Mutagenetix > Incidental Mutation

Incidental Mutation 'R1966:Lrba'

218930

Institutional Source

Beutler Lab

Gene Symbol

Lrba

Ensembl Gene

ENSMUSG00000028080

Gene Name

LPS-responsive beige-like anchor

Synonyms

Lba, D3Ertd775e

MMRRC Submission

039979-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R1966 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

86131987-86689999 bp(+) (GRCm39)

Type of Mutation

critical splice acceptor site

DNA Base Change (assembly)

A to G at 86513175 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000141734 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000107635] [ENSMUST00000192145] [ENSMUST00000194759] [ENSMUST00000195524] [ENSMUST00000195524]

AlphaFold

no structure available at present

Predicted Effect

probably null
Transcript: ENSMUST00000107635

SMART Domains

Protein: ENSMUSP00000103261
Gene: ENSMUSG00000028080

Domain	Start	End	E-Value	Type
low complexity region	12	31	N/A	INTRINSIC
Pfam:Laminin_G_3	211	377	4.6e-13	PFAM
Pfam:DUF4704	446	717	2.5e-109	PFAM
coiled coil region	1019	1037	N/A	INTRINSIC
low complexity region	1073	1089	N/A	INTRINSIC
low complexity region	1100	1113	N/A	INTRINSIC
low complexity region	1585	1600	N/A	INTRINSIC
low complexity region	1614	1630	N/A	INTRINSIC
low complexity region	1698	1713	N/A	INTRINSIC
low complexity region	1738	1757	N/A	INTRINSIC
low complexity region	1848	1861	N/A	INTRINSIC
Pfam:DUF1088	1882	2049	7e-88	PFAM
Pfam:PH_BEACH	2075	2172	9.1e-31	PFAM
Beach	2203	2480	2.87e-207	SMART
WD40	2578	2615	7.4e0	SMART
WD40	2618	2661	1.72e0	SMART
WD40	2677	2716	3.99e-1	SMART
WD40	2760	2798	1.79e-1	SMART
WD40	2801	2840	4.28e0	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000192145

SMART Domains

Protein: ENSMUSP00000142179
Gene: ENSMUSG00000028080

Domain	Start	End	E-Value	Type
low complexity region	12	31	N/A	INTRINSIC
Pfam:Laminin_G_3	205	377	7.4e-18	PFAM
coiled coil region	1019	1037	N/A	INTRINSIC
low complexity region	1073	1089	N/A	INTRINSIC
low complexity region	1100	1113	N/A	INTRINSIC
low complexity region	1585	1600	N/A	INTRINSIC
low complexity region	1614	1630	N/A	INTRINSIC
low complexity region	1698	1713	N/A	INTRINSIC
low complexity region	1738	1757	N/A	INTRINSIC
low complexity region	1848	1861	N/A	INTRINSIC
Pfam:DUF1088	1882	2050	1.5e-92	PFAM
Pfam:PH_BEACH	2068	2172	7.5e-32	PFAM
Beach	2203	2480	2.87e-207	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000194674

Predicted Effect

probably null
Transcript: ENSMUST00000194759

SMART Domains

Protein: ENSMUSP00000142043
Gene: ENSMUSG00000028080

Domain	Start	End	E-Value	Type
low complexity region	12	31	N/A	INTRINSIC
Pfam:Laminin_G_3	205	377	8.1e-18	PFAM
coiled coil region	1019	1037	N/A	INTRINSIC
low complexity region	1073	1089	N/A	INTRINSIC
low complexity region	1100	1113	N/A	INTRINSIC
low complexity region	1585	1600	N/A	INTRINSIC
low complexity region	1614	1630	N/A	INTRINSIC
low complexity region	1698	1713	N/A	INTRINSIC
low complexity region	1738	1757	N/A	INTRINSIC
low complexity region	1848	1861	N/A	INTRINSIC
Pfam:DUF1088	1882	2050	1.6e-92	PFAM
Pfam:PH_BEACH	2068	2172	8.3e-32	PFAM
Beach	2203	2480	2.87e-207	SMART
WD40	2578	2615	7.4e0	SMART
WD40	2618	2661	1.72e0	SMART
WD40	2677	2716	3.99e-1	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000195398

