Incidental Mutation 'R1986:Dab1'
| ID |
220608 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Dab1
|
| Ensembl Gene |
ENSMUSG00000028519 |
| Gene Name |
disabled 1 |
| Synonyms |
C630028C02Rik |
| MMRRC Submission |
039998-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.877)
|
| Stock # |
R1986 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
4 |
| Chromosomal Location |
103476556-104602041 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 104470412 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Threonine
at position 65
(I65T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000102439
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000106826]
[ENSMUST00000106827]
[ENSMUST00000106830]
[ENSMUST00000143644]
[ENSMUST00000146078]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000106826
AA Change: I65T
PolyPhen 2
Score 0.969 (Sensitivity: 0.77; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000102439
Gene: ENSMUSG00000028519
AA Change: I65T
| Domain | Start | End | E-Value | Type |
|---|
|
PTB
|
17 |
151 |
3.51e-36 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000106827
AA Change: I85T
PolyPhen 2
Score 0.025 (Sensitivity: 0.95; Specificity: 0.81)
|
| SMART Domains |
Protein: ENSMUSP00000102440
Gene: ENSMUSG00000028519
AA Change: I85T
| Domain | Start | End | E-Value | Type |
|---|
|
PTB
|
37 |
171 |
3.51e-36 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000106830
AA Change: I85T
PolyPhen 2
Score 0.025 (Sensitivity: 0.95; Specificity: 0.81)
|
| SMART Domains |
Protein: ENSMUSP00000102443
Gene: ENSMUSG00000028519
AA Change: I85T
| Domain | Start | End | E-Value | Type |
|---|
|
PTB
|
37 |
171 |
3.51e-36 |
SMART |
|
low complexity region
|
254 |
267 |
N/A |
INTRINSIC |
|
low complexity region
|
470 |
487 |
N/A |
INTRINSIC |
|
low complexity region
|
490 |
501 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000141037
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000143644
AA Change: I85T
PolyPhen 2
Score 0.199 (Sensitivity: 0.92; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000118650
Gene: ENSMUSG00000028519
AA Change: I85T
| Domain | Start | End | E-Value | Type |
|---|
|
PTB
|
37 |
160 |
5.54e-25 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000146078
AA Change: I85T
PolyPhen 2
Score 0.853 (Sensitivity: 0.83; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000125033
Gene: ENSMUSG00000028519
AA Change: I85T
| Domain | Start | End | E-Value | Type |
|---|
|
PTB
|
37 |
171 |
3.51e-36 |
SMART |
|
low complexity region
|
235 |
242 |
N/A |
INTRINSIC |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000149672
AA Change: I63T
|
| SMART Domains |
Protein: ENSMUSP00000118532
Gene: ENSMUSG00000028519
AA Change: I63T
| Domain | Start | End | E-Value | Type |
|---|
|
PTB
|
16 |
150 |
3.51e-36 |
SMART |
|
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.7%
- 20x: 93.7%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. [provided by RefSeq, Jan 2017]
PHENOTYPE: Homozygous null display unstable gait and whole-body tremor with a hypoplastic cerebellum devoid of folia, a probable consequence of defective neuronal migration. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 91 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700006A11Rik |
A |
G |
3: 124,212,977 (GRCm39) |
S105P |
probably damaging |
Het |
| 9930111J21Rik2 |
T |
A |
11: 48,910,119 (GRCm39) |
K771N |
possibly damaging |
Het |
| Abcc2 |
A |
G |
19: 43,818,318 (GRCm39) |
E1268G |
probably damaging |
Het |
| Adamts4 |
T |
C |
1: 171,084,244 (GRCm39) |
F574L |
possibly damaging |
Het |
| Adamts9 |
A |
G |
6: 92,773,375 (GRCm39) |
V1165A |
probably benign |
Het |
| Agap2 |
A |
T |
10: 126,918,913 (GRCm39) |
K430* |
probably null |
Het |
| Amn |
G |
T |
12: 111,241,431 (GRCm39) |
G232V |
probably damaging |
Het |
| Ank3 |
A |
G |
10: 69,703,258 (GRCm39) |
E297G |
probably damaging |
Het |
| Arhgap45 |
T |
C |
10: 79,856,530 (GRCm39) |
L26P |
probably damaging |
Het |
| Atp10b |
C |
A |
11: 43,063,595 (GRCm39) |
Q177K |
probably benign |
Het |
| Bbs10 |
A |
T |
10: 111,135,118 (GRCm39) |
D77V |
probably damaging |
Het |
| Bltp2 |
A |
T |
11: 78,165,438 (GRCm39) |
H1318L |
probably damaging |
Het |
| Bpifa1 |
T |
A |
2: 153,986,256 (GRCm39) |
L127Q |
