Incidental Mutation 'R1758:Lrp1'
ID 195100
Institutional Source Beutler Lab
Gene Symbol Lrp1
Ensembl Gene ENSMUSG00000040249
Gene Name low density lipoprotein receptor-related protein 1
Synonyms b2b1554Clo, CD91, A2mr
MMRRC Submission 039790-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R1758 (G1)
Quality Score 225
Status Not validated
Chromosome 10
Chromosomal Location 127374030-127457017 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 127424453 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Lysine at position 744 (N744K)
Ref Sequence ENSEMBL: ENSMUSP00000044004 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000049149] [ENSMUST00000121829]
AlphaFold no structure available at present
Predicted Effect possibly damaging
Transcript: ENSMUST00000049149
AA Change: N744K

PolyPhen 2 Score 0.759 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000044004
Gene: ENSMUSG00000040249
AA Change: N744K

DomainStartEndE-ValueType
low complexity region 2 13 N/A INTRINSIC
LDLa 27 67 1.03e-15 SMART
LDLa 72 111 1.04e-11 SMART
EGF 115 150 8.78e-2 SMART
EGF_CA 151 190 4.49e-8 SMART
low complexity region 222 232 N/A INTRINSIC
LY 273 315 7.07e-6 SMART
LY 316 359 2.31e-10 SMART
LY 360 402 8.3e-12 SMART
EGF 478 521 9.93e-1 SMART
LY 552 594 8.84e-7 SMART
LY 595 638 6.54e-10 SMART
LY 641 690 2.5e-15 SMART
LY 691 734 1.06e-9 SMART
EGF 807 844 1.38e1 SMART
LDLa 854 893 3.39e-16 SMART
LDLa 895 934 1.73e-13 SMART
LDLa 936 974 4.47e-16 SMART
LDLa 976 1014 2.53e-15 SMART
LDLa 1015 1054 2.95e-16 SMART
LDLa 1062 1100 3.24e-13 SMART
LDLa 1104 1143 2.97e-12 SMART
LDLa 1145 1185 1.24e-9 SMART
EGF 1185 1223 4.97e-1 SMART
EGF 1227 1263 6.02e0 SMART
LY 1290 1332 3.76e-1 SMART
LY 1337 1379 8.56e-14 SMART
LY 1380 1424 8.43e-13 SMART
LY 1425 1469 3.05e-10 SMART
LY 1471 1513 3.88e-3 SMART
EGF 1540 1580 1.85e0 SMART
LY 1606 1650 2.83e-5 SMART
LY 1651 1695 2.01e-10 SMART
LY 1698 1735 1.87e-5 SMART
LY 1736 1777 3.54e-6 SMART
LY 1778 1820 4.17e1 SMART
EGF 1850 1888 1.24e-1 SMART
LY 1915 1957 3.2e-4 SMART
LY 1958 2000 2.33e-15 SMART
LY 2001 2044 7.45e-14 SMART
LY 2045 2087 3.87e-12 SMART
LY 2089 2131 1.37e0 SMART
EGF 2159 2196 1.66e1 SMART
LY 2276 2318 5.57e-4 SMART
LY 2324 2369 3.3e-6 SMART
LY 2370 2412 3.93e-13 SMART
LY 2413 2454 3.62e-3 SMART
EGF_like 2482 2519 3.16e1 SMART
LDLa 2524 2564 3.31e-10 SMART
LDLa 2566 2603 7.21e-11 SMART
LDLa 2605 2642 1.09e-10 SMART
LDLa 2660 2691 6.05e-4 SMART
LDLa 2696 2733 2.49e-14 SMART
LDLa 2734 2772 4.65e-14 SMART
LDLa 2774 2815 3.92e-12 SMART
LDLa 2818 2856 1.51e-13 SMART
LDLa 2858 2900 1.93e-11 SMART
LDLa 2904 2942 1.73e-13 SMART
EGF_CA 2941 2982 6.16e-6 SMART
EGF_CA 2983 3023 2.66e-10 SMART
LY 3050 3094 6.64e-11 SMART
LY 3095 3137 7.17e-16 SMART
LY 3138 3181 4.28e-14 SMART
LY 3182 3224 8.11e-15 SMART
LY 3225 3265 1.44e-6 SMART
EGF 3294 3332 1.02e-2 SMART
LDLa 3334 3372 2.25e-12 SMART
LDLa 3374 3411 9.81e-13 SMART
LDLa 3413 3451 9.81e-13 SMART
LDLa 3453 3492 5.67e-18 SMART
LDLa 3494 3534 7.15e-15 SMART
LDLa 3536 3573 1.79e-15 SMART
EGF_like 3575 3611 4.83e1 SMART
LDLa 3575 3612 1.92e-15 SMART
LDLa 3613 3650 1.18e-15 SMART
LDLa 3654 3693 7.55e-14 SMART
LDLa 3695 3734 1.14e-8 SMART
LDLa 3741 3779 6.28e-11 SMART
EGF 3785 3824 1.06e1 SMART
EGF 3828 3862 1.51e0 SMART
LY 3893 3935 9.43e0 SMART
LY 3951 3993 1.23e-14 SMART
LY 3994 4037 2.98e-13 SMART
LY 4038 4080 4.28e-14 SMART
EGF 4151 4184 3.76e-1 SMART
low complexity region 4185 4198 N/A INTRINSIC
EGF 4200 4233 3.82e-2 SMART