Predicted Effect

probably null
Transcript: ENSMUST00000195524

SMART Domains

Protein: ENSMUSP00000141734
Gene: ENSMUSG00000028080

Domain	Start	End	E-Value	Type
Pfam:PH_BEACH	3	76	3.6e-20	PFAM
Beach	107	384	2.87e-207	SMART
WD40	482	519	7.4e0	SMART
WD40	522	565	1.72e0	SMART
WD40	581	620	3.99e-1	SMART
WD40	664	702	1.79e-1	SMART
WD40	705	744	4.28e0	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000195524

SMART Domains

Protein: ENSMUSP00000141734
Gene: ENSMUSG00000028080

Domain	Start	End	E-Value	Type
Pfam:PH_BEACH	3	76	3.6e-20	PFAM
Beach	107	384	2.87e-207	SMART
WD40	482	519	7.4e0	SMART
WD40	522	565	1.72e0	SMART
WD40	581	620	3.99e-1	SMART
WD40	664	702	1.79e-1	SMART
WD40	705	744	4.28e0	SMART

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 97.0%
20x: 94.6%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the WDL-BEACH-WD (WBW) gene family. Its expression is induced in B cells and macrophages by bacterial lipopolysaccharides (LPS). The encoded protein associates with protein kinase A and may be involved in leading intracellular vesicles to activated receptor complexes, which aids in the secretion and/or membrane deposition of immune effector molecules. Defects in this gene are associated with the disorder common variable immunodeficiency-8 with autoimmunity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased numbers of myeloid-derived suppressor cells and regulatory T cells, abnormal NK cell physiology, impaired rejection of allogeneic, xenogeneic and missing self bone-marrow grafts, and resistance to acute graft vs host disease. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 100 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2410002F23Rik	T	A	7: 43,900,650 (GRCm39)	V185E	probably benign	Het
Abca1	A	C	4: 53,050,409 (GRCm39)	V1608G	probably damaging	Het
Ap2b1	T	C	11: 83,237,721 (GRCm39)	I557T	probably benign	Het
Arhgef15	G	T	11: 68,845,501 (GRCm39)	P117Q	probably damaging	Het
Arhgef39	T	C	4: 43,496,710 (GRCm39)	S335G	probably benign	Het
Blm	A	T	7: 80,162,934 (GRCm39)	F139Y	possibly damaging	Het
Cacna2d1	C	T	5: 16,538,783 (GRCm39)	R581*	probably null	Het
Cadps	C	A	14: 12,822,450 (GRCm38)	E97*	probably null	Het
Cavin2	T	A	1: 51,328,801 (GRCm39)	L86Q	probably damaging	Het
Ccdc136	A	G	6: 29,418,091 (GRCm39)	E787G	probably damaging	Het
Ccdc39	T	C	3: 33,880,629 (GRCm39)	K446R	probably damaging	Het
Cdh23	T	C	10: 60,159,361 (GRCm39)	Y2138C	probably damaging	Het
Cdk12	T	A	11: 98,094,916 (GRCm39)	Y241*	probably null	Het
Clcn4	T	A	7: 7,287,184 (GRCm39)	*688L	probably null	Het
Cntnap1	T	C	11: 101,071,212 (GRCm39)	V375A	possibly damaging	Het
