Incidental Mutation 'R1757:Nek1'
| ID |
194972 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Nek1
|
| Ensembl Gene |
ENSMUSG00000031644 |
| Gene Name |
NIMA (never in mitosis gene a)-related expressed kinase 1 |
| Synonyms |
kat, D8Ertd790e, kidney, anemia and testis |
| MMRRC Submission |
039789-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R1757 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
8 |
| Chromosomal Location |
61446229-61584380 bp(+) (GRCm39) |
| Type of Mutation |
splice site (14 bp from exon) |
| DNA Base Change (assembly) |
T to A
at 61542847 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000147809
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000034065]
[ENSMUST00000034065]
[ENSMUST00000120689]
[ENSMUST00000120689]
[ENSMUST00000211256]
[ENSMUST00000211256]
[ENSMUST00000211672]
[ENSMUST00000211672]
|
| AlphaFold |
P51954 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000034065
|
| SMART Domains |
Protein: ENSMUSP00000034065
Gene: ENSMUSG00000031644
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
4 |
258 |
4.23e-95 |
SMART |
|
Blast:S_TKc
|
266 |
303 |
3e-7 |
BLAST |
|
low complexity region
|
321 |
337 |
N/A |
INTRINSIC |
|
coiled coil region
|
372 |
402 |
N/A |
INTRINSIC |
|
coiled coil region
|
556 |
592 |
N/A |
INTRINSIC |
|
coiled coil region
|
647 |
685 |
N/A |
INTRINSIC |
|
low complexity region
|
767 |
780 |
N/A |
INTRINSIC |
|
low complexity region
|
1130 |
1141 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000034065
|
| SMART Domains |
Protein: ENSMUSP00000034065
Gene: ENSMUSG00000031644
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
4 |
258 |
4.23e-95 |
SMART |
|
Blast:S_TKc
|
266 |
303 |
3e-7 |
BLAST |
|
low complexity region
|
321 |
337 |
N/A |
INTRINSIC |
|
coiled coil region
|
372 |
402 |
N/A |
INTRINSIC |
|
coiled coil region
|
556 |
592 |
N/A |
INTRINSIC |
|
coiled coil region
|
647 |
685 |
N/A |
INTRINSIC |
|
low complexity region
|
767 |
780 |
N/A |
INTRINSIC |
|
low complexity region
|
1130 |
1141 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000120689
|
| SMART Domains |
Protein: ENSMUSP00000113932
Gene: ENSMUSG00000031644
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
4 |
258 |
4.23e-95 |
SMART |
|
Blast:S_TKc
|
266 |
303 |
3e-7 |
BLAST |
|
low complexity region
|
321 |
337 |
N/A |
INTRINSIC |
|
coiled coil region
|
372 |
402 |
N/A |
INTRINSIC |
|
coiled coil region
|
487 |
510 |
N/A |
INTRINSIC |
|
low complexity region
|
521 |
533 |
N/A |
INTRINSIC |
|
coiled coil region
|
584 |
620 |
N/A |
INTRINSIC |
|
coiled coil region
|
675 |
713 |
N/A |
INTRINSIC |
|
low complexity region
|
795 |
808 |
N/A |
INTRINSIC |
|
low complexity region
|
1158 |
1169 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000120689
|
| SMART Domains |
Protein: ENSMUSP00000113932
Gene: ENSMUSG00000031644
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
4 |
258 |
4.23e-95 |
SMART |
|
Blast:S_TKc
|
266 |
303 |
3e-7 |
BLAST |
|
low complexity region
|
321 |
337 |
N/A |
INTRINSIC |
|
coiled coil region
|
372 |
402 |
N/A |
INTRINSIC |
|
coiled coil region
|
487 |
510 |
N/A |
INTRINSIC |
|
low complexity region
|
521 |
533 |
N/A |
INTRINSIC |
|
coiled coil region
|
584 |
620 |
N/A |
INTRINSIC |
|
coiled coil region
|
675 |
713 |
N/A |
INTRINSIC |
|
low complexity region
|
795 |
808 |
N/A |
INTRINSIC |
|
low complexity region
|
1158 |