EGF 4236 4269 4.03e-1 SMART
EGF 4272 4305 5.2e-4 SMART
EGF 4308 4341 1.22e0 SMART
EGF_like 4344 4376 4.11e1 SMART
EGF 4377 4410 5.12e-3 SMART
transmembrane domain 4423 4445 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000121829
SMART Domains Protein: ENSMUSP00000113584
Gene: ENSMUSG00000040249

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
LDLa 27 67 1.03e-15 SMART
LDLa 72 111 1.04e-11 SMART
EGF 115 150 8.78e-2 SMART
EGF_CA 151 190 4.49e-8 SMART
low complexity region 222 232 N/A INTRINSIC
LY 273 315 7.07e-6 SMART
LY 316 359 2.31e-10 SMART
LY 360 402 8.3e-12 SMART
EGF 478 521 9.93e-1 SMART
LY 552 594 8.84e-7 SMART
LY 595 638 6.54e-10 SMART
LY 641 690 2.5e-15 SMART
LY 691 734 1.06e-9 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000125480
Coding Region Coverage
  • 1x: 97.5%
  • 3x: 97.0%
  • 10x: 95.6%
  • 20x: 93.2%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients. [provided by RefSeq, Oct 2015]
PHENOTYPE: Mice homozygous for a null allele exhibit lethality during late organogenesis. [provided by MGI curators]
Allele List at MGI

All alleles(42) : Targeted(9) Gene trapped(33)

Other mutations in this stock
Total: 95 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700029H14Rik T C 8: 13,612,237 (GRCm39) R38G possibly damaging Het
4930590J08Rik T C 6: 91,892,203 (GRCm39) V155A possibly damaging Het
Adgb A G 10: 10,302,349 (GRCm39) S406P probably damaging Het
Adgrb2 C A 4: 129,905,668 (GRCm39) T893N probably damaging Het
Adgrf5 T C 17: 43,735,484 (GRCm39) probably null Het
Alms1 T A 6: 85,605,487 (GRCm39) I2379N probably damaging Het
Arap3 C T 18: 38,122,965 (GRCm39) V512I probably benign Het
Atf4 C T 15: 80,141,414 (GRCm39) T268I probably benign Het
Cblif G A 19: 11,735,179 (GRCm39) M266I probably damaging Het
Ccdc154 T C 17: 25,382,156 (GRCm39) L25P probably damaging Het
Ccdc9 G A 7: 16,010,161 (GRCm39) S381F probably damaging Het
Cdk17 C T 10: 93,044,112 (GRCm39) T17M probably damaging Het
Cep128 T C 12: 91,314,352 (GRCm39) N142S probably benign Het
Cep78 A G 19: 15,936,900 (GRCm39) I602T probably damaging Het
Clasp1 C T 1: 118,475,755 (GRCm39) T935I probably damaging Het
Cnr1 T C 4: 33,945,000 (GRCm39) S463P probably damaging Het
Cntnap1 T A 11: 101,075,449 (GRCm39) W876R probably damaging Het
Cntnap5c A G 17: 58,349,545 (GRCm39) D286G probably damaging Het
Copa C T 1: 171,931,711 (GRCm39) R321C probably damaging Het
Cspg4b A G 13: 113,505,266 (GRCm39) T2132A possibly damaging Het
Ctla2a T G 13: 61,083,256 (GRCm39) E98A probably damaging Het
Cux1 A T 5: 136,421,176 (GRCm39) D183E probably damaging Het
Cxcl15 A C 5: 90,949,323 (GRCm39) T163P unknown Het
Ddias T C 7: 92,508,571 (GRCm39) N448S probably benign Het
Dhx8 T C 11: 101,657,564 (GRCm39) F1152S probably damaging Het
Dnah12 C A 14: 26,488,071 (GRCm39) Q992K probably benign Het
Eno3 G T 11: 70,552,251 (GRCm39) W301L possibly damaging Het
Faap100 A T 11: 120,268,059 (GRCm39) V238E probably damaging Het
Fgf4 A G 7: 144,416,049 (GRCm39) S137G probably benign Het
Fhod3 A C 18: 25,253,367 (GRCm39) D1439A possibly damaging Het
Frem2 A G 3: 53,560,778 (GRCm39) L1243P probably damaging Het
Gkn3 T G 6: 87,365,817 (GRCm39) M1L probably benign Het
Gm10250 T C 15: 5,150,509 (GRCm39) probably benign Het
Gm12185 T C 11: 48,798,859 (GRCm39) T545A possibly damaging Het
Gm14226 T A 2: 154,867,378 (GRCm39) L445H probably damaging Het
Gm3404 A T 5: 146,463,036 (GRCm39) M73L probably benign Het
Gm973 G T 1: 59,673,169 (GRCm39) R976S unknown Het