probably damaging |
Het |
| Brinp2 |
T |
C |
1: 158,074,348 (GRCm39) |
N591S |
probably damaging |
Het |
| C2cd2 |
A |
C |
16: 97,671,471 (GRCm39) |
V476G |
probably damaging |
Het |
| C7 |
T |
A |
15: 5,041,494 (GRCm39) |
T471S |
possibly damaging |
Het |
| Cacna1b |
A |
T |
2: 24,538,998 (GRCm39) |
Y1488N |
probably damaging |
Het |
| Cadps2 |
A |
G |
6: 23,323,379 (GRCm39) |
F1001L |
probably damaging |
Het |
| Ccdc188 |
T |
C |
16: 18,036,707 (GRCm39) |
S216P |
probably damaging |
Het |
| Ccdc24 |
A |
G |
4: 117,729,213 (GRCm39) |
L88P |
probably damaging |
Het |
| Dock4 |
A |
T |
12: 40,780,062 (GRCm39) |
D621V |
probably damaging |
Het |
| Drd5 |
A |
T |
5: 38,477,456 (GRCm39) |
M150L |
probably damaging |
Het |
| Eef2k |
T |
A |
7: 120,472,569 (GRCm39) |
M94K |
possibly damaging |
Het |
| Epg5 |
A |
G |
18: 78,025,521 (GRCm39) |
|
probably null |
Het |
| Epsti1 |
T |
C |
14: 78,169,673 (GRCm39) |
|
probably null |
Het |
| Ern2 |
T |
A |
7: 121,770,752 (GRCm39) |
D754V |
probably benign |
Het |
| Fbxo6 |
A |
G |
4: 148,230,552 (GRCm39) |
Y237H |
probably damaging |
Het |
| Fbxw24 |
A |
G |
9: 109,436,124 (GRCm39) |
S303P |
probably damaging |
Het |
| Fpr-rs3 |
A |
T |
17: 20,844,103 (GRCm39) |
|
probably null |
Het |
| Gab1 |
G |
T |
8: 81,493,010 (GRCm39) |
T679K |
probably damaging |
Het |
| Gbp9 |
C |
A |
5: 105,253,590 (GRCm39) |
V42F |
probably damaging |
Het |
| Gbp9 |
A |
T |
5: 105,253,652 (GRCm39) |
V21E |
probably damaging |
Het |
| Gm20821 |
A |
G |
Y: 9,783,927 (GRCm39) |
Q183R |
probably benign |
Het |
| Gpatch11 |
A |
T |
17: 79,151,266 (GRCm39) |
I226F |
probably benign |
Het |
| Hephl1 |
T |
G |
9: 14,965,848 (GRCm39) |
E1035A |
probably damaging |
Het |
| Hspa4l |
T |
C |
3: 40,714,833 (GRCm39) |
V156A |
probably damaging |
Het |
| Ifna13 |
A |
G |
4: 88,562,588 (GRCm39) |
V12A |
probably benign |
Het |
| Il24 |
G |
A |
1: 130,810,268 (GRCm39) |
T196I |
probably benign |
Het |
| Irgm2 |
A |
G |
11: 58,110,384 (GRCm39) |
D37G |
probably benign |
Het |
| Irs1 |
A |
G |
1: 82,266,486 (GRCm39) |
S577P |
probably damaging |
Het |
| Kif21b |
G |
A |
1: 136,075,284 (GRCm39) |
D166N |
probably damaging |
Het |
| Krtap4-16 |
T |
C |
11: 99,742,322 (GRCm39) |
Q26R |
unknown |
Het |
| Lig1 |
T |
A |
7: 13,043,067 (GRCm39) |
Y837* |
probably null |
Het |
| Lrrc69 |
T |
C |
4: 14,708,669 (GRCm39) |
E225G |
possibly damaging |
Het |
| Map3k20 |
C |
T |
2: 72,271,638 (GRCm39) |
Q589* |
probably null |
Het |
| Masp1 |
T |
G |
16: 23,302,211 (GRCm39) |
M347L |
probably benign |
Het |
| Mgat3 |
A |
T |
15: 80,096,390 (GRCm39) |
I406F |
probably benign |
Het |
| Mmp1b |
T |
G |
9: 7,368,577 (GRCm39) |
D425A |
probably benign |
Het |
| Mss51 |
T |
C |
14: 20,533,259 (GRCm39) |
H404R |
probably benign |
Het |
| Myo15b |
A |
T |
11: 115,773,701 (GRCm39) |
H1911L |
probably benign |
Het |
| Nedd4l |
A |
G |
18: 65,276,874 (GRCm39) |
D102G |
probably damaging |
Het |
| Niban3 |
T |
A |
8: 72,056,404 (GRCm39) |
I368N |
possibly damaging |
Het |
| Npc2 |
T |
C |
12: 84,807,523 (GRCm39) |
K112E |
probably benign |
Het |
| Nuggc |
T |
A |
14: 65,879,370 (GRCm39) |
V694E |
probably damaging |
Het |
| Olfm1 |
T |
G |
2: 28,104,718 (GRCm39) |
V157G |
probably benign |
Het |
| Or10h28 |
T |
C |
17: 33,488,489 (GRCm39) |
S264P |
probably benign |
Het |
| Or5p55 |
T |
C |
7: 107,566,877 (GRCm39) |
V91A |
probably benign |
Het |
| Otogl |
T |
A |
10: 107,630,051 (GRCm39) |
|
probably null |
Het |
| Ovgp1 |
G |
A |
3: 105,882,251 (GRCm39) |
C38Y |
probably damaging |
Het |
| Pisd |
A |
T |
5: 32,894,672 (GRCm39) |
S344T |
probably damaging |
Het |
| Psme4 |
T |
C |
11: 30,780,352 (GRCm39) |
V840A |
probably benign |
Het |
| Ptch1 |
T |
G |
13: 63,672,773 (GRCm39) |
E944A |
probably benign |
Het |
| Rims2 |
T |
A |
15: 39,208,710 (GRCm39) |
M171K |
probably damaging |
Het |
| Rin2 |
T |
A |
2: 145,720,860 (GRCm39) |
M731K |
probably damaging |
Het |
| Scgb1b19 |
T |
C |
7: 32,987,108 (GRCm39) |
|
probably null |
Het |
| Serpina10 |
A |
G |
12: 103,594,514 (GRCm39) |
I235T |
possibly damaging |
Het |
| Setbp1 |
T |
A |
18: 78,901,759 (GRCm39) |
E636V |
probably damaging |
Het |
| Sh3d21 |
C |
T |
4: 126,056,290 (GRCm39) |
E101K |
probably damaging |
Het |
| Ski |
T |
G |
4: 155,306,148 (GRCm39) |