1169 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000142601
|
| SMART Domains |
Protein: ENSMUSP00000121479
Gene: ENSMUSG00000031644
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
38 |
47 |
N/A |
INTRINSIC |
|
coiled coil region
|
162 |
198 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000155664
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000211256
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000211256
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000211672
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000211672
|
| Coding Region Coverage |
- 1x: 97.5%
- 3x: 96.9%
- 10x: 95.3%
- 20x: 92.4%
|
| Validation Efficiency |
100% (111/111) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a serine/threonine kinase involved in cell cycle regulation. The encoded protein is found in a centrosomal complex with FEZ1, a neuronal protein that plays a role in axonal development. Defects in this gene are a cause of polycystic kidney disease (PKD). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2010]
PHENOTYPE: Spontaneous mutations of this gene result in pleiotropic effects that include facial dysmorphism, dwarfism, male sterility, anemia, cystic choroid plexus, a late-onset slowly progressive polycystic kidney disease, and premature death. Postnatal survival is sensitive to genetic background. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(4) : Targeted(1) Gene trapped(1) Spontaneous(2)
|
| Other mutations in this stock |
Total: 108 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abhd6 |
A |
T |
14: 8,049,867 (GRCm38) |
I219F |
probably damaging |
Het |
| Acvr1b |
A |
G |
15: 101,096,703 (GRCm39) |
I207V |
possibly damaging |
Het |
| Adamtsl4 |
T |
C |
3: 95,585,252 (GRCm39) |
T839A |
probably benign |
Het |
| Akap1 |
C |
T |
11: 88,736,578 (GRCm39) |
R61H |
probably damaging |
Het |
| Akap9 |
A |
G |
5: 4,051,667 (GRCm39) |
D1478G |
probably benign |
Het |
| Aloxe3 |
T |
A |
11: 69,026,775 (GRCm39) |
V547E |
possibly damaging |
Het |
| Ano6 |
G |
A |
15: 95,860,148 (GRCm39) |
A757T |
probably damaging |
Het |
| Armc10 |
A |
G |
5: 21,858,455 (GRCm39) |
T167A |
probably damaging |
Het |
| BB019430 |
A |
C |
10: 58,539,869 (GRCm39) |
|
noncoding transcript |
Het |
| Brms1 |
C |
T |
19: 5,096,435 (GRCm39) |
R82W |
probably damaging |
Het |
| Btnl6 |
G |
A |
17: 34,733,062 (GRCm39) |
T267I |
probably benign |
Het |
| Catsper4 |
A |
T |
4: 133,945,212 (GRCm39) |
F215L |
probably benign |
Het |
| Ccdc188 |
T |
C |
16: 18,036,552 (GRCm39) |
F197S |
probably damaging |
Het |
| Cers5 |
A |
C |
15: 99,634,212 (GRCm39) |
C379G |
probably benign |
Het |
| Chchd6 |
A |
G |
6: 89,361,626 (GRCm39) |
L259P |
probably damaging |
Het |
| Cntnap2 |
T |
A |
6: 46,736,763 (GRCm39) |
C730S |
probably damaging |
Het |
| Coch |
T |
G |
12: 51,649,631 (GRCm39) |
V314G |
probably damaging |
Het |
| Cog1 |
T |
A |
11: 113,543,130 (GRCm39) |
S213T |
possibly damaging |
Het |
| Crot |
A |
T |
5: 9,037,828 (GRCm39) |
F163I |
probably damaging |
Het |
| Cyp4f13 |
A |
T |
17: 33,148,932 (GRCm39) |
I162N |
probably damaging |
Het |
| Dab2 |
A |
T |
15: 6,359,933 (GRCm39) |
|
probably benign |
Het |
| Depdc1b |
C |
T |
13: 108,460,482 (GRCm39) |
R31W |
probably damaging |
Het |
| Dlk1 |
T |
C |
12: 109,425,613 (GRCm39) |
F161S |
probably damaging |
Het |
| Dnah6 |
T |
C |
6: 73,137,965 (GRCm39) |
E913G |
probably damaging |
Het |
| Dnajc6 |
A |
G |