Gpr146 A T 5: 139,379,137 (GRCm39) H313L probably benign Het
Gys2 T A 6: 142,418,432 (GRCm39) E32D probably damaging Het
Igsf10 G A 3: 59,236,617 (GRCm39) T1188I probably benign Het
Igsf9b A T 9: 27,245,548 (GRCm39) T1172S possibly damaging Het
Itga8 T A 2: 12,270,144 (GRCm39) N114I possibly damaging Het
Itsn2 T A 12: 4,708,160 (GRCm39) V795E possibly damaging Het
Kdm1b T A 13: 47,214,244 (GRCm39) S197T probably benign Het
Kif5c G A 2: 49,613,145 (GRCm39) R161Q probably benign Het
Krt33b T C 11: 99,916,361 (GRCm39) Y232C probably damaging Het
Lonrf2 G A 1: 38,852,357 (GRCm39) P165S probably benign Het
Mcm10 C A 2: 5,008,861 (GRCm39) L369F probably damaging Het
Muc5ac T A 7: 141,355,268 (GRCm39) I1018N possibly damaging Het
Myom2 T C 8: 15,115,795 (GRCm39) L70P probably benign Het
Myt1l T A 12: 29,877,241 (GRCm39) N297K unknown Het
Ncr1 C T 7: 4,343,807 (GRCm39) T98I probably benign Het
Nek3 T C 8: 22,650,278 (GRCm39) E78G probably damaging Het
Nfatc3 T A 8: 106,825,768 (GRCm39) N606K probably damaging Het
Nup107 T G 10: 117,597,248 (GRCm39) D669A probably damaging Het
Or10ag52 A T 2: 87,043,758 (GRCm39) Q174L probably benign Het
Or10c1 A T 17: 37,522,204 (GRCm39) I180N possibly damaging Het
Or4c3 T C 2: 89,851,673 (GRCm39) T246A probably benign Het
Or8b55 A T 9: 38,726,871 (GRCm39) H24L probably benign Het
Pcnx1 T C 12: 82,030,258 (GRCm39) V1711A probably benign Het
Pik3c3 A G 18: 30,410,063 (GRCm39) D99G probably damaging Het
Pinx1 C A 14: 64,157,024 (GRCm39) T317K probably benign Het
Ppargc1b G T 18: 61,431,857 (GRCm39) probably null Het
Pradc1 T A 6: 85,424,203 (GRCm39) I119F possibly damaging Het
Psat1 G T 19: 15,892,243 (GRCm39) T242K probably damaging Het
Psma6 G A 12: 55,454,317 (GRCm39) C28Y probably damaging Het
Pyurf A T 6: 57,668,817 (GRCm39) C58* probably null Het
Rab3gap2 C A 1: 185,016,081 (GRCm39) A1331E probably benign Het
Rnase4 T C 14: 51,342,722 (GRCm39) *149Q probably null Het
Ruvbl2 T C 7: 45,074,586 (GRCm39) K184R probably benign Het
Scn7a T G 2: 66,510,527 (GRCm39) M1292L probably benign Het
Scn7a A T 2: 66,531,231 (GRCm39) Y549N probably damaging Het
Selp A G 1: 163,959,854 (GRCm39) D370G possibly damaging Het
Slc22a15 G A 3: 101,767,769 (GRCm39) Q386* probably null Het
Slc22a29 A G 19: 8,195,126 (GRCm39) probably null Het
Slc26a7 A C 4: 14,548,491 (GRCm39) I266S possibly damaging Het
Smpd4 T C 16: 17,443,872 (GRCm39) S112P probably damaging Het
Smpd4 T A 16: 17,458,744 (GRCm39) L165Q probably damaging Het
Snx33 A G 9: 56,833,982 (GRCm39) I29T probably benign Het
Spen G A 4: 141,203,686 (GRCm39) P1647L unknown Het
Strip2 T C 6: 29,941,940 (GRCm39) probably null Het
Swsap1 C T 9: 21,867,280 (GRCm39) R75* probably null Het
Tesl1 A G X: 23,772,990 (GRCm39) I164V probably benign Het
Tmem210 C T 2: 25,178,435 (GRCm39) T32I probably damaging Het
Tnn C T 1: 159,975,154 (GRCm39) R91H possibly damaging Het
Tnni1 G A 1: 135,736,420 (GRCm39) R94H probably damaging Het
Tnrc6c T A 11: 117,651,556 (GRCm39) V1693D probably benign Het
Trip4 G A 9: 65,782,259 (GRCm39) Q158* probably null Het
Ttc39b T C 4: 83,155,586 (GRCm39) E474G probably damaging Het
Usp50 C A 2: 126,617,782 (GRCm39) C221F probably damaging Het
Vmn1r171 T C 7: 23,331,781 (GRCm39) I2T probably benign Het
Wdr62 T A 7: 29,967,328 (GRCm39) I309F probably damaging Het
Xdh A T 17: 74,217,204 (GRCm39) V688E probably damaging Het
Zfyve26 A G 12: 79,285,718 (GRCm39) L2353P probably damaging Het
