Incidental Mutation 'R1974:Vmn2r77'
| ID |
221409 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r77
|
| Ensembl Gene |
ENSMUSG00000090949 |
| Gene Name |
vomeronasal 2, receptor 77 |
| Synonyms |
EG546983 |
| MMRRC Submission |
039987-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.079)
|
| Stock # |
R1974 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
86444349-86461240 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 86449964 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 70
(V70A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000129540
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000164996]
|
| AlphaFold |
L7N2B7 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000164996
AA Change: V70A
PolyPhen 2
Score 0.166 (Sensitivity: 0.92; Specificity: 0.87)
|
| SMART Domains |
Protein: ENSMUSP00000129540
Gene: ENSMUSG00000090949
AA Change: V70A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
78 |
467 |
1.4e-30 |
PFAM |
|
Pfam:NCD3G
|
510 |
562 |
1e-20 |
PFAM |
|
Pfam:7tm_3
|
594 |
830 |
2.6e-52 |
PFAM |
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.5%
- 10x: 96.9%
- 20x: 94.3%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 80 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1110002E22Rik |
T |
A |
3: 137,773,028 (GRCm39) |
L739Q |
probably damaging |
Het |
| 4933436I01Rik |
A |
T |
X: 66,963,655 (GRCm39) |
Y401* |
probably null |
Het |
| Abcg3 |
A |
G |
5: 105,111,504 (GRCm39) |
V321A |
probably benign |
Het |
| Acad10 |
C |
A |
5: 121,764,248 (GRCm39) |
V894L |
possibly damaging |
Het |
| Adam9 |
A |
G |
8: 25,482,240 (GRCm39) |
I255T |
probably damaging |
Het |
| Ago3 |
T |
C |
4: 126,240,544 (GRCm39) |
Y785C |
probably damaging |
Het |
| Aif1 |
G |
A |
17: 35,391,127 (GRCm39) |
P44L |
probably benign |
Het |
| Akap4 |
A |
G |
X: 6,943,595 (GRCm39) |
S633G |
probably benign |
Het |
| Alox15 |
T |
A |
11: 70,240,799 (GRCm39) |
T194S |
probably benign |
Het |
| Amh |
T |
C |
10: 80,642,250 (GRCm39) |
S207P |
probably benign |
Het |
| Apc |
T |
A |
18: 34,433,057 (GRCm39) |
C415S |
possibly damaging |
Het |
| Atg14 |
G |
A |
14: 47,783,298 (GRCm39) |
R346C |
probably damaging |
Het |
| Atp5mf |
A |
T |
5: 145,121,389 (GRCm39) |
L64Q |
probably damaging |
Het |
| Barhl2 |
C |
G |
5: 106,605,179 (GRCm39) |
E177Q |
probably benign |
Het |
| C1qtnf5 |
T |
C |
9: 44,020,072 (GRCm39) |
V232A |
probably damaging |
Het |
| Calr |
T |
C |
8: 85,570,786 (GRCm39) |
I290V |
probably benign |
Het |
| Cdh19 |
G |
C |
1: 110,817,889 (GRCm39) |
Q618E |
possibly damaging |
Het |
| Celsr2 |
G |
T |
3: 108,321,530 (GRCm39) |
D427E |
probably damaging |
Het |
| Cep250 |
T |
C |
2: 155,831,424 (GRCm39) |
S1294P |
probably damaging |
Het |
| Chrna7 |
T |
A |
7: 62,749,034 (GRCm39) |
T483S |
probably damaging |
Het |
| Clmn |
A |
T |
12: 104,758,121 (GRCm39) |
W132R |
probably damaging |
Het |
| Cpsf2 |
G |
A |
12: 101,956,306 (GRCm39) |
D370N |
probably benign |
Het |
| Crnn |
T |
C |
3: 93,056,594 (GRCm39) |
