Incidental Mutation 'R1676:Myo7a'
| ID |
188075 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Myo7a
|
| Ensembl Gene |
ENSMUSG00000030761 |
| Gene Name |
myosin VIIA |
| Synonyms |
nmf371, USH1B, polka, Hdb, Myo7 |
| MMRRC Submission |
039712-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R1676 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
97700267-97768731 bp(-) (GRCm39) |
| Type of Mutation |
critical splice donor site (2 bp from exon) |
| DNA Base Change (assembly) |
A to G
at 97748679 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000114944
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000084979]
[ENSMUST00000107122]
[ENSMUST00000107127]
[ENSMUST00000107128]
[ENSMUST00000138627]
[ENSMUST00000138627]
[ENSMUST00000205746]
|
| AlphaFold |
P97479 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000084979
|
| SMART Domains |
Protein: ENSMUSP00000082046
Gene: ENSMUSG00000030761
| Domain | Start | End | E-Value | Type |
|---|
|
MYSc
|
48 |
731 |
N/A |
SMART |
|
IQ
|
732 |
754 |
2.99e0 |
SMART |
|
IQ
|
755 |
777 |
8.77e-7 |
SMART |
|
IQ
|
801 |
823 |
8e0 |
SMART |
|
IQ
|
824 |
846 |
8.7e0 |
SMART |
|
low complexity region
|
854 |
889 |
N/A |
INTRINSIC |
|
low complexity region
|
893 |
916 |
N/A |
INTRINSIC |
|
low complexity region
|
972 |
985 |
N/A |
INTRINSIC |
|
MyTH4
|
1006 |
1242 |
1.4e-71 |
SMART |
|
B41
|
1243 |
1458 |
8.82e-42 |
SMART |
|
SH3
|
1557 |
1622 |
4.93e-7 |
SMART |
|
MyTH4
|
1698 |
1847 |
3.95e-57 |
SMART |
|
B41
|
1849 |
2066 |
8.27e-56 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000107122
|
| SMART Domains |
Protein: ENSMUSP00000102739
Gene: ENSMUSG00000030761
| Domain | Start | End | E-Value | Type |
|---|
|
MYSc
|
48 |
737 |
N/A |
SMART |
|
IQ
|
738 |
760 |
2.99e0 |
SMART |
|
IQ
|
761 |
783 |
8.77e-7 |
SMART |
|
IQ
|
807 |
829 |
8e0 |
SMART |
|
IQ
|
830 |
852 |
8.7e0 |
SMART |
|
low complexity region
|
860 |
895 |
N/A |
INTRINSIC |
|
low complexity region
|
899 |
922 |
N/A |
INTRINSIC |
|
low complexity region
|
978 |
991 |
N/A |
INTRINSIC |
|
MyTH4
|
1012 |
1248 |
1.4e-71 |
SMART |
|
B41
|
1249 |
1464 |
8.82e-42 |
SMART |
|
SH3
|
1563 |
1628 |
4.93e-7 |
SMART |
|
MyTH4
|
1704 |
1853 |
3.95e-57 |
SMART |
|
B41
|
1855 |
2072 |
8.27e-56 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000107127
|
| SMART Domains |
Protein: ENSMUSP00000102744
Gene: ENSMUSG00000030761
| Domain | Start | End | E-Value | Type |
|---|
|
MYSc
|
59 |
742 |
N/A |
SMART |
|
IQ
|
743 |
765 |
2.99e0 |
SMART |
|
IQ
|
766 |
788 |
8.77e-7 |
SMART |
|
IQ
|
812 |
834 |
8e0 |
SMART |
|
IQ
|
835 |
857 |
8.7e0 |
SMART |
|
low complexity region
|
865 |
900 |
N/A |
INTRINSIC |
|
low complexity region
|
904 |
927 |
N/A |
INTRINSIC |
|
low complexity region
|
983 |
996 |
N/A |
INTRINSIC |
|
MyTH4
|
1017 |
1253 |
1.4e-71 |
SMART |
|
B41
|
1254 |
1469 |
8.82e-42 |
SMART |
|
SH3
|
1568 |
1633 |
4.93e-7 |
SMART |
|
MyTH4
|
1709 |
1858 |
3.95e-57 |
SMART |
|
B41
|
1860 |
2077 |
8.27e-56 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000107128
|
| SMART Domains |
Protein: ENSMUSP00000102745
Gene: ENSMUSG00000030761
| Domain | Start | End | E-Value | Type |
|---|
|
MYSc
|
59 |
742 |
N/A |
SMART |
|
IQ
|
743 |
765 |
2.99e0 |
SMART |
|
IQ
|
766 |
788 |
8.77e-7 |
SMART |
|
IQ
|
812 |
834 |
8e0 |
SMART |
|
IQ
|
835 |