Zgpat C A 2: 181,020,633 (GRCm39) R269S probably damaging Het
Other mutations in Lrp1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00793:Lrp1 APN 10 127,378,074 (GRCm39) missense possibly damaging 0.89
IGL01065:Lrp1 APN 10 127,410,907 (GRCm39) missense probably benign 0.10
IGL01121:Lrp1 APN 10 127,419,722 (GRCm39) nonsense probably null
IGL01360:Lrp1 APN 10 127,381,689 (GRCm39) missense possibly damaging 0.93
IGL01402:Lrp1 APN 10 127,430,901 (GRCm39) missense probably damaging 1.00
IGL01404:Lrp1 APN 10 127,430,901 (GRCm39) missense probably damaging 1.00
IGL01411:Lrp1 APN 10 127,417,634 (GRCm39) nonsense probably null
IGL01469:Lrp1 APN 10 127,420,283 (GRCm39) missense probably damaging 1.00
IGL01552:Lrp1 APN 10 127,424,379 (GRCm39) nonsense probably null
IGL01682:Lrp1 APN 10 127,410,847 (GRCm39) missense probably benign 0.00
IGL01760:Lrp1 APN 10 127,409,370 (GRCm39) missense probably benign 0.00
IGL01918:Lrp1 APN 10 127,390,458 (GRCm39) missense probably damaging 0.99
IGL01989:Lrp1 APN 10 127,413,998 (GRCm39) missense probably damaging 1.00
IGL02105:Lrp1 APN 10 127,380,448 (GRCm39) missense probably damaging 1.00
IGL02158:Lrp1 APN 10 127,390,140 (GRCm39) missense probably benign 0.02
IGL02164:Lrp1 APN 10 127,399,536 (GRCm39) missense probably benign 0.39
IGL02337:Lrp1 APN 10 127,412,756 (GRCm39) missense possibly damaging 0.87
IGL02425:Lrp1 APN 10 127,407,756 (GRCm39) critical splice donor site probably null
IGL02493:Lrp1 APN 10 127,417,647 (GRCm39) missense probably damaging 0.99
IGL02563:Lrp1 APN 10 127,387,555 (GRCm39) missense probably damaging 1.00
IGL02590:Lrp1 APN 10 127,388,660 (GRCm39) missense probably damaging 1.00
IGL02624:Lrp1 APN 10 127,408,291 (GRCm39) missense probably damaging 0.98
IGL02625:Lrp1 APN 10 127,410,355 (GRCm39) missense probably damaging 1.00
IGL02825:Lrp1 APN 10 127,378,474 (GRCm39) missense probably damaging 1.00
IGL02880:Lrp1 APN 10 127,376,091 (GRCm39) missense probably benign 0.12
IGL02900:Lrp1 APN 10 127,412,516 (GRCm39) splice site probably benign
IGL02956:Lrp1 APN 10 127,380,428 (GRCm39) missense probably benign 0.00
IGL02974:Lrp1 APN 10 127,390,885 (GRCm39) missense probably damaging 0.99
IGL02983:Lrp1 APN 10 127,386,068 (GRCm39) missense probably damaging 1.00
IGL03002:Lrp1 APN 10 127,425,505 (GRCm39) missense probably damaging 1.00
IGL03091:Lrp1 APN 10 127,394,993 (GRCm39) missense probably benign 0.30
IGL03109:Lrp1 APN 10 127,402,514 (GRCm39) missense probably benign
IGL03194:Lrp1 APN 10 127,404,554 (GRCm39) missense probably damaging 1.00
IGL03232:Lrp1 APN 10 127,375,245 (GRCm39) missense probably damaging 1.00
calculus UTSW 10 127,393,937 (GRCm39) splice site probably null
Delimiter UTSW 10 127,382,731 (GRCm39) missense probably damaging 1.00
extremis UTSW 10 127,392,857 (GRCm39) missense probably benign 0.00
Jockey UTSW 10 127,396,005 (GRCm39) missense probably damaging 1.00
peripheral UTSW 10 127,446,250 (GRCm39) missense probably damaging 1.00
tangential UTSW 10 127,429,717 (GRCm39) missense probably damaging 0.99
P0015:Lrp1 UTSW 10 127,402,532 (GRCm39) missense probably damaging 0.99
PIT4519001:Lrp1 UTSW 10 127,443,843 (GRCm39) missense possibly damaging 0.91
PIT4520001:Lrp1 UTSW 10 127,443,843 (GRCm39) missense possibly damaging 0.91
R0004:Lrp1 UTSW 10 127,377,694 (GRCm39) splice site probably null
R0034:Lrp1 UTSW 10 127,381,520 (GRCm39) missense probably benign 0.42
R0091:Lrp1 UTSW 10 127,376,848 (GRCm39) missense probably damaging 1.00