V460A |
probably benign |
Het |
| Daam1 |
T |
A |
12: 72,035,703 (GRCm39) |
I957N |
probably damaging |
Het |
| Defb9 |
T |
C |
8: 22,371,905 (GRCm39) |
K36R |
probably benign |
Het |
| Dock10 |
T |
A |
1: 80,488,143 (GRCm39) |
I2007F |
possibly damaging |
Het |
| Dpm1 |
A |
T |
2: 168,059,667 (GRCm39) |
V143D |
probably damaging |
Het |
| Dync1h1 |
T |
C |
12: 110,592,166 (GRCm39) |
V1110A |
possibly damaging |
Het |
| Erlec1 |
T |
G |
11: 30,889,604 (GRCm39) |
K373N |
possibly damaging |
Het |
| Fbxo40 |
C |
T |
16: 36,790,303 (GRCm39) |
G269E |
probably benign |
Het |
| Fbxw7 |
T |
A |
3: 84,862,242 (GRCm39) |
C70S |
possibly damaging |
Het |
| Fhip2a |
T |
C |
19: 57,373,809 (GRCm39) |
F690L |
probably damaging |
Het |
| Fnbp1 |
G |
T |
2: 30,943,059 (GRCm39) |
R280S |
probably null |
Het |
| Gapvd1 |
G |
A |
2: 34,590,853 (GRCm39) |
R940C |
probably damaging |
Het |
| Gfod2 |
T |
C |
8: 106,444,142 (GRCm39) |
K134E |
possibly damaging |
Het |
| Gpi1 |
A |
T |
7: 33,920,228 (GRCm39) |
|
probably null |
Het |
| Grik2 |
A |
T |
10: 49,008,923 (GRCm39) |
N721K |
possibly damaging |
Het |
| Gsn |
G |
T |
2: 35,191,483 (GRCm39) |
G455V |
probably damaging |
Het |
| Hlx |
G |
T |
1: 184,464,184 (GRCm39) |
A52D |
probably damaging |
Het |
| Hpse |
A |
G |
5: 100,840,104 (GRCm39) |
S338P |
probably damaging |
Het |
| Hyal2 |
T |
C |
9: 107,449,371 (GRCm39) |
C376R |
probably damaging |
Het |
| Inf2 |
A |
G |
12: 112,574,771 (GRCm39) |
T781A |
unknown |
Het |
| Iscu |
A |
G |
5: 113,915,079 (GRCm39) |
|
probably benign |
Het |
| Kcna4 |
G |
A |
2: 107,126,565 (GRCm39) |
G433D |
possibly damaging |
Het |
| Kir3dl2 |
T |
A |
X: 135,357,024 (GRCm39) |
N146I |
probably benign |
Het |
| Klrg1 |
T |
A |
6: 122,259,721 (GRCm39) |
Q17L |
possibly damaging |
Het |
| Krt82 |
T |
G |
15: 101,453,597 (GRCm39) |
Q263P |
probably benign |
Het |
| Mfrp |
T |
C |
9: 44,017,669 (GRCm39) |
C554R |
probably damaging |
Het |
| Minar1 |
T |
G |
9: 89,483,256 (GRCm39) |
T714P |
probably damaging |
Het |
| Mst1r |
T |
C |
9: 107,791,962 (GRCm39) |
Y833H |
probably damaging |
Het |
| Mst1r |
T |
A |
9: 107,793,132 (GRCm39) |
|
probably null |
Het |
| Nfix |
G |
A |
8: 85,453,155 (GRCm39) |
R300C |
probably damaging |
Het |
| Nipal4 |
T |
C |
11: 46,042,210 (GRCm39) |
N157S |
probably damaging |
Het |
| Notch2 |
G |
A |
3: 97,980,071 (GRCm39) |
G195D |
probably damaging |
Het |
| Nrcam |
A |
T |
12: 44,610,776 (GRCm39) |
H492L |
probably benign |
Het |
| Or10aa1 |
A |
T |
1: 173,870,154 (GRCm39) |
I213F |
probably damaging |
Het |
| Or4p21 |
A |
T |
2: 88,276,853 (GRCm39) |
I143N |
probably damaging |
Het |
| Papln |
G |
A |
12: 83,828,811 (GRCm39) |
R817H |
probably damaging |
Het |
| Pcnx2 |
T |
C |
8: 126,614,110 (GRCm39) |
E447G |
probably benign |
Het |
| Pdp2 |
T |
C |
8: 105,320,538 (GRCm39) |
V129A |
probably benign |
Het |
| Plch2 |
A |
G |
4: 155,069,410 (GRCm39) |
F1072S |
possibly damaging |
Het |
| Prag1 |
T |
A |
8: 36,570,081 (GRCm39) |
D221E |
probably damaging |
Het |