D225A |
probably damaging |
Het |
| Slc28a2b |
A |
G |
2: 122,357,910 (GRCm39) |
T655A |
probably benign |
Het |
| Slc29a3 |
T |
C |
10: 60,559,593 (GRCm39) |
Y187C |
probably damaging |
Het |
| Sort1 |
T |
A |
3: 108,253,043 (GRCm39) |
D494E |
possibly damaging |
Het |
| Sphkap |
A |
T |
1: 83,255,643 (GRCm39) |
L702Q |
probably damaging |
Het |
| Srr |
A |
G |
11: 74,799,545 (GRCm39) |
I285T |
probably damaging |
Het |
| Stam2 |
T |
C |
2: 52,599,638 (GRCm39) |
T257A |
possibly damaging |
Het |
| Suds3 |
A |
T |
5: 117,246,417 (GRCm39) |
N112K |
probably damaging |
Het |
| Tedc2 |
T |
A |
17: 24,435,291 (GRCm39) |
E366V |
probably damaging |
Het |
| Tedc2 |
C |
A |
17: 24,435,292 (GRCm39) |
E366* |
probably null |
Het |
| Tesk2 |
T |
C |
4: 116,608,390 (GRCm39) |
L104P |
probably damaging |
Het |
| Tie1 |
C |
T |
4: 118,336,160 (GRCm39) |
R702H |
probably benign |
Het |
| Tpo |
G |
T |
12: 30,169,465 (GRCm39) |
A90E |
probably damaging |
Het |
| Trim30a |
T |
C |
7: 104,060,672 (GRCm39) |
D368G |
probably damaging |
Het |
| Ugt2a2 |
A |
T |
5: 87,608,438 (GRCm39) |
M633K |
possibly damaging |
Het |
| Vars2 |
A |
G |
17: 35,970,953 (GRCm39) |
W626R |
probably damaging |
Het |
| Vmn2r10 |
A |
T |
5: 109,154,120 (GRCm39) |
Y61* |
probably null |
Het |
| Vmn2r95 |
T |
C |
17: 18,671,805 (GRCm39) |
V514A |
probably benign |
Het |
| Vwa5a |
T |
G |
9: 38,649,110 (GRCm39) |
|
probably benign |
Het |
| Zfp365 |
A |
T |
10: 67,745,686 (GRCm39) |
C31S |
probably damaging |
Het |
| Zfp397 |
A |
T |
18: 24,093,108 (GRCm39) |
I198F |
possibly damaging |
Het |
| Zfp407 |
C |
T |
18: 84,577,898 (GRCm39) |
A1072T |
probably benign |
Het |
| Zfp593 |
T |
C |
4: 133,972,206 (GRCm39) |
E100G |
possibly damaging |
Het |
|
| Other mutations in Dab1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00087:Dab1
|
APN |
4 |
104,535,950 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL00087:Dab1
|
APN |
4 |
104,536,007 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00328:Dab1
|
APN |
4 |
104,545,635 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
IGL00756:Dab1
|
APN |
4 |
104,585,075 (GRCm39) |
missense |
probably benign |
|
|
IGL02074:Dab1
|
APN |
4 |
104,585,051 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL02286:Dab1
|
APN |
4 |
104,537,267 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02986:Dab1
|
APN |
4 |
104,336,418 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03008:Dab1
|
APN |
4 |
104,584,777 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03133:Dab1
|
APN |
4 |
104,584,777 (GRCm39) |
missense |
probably benign |
0.41 |
|
IGL03375:Dab1
|
APN |
4 |
104,538,798 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
LCD18:Dab1
|
UTSW |
4 |
103,903,769 (GRCm39) |
intron |
probably benign |
|
|
R0027:Dab1
|
UTSW |
4 |
104,561,396 (GRCm39) |
intron |
probably benign |
|
|
R0466:Dab1
|
UTSW |
4 |
104,577,747 (GRCm39) |
missense |
probably benign |
0.15 |
|
R0838:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R0840:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R1086:Dab1
|
UTSW |
4 |
104,185,769 (GRCm39) |
intron |
probably benign |
|
|
R1598:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R1640:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R1699:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R1749:Dab1
|
UTSW |
4 |
104,185,495 (GRCm39) |
intron |
probably benign |
|
|
R1770:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R1846:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R1847:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R1848:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R1885:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R1990:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R2006:Dab1
|
UTSW |
4 |
104,462,522 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2030:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R2032:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R2034:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R2061:Dab1
|
UTSW |
4 |
104,535,938 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2088:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R2089:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R2091:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R2091:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R2092:Dab1