R0098:Lrp1 UTSW 10 127,388,607 (GRCm39) missense probably benign
R0098:Lrp1 UTSW 10 127,388,607 (GRCm39) missense probably benign
R0143:Lrp1 UTSW 10 127,429,811 (GRCm39) missense probably damaging 1.00
R0372:Lrp1 UTSW 10 127,428,005 (GRCm39) missense probably damaging 1.00
R0379:Lrp1 UTSW 10 127,430,838 (GRCm39) missense probably damaging 1.00
R0445:Lrp1 UTSW 10 127,426,505 (GRCm39) nonsense probably null
R0529:Lrp1 UTSW 10 127,377,463 (GRCm39) splice site probably null
R0551:Lrp1 UTSW 10 127,407,827 (GRCm39) missense probably benign
R0570:Lrp1 UTSW 10 127,390,878 (GRCm39) nonsense probably null
R0600:Lrp1 UTSW 10 127,403,252 (GRCm39) missense probably benign 0.00
R0626:Lrp1 UTSW 10 127,403,233 (GRCm39) missense probably damaging 1.00
R0647:Lrp1 UTSW 10 127,407,346 (GRCm39) missense probably damaging 1.00
R0680:Lrp1 UTSW 10 127,425,530 (GRCm39) missense probably damaging 1.00
R0792:Lrp1 UTSW 10 127,411,155 (GRCm39) missense probably benign 0.04
R0792:Lrp1 UTSW 10 127,403,233 (GRCm39) missense probably damaging 1.00
R0848:Lrp1 UTSW 10 127,389,231 (GRCm39) splice site probably null
R0866:Lrp1 UTSW 10 127,375,147 (GRCm39) missense probably damaging 1.00
R0918:Lrp1 UTSW 10 127,429,834 (GRCm39) missense probably damaging 1.00
R1076:Lrp1 UTSW 10 127,399,666 (GRCm39) splice site probably benign
R1107:Lrp1 UTSW 10 127,393,304 (GRCm39) missense probably damaging 1.00
R1346:Lrp1 UTSW 10 127,441,735 (GRCm39) missense probably damaging 1.00
R1403:Lrp1 UTSW 10 127,417,760 (GRCm39) critical splice acceptor site probably null
R1403:Lrp1 UTSW 10 127,417,760 (GRCm39) critical splice acceptor site probably null
R1496:Lrp1 UTSW 10 127,374,880 (GRCm39) missense probably damaging 1.00
R1522:Lrp1 UTSW 10 127,411,155 (GRCm39) missense probably benign 0.04
R1522:Lrp1 UTSW 10 127,403,233 (GRCm39) missense probably damaging 1.00
R1525:Lrp1 UTSW 10 127,375,398 (GRCm39) missense probably damaging 1.00
R1539:Lrp1 UTSW 10 127,420,250 (GRCm39) splice site probably null
R1589:Lrp1 UTSW 10 127,441,475 (GRCm39) missense probably benign 0.00
R1591:Lrp1 UTSW 10 127,441,475 (GRCm39) missense probably benign 0.00
R1663:Lrp1 UTSW 10 127,392,790 (GRCm39) missense probably damaging 1.00
R1682:Lrp1 UTSW 10 127,410,201 (GRCm39) missense probably damaging 1.00
R1717:Lrp1 UTSW 10 127,399,534 (GRCm39) missense probably damaging 1.00
R1717:Lrp1 UTSW 10 127,392,138 (GRCm39) missense possibly damaging 0.59
R1826:Lrp1 UTSW 10 127,389,576 (GRCm39) missense probably damaging 1.00
R1842:Lrp1 UTSW 10 127,409,337 (GRCm39) missense possibly damaging 0.93
R1844:Lrp1 UTSW 10 127,431,152 (GRCm39) critical splice donor site probably null
R1845:Lrp1 UTSW 10 127,414,542 (GRCm39) missense probably damaging 1.00
R1896:Lrp1 UTSW 10 127,395,867 (GRCm39) missense possibly damaging 0.64
R1952:Lrp1 UTSW 10 127,403,300 (GRCm39) missense probably damaging 1.00
R2009:Lrp1 UTSW 10 127,380,385 (GRCm39) missense probably damaging 1.00
R2015:Lrp1 UTSW 10 127,376,563 (GRCm39) missense probably benign 0.00
R2116:Lrp1 UTSW 10 127,412,362 (GRCm39) nonsense probably null
R2161:Lrp1 UTSW 10 127,391,607 (GRCm39) missense probably damaging 1.00
R2199:Lrp1 UTSW 10 127,382,709 (GRCm39) missense probably damaging 1.00
R2213:Lrp1 UTSW 10 127,376,571 (GRCm39) missense probably damaging 1.00
R2300:Lrp1 UTSW 10 127,392,784 (GRCm39) nonsense probably null
R2324:Lrp1 UTSW 10 127,402,455 (GRCm39) missense possibly damaging 0.92
R2849:Lrp1 UTSW 10 127,378,165 (GRCm39) missense probably damaging 1.00