Coq5	T	A	5: 115,432,890 (GRCm39)		probably null	Het
Cyp4b1	A	G	4: 115,483,076 (GRCm39)	I405T	probably benign	Het
Det1	T	C	7: 78,492,966 (GRCm39)	Y346C	probably damaging	Het
Enpp3	A	T	10: 24,683,389 (GRCm39)	V276E	probably damaging	Het
Epb41l2	G	A	10: 25,317,666 (GRCm39)	R61Q	probably benign	Het
Fam76b	G	A	9: 13,739,362 (GRCm39)		probably null	Het
Fbxo45	A	T	16: 32,052,048 (GRCm39)	D238E	probably benign	Het
Fnip2	G	A	3: 79,400,779 (GRCm39)	T314I	probably benign	Het
Fsip2	T	C	2: 82,823,124 (GRCm39)	S6286P	possibly damaging	Het
Gbf1	T	C	19: 46,260,003 (GRCm39)	F999L	probably damaging	Het
Gnao1	C	A	8: 94,670,827 (GRCm39)	T102K	probably benign	Het
Gpatch2	T	A	1: 187,054,498 (GRCm39)	D76E	probably damaging	Het
Gpd1l	A	G	9: 114,743,462 (GRCm39)	I146T	probably benign	Het
Grik2	A	T	10: 49,232,005 (GRCm39)	H508Q	probably damaging	Het
Hapstr1	A	G	16: 8,648,445 (GRCm39)	E41G	possibly damaging	Het
Hk3	A	T	13: 55,162,268 (GRCm39)	F112Y	probably damaging	Het
Hmcn2	T	G	2: 31,279,341 (GRCm39)	I1781S	probably damaging	Het
Inhba	A	T	13: 16,201,221 (GRCm39)	K261M	probably damaging	Het
Jarid2	T	A	13: 45,059,752 (GRCm39)	N661K	probably damaging	Het
Kcna2	T	C	3: 107,011,946 (GRCm39)	S176P	probably damaging	Het
Kcnj3	A	T	2: 55,327,343 (GRCm39)	Q44L	probably damaging	Het
Kcns1	G	T	2: 164,010,455 (GRCm39)	F101L	probably damaging	Het
Kdm5b	T	A	1: 134,541,611 (GRCm39)		probably null	Het
Klhl14	C	T	18: 21,687,730 (GRCm39)	G564D	probably damaging	Het
Klhl18	A	T	9: 110,305,658 (GRCm39)	V2E	probably benign	Het
Klhl6	T	C	16: 19,801,572 (GRCm39)	E61G	probably damaging	Het
Krt1	T	C	15: 101,757,427 (GRCm39)	D261G	probably benign	Het
Lama5	C	A	2: 179,830,145 (GRCm39)	C1896F	probably damaging	Het
Lrch3	A	G	16: 32,734,755 (GRCm39)	T82A	possibly damaging	Het
Maml3	C	G	3: 52,011,560 (GRCm39)	G2A	unknown	Het
Mapkap1	T	A	2: 34,408,691 (GRCm39)	N34K	probably damaging	Het
Muc13	A	T	16: 33,634,909 (GRCm39)	I488F	probably damaging	Het
Muc5ac	A	G	7: 141,357,113 (GRCm39)	D1129G	possibly damaging	Het
Nacc1	A	T	8: 85,403,010 (GRCm39)	N288K	probably damaging	Het
Nek1	T	G	8: 61,469,330 (GRCm39)	I129R	probably damaging	Het
Nf1	T	A	11: 79,302,390 (GRCm39)	S319R	possibly damaging	Het
Nle1	C	T	11: 82,792,614 (GRCm39)	G432D	probably damaging	Het
Nol4l	A	G	2: 153,371,375 (GRCm39)	V103A	probably benign	Het
Oca2	A	G	7: 56,064,215 (GRCm39)	I737V	probably damaging	Het
Or12k5	A	T	2: 36,894,960 (GRCm39)	F222Y	possibly damaging	Het
Or1j17	G	A	2: 36,578,796 (GRCm39)	V261I	probably benign	Het
Or4b1	T	C	2: 89,979,748 (GRCm39)	S201G	probably damaging	Het