| Prkg1 |
T |
C |
19: 31,563,095 (GRCm39) |
D102G |
probably damaging |
Het |
| Psme4 |
T |
A |
11: 30,769,011 (GRCm39) |
D662E |
probably benign |
Het |
| Ptprn |
T |
C |
1: 75,231,464 (GRCm39) |
|
probably null |
Het |
| Ptprz1 |
A |
G |
6: 22,986,310 (GRCm39) |
D370G |
probably damaging |
Het |
| Qser1 |
A |
G |
2: 104,590,886 (GRCm39) |
S1637P |
probably damaging |
Het |
| Sema6a |
T |
A |
18: 47,403,696 (GRCm39) |
H642L |
probably benign |
Het |
| Slc30a5 |
A |
T |
13: 100,950,461 (GRCm39) |
F209I |
probably benign |
Het |
| Slc4a3 |
G |
T |
1: 75,528,835 (GRCm39) |
E508* |
probably null |
Het |
| Stpg2 |
C |
T |
3: 139,014,944 (GRCm39) |
R370* |
probably null |
Het |
| Tas2r113 |
T |
A |
6: 132,870,796 (GRCm39) |
F275I |
probably benign |
Het |
| Tmem132d |
T |
G |
5: 128,346,263 (GRCm39) |
K86N |
probably damaging |
Het |
| Tpgs2 |
A |
T |
18: 25,273,593 (GRCm39) |
F189L |
probably damaging |
Het |
| Trmt6 |
A |
G |
2: 132,652,968 (GRCm39) |
S104P |
probably damaging |
Het |
| Trpv3 |
T |
C |
11: 73,174,514 (GRCm39) |
S294P |
probably damaging |
Het |
| Ugt2b36 |
A |
G |
5: 87,228,727 (GRCm39) |
|
probably null |
Het |
| Vmn1r170 |
A |
T |
7: 23,305,906 (GRCm39) |
M103L |
probably benign |
Het |
| Vmn2r107 |
T |
A |
17: 20,575,879 (GRCm39) |
|
probably null |
Het |
| Vmn2r5 |
C |
T |
3: 64,411,642 (GRCm39) |
E309K |
probably damaging |
Het |
|
| Other mutations in Vmn2r77 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00954:Vmn2r77
|
APN |
7 |
86,449,975 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL01105:Vmn2r77
|
APN |
7 |
86,460,872 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01367:Vmn2r77
|
APN |
7 |
86,461,124 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01634:Vmn2r77
|
APN |
7 |
86,460,857 (GRCm39) |
missense |
probably benign |
|
|
IGL01805:Vmn2r77
|
APN |
7 |
86,460,395 (GRCm39) |
missense |
probably benign |
0.18 |
|
IGL01868:Vmn2r77
|
APN |
7 |
86,452,224 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01980:Vmn2r77
|
APN |
7 |
86,450,678 (GRCm39) |
missense |
probably benign |
0.14 |
|
IGL02055:Vmn2r77
|
APN |
7 |
86,450,763 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02066:Vmn2r77
|
APN |
7 |
86,452,836 (GRCm39) |
nonsense |
probably null |
|
|
IGL02185:Vmn2r77
|
APN |
7 |
86,444,360 (GRCm39) |
missense |
unknown |
|
|
IGL02200:Vmn2r77
|
APN |
7 |
86,451,187 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL02336:Vmn2r77
|
APN |
7 |
86,451,224 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02445:Vmn2r77
|
APN |
7 |
86,452,848 (GRCm39) |
nonsense |
probably null |
|
|
IGL02557:Vmn2r77
|
APN |
7 |
86,444,342 (GRCm39) |
unclassified |
probably benign |
|
|
IGL02659:Vmn2r77
|
APN |
7 |
86,449,979 (GRCm39) |
missense |
probably benign |
0.32 |
|
IGL02978:Vmn2r77
|
APN |
7 |
86,460,555 (GRCm39) |
missense |
probably benign |
|
|
IGL03180:Vmn2r77
|
APN |
7 |
86,450,843 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
IGL03255:Vmn2r77
|
APN |
7 |