4: 101,455,028 (GRCm39) |
Y5C |
probably damaging |
Het |
| Dock10 |
T |
C |
1: 80,511,586 (GRCm39) |
T1508A |
probably damaging |
Het |
| Dstyk |
A |
G |
1: 132,361,832 (GRCm39) |
|
probably benign |
Het |
| Efcc1 |
T |
C |
6: 87,726,265 (GRCm39) |
|
probably benign |
Het |
| Entpd1 |
T |
C |
19: 40,727,450 (GRCm39) |
Y533H |
probably benign |
Het |
| Epha8 |
A |
T |
4: 136,658,789 (GRCm39) |
|
probably null |
Het |
| Erich3 |
C |
T |
3: 154,401,402 (GRCm39) |
T17M |
probably damaging |
Het |
| Ethe1 |
T |
C |
7: 24,307,899 (GRCm39) |
|
probably benign |
Het |
| Fbxw15 |
A |
T |
9: 109,386,347 (GRCm39) |
M211K |
probably damaging |
Het |
| Fhod3 |
G |
A |
18: 25,199,335 (GRCm39) |
V669M |
possibly damaging |
Het |
| Fktn |
C |
T |
4: 53,747,003 (GRCm39) |
|
probably benign |
Het |
| Foxred1 |
G |
A |
9: 35,122,130 (GRCm39) |
R20C |
probably benign |
Het |
| Gbp9 |
A |
G |
5: 105,242,319 (GRCm39) |
L140P |
probably damaging |
Het |
| Gga1 |
T |
C |
15: 78,773,230 (GRCm39) |
L286P |
probably damaging |
Het |
| Gml |
T |
C |
15: 74,685,462 (GRCm39) |
|
probably benign |
Het |
| Gsap |
A |
T |
5: 21,486,035 (GRCm39) |
K628N |
probably damaging |
Het |
| Gtf3c4 |
G |
A |
2: 28,720,648 (GRCm39) |
|
probably benign |
Het |
| H2-M10.6 |
A |
C |
17: 37,124,043 (GRCm39) |
Y169S |
probably benign |
Het |
| Hal |
G |
A |
10: 93,330,490 (GRCm39) |
V245I |
probably benign |
Het |
| Hebp2 |
T |
C |
10: 18,420,849 (GRCm39) |
Y72C |
probably damaging |
Het |
| Helz2 |
T |
C |
2: 180,878,056 (GRCm39) |
E914G |
probably damaging |
Het |
| Herc3 |
T |
C |
6: 58,893,455 (GRCm39) |
Y906H |
probably damaging |
Het |
| Hfm1 |
A |
T |
5: 107,028,226 (GRCm39) |
|
probably null |
Het |
| Hgs |
C |
T |
11: 120,370,889 (GRCm39) |
P582S |
probably damaging |
Het |
| Hoxa10 |
G |
A |
6: 52,211,469 (GRCm39) |
P149L |
probably damaging |
Het |
| Inpp5j |
T |
A |
11: 3,454,738 (GRCm39) |
Q4L |
possibly damaging |
Het |
| Ints8 |
A |
C |
4: 11,254,109 (GRCm39) |
M1R |
probably null |
Het |
| Isg15 |
T |
C |
4: 156,284,447 (GRCm39) |
E27G |
possibly damaging |
Het |
| Klf13 |
A |
T |
7: 63,541,513 (GRCm39) |
C205S |
probably damaging |
Het |
| Lama1 |
A |
T |
17: 68,070,831 (GRCm39) |
Y830F |
probably benign |
Het |
| Lama1 |
G |
A |
17: 68,004,378 (GRCm39) |
V17M |
unknown |
Het |
| Lama3 |
A |
G |
18: 12,598,556 (GRCm39) |
N988D |
probably benign |
Het |
| Lcat |
CAT |
C |
8: 106,668,446 (GRCm39) |
|
probably null |
Het |
| Lct |
G |
T |
1: 128,228,994 (GRCm39) |
P833H |
probably damaging |
Het |
| Lmf1 |
A |
T |
17: 25,874,184 (GRCm39) |
R403W |
probably damaging |
Het |
| Me3 |
T |
G |
7: 89,282,230 (GRCm39) |
S38A |
probably benign |
Het |
| Myg1 |
A |
T |
15: 102,240,264 (GRCm39) |
D30V |
probably benign |
Het |
| Nbea |
A |
G |
3: 55,537,610 (GRCm39) |
I2841T |
possibly damaging |
Het |
| Obsl1 |
C |
T |
1: 75,470,527 (GRCm39) |
R1043H |
probably benign |
Het |
| Or4p23 |
G |
T |
2: 88,576,361 (GRCm39) |
D290E |
probably benign |
Het |
| Or5b119 |
A |
C |
19: 13,456,971 (GRCm39) |
V197G |
possibly damaging |
Het |
| Or6n2 |
A |
T |
1: 173,897,224 (GRCm39) |
Y120F |
probably damaging |
Het |
| Or9m2 |
T |
G |
2: 87,820,926 (GRCm39) |
I157R |
probably damaging |
Het |
| Osbpl9 |
A |
G |
4: 108,921,780 (GRCm39) |
Y613H |
probably damaging |
Het |
| Per3 |
C |
T |
4: 151,127,249 (GRCm39) |
|
probably null |
Het |
| Pex6 |
G |
T |
17: 47,034,424 (GRCm39) |
V758L |
probably damaging |
Het |