Or51l4	G	T	7: 103,404,375 (GRCm39)	T139K	probably damaging	Het
Or52ac1	A	G	7: 104,246,008 (GRCm39)	C127R	probably damaging	Het
Or6k6	G	T	1: 173,944,817 (GRCm39)	S255*	probably null	Het
Or6s1	T	A	14: 51,308,614 (GRCm39)	I79F	probably damaging	Het
Orc1	T	A	4: 108,469,414 (GRCm39)	I746N	probably damaging	Het
Pbxip1	A	G	3: 89,352,795 (GRCm39)	D147G	probably damaging	Het
Pirb	A	T	7: 3,720,637 (GRCm39)	L287Q	probably benign	Het
Plin5	T	A	17: 56,419,186 (GRCm39)	D412V	probably damaging	Het
Plxna2	A	T	1: 194,327,008 (GRCm39)	Y314F	possibly damaging	Het
Ppid	A	T	3: 79,509,606 (GRCm39)	K308*	probably null	Het
Prss38	T	C	11: 59,264,310 (GRCm39)	Y219C	probably damaging	Het
Ptx3	C	T	3: 66,132,042 (GRCm39)	R188C	probably damaging	Het
Ralgds	T	A	2: 28,435,887 (GRCm39)	V504E	probably damaging	Het
Rere	T	C	4: 150,701,330 (GRCm39)	Y1237H	probably damaging	Het
Rpp30	C	T	19: 36,066,549 (GRCm39)	S94L	probably damaging	Het
Rrp15	C	T	1: 186,468,402 (GRCm39)	V205I	possibly damaging	Het
Scpep1	A	G	11: 88,843,240 (GRCm39)	W73R	probably damaging	Het
Sec23ip	A	G	7: 128,357,077 (GRCm39)	H376R	probably damaging	Het
Serping1	G	T	2: 84,596,072 (GRCm39)	T454K	probably damaging	Het
Shtn1	T	G	19: 58,963,470 (GRCm39)	Y615S	probably benign	Het
Slc20a2	C	A	8: 23,035,553 (GRCm39)	P184T	probably damaging	Het
Slc22a29	C	A	19: 8,195,772 (GRCm39)	R89L	probably damaging	Het
Slc2a2	A	G	3: 28,773,634 (GRCm39)	Q313R	probably damaging	Het
Tas2r122	A	T	6: 132,688,157 (GRCm39)	Y245*	probably null	Het
Ticrr	C	A	7: 79,344,483 (GRCm39)	C1449*	probably null	Het
Tmem181a	T	C	17: 6,353,501 (GRCm39)	V412A	probably benign	Het
Tmtc4	T	A	14: 123,165,011 (GRCm39)	E616V	probably benign	Het
Tnrc6b	A	G	15: 80,764,640 (GRCm39)	K714R	probably damaging	Het
Trpm8	T	A	1: 88,260,470 (GRCm39)		probably null	Het
Ubr2	T	C	17: 47,265,845 (GRCm39)	T1163A	probably benign	Het
Ubr4	A	G	4: 139,178,555 (GRCm39)		probably null	Het
Ulk2	A	T	11: 61,710,297 (GRCm39)		probably null	Het
Ulk4	T	A	9: 121,086,182 (GRCm39)	M350L	probably benign	Het
Vmn1r185	T	C	7: 26,310,956 (GRCm39)	E183G	probably benign	Het
Vmn1r76	T	A	7: 11,664,441 (GRCm39)	I223F	probably damaging	Het
Wdr27	T	C	17: 15,154,861 (GRCm39)	T19A	possibly damaging	Het
Wdr59	T	G	8: 112,177,535 (GRCm39)	T973P	possibly damaging	Het
Wnk2	A	G	13: 49,192,487 (GRCm39)	S664P	probably damaging	Het
Zfp1004	T	A	2: 150,033,827 (GRCm39)	D49E	probably benign	Het
Zfp120	A	T	2: 149,959,318 (GRCm39)	C335S	probably damaging	Het
Zfp30	C	A	7: 29,491,877 (GRCm39)	Q44K	probably benign	Het
Zfp541	T	C	7: 15,812,996 (GRCm39)	S550P	probably benign	Het
Zw10	C	A	9: 48,980,133 (GRCm39)	N421K	probably damaging	Het

