Incidental Mutation 'R0041:Or6d13'
ID 201486
Institutional Source Beutler Lab
Gene Symbol Or6d13
Ensembl Gene ENSMUSG00000081649
Gene Name olfactory receptor family 6 subfamily D member 13
Synonyms GA_x54KRFPKN04-58174409-58175392, Olfr213, MOR119-3
MMRRC Submission 038335-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.068) question?
Stock # R0041 (G1)
Quality Score 67
Status Validated
Chromosome 6
Chromosomal Location 116517416-116518399 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 116518295 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Isoleucine at position 294 (V294I)
Ref Sequence ENSEMBL: ENSMUSP00000151916 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000121958] [ENSMUST00000220008]
AlphaFold Q7TS32
Predicted Effect possibly damaging
Transcript: ENSMUST00000121958
AA Change: V294I

PolyPhen 2 Score 0.546 (Sensitivity: 0.88; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000112931
Gene: ENSMUSG00000081649
AA Change: V294I

DomainStartEndE-ValueType
Pfam:7tm_4 37 314 4e-45 PFAM
Pfam:7tm_1 47 296 5.4e-15 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000220008
AA Change: V294I

PolyPhen 2 Score 0.546 (Sensitivity: 0.88; Specificity: 0.91)
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.9%
  • 10x: 97.8%
  • 20x: 96.3%
Validation Efficiency 97% (58/60)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts13 A G 2: 26,873,986 (GRCm39) R412G probably damaging Het
Adamts3 T A 5: 89,832,326 (GRCm39) N927Y probably benign Het
Adgra3 A G 5: 50,117,901 (GRCm39) Y1216H probably benign Het
Agpat3 C A 10: 78,123,881 (GRCm39) probably benign Het
AI182371 T A 2: 34,975,733 (GRCm39) Q277L possibly damaging Het
Arhgef15 A T 11: 68,845,342 (GRCm39) L170Q possibly damaging Het
Avpi1 C A 19: 42,112,223 (GRCm39) E112* probably null Het
Braf C T 6: 39,617,413 (GRCm39) A534T probably damaging Het
Bspry G C 4: 62,404,791 (GRCm39) A196P probably damaging Het
Cacna1c T A 6: 118,570,988 (GRCm39) L2095F probably damaging Het
Cdhr2 A T 13: 54,874,651 (GRCm39) S908C probably damaging Het
Cntnap5c C A 17: 58,183,464 (GRCm39) Q57K probably benign Het
Dtna C T 18: 23,779,932 (GRCm39) probably benign Het
Dynap A G 18: 70,375,105 (GRCm39) S37P possibly damaging Het
Efna5 A T 17: 62,914,467 (GRCm39) probably benign Het
Fancm T A 12: 65,153,217 (GRCm39) C1224* probably null Het
Fbxw16 T A 9: 109,277,232 (GRCm39) S37C probably damaging Het
Galnt4 A G 10: 98,944,374 (GRCm39) Y33C probably benign Het
Kcnk2 G T 1: 189,027,888 (GRCm39) N122K probably benign Het
Krt71 C A 15: 101,647,753 (GRCm39) E222D probably damaging Het
Ltf T A 9: 110,858,636 (GRCm39) D461E possibly damaging Het
Mapk4 A T 18: 74,068,109 (GRCm39) L274Q probably damaging Het
Mbd6 A G 10: 127,122,741 (GRCm39) C103R probably damaging Het
Nbeal1 A G 1: 60,321,030 (GRCm39) N2047S probably benign Het
Nefh C T 11: 4,895,184 (GRCm39) S335N possibly damaging Het
Obscn G T 11: 58,934,803 (GRCm39) H4715N probably damaging Het
Olfml1 A T 7: 107,189,393 (GRCm39) I153L possibly damaging Het
Or8g34 T A 9: 39,372,772 (GRCm39) F12Y probably benign Het
Pck1 A G 2: 172,997,003 (GRCm39) E215G probably benign Het
Peg12 T A 7: 62,113,308 (GRCm39) E263V unknown Het
Phkg1 T A 5: 129,903,103 (GRCm39) T15S probably benign Het
Plekhg1 T A 10: 3,914,076 (GRCm39) L1120* probably null Het