857 |
8.7e0 |
SMART |
|
low complexity region
|
865 |
900 |
N/A |
INTRINSIC |
|
low complexity region
|
904 |
927 |
N/A |
INTRINSIC |
|
low complexity region
|
983 |
996 |
N/A |
INTRINSIC |
|
MyTH4
|
1017 |
1253 |
1.4e-71 |
SMART |
|
B41
|
1254 |
1469 |
8.82e-42 |
SMART |
|
SH3
|
1606 |
1671 |
4.93e-7 |
SMART |
|
MyTH4
|
1747 |
1896 |
3.95e-57 |
SMART |
|
B41
|
1898 |
2115 |
8.27e-56 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000138627
|
| SMART Domains |
Protein: ENSMUSP00000114944
Gene: ENSMUSG00000030761
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Myosin_head
|
67 |
139 |
7.1e-20 |
PFAM |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000138627
|
| SMART Domains |
Protein: ENSMUSP00000114944
Gene: ENSMUSG00000030761
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Myosin_head
|
67 |
139 |
7.1e-20 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000149079
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000153657
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000205746
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000155637
|
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.5%
- 20x: 93.0%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the myosin gene family. Myosins are mechanochemical proteins characterized by the presence of a motor domain, an actin-binding domain, a neck domain that interacts with other proteins, and a tail domain that serves as an anchor. This gene encodes an unconventional myosin with a very short tail. Defects in this gene are associated with the mouse shaker-1 phenotype and the human Usher syndrome 1B which are characterized by deafness, reduced vestibular function, and (in human) retinal degeneration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
PHENOTYPE: A number of spontaneous and ENU-induced mutations cause head-shaking, circling and deafness, often associated with cochlear hair cell degeneration and stereocilia anomalies. Defects in retinal pigment epithelial cells, male infertility, and light-inducedphotoreceptor damage have also been observed. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 91 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2810021J22Rik |
G |
T |
11: 58,771,819 (GRCm39) |
A434S |
possibly damaging |
Het |
| Abhd8 |
T |
A |
8: 71,914,517 (GRCm39) |
D37V |
probably damaging |
Het |
| Acvr2a |
G |
A |
2: 48,763,095 (GRCm39) |
S97N |
probably benign |
Het |
| Ampd3 |
T |
A |
7: 110,394,940 (GRCm39) |
H296Q |
probably damaging |
Het |
| Arid4a |
G |
A |
12: 71,122,112 (GRCm39) |
S509N |
probably benign |
Het |
| Cap2 |
T |
G |
13: 46,791,335 (GRCm39) |
H167Q |
probably damaging |
Het |
| Car8 |
A |
G |
4: 8,185,616 (GRCm39) |
L180S |
probably damaging |
Het |
| Casp8 |
T |
A |
1: 58,883,575 (GRCm39) |
I314N |
probably damaging |
Het |
| Cavin2 |
T |
A |
1: 51,340,330 (GRCm39) |
S336T |
probably benign |
Het |
| Cdc14b |
A |
T |
13: 64,373,416 (GRCm39) |
I119N |
possibly damaging |
Het |
| Cemip |
T |
A |
7: 83,613,246 (GRCm39) |
I651F |
possibly damaging |
Het |
| Cfap57 |
T |
A |
4: 118,453,137 (GRCm39) |
D522V |
probably damaging |
Het |
| Clrn3 |
A |
T |
7: 135,120,307 (GRCm39) |
V93D |
probably damaging |
Het |
| Crppa |
T |
C |
12: 36,526,720 (GRCm39) |
C170R |
probably benign |
Het |
| Cyp4f39 |
A |
G |