| Pikfyve |
A |
G |
1: 65,291,707 (GRCm39) |
I1309V |
probably damaging |
Het |
| Pimreg |
A |
G |
11: 71,933,985 (GRCm39) |
E37G |
possibly damaging |
Het |
| Pjvk |
G |
A |
2: 76,486,232 (GRCm39) |
V211I |
probably benign |
Het |
| Plekhg4 |
T |
A |
8: 106,108,293 (GRCm39) |
V1112E |
probably damaging |
Het |
| Ptprz1 |
T |
A |
6: 23,044,319 (GRCm39) |
M2106K |
probably damaging |
Het |
| Rdh16f2 |
G |
T |
10: 127,712,765 (GRCm39) |
L254F |
probably benign |
Het |
| Rictor |
G |
A |
15: 6,803,343 (GRCm39) |
R485Q |
possibly damaging |
Het |
| Rnf146 |
G |
A |
10: 29,223,475 (GRCm39) |
T137M |
probably damaging |
Het |
| Rrp9 |
T |
A |
9: 106,360,203 (GRCm39) |
C204S |
probably damaging |
Het |
| Rxylt1 |
T |
C |
10: 121,924,920 (GRCm39) |
T261A |
probably benign |
Het |
| Serpinb9h |
T |
C |
13: 33,583,336 (GRCm39) |
S150P |
probably benign |
Het |
| Shkbp1 |
T |
C |
7: 27,041,776 (GRCm39) |
T693A |
probably benign |
Het |
| Skint9 |
A |
G |
4: 112,271,159 (GRCm39) |
Y84H |
probably benign |
Het |
| Slc22a12 |
A |
T |
19: 6,586,761 (GRCm39) |
|
probably null |
Het |
| Slfn4 |
T |
C |
11: 83,076,211 (GRCm39) |
C26R |
possibly damaging |
Het |
| Snrnp200 |
T |
C |
2: 127,074,363 (GRCm39) |
L1401P |
probably damaging |
Het |
| Specc1 |
T |
A |
11: 62,010,110 (GRCm39) |
|
probably null |
Het |
| Spef2 |
A |
T |
15: 9,717,568 (GRCm39) |
M316K |
probably damaging |
Het |
| Tbc1d22b |
A |
G |
17: 29,790,647 (GRCm39) |
R204G |
probably damaging |
Het |
| Tektl1 |
T |
C |
10: 78,583,058 (GRCm39) |
N442S |
probably benign |
Het |
| Tgfbr3l |
C |
A |
8: 4,299,548 (GRCm39) |
D110E |
probably benign |
Het |
| Ticrr |
T |
G |
7: 79,325,071 (GRCm39) |
S532R |
probably damaging |
Het |
| Ticrr |
C |
A |
7: 79,328,794 (GRCm39) |
Y644* |
probably null |
Het |
| Traf3ip1 |
A |
T |
1: 91,450,579 (GRCm39) |
T509S |
probably damaging |
Het |
| Trmt10b |
T |
C |
4: 45,307,946 (GRCm39) |
Y209H |
probably damaging |
Het |
| Trmt6 |
T |
C |
2: 132,652,157 (GRCm39) |
M172V |
probably damaging |
Het |
| Tsc1 |
A |
G |
2: 28,576,125 (GRCm39) |
D978G |
probably benign |
Het |
| Tshz2 |
C |
A |
2: 169,725,843 (GRCm39) |
F146L |
probably benign |
Het |
| Tspyl4 |
G |
T |
10: 34,173,576 (GRCm39) |
E23* |
probably null |
Het |
| Ulk2 |
A |
T |
11: 61,732,165 (GRCm39) |
|
probably benign |
Het |
| Umodl1 |
A |
T |
17: 31,227,674 (GRCm39) |
I1336F |
probably damaging |
Het |
| Vezt |
T |
C |
10: 93,806,425 (GRCm39) |
D662G |
probably benign |
Het |
| Vnn1 |
G |
T |
10: 23,776,727 (GRCm39) |
Q359H |
probably benign |
Het |
| Vnn1 |
A |
T |
10: 23,776,726 (GRCm39) |
Q359L |
possibly damaging |
Het |
| Zdhhc16 |
A |
G |
19: 41,930,394 (GRCm39) |
N14S |
probably damaging |
Het |
| Zfp455 |
T |
C |
13: 67,355,601 (GRCm39) |
S225P |
probably damaging |
Het |
| Zfp74 |
T |
A |
7: 29,634,486 (GRCm39) |
E407D |
probably benign |
Het |
| Zic2 |
T |
A |
14: 122,716,031 (GRCm39) |
H384Q |
possibly damaging |
Het |
|
| Other mutations in Nek1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00471:Nek1
|
APN |
8 |
61,496,318 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01075:Nek1
|
APN |
8 |
61,577,166 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
IGL01122:Nek1
|
APN |
8 |
61,574,000 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
IGL01151:Nek1
|
APN |
8 |
61,473,111 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01286:Nek1
|
APN |
8 |