Other mutations in Lrba

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00420:Lrba	APN	3	86,267,089 (GRCm39)	missense	probably benign	0.00
IGL00788:Lrba	APN	3	86,234,992 (GRCm39)	missense	probably damaging	0.97
IGL01139:Lrba	APN	3	86,549,969 (GRCm39)	missense	possibly damaging	0.88
IGL01302:Lrba	APN	3	86,202,707 (GRCm39)	missense	probably damaging	1.00
IGL01612:Lrba	APN	3	86,683,484 (GRCm39)	missense	possibly damaging	0.89
IGL01718:Lrba	APN	3	86,258,555 (GRCm39)	missense	probably damaging	1.00
IGL01719:Lrba	APN	3	86,234,903 (GRCm39)	splice site	probably benign
IGL01730:Lrba	APN	3	86,648,731 (GRCm39)	missense	possibly damaging	0.89
IGL01735:Lrba	APN	3	86,234,968 (GRCm39)	missense	probably benign	0.28
IGL01875:Lrba	APN	3	86,217,354 (GRCm39)	missense	probably damaging	1.00
IGL01884:Lrba	APN	3	86,217,719 (GRCm39)	missense	possibly damaging	0.86
IGL02264:Lrba	APN	3	86,687,569 (GRCm39)	missense	probably damaging	0.99
IGL02638:Lrba	APN	3	86,232,380 (GRCm39)	missense	probably damaging	0.97
IGL02647:Lrba	APN	3	86,267,038 (GRCm39)	missense	probably benign	0.00
IGL02664:Lrba	APN	3	86,233,038 (GRCm39)	missense	possibly damaging	0.84
IGL02728:Lrba	APN	3	86,683,356 (GRCm39)	missense	probably damaging	0.99
IGL02730:Lrba	APN	3	86,235,506 (GRCm39)	missense	probably damaging	1.00
IGL02883:Lrba	APN	3	86,352,720 (GRCm39)	missense	probably damaging	0.99
IGL02883:Lrba	APN	3	86,261,513 (GRCm39)	missense	probably damaging	1.00
IGL02948:Lrba	APN	3	86,217,691 (GRCm39)	splice site	probably null
IGL03090:Lrba	APN	3	86,680,448 (GRCm39)	missense	probably benign	0.01
molasses	UTSW	3	86,261,614 (GRCm39)	critical splice donor site	probably null
oscar	UTSW	3	86,257,611 (GRCm39)	nonsense	probably null
oscar2	UTSW	3	86,571,765 (GRCm39)	nonsense	probably null
P0023:Lrba	UTSW	3	86,325,242 (GRCm39)	missense	probably damaging	1.00
PIT4802001:Lrba	UTSW	3	86,571,801 (GRCm39)	nonsense	probably null
R0077:Lrba	UTSW	3	86,449,995 (GRCm39)	missense	probably damaging	0.99
R0189:Lrba	UTSW	3	86,275,816 (GRCm39)	missense	probably damaging	1.00
R0217:Lrba	UTSW	3	86,550,029 (GRCm39)	missense	probably damaging	1.00
R0349:Lrba	UTSW	3	86,447,312 (GRCm39)	missense	probably damaging	1.00
R0396:Lrba	UTSW	3	86,202,486 (GRCm39)	missense	probably damaging	1.00
R0417:Lrba	UTSW	3	86,622,961 (GRCm39)	missense	probably damaging	1.00
R0536:Lrba	UTSW	3	86,622,839 (GRCm39)	missense	probably damaging	1.00
R0712:Lrba	UTSW	3	86,205,297 (GRCm39)	nonsense	probably null
R0722:Lrba	UTSW	3	86,513,296 (GRCm39)	critical splice donor site	probably null
R0828:Lrba	UTSW	3	86,515,677 (GRCm39)	splice site	probably null
R0927:Lrba	UTSW	3	86,687,540 (GRCm39)	missense	probably damaging	1.00
R1120:Lrba	UTSW	3	86,202,499 (GRCm39)	missense	probably damaging	1.00