17: 32,701,176 (GRCm39) |
D222G |
probably benign |
Het |
| D5Ertd579e |
A |
G |
5: 36,773,453 (GRCm39) |
V314A |
probably benign |
Het |
| Dchs1 |
C |
T |
7: 105,404,128 (GRCm39) |
V2805I |
probably benign |
Het |
| Dsp |
A |
T |
13: 38,377,350 (GRCm39) |
K1712* |
probably null |
Het |
| Emilin2 |
T |
C |
17: 71,581,085 (GRCm39) |
D547G |
probably benign |
Het |
| Erbb3 |
T |
C |
10: 128,419,117 (GRCm39) |
H248R |
probably benign |
Het |
| Erich3 |
A |
G |
3: 154,468,260 (GRCm39) |
|
probably benign |
Het |
| Fbn1 |
T |
C |
2: 125,151,701 (GRCm39) |
T2518A |
probably damaging |
Het |
| Fzd2 |
G |
A |
11: 102,496,707 (GRCm39) |
V384M |
probably damaging |
Het |
| Gpc5 |
T |
A |
14: 115,607,510 (GRCm39) |
S371T |
probably damaging |
Het |
| Hbb-bh2 |
T |
C |
7: 103,488,362 (GRCm39) |
K145R |
probably null |
Het |
| Hectd1 |
G |
T |
12: 51,791,571 (GRCm39) |
P2558Q |
probably damaging |
Het |
| Hgsnat |
C |
T |
8: 26,444,633 (GRCm39) |
|
probably null |
Het |
| Hirip3 |
T |
C |
7: 126,462,647 (GRCm39) |
|
probably null |
Het |
| Itpkc |
T |
C |
7: 26,907,706 (GRCm39) |
D666G |
probably damaging |
Het |
| Jmjd1c |
T |
A |
10: 67,060,588 (GRCm39) |
D693E |
probably benign |
Het |
| Katnbl1 |
T |
C |
2: 112,236,454 (GRCm39) |
L60P |
probably damaging |
Het |
| Kcna1 |
T |
A |
6: 126,619,645 (GRCm39) |
E225V |
probably damaging |
Het |
| Kcnj6 |
T |
A |
16: 94,633,443 (GRCm39) |
M223L |
probably damaging |
Het |
| Kcnk7 |
G |
T |
19: 5,757,006 (GRCm39) |
V332F |
probably benign |
Het |
| Kmt5a |
GAA |
GA |
5: 124,597,948 (GRCm39) |
|
probably null |
Het |
| Mdga2 |
C |
A |
12: 66,615,546 (GRCm39) |
G618V |
probably damaging |
Het |
| Mdga2 |
C |
A |
12: 66,615,547 (GRCm39) |
G618* |
probably null |
Het |
| Morc2b |
T |
C |
17: 33,354,955 (GRCm39) |
E939G |
possibly damaging |
Het |
| Mstn |
T |
A |
1: 53,101,224 (GRCm39) |
D100E |
probably benign |
Het |
| Mthfd1l |
G |
A |
10: 4,033,877 (GRCm39) |
|
probably null |
Het |
| Muc20 |
T |
A |
16: 32,614,649 (GRCm39) |
T243S |
probably damaging |
Het |
| Myo1d |
A |
T |
11: 80,575,247 (GRCm39) |
N156K |
probably damaging |
Het |
| Naa35 |
A |
T |
13: 59,760,490 (GRCm39) |
Q274L |
probably damaging |
Het |
| Ncam1 |
G |
A |
9: 49,468,472 (GRCm39) |
T329I |
probably damaging |
Het |
| Nisch |
T |
C |
14: 30,902,859 (GRCm39) |
|
probably benign |
Het |
| Nlrp1b |
A |
T |
11: 71,073,637 (GRCm39) |
W69R |
probably benign |
Het |
| Nrap |
T |
A |
19: 56,323,687 (GRCm39) |
H1294L |
probably damaging |
Het |
| Nsun6 |
T |
A |
2: 15,052,024 (GRCm39) |
R56* |
probably null |
Het |
| Nudt1 |
A |
G |
5: 140,320,378 (GRCm39) |
|
probably null |
Het |
| Nxph4 |
T |
G |
10: 127,362,077 (GRCm39) |
K271N |
probably damaging |
Het |
| Or1af1 |
A |
T |
2: 37,109,653 (GRCm39) |
R51* |
probably null |
Het |
| Or4a66 |
T |
G |
2: 88,531,661 (GRCm39) |
H4P |
probably benign |
Het |
| Or51e2 |
T |
A |
7: 102,391,605 (GRCm39) |
I202F |
probably damaging |
Het |
| Or52a20 |
T |
C |
7: 103,366,319 (GRCm39) |
W173R |
probably benign |
Het |
| Otud6b |
T |
A |
4: 14,825,617 (GRCm39) |
N71I |
probably damaging |
Het |
| Parp8 |
T |
A |
13: 117,014,064 (GRCm39) |
D623V |
probably damaging |
Het |
| Pcdhb5 |
T |
C |
18: 37,453,805 (GRCm39) |
S62P |
probably benign |
Het |
| Ppp1r12b |
A |
G |
1: 134,705,190 (GRCm39) |
S833P |