86,461,131 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL03273:Vmn2r77
|
APN |
7 |
86,460,494 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0046:Vmn2r77
|
UTSW |
7 |
86,451,146 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R0047:Vmn2r77
|
UTSW |
7 |
86,460,858 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0066:Vmn2r77
|
UTSW |
7 |
86,449,964 (GRCm39) |
missense |
probably benign |
0.17 |
|
R0066:Vmn2r77
|
UTSW |
7 |
86,449,964 (GRCm39) |
missense |
probably benign |
0.17 |
|
R0389:Vmn2r77
|
UTSW |
7 |
86,450,702 (GRCm39) |
missense |
probably benign |
0.29 |
|
R0635:Vmn2r77
|
UTSW |
7 |
86,460,383 (GRCm39) |
missense |
probably benign |
|
|
R0689:Vmn2r77
|
UTSW |
7 |
86,460,872 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0827:Vmn2r77
|
UTSW |
7 |
86,451,224 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1167:Vmn2r77
|
UTSW |
7 |
86,450,954 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1228:Vmn2r77
|
UTSW |
7 |
86,450,242 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1353:Vmn2r77
|
UTSW |
7 |
86,451,394 (GRCm39) |
missense |
probably benign |
0.29 |
|
R1392:Vmn2r77
|
UTSW |
7 |
86,450,830 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1392:Vmn2r77
|
UTSW |
7 |
86,450,830 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1613:Vmn2r77
|
UTSW |
7 |
86,460,356 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1654:Vmn2r77
|
UTSW |
7 |
86,461,123 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1742:Vmn2r77
|
UTSW |
7 |
86,444,543 (GRCm39) |
missense |
probably benign |
0.35 |
|
R1827:Vmn2r77
|
UTSW |
7 |
86,450,821 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1911:Vmn2r77
|
UTSW |
7 |
86,461,001 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2008:Vmn2r77
|
UTSW |
7 |
86,450,921 (GRCm39) |
missense |
probably benign |
0.31 |
|
R2093:Vmn2r77
|
UTSW |
7 |
86,450,702 (GRCm39) |
missense |
probably benign |
0.29 |
|
R2143:Vmn2r77
|
UTSW |
7 |
86,461,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2269:Vmn2r77
|
UTSW |
7 |
86,460,897 (GRCm39) |
missense |
probably benign |
0.03 |
|
R2972:Vmn2r77
|
UTSW |
7 |
86,452,893 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2974:Vmn2r77
|
UTSW |
7 |
86,452,893 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3037:Vmn2r77
|
UTSW |
7 |
86,450,191 (GRCm39) |
missense |
probably benign |
|
|
R3694:Vmn2r77
|
UTSW |
7 |
86,450,044 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3695:Vmn2r77
|
UTSW |
7 |
86,450,044 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3805:Vmn2r77
|
UTSW |
7 |
86,444,368 (GRCm39) |
nonsense |
probably null |
|
|
R3870:Vmn2r77
|
UTSW |
7 |
86,461,050 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4732:Vmn2r77
|
UTSW |
7 |
86,450,195 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4733:Vmn2r77
|
UTSW |
7 |
86,450,195 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5009:Vmn2r77
|
UTSW |
7 |
86,451,015 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R5201:Vmn2r77
|
UTSW |
7 |