|
UTSW |
4 |
104,535,974 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2193:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R2194:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R2361:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R2362:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R2391:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R2424:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R2865:Dab1
|
UTSW |
4 |
104,537,343 (GRCm39) |
missense |
probably benign |
|
|
R3118:Dab1
|
UTSW |
4 |
104,537,266 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R3716:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R3718:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R3740:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R3742:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R3965:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R4057:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R4393:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R4396:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R4418:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R4607:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R4608:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R4648:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R4693:Dab1
|
UTSW |
4 |
104,536,750 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4701:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R4730:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R4760:Dab1
|
UTSW |
4 |
104,589,342 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4927:Dab1
|
UTSW |
4 |
104,561,449 (GRCm39) |
missense |
probably benign |
|
|
R5173:Dab1
|
UTSW |
4 |
104,545,645 (GRCm39) |
splice site |
probably null |
|
|
R5503:Dab1
|
UTSW |
4 |
104,369,461 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6199:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R6200:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R6207:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R6224:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R6227:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R6228:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R6229:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R6246:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R6247:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R6248:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R6249:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R6250:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R6258:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R6259:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R6260:Dab1
|
UTSW |
4 |
104,588,948 (GRCm39) |
missense |
probably benign |
0.29 |
|
R6505:Dab1
|
UTSW |
4 |
104,369,461 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6817:Dab1
|
UTSW |
4 |
104,536,743 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7305:Dab1
|
UTSW |
4 |
104,570,987 (GRCm39) |
missense |
|
|
|
R7709:Dab1
|
UTSW |
4 |
104,577,756 (GRCm39) |
nonsense |
probably null |
|
|
R7894:Dab1
|
UTSW |
4 |
104,589,335 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8142:Dab1
|
UTSW |
4 |
104,535,921 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8462:Dab1
|
UTSW |
4 |
104,561,404 (GRCm39) |
missense |
probably benign |
0.10 |
|
R8472:Dab1
|
UTSW |
4 |
104,336,439 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R9138:Dab1
|
UTSW |
4 |
104,588,929 (GRCm39) |
nonsense |
probably null |
|
|
R9311:Dab1
|
UTSW |
4 |
104,369,463 (GRCm39) |
critical splice donor site |
probably null |
|
|
RF017:Dab1
|
UTSW |
4 |
104,570,849 (GRCm39) |
missense |
probably benign |
0.01 |
|
Z1088:Dab1
|
UTSW |
4 |
104,336,429 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1176:Dab1
|
UTSW |
4 |
104,585,275 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1177:Dab1
|
UTSW |
4 |
104,584,937 (GRCm39) |
missense |
probably benign |
0.05 |
|
| Predicted Primers |
PCR Primer
(F):5'- GAGGATATGATGTAGACTCCCGC -3'
(R):5'- AGAGCCTTGATGGATGATCAC -3'
Sequencing Primer
(F):5'- CGCAGGAGGGCAAAGGAAG -3'
(R):5'- CACAGTTGATCAAGTTTGTCAGTTGC -3'
|
| Posted On |
2014-08-25 |
Incidental Mutation