R1141:Lrba	UTSW	3	86,526,865 (GRCm39)	missense	probably damaging	1.00
R1276:Lrba	UTSW	3	86,571,833 (GRCm39)	missense	probably damaging	1.00
R1449:Lrba	UTSW	3	86,261,585 (GRCm39)	missense	probably damaging	1.00
R1470:Lrba	UTSW	3	86,644,449 (GRCm39)	missense	probably damaging	1.00
R1470:Lrba	UTSW	3	86,644,449 (GRCm39)	missense	probably damaging	1.00
R1474:Lrba	UTSW	3	86,687,573 (GRCm39)	splice site	probably benign
R1558:Lrba	UTSW	3	86,258,622 (GRCm39)	missense	probably damaging	1.00
R1596:Lrba	UTSW	3	86,257,611 (GRCm39)	nonsense	probably null
R1652:Lrba	UTSW	3	86,447,245 (GRCm39)	missense	probably damaging	1.00
R1800:Lrba	UTSW	3	86,259,175 (GRCm39)	missense	probably benign	0.00
R1819:Lrba	UTSW	3	86,449,941 (GRCm39)	missense	possibly damaging	0.80
R1862:Lrba	UTSW	3	86,680,510 (GRCm39)	critical splice donor site	probably null
R1917:Lrba	UTSW	3	86,571,808 (GRCm39)	missense	probably damaging	1.00
R1965:Lrba	UTSW	3	86,513,175 (GRCm39)	critical splice acceptor site	probably null
R1969:Lrba	UTSW	3	86,515,696 (GRCm39)	missense	probably damaging	0.99
R2011:Lrba	UTSW	3	86,217,324 (GRCm39)	missense	probably damaging	0.99
R2179:Lrba	UTSW	3	86,261,588 (GRCm39)	missense	probably damaging	1.00
R2186:Lrba	UTSW	3	86,211,643 (GRCm39)	missense	probably damaging	1.00
R2281:Lrba	UTSW	3	86,683,410 (GRCm39)	missense	possibly damaging	0.46
R2359:Lrba	UTSW	3	86,256,057 (GRCm39)	missense	probably benign	0.01
R2412:Lrba	UTSW	3	86,235,007 (GRCm39)	missense	probably damaging	1.00
R2496:Lrba	UTSW	3	86,439,394 (GRCm39)	missense	probably damaging	1.00
R3153:Lrba	UTSW	3	86,192,526 (GRCm39)	missense	probably damaging	0.99
R3708:Lrba	UTSW	3	86,192,331 (GRCm39)	missense	possibly damaging	0.80
R3746:Lrba	UTSW	3	86,283,260 (GRCm39)	missense	probably damaging	1.00
R3747:Lrba	UTSW	3	86,283,260 (GRCm39)	missense	probably damaging	1.00
R3748:Lrba	UTSW	3	86,283,260 (GRCm39)	missense	probably damaging	1.00
R3749:Lrba	UTSW	3	86,283,260 (GRCm39)	missense	probably damaging	1.00
R3750:Lrba	UTSW	3	86,283,260 (GRCm39)	missense	probably damaging	1.00
R3758:Lrba	UTSW	3	86,683,356 (GRCm39)	missense	probably damaging	0.99
R3975:Lrba	UTSW	3	86,258,562 (GRCm39)	missense	probably damaging	1.00
R4210:Lrba	UTSW	3	86,267,433 (GRCm39)	missense	probably damaging	1.00
R4258:Lrba	UTSW	3	86,352,656 (GRCm39)	missense	probably damaging	1.00
R4657:Lrba	UTSW	3	86,644,471 (GRCm39)	missense	probably damaging	1.00
R4713:Lrba	UTSW	3	86,267,175 (GRCm39)	missense	probably benign	0.13
R4716:Lrba	UTSW	3	86,550,021 (GRCm39)	missense	probably damaging	0.99
R4811:Lrba	UTSW	3	86,683,448 (GRCm39)	missense	probably damaging	1.00
R4827:Lrba	UTSW	3	86,267,457 (GRCm39)	missense	possibly damaging	0.85
R4840:Lrba	UTSW	3	86,526,816 (GRCm39)	critical splice acceptor site	probably null
R4920:Lrba	UTSW	3	86,571,765 (GRCm39)	nonsense	probably null
