -3'

Posted On

2014-08-25