R2926:Lrp1 UTSW 10 127,423,982 (GRCm39) missense probably damaging 0.98
R2993:Lrp1 UTSW 10 127,446,250 (GRCm39) missense probably damaging 1.00
R3522:Lrp1 UTSW 10 127,389,424 (GRCm39) missense probably damaging 1.00
R3702:Lrp1 UTSW 10 127,430,972 (GRCm39) missense probably damaging 1.00
R3789:Lrp1 UTSW 10 127,407,838 (GRCm39) missense possibly damaging 0.94
R3898:Lrp1 UTSW 10 127,427,969 (GRCm39) nonsense probably null
R3941:Lrp1 UTSW 10 127,389,265 (GRCm39) missense probably damaging 1.00
R3958:Lrp1 UTSW 10 127,407,827 (GRCm39) missense probably benign
R4369:Lrp1 UTSW 10 127,386,155 (GRCm39) missense possibly damaging 0.87
R4510:Lrp1 UTSW 10 127,429,717 (GRCm39) missense probably damaging 0.99
R4511:Lrp1 UTSW 10 127,429,717 (GRCm39) missense probably damaging 0.99
R4576:Lrp1 UTSW 10 127,376,057 (GRCm39) small deletion probably benign
R4583:Lrp1 UTSW 10 127,377,241 (GRCm39) missense probably benign 0.00
R4662:Lrp1 UTSW 10 127,388,054 (GRCm39) nonsense probably null
R4721:Lrp1 UTSW 10 127,390,928 (GRCm39) missense possibly damaging 0.58
R4728:Lrp1 UTSW 10 127,399,606 (GRCm39) missense probably damaging 1.00
R4745:Lrp1 UTSW 10 127,385,813 (GRCm39) missense probably benign 0.20
R4785:Lrp1 UTSW 10 127,394,002 (GRCm39) missense probably benign 0.12
R4841:Lrp1 UTSW 10 127,419,805 (GRCm39) missense probably damaging 1.00
R4842:Lrp1 UTSW 10 127,419,805 (GRCm39) missense probably damaging 1.00
R4855:Lrp1 UTSW 10 127,446,311 (GRCm39) missense probably benign 0.03
R4860:Lrp1 UTSW 10 127,389,693 (GRCm39) missense probably damaging 1.00
R4860:Lrp1 UTSW 10 127,389,693 (GRCm39) missense probably damaging 1.00
R4891:Lrp1 UTSW 10 127,377,621 (GRCm39) missense probably damaging 1.00
R4925:Lrp1 UTSW 10 127,410,944 (GRCm39) nonsense probably null
R4970:Lrp1 UTSW 10 127,375,389 (GRCm39) missense probably benign 0.11
R4999:Lrp1 UTSW 10 127,389,648 (GRCm39) missense probably damaging 1.00
R5044:Lrp1 UTSW 10 127,403,364 (GRCm39) missense probably damaging 1.00
R5127:Lrp1 UTSW 10 127,375,503 (GRCm39) intron probably benign
R5188:Lrp1 UTSW 10 127,443,821 (GRCm39) missense probably damaging 1.00
R5218:Lrp1 UTSW 10 127,384,488 (GRCm39) missense probably damaging 1.00
R5225:Lrp1 UTSW 10 127,391,965 (GRCm39) missense probably benign 0.04
R5291:Lrp1 UTSW 10 127,429,747 (GRCm39) missense probably damaging 1.00
R5386:Lrp1 UTSW 10 127,427,983 (GRCm39) missense probably damaging 1.00
R5395:Lrp1 UTSW 10 127,431,166 (GRCm39) missense probably damaging 1.00
R5413:Lrp1 UTSW 10 127,423,936 (GRCm39) critical splice donor site probably null
R5430:Lrp1 UTSW 10 127,376,930 (GRCm39) missense probably damaging 0.99
R5499:Lrp1 UTSW 10 127,408,813 (GRCm39) missense possibly damaging 0.58
R5526:Lrp1 UTSW 10 127,391,593 (GRCm39) missense probably benign 0.37
R5580:Lrp1 UTSW 10 127,424,389 (GRCm39) missense probably benign
R5583:Lrp1 UTSW 10 127,424,332 (GRCm39) missense probably benign 0.08
R5599:Lrp1 UTSW 10 127,429,738 (GRCm39) missense probably damaging 1.00
R5639:Lrp1 UTSW 10 127,429,708 (GRCm39) missense probably damaging 0.99
R5677:Lrp1 UTSW 10 127,410,298 (GRCm39) missense probably damaging 1.00
R5730:Lrp1 UTSW 10 127,419,703 (GRCm39) missense probably benign 0.00
R5742:Lrp1 UTSW 10 127,384,216 (GRCm39) missense probably damaging 0.98
R5764:Lrp1 UTSW 10 127,431,187 (GRCm39) missense probably benign 0.41
R5864:Lrp1 UTSW 10 127,403,374 (GRCm39) missense possibly damaging 0.58
R5937:Lrp1 UTSW 10 127,419,745 (GRCm39) missense possibly damaging 0.93