61,577,250 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
IGL01377:Nek1
|
APN |
8 |
61,542,490 (GRCm39) |
missense |
probably benign |
|
|
IGL01485:Nek1
|
APN |
8 |
61,502,860 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL01688:Nek1
|
APN |
8 |
61,558,631 (GRCm39) |
nonsense |
probably null |
|
|
IGL01806:Nek1
|
APN |
8 |
61,577,246 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL02006:Nek1
|
APN |
8 |
61,557,226 (GRCm39) |
missense |
probably benign |
0.20 |
|
IGL02304:Nek1
|
APN |
8 |
61,465,201 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02659:Nek1
|
APN |
8 |
61,542,514 (GRCm39) |
missense |
probably benign |
0.16 |
|
IGL02662:Nek1
|
APN |
8 |
61,557,218 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02801:Nek1
|
APN |
8 |
61,574,095 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02806:Nek1
|
APN |
8 |
61,497,120 (GRCm39) |
missense |
probably benign |
0.15 |
|
IGL03037:Nek1
|
APN |
8 |
61,487,086 (GRCm39) |
missense |
probably benign |
0.16 |
|
IGL03252:Nek1
|
APN |
8 |
61,525,364 (GRCm39) |
nonsense |
probably null |
|
|
P0014:Nek1
|
UTSW |
8 |
61,524,781 (GRCm39) |
splice site |
probably benign |
|
|
R0019:Nek1
|
UTSW |
8 |
61,542,768 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0403:Nek1
|
UTSW |
8 |
61,559,889 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0464:Nek1
|
UTSW |
8 |
61,525,307 (GRCm39) |
splice site |
probably benign |
|
|
R0726:Nek1
|
UTSW |
8 |
61,542,626 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0761:Nek1
|
UTSW |
8 |
61,542,489 (GRCm39) |
missense |
probably benign |
|
|
R0827:Nek1
|
UTSW |
8 |
61,558,682 (GRCm39) |
splice site |
probably benign |
|
|
R0972:Nek1
|
UTSW |
8 |
61,542,465 (GRCm39) |
splice site |
probably null |
|
|
R1268:Nek1
|
UTSW |
8 |
61,475,298 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1343:Nek1
|
UTSW |
8 |
61,481,709 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1415:Nek1
|
UTSW |
8 |
61,542,720 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1466:Nek1
|
UTSW |
8 |
61,578,170 (GRCm39) |
splice site |
probably benign |
|
|
R1480:Nek1
|
UTSW |
8 |
61,577,360 (GRCm39) |
splice site |
probably null |
|
|
R1526:Nek1
|
UTSW |
8 |
61,502,975 (GRCm39) |
missense |
probably benign |
0.26 |
|
R1552:Nek1
|
UTSW |
8 |
61,459,771 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1606:Nek1
|
UTSW |
8 |
61,577,310 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1650:Nek1
|
UTSW |
8 |
61,489,110 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1808:Nek1
|
UTSW |
8 |
61,469,264 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1966:Nek1
|
UTSW |
8 |
61,469,330 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2067:Nek1
|
UTSW |
8 |
61,460,196 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2111:Nek1
|
UTSW |
8 |
61,577,360 (GRCm39) |
splice site |
probably null |
|
|
R2113:Nek1
|
UTSW |
8 |
61,469,327 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2143:Nek1
|
UTSW |
8 |
61,481,730 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2255:Nek1
|
UTSW |
8 |
61,542,807 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2422:Nek1
|
UTSW |
8 |
61,472,935 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3848:Nek1
|
UTSW |
8 |
61,525,349 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3849:Nek1
|
UTSW |
8 |
61,525,349 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3850:Nek1
|
UTSW |
8 |