R4948:Lrba	UTSW	3	86,192,335 (GRCm39)	missense	probably damaging	1.00
R4970:Lrba	UTSW	3	86,132,678 (GRCm39)	missense	probably benign	0.23
R4985:Lrba	UTSW	3	86,234,743 (GRCm39)	splice site	probably null
R4993:Lrba	UTSW	3	86,267,344 (GRCm39)	missense	probably damaging	1.00
R5107:Lrba	UTSW	3	86,267,086 (GRCm39)	missense	possibly damaging	0.47
R5112:Lrba	UTSW	3	86,132,678 (GRCm39)	missense	probably benign	0.23
R5122:Lrba	UTSW	3	86,256,461 (GRCm39)	nonsense	probably null
R5155:Lrba	UTSW	3	86,258,607 (GRCm39)	missense	probably benign	0.25
R5194:Lrba	UTSW	3	86,235,526 (GRCm39)	missense	probably damaging	1.00
R5280:Lrba	UTSW	3	86,232,329 (GRCm39)	missense	possibly damaging	0.94
R5445:Lrba	UTSW	3	86,275,902 (GRCm39)	missense	probably benign
R5469:Lrba	UTSW	3	86,449,948 (GRCm39)	missense	probably damaging	1.00
R5513:Lrba	UTSW	3	86,449,948 (GRCm39)	missense	probably damaging	1.00
R5578:Lrba	UTSW	3	86,664,814 (GRCm39)	missense	probably benign	0.27
R5740:Lrba	UTSW	3	86,235,649 (GRCm39)	missense	probably damaging	1.00
R5868:Lrba	UTSW	3	86,226,911 (GRCm39)	missense	probably damaging	1.00
R6104:Lrba	UTSW	3	86,261,099 (GRCm39)	missense	probably damaging	1.00
R6166:Lrba	UTSW	3	86,261,614 (GRCm39)	critical splice donor site	probably null
R6279:Lrba	UTSW	3	86,256,171 (GRCm39)	missense	probably benign	0.26
R6330:Lrba	UTSW	3	86,255,664 (GRCm39)	missense	probably benign	0.07
R6367:Lrba	UTSW	3	86,275,869 (GRCm39)	missense	probably benign	0.42
R6571:Lrba	UTSW	3	86,267,367 (GRCm39)	missense	probably damaging	1.00
R6584:Lrba	UTSW	3	86,571,883 (GRCm39)	missense	probably damaging	1.00
R6698:Lrba	UTSW	3	86,211,732 (GRCm39)	missense	probably damaging	0.99
R6763:Lrba	UTSW	3	86,261,570 (GRCm39)	missense	probably damaging	1.00
R6834:Lrba	UTSW	3	86,257,593 (GRCm39)	missense	probably benign	0.00
R6951:Lrba	UTSW	3	86,653,180 (GRCm39)	missense	probably benign	0.01
R6969:Lrba	UTSW	3	86,526,897 (GRCm39)	missense	probably benign	0.21
R7045:Lrba	UTSW	3	86,192,398 (GRCm39)	missense	probably benign	0.03
R7133:Lrba	UTSW	3	86,302,238 (GRCm39)	splice site	probably null
R7182:Lrba	UTSW	3	86,648,765 (GRCm39)	frame shift	probably null
R7214:Lrba	UTSW	3	86,235,633 (GRCm39)	missense	probably damaging	1.00
R7224:Lrba	UTSW	3	86,302,553 (GRCm39)	missense	probably damaging	1.00
R7243:Lrba	UTSW	3	86,658,823 (GRCm39)	splice site	probably null
R7350:Lrba	UTSW	3	86,259,209 (GRCm39)	missense	probably damaging	0.96
R7380:Lrba	UTSW	3	86,232,381 (GRCm39)	missense	probably damaging	1.00
R7492:Lrba	UTSW	3	86,571,835 (GRCm39)	missense	probably damaging	1.00
R7651:Lrba	UTSW	3	86,648,773 (GRCm39)	nonsense	probably null
R7729:Lrba	UTSW	3	86,225,474 (GRCm39)	missense	probably damaging	1.00
R7754:Lrba	UTSW	3	86,352,704 (GRCm39)	missense	probably damaging	1.00