R5947:Lrp1 UTSW 10 127,425,423 (GRCm39) critical splice donor site probably null
R5976:Lrp1 UTSW 10 127,419,770 (GRCm39) missense probably damaging 1.00
R6021:Lrp1 UTSW 10 127,413,883 (GRCm39) missense probably damaging 1.00
R6026:Lrp1 UTSW 10 127,409,272 (GRCm39) missense probably damaging 1.00
R6045:Lrp1 UTSW 10 127,402,469 (GRCm39) missense probably damaging 0.98
R6057:Lrp1 UTSW 10 127,403,359 (GRCm39) missense probably damaging 1.00
R6084:Lrp1 UTSW 10 127,396,422 (GRCm39) missense probably benign 0.09
R6131:Lrp1 UTSW 10 127,396,026 (GRCm39) missense probably benign
R6235:Lrp1 UTSW 10 127,424,046 (GRCm39) missense probably damaging 1.00
R6280:Lrp1 UTSW 10 127,425,453 (GRCm39) missense probably benign 0.04
R6307:Lrp1 UTSW 10 127,427,944 (GRCm39) missense probably damaging 1.00
R6532:Lrp1 UTSW 10 127,385,276 (GRCm39) missense probably damaging 1.00
R6532:Lrp1 UTSW 10 127,377,551 (GRCm39) missense probably damaging 1.00
R6536:Lrp1 UTSW 10 127,393,937 (GRCm39) splice site probably null
R6605:Lrp1 UTSW 10 127,396,005 (GRCm39) missense probably damaging 1.00
R6607:Lrp1 UTSW 10 127,396,005 (GRCm39) missense probably damaging 1.00
R6631:Lrp1 UTSW 10 127,410,201 (GRCm39) missense probably damaging 1.00
R6676:Lrp1 UTSW 10 127,396,005 (GRCm39) missense probably damaging 1.00
R6678:Lrp1 UTSW 10 127,396,005 (GRCm39) missense probably damaging 1.00
R6809:Lrp1 UTSW 10 127,390,925 (GRCm39) missense probably benign 0.04
R6884:Lrp1 UTSW 10 127,394,986 (GRCm39) missense probably benign 0.00
R6925:Lrp1 UTSW 10 127,392,857 (GRCm39) missense probably benign 0.00
R6987:Lrp1 UTSW 10 127,410,874 (GRCm39) missense probably damaging 1.00
R7016:Lrp1 UTSW 10 127,395,836 (GRCm39) critical splice donor site probably null
R7030:Lrp1 UTSW 10 127,388,745 (GRCm39) missense probably damaging 0.97
R7053:Lrp1 UTSW 10 127,376,963 (GRCm39) missense probably damaging 1.00
R7076:Lrp1 UTSW 10 127,386,052 (GRCm39) critical splice donor site probably null
R7136:Lrp1 UTSW 10 127,394,491 (GRCm39) missense probably damaging 1.00
R7180:Lrp1 UTSW 10 127,392,834 (GRCm39) missense probably damaging 1.00
R7199:Lrp1 UTSW 10 127,409,325 (GRCm39) missense probably damaging 0.99
R7219:Lrp1 UTSW 10 127,393,097 (GRCm39) missense probably benign 0.40
R7233:Lrp1 UTSW 10 127,430,930 (GRCm39) missense probably damaging 1.00
R7251:Lrp1 UTSW 10 127,408,423 (GRCm39) missense probably damaging 1.00
R7264:Lrp1 UTSW 10 127,427,962 (GRCm39) missense probably damaging 1.00
R7302:Lrp1 UTSW 10 127,374,856 (GRCm39) missense probably benign 0.01
R7313:Lrp1 UTSW 10 127,389,337 (GRCm39) missense probably damaging 1.00
R7322:Lrp1 UTSW 10 127,381,433 (GRCm39) missense probably benign 0.24
R7354:Lrp1 UTSW 10 127,407,277 (GRCm39) missense probably damaging 1.00
R7375:Lrp1 UTSW 10 127,375,217 (GRCm39) missense probably damaging 1.00
R7388:Lrp1 UTSW 10 127,419,766 (GRCm39) nonsense probably null
R7404:Lrp1 UTSW 10 127,418,577 (GRCm39) missense
R7405:Lrp1 UTSW 10 127,417,620 (GRCm39) missense possibly damaging 0.93
R7477:Lrp1 UTSW 10 127,404,789 (GRCm39) missense probably damaging 1.00
R7555:Lrp1 UTSW 10 127,382,731 (GRCm39) missense probably damaging 1.00
R7600:Lrp1 UTSW 10 127,391,575 (GRCm39) missense probably benign
R7678:Lrp1 UTSW 10 127,409,922 (GRCm39) missense probably damaging 1.00
R7679:Lrp1 UTSW 10 127,424,297 (GRCm39) nonsense probably null
R7951:Lrp1 UTSW 10 127,374,933 (GRCm39) nonsense probably null
R7964:Lrp1 UTSW 10 127,410,913 (GRCm39) missense possibly damaging 0.94