86,460,846 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5218:Vmn2r77
|
UTSW |
7 |
86,451,341 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5469:Vmn2r77
|
UTSW |
7 |
86,451,271 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5673:Vmn2r77
|
UTSW |
7 |
86,461,214 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5771:Vmn2r77
|
UTSW |
7 |
86,461,235 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5832:Vmn2r77
|
UTSW |
7 |
86,460,670 (GRCm39) |
nonsense |
probably null |
|
|
R5899:Vmn2r77
|
UTSW |
7 |
86,460,924 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6151:Vmn2r77
|
UTSW |
7 |
86,450,878 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6182:Vmn2r77
|
UTSW |
7 |
86,460,957 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6326:Vmn2r77
|
UTSW |
7 |
86,451,031 (GRCm39) |
missense |
probably benign |
|
|
R6419:Vmn2r77
|
UTSW |
7 |
86,460,767 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6549:Vmn2r77
|
UTSW |
7 |
86,450,065 (GRCm39) |
missense |
probably benign |
0.06 |
|
R6874:Vmn2r77
|
UTSW |
7 |
86,451,286 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6972:Vmn2r77
|
UTSW |
7 |
86,452,202 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7056:Vmn2r77
|
UTSW |
7 |
86,451,023 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7185:Vmn2r77
|
UTSW |
7 |
86,451,035 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7261:Vmn2r77
|
UTSW |
7 |
86,460,518 (GRCm39) |
nonsense |
probably null |
|
|
R7298:Vmn2r77
|
UTSW |
7 |
86,449,979 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7662:Vmn2r77
|
UTSW |
7 |
86,460,492 (GRCm39) |
nonsense |
probably null |
|
|
R8182:Vmn2r77
|
UTSW |
7 |
86,460,801 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8327:Vmn2r77
|
UTSW |
7 |
86,450,680 (GRCm39) |
missense |
probably benign |
0.08 |
|
R8387:Vmn2r77
|
UTSW |
7 |
86,450,947 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8825:Vmn2r77
|
UTSW |
7 |
86,452,855 (GRCm39) |
missense |
probably benign |
|
|
R8898:Vmn2r77
|
UTSW |
7 |
86,444,430 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8973:Vmn2r77
|
UTSW |
7 |
86,452,150 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R9258:Vmn2r77
|
UTSW |
7 |
86,452,302 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R9338:Vmn2r77
|
UTSW |
7 |
86,460,994 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9358:Vmn2r77
|
UTSW |
7 |
86,452,236 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9377:Vmn2r77
|
UTSW |
7 |
86,444,442 (GRCm39) |
missense |
probably benign |
0.05 |
|
R9404:Vmn2r77
|
UTSW |
7 |
86,451,247 (GRCm39) |
missense |
probably benign |
|
|
R9673:Vmn2r77
|
UTSW |
7 |
86,450,171 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R9679:Vmn2r77
|
UTSW |
7 |
86,460,741 (GRCm39) |
missense |
probably benign |
0.07 |
|
| Predicted Primers |
PCR Primer
(F):5'- GGTACATGGTGTCTAATTTCATAACAC -3'
(R):5'- TGTTATCCATATAGGCCCCGTAAG -3'
Sequencing Primer
(F):5'- GTTAAGAGCACTGACTCCTGAGTTC -3'
(R):5'- GGCCCCGTAAGTACAATTAAATATC -3'
|
| Posted On |
2014-08-25 |
Incidental Mutation