R7762:Lrba	UTSW	3	86,439,508 (GRCm39)	missense	probably damaging	0.99
R7855:Lrba	UTSW	3	86,222,737 (GRCm39)	missense	possibly damaging	0.94
R7867:Lrba	UTSW	3	86,275,896 (GRCm39)	missense	probably damaging	1.00
R7912:Lrba	UTSW	3	86,622,872 (GRCm39)	missense	probably damaging	1.00
R7995:Lrba	UTSW	3	86,526,858 (GRCm39)	missense	probably damaging	1.00
R8013:Lrba	UTSW	3	86,325,278 (GRCm39)	missense	probably damaging	1.00
R8014:Lrba	UTSW	3	86,325,278 (GRCm39)	missense	probably damaging	1.00
R8024:Lrba	UTSW	3	86,202,708 (GRCm39)	nonsense	probably null
R8027:Lrba	UTSW	3	86,325,219 (GRCm39)	missense	probably benign	0.05
R8090:Lrba	UTSW	3	86,255,796 (GRCm39)	missense	probably benign
R8111:Lrba	UTSW	3	86,235,012 (GRCm39)	missense	probably damaging	1.00
R8118:Lrba	UTSW	3	86,261,533 (GRCm39)	missense	probably benign
R8204:Lrba	UTSW	3	86,222,710 (GRCm39)	missense	possibly damaging	0.95
R8239:Lrba	UTSW	3	86,449,882 (GRCm39)	missense	probably damaging	1.00
R8509:Lrba	UTSW	3	86,255,483 (GRCm39)	missense	probably benign	0.04
R8532:Lrba	UTSW	3	86,664,790 (GRCm39)	missense	probably damaging	1.00
R8726:Lrba	UTSW	3	86,261,062 (GRCm39)	missense	probably benign
R8744:Lrba	UTSW	3	86,211,640 (GRCm39)	missense	probably benign	0.08
R8782:Lrba	UTSW	3	86,549,976 (GRCm39)	missense	probably benign	0.00
R8784:Lrba	UTSW	3	86,283,235 (GRCm39)	missense	probably damaging	1.00
R8922:Lrba	UTSW	3	86,263,973 (GRCm39)	missense	probably damaging	1.00
R8964:Lrba	UTSW	3	86,258,552 (GRCm39)	missense	probably benign	0.22
R8971:Lrba	UTSW	3	86,522,388 (GRCm39)	missense	probably benign	0.00
R9046:Lrba	UTSW	3	86,302,543 (GRCm39)	missense	possibly damaging	0.94
R9155:Lrba	UTSW	3	86,202,508 (GRCm39)	missense	probably damaging	1.00
R9236:Lrba	UTSW	3	86,261,066 (GRCm39)	missense	probably benign	0.05
R9266:Lrba	UTSW	3	86,198,774 (GRCm39)	missense	probably benign	0.08
R9297:Lrba	UTSW	3	86,280,873 (GRCm39)	missense	probably damaging	1.00
R9404:Lrba	UTSW	3	86,205,224 (GRCm39)	missense	probably damaging	0.99
R9617:Lrba	UTSW	3	86,267,169 (GRCm39)	missense	probably benign
R9640:Lrba	UTSW	3	86,526,875 (GRCm39)	nonsense	probably null
R9779:Lrba	UTSW	3	86,233,078 (GRCm39)	missense	probably damaging	1.00
X0065:Lrba	UTSW	3	86,232,396 (GRCm39)	missense	possibly damaging	0.95
X0065:Lrba	UTSW	3	86,205,206 (GRCm39)	missense	probably damaging	1.00
Z1176:Lrba	UTSW	3	86,658,839 (GRCm39)	missense	possibly damaging	0.85
Z1176:Lrba	UTSW	3	86,622,845 (GRCm39)	missense	probably benign	0.31
Z1177:Lrba	UTSW	3	86,447,356 (GRCm39)	missense	probably null	1.00

Predicted Primers

PCR Primer
(F):5'- AGTTGCCCTTTCACTAATTACAACC -3'
(R):5'- CAGAGGGTAAACTACAGATCCG -3'

Sequencing Primer
(F):5'- TCACTAATTACAACCCATTTTCTTCC -3'
(R):5'- GGTGTGTTCAAAAATGACATCCC -3'

Posted On

2014-08-25