R8006:Lrp1 UTSW 10 127,425,488 (GRCm39) missense probably damaging 1.00
R8021:Lrp1 UTSW 10 127,384,215 (GRCm39) missense possibly damaging 0.92
R8098:Lrp1 UTSW 10 127,410,324 (GRCm39) missense possibly damaging 0.78
R8112:Lrp1 UTSW 10 127,441,715 (GRCm39) missense probably damaging 1.00
R8210:Lrp1 UTSW 10 127,412,354 (GRCm39) missense probably damaging 1.00
R8249:Lrp1 UTSW 10 127,441,412 (GRCm39) missense probably benign
R8291:Lrp1 UTSW 10 127,425,572 (GRCm39) missense probably damaging 1.00
R8332:Lrp1 UTSW 10 127,407,805 (GRCm39) missense probably damaging 1.00
R8435:Lrp1 UTSW 10 127,392,199 (GRCm39) missense probably damaging 0.97
R8467:Lrp1 UTSW 10 127,394,519 (GRCm39) missense probably damaging 1.00
R8468:Lrp1 UTSW 10 127,394,519 (GRCm39) missense probably damaging 1.00
R8474:Lrp1 UTSW 10 127,375,572 (GRCm39) missense probably damaging 1.00
R8481:Lrp1 UTSW 10 127,404,779 (GRCm39) missense probably damaging 1.00
R8483:Lrp1 UTSW 10 127,394,519 (GRCm39) missense probably damaging 1.00
R8485:Lrp1 UTSW 10 127,394,519 (GRCm39) missense probably damaging 1.00
R8488:Lrp1 UTSW 10 127,396,356 (GRCm39) missense probably damaging 1.00
R8715:Lrp1 UTSW 10 127,396,490 (GRCm39) missense possibly damaging 0.77
R8790:Lrp1 UTSW 10 127,374,946 (GRCm39) missense probably damaging 1.00
R8854:Lrp1 UTSW 10 127,378,968 (GRCm39) missense probably damaging 1.00
R8926:Lrp1 UTSW 10 127,381,671 (GRCm39) missense probably benign
R8949:Lrp1 UTSW 10 127,425,405 (GRCm39) intron probably benign
R8971:Lrp1 UTSW 10 127,391,896 (GRCm39) missense possibly damaging 0.94
R9103:Lrp1 UTSW 10 127,430,979 (GRCm39) nonsense probably null
R9108:Lrp1 UTSW 10 127,390,206 (GRCm39) missense probably damaging 0.99
R9130:Lrp1 UTSW 10 127,382,281 (GRCm39) missense probably benign 0.18
R9157:Lrp1 UTSW 10 127,410,209 (GRCm39) missense probably damaging 1.00
R9162:Lrp1 UTSW 10 127,441,368 (GRCm39) missense probably benign 0.32
R9205:Lrp1 UTSW 10 127,430,850 (GRCm39) nonsense probably null
R9228:Lrp1 UTSW 10 127,382,807 (GRCm39) missense probably damaging 0.98
R9231:Lrp1 UTSW 10 127,382,268 (GRCm39) missense probably benign 0.06
R9287:Lrp1 UTSW 10 127,403,233 (GRCm39) missense probably damaging 1.00
R9381:Lrp1 UTSW 10 127,441,337 (GRCm39) missense probably benign 0.17
R9412:Lrp1 UTSW 10 127,409,287 (GRCm39) missense probably damaging 1.00
R9434:Lrp1 UTSW 10 127,381,689 (GRCm39) missense possibly damaging 0.93
R9463:Lrp1 UTSW 10 127,429,334 (GRCm39) nonsense probably null
R9526:Lrp1 UTSW 10 127,431,229 (GRCm39) missense probably damaging 0.96
R9548:Lrp1 UTSW 10 127,388,733 (GRCm39) missense probably damaging 0.99
R9599:Lrp1 UTSW 10 127,410,246 (GRCm39) missense probably damaging 1.00
R9649:Lrp1 UTSW 10 127,409,368 (GRCm39) missense probably benign 0.14
R9687:Lrp1 UTSW 10 127,402,562 (GRCm39) missense probably damaging 1.00
R9707:Lrp1 UTSW 10 127,408,414 (GRCm39) missense probably benign 0.08
R9770:Lrp1 UTSW 10 127,420,268 (GRCm39) missense probably damaging 1.00
V3553:Lrp1 UTSW 10 127,407,311 (GRCm39) missense probably damaging 1.00
Y5406:Lrp1 UTSW 10 127,390,152 (GRCm39) missense probably damaging 1.00
Z1088:Lrp1 UTSW 10 127,420,248 (GRCm39) missense probably damaging 1.00
Z1176:Lrp1 UTSW 10 127,390,831 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGCCCATAAAGGAGCACCTTGC -3'
(R):5'- TCTTAGTACCCATCACAGCTCAGCC -3'

Sequencing Primer
(F):5'- AAGGAGCACCTTGCTGCTG -3'
(R):5'- gagagagagagagagagagagag -3'
Posted On 2014-05-23