Prss59 A T 6: 40,903,042 (GRCm39) L110* probably null Het
Rlf T A 4: 121,007,126 (GRCm39) H618L probably damaging Het
Rnf112 T A 11: 61,343,181 (GRCm39) R165W probably damaging Het
Rnf213 A G 11: 119,293,401 (GRCm39) T51A probably benign Het
Rnf220 A G 4: 117,130,481 (GRCm39) L293P probably damaging Het
Rock1 T C 18: 10,140,240 (GRCm39) D117G probably damaging Het
Rp1 A G 1: 4,414,851 (GRCm39) V2087A probably benign Het
Rpl7a A G 2: 26,801,563 (GRCm39) probably null Het
Serpinb6d A G 13: 33,851,615 (GRCm39) D124G probably damaging Het
Skor1 T G 9: 63,053,133 (GRCm39) T279P probably damaging Het
Son A T 16: 91,456,221 (GRCm39) E1656V probably damaging Het
Swap70 A G 7: 109,878,562 (GRCm39) K511E probably benign Het
Treh T C 9: 44,594,910 (GRCm39) V262A probably benign Het
Trpm4 A G 7: 44,954,370 (GRCm39) probably null Het
Ugt8a T C 3: 125,708,739 (GRCm39) I124V probably benign Het
Wdr53 T C 16: 32,075,473 (GRCm39) V226A probably damaging Het
Wdr64 G A 1: 175,554,037 (GRCm39) W189* probably null Het
Other mutations in Or6d13
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01063:Or6d13 APN 6 116,517,968 (GRCm39) missense probably damaging 1.00
IGL02671:Or6d13 APN 6 116,518,104 (GRCm39) missense possibly damaging 0.50
IGL03107:Or6d13 APN 6 116,517,900 (GRCm39) missense possibly damaging 0.82
R0426:Or6d13 UTSW 6 116,517,446 (GRCm39) missense probably damaging 1.00
R0627:Or6d13 UTSW 6 116,517,949 (GRCm39) missense possibly damaging 0.56
R0829:Or6d13 UTSW 6 116,518,226 (GRCm39) missense probably benign 0.01
R2111:Or6d13 UTSW 6 116,517,611 (GRCm39) missense possibly damaging 0.95
R2112:Or6d13 UTSW 6 116,517,611 (GRCm39) missense possibly damaging 0.95
R2120:Or6d13 UTSW 6 116,517,416 (GRCm39) start codon destroyed probably null 0.04
R3161:Or6d13 UTSW 6 116,517,807 (GRCm39) missense probably damaging 1.00
R3700:Or6d13 UTSW 6 116,517,489 (GRCm39) missense probably benign 0.10
R4710:Or6d13 UTSW 6 116,517,611 (GRCm39) missense possibly damaging 0.95
R5244:Or6d13 UTSW 6 116,518,187 (GRCm39) missense probably damaging 1.00
R5859:Or6d13 UTSW 6 116,517,861 (GRCm39) missense probably damaging 1.00
R6273:Or6d13 UTSW 6 116,518,277 (GRCm39) missense possibly damaging 0.74
R6505:Or6d13 UTSW 6 116,517,561 (GRCm39) missense probably benign 0.01
R7350:Or6d13 UTSW 6 116,517,495 (GRCm39) missense probably benign 0.28
R7380:Or6d13 UTSW 6 116,517,894 (GRCm39) missense probably benign 0.03
R7474:Or6d13 UTSW 6 116,517,999 (GRCm39) missense probably damaging 0.99
R8054:Or6d13 UTSW 6 116,517,960 (GRCm39) missense probably damaging 1.00
R8476:Or6d13 UTSW 6 116,517,507 (GRCm39) missense probably benign
R8862:Or6d13 UTSW 6 116,518,186 (GRCm39) missense probably benign 0.03
R9082:Or6d13 UTSW 6 116,517,969 (GRCm39) missense probably damaging 1.00
R9100:Or6d13 UTSW 6 116,517,990 (GRCm39) missense possibly damaging 0.93
R9124:Or6d13 UTSW 6 116,517,416 (GRCm39) start codon destroyed probably null 0.04
R9151:Or6d13 UTSW 6 116,517,990 (GRCm39) missense possibly damaging 0.93
R9321:Or6d13 UTSW 6 116,518,370 (GRCm39) missense probably benign
R9404:Or6d13 UTSW 6 116,517,708 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGGTCACAATAGTGGGTCTCCCTTC -3'
(R):5'- TTGGTCTTCATTGACACCAAAGCAGA -3'

Sequencing Primer
(F):5'- TTCGGCCAGGGAGAGAC -3'
(R):5'- GCCTTCAGATGGAATTACTGGATAC -3'
Posted On 2014-06-13