61,525,349 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4418:Nek1
|
UTSW |
8 |
61,559,898 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4526:Nek1
|
UTSW |
8 |
61,559,978 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4533:Nek1
|
UTSW |
8 |
61,460,247 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4544:Nek1
|
UTSW |
8 |
61,469,338 (GRCm39) |
nonsense |
probably null |
|
|
R4677:Nek1
|
UTSW |
8 |
61,481,840 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4739:Nek1
|
UTSW |
8 |
61,551,545 (GRCm39) |
missense |
probably benign |
0.32 |
|
R5068:Nek1
|
UTSW |
8 |
61,469,330 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5421:Nek1
|
UTSW |
8 |
61,459,711 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R5516:Nek1
|
UTSW |
8 |
61,542,523 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5855:Nek1
|
UTSW |
8 |
61,469,306 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6125:Nek1
|
UTSW |
8 |
61,481,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6267:Nek1
|
UTSW |
8 |
61,525,343 (GRCm39) |
nonsense |
probably null |
|
|
R6292:Nek1
|
UTSW |
8 |
61,507,770 (GRCm39) |
splice site |
probably null |
|
|
R6296:Nek1
|
UTSW |
8 |
61,525,343 (GRCm39) |
nonsense |
probably null |
|
|
R6458:Nek1
|
UTSW |
8 |
61,553,046 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6568:Nek1
|
UTSW |
8 |
61,559,855 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6629:Nek1
|
UTSW |
8 |
61,507,367 (GRCm39) |
splice site |
probably null |
|
|
R6867:Nek1
|
UTSW |
8 |
61,525,364 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R7122:Nek1
|
UTSW |
8 |
61,559,829 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7193:Nek1
|
UTSW |
8 |
61,526,612 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7272:Nek1
|
UTSW |
8 |
61,578,120 (GRCm39) |
missense |
probably benign |
0.34 |
|
R7356:Nek1
|
UTSW |
8 |
61,573,994 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7368:Nek1
|
UTSW |
8 |
61,542,741 (GRCm39) |
missense |
probably benign |
0.24 |
|
R7478:Nek1
|
UTSW |
8 |
61,583,179 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7479:Nek1
|
UTSW |
8 |
61,583,179 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7512:Nek1
|
UTSW |
8 |
61,583,179 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7715:Nek1
|
UTSW |
8 |
61,459,794 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7984:Nek1
|
UTSW |
8 |
61,574,087 (GRCm39) |
nonsense |
probably null |
|
|
R8271:Nek1
|
UTSW |
8 |
61,558,646 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8431:Nek1
|
UTSW |
8 |
61,487,066 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9076:Nek1
|
UTSW |
8 |
61,481,768 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9149:Nek1
|
UTSW |
8 |
61,574,055 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9250:Nek1
|
UTSW |
8 |
61,465,151 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9429:Nek1
|
UTSW |
8 |
61,559,892 (GRCm39) |
missense |
probably benign |
|
|
R9563:Nek1
|
UTSW |
8 |
61,577,157 (GRCm39) |
missense |
probably benign |
0.36 |
|
R9616:Nek1
|
UTSW |
8 |
61,473,107 (GRCm39) |
missense |
probably damaging |
0.99 |
|
RF023:Nek1
|
UTSW |
8 |
61,525,779 (GRCm39) |
splice site |
probably null |
|
|
X0028:Nek1
|
UTSW |
8 |
61,496,292 (GRCm39) |
missense |
probably benign |
0.19 |
|
X0066:Nek1
|
UTSW |
8 |
61,578,162 (GRCm39) |
critical splice donor site |
probably null |
|
|
| Predicted Primers |
|
| Posted On |
2014-05-23 |
Incidental Mutation