probably damaging |
Het |
| Ppp1r1a |
T |
G |
15: 103,441,915 (GRCm39) |
D51A |
probably damaging |
Het |
| Prag1 |
C |
A |
8: 36,570,052 (GRCm39) |
P212T |
probably damaging |
Het |
| Prxl2b |
C |
T |
4: 154,981,520 (GRCm39) |
V186I |
probably benign |
Het |
| Ptdss1 |
A |
G |
13: 67,081,701 (GRCm39) |
T44A |
probably damaging |
Het |
| Rab14 |
T |
C |
2: 35,076,735 (GRCm39) |
H83R |
possibly damaging |
Het |
| Rapgef3 |
C |
T |
15: 97,659,063 (GRCm39) |
G101E |
probably benign |
Het |
| Rimbp3 |
T |
A |
16: 17,028,977 (GRCm39) |
D800E |
probably benign |
Het |
| Rsf1 |
ATGGCG |
ATGGCGACGGTGGCG |
7: 97,229,111 (GRCm39) |
|
probably benign |
Het |
| Selenbp1 |
A |
G |
3: 94,851,854 (GRCm39) |
D465G |
probably damaging |
Het |
| Slc28a2b |
T |
C |
2: 122,352,340 (GRCm39) |
S366P |
probably damaging |
Het |
| Slc29a1 |
T |
C |
17: 45,899,936 (GRCm39) |
D251G |
probably damaging |
Het |
| Slc6a11 |
G |
T |
6: 114,224,627 (GRCm39) |
V604F |
probably benign |
Het |
| Sltm |
T |
A |
9: 70,480,929 (GRCm39) |
D260E |
probably damaging |
Het |
| Spta1 |
G |
A |
1: 174,007,405 (GRCm39) |
V212M |
probably damaging |
Het |
| St6gal2 |
T |
C |
17: 55,803,396 (GRCm39) |
|
probably null |
Het |
| Tc2n |
A |
G |
12: 101,655,251 (GRCm39) |
S235P |
probably damaging |
Het |
| Tenm3 |
T |
A |
8: 48,870,154 (GRCm39) |
N213I |
possibly damaging |
Het |
| Ticam2 |
T |
C |
18: 46,693,677 (GRCm39) |
T137A |
probably damaging |
Het |
| Ttn |
TCCC |
TCCCC |
2: 76,573,251 (GRCm39) |
|
probably null |
Het |
| Tyk2 |
G |
A |
9: 21,026,545 (GRCm39) |
Q684* |
probably null |
Het |
| Ubqln1 |
A |
G |
13: 58,327,205 (GRCm39) |
F478S |
possibly damaging |
Het |
| Uckl1 |
G |
A |
2: 181,216,711 (GRCm39) |
T78I |
probably damaging |
Het |
| Uhmk1 |
A |
G |
1: 170,027,581 (GRCm39) |
V372A |
probably damaging |
Het |
| Unc5c |
G |
A |
3: 141,463,598 (GRCm39) |
V240I |
possibly damaging |
Het |
| Ush2a |
T |
C |
1: 188,460,782 (GRCm39) |
L2681P |
probably damaging |
Het |
| Vmn2r1 |
C |
T |
3: 63,997,603 (GRCm39) |
Q420* |
probably null |
Het |
| Vmn2r101 |
A |
T |
17: 19,832,184 (GRCm39) |
T727S |
probably benign |
Het |
| Vmn2r79 |
A |
G |
7: 86,651,839 (GRCm39) |
T413A |
probably benign |
Het |
| Vps13c |
T |
C |
9: 67,834,244 (GRCm39) |
V1637A |
probably benign |
Het |
| Xpc |
A |
G |
6: 91,469,929 (GRCm39) |
V765A |
possibly damaging |
Het |
| Zbtb18 |
T |
G |
1: 177,274,913 (GRCm39) |
|
probably null |
Het |
| Zfp712 |
A |
T |
13: 67,200,400 (GRCm39) |
D28E |
probably benign |
Het |
| Zfp735 |
A |
G |
11: 73,602,301 (GRCm39) |
N415S |
possibly damaging |
Het |
|
| Other mutations in Myo7a |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00465:Myo7a
|
APN |
7 |
97,751,833 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00785:Myo7a
|
APN |
7 |
97,703,555 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL00840:Myo7a
|
APN |
7 |
97,700,866 (GRCm39) |
missense |
probably benign |
0.25 |
|
IGL01362:Myo7a
|
APN |
7 |
97,746,909 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01484:Myo7a
|
APN |
7 |
97,734,629 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01673:Myo7a
|
APN |
7 |
97,703,915 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01933:Myo7a
|
APN |
7 |
97,732,349 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01943:Myo7a
|
APN |
7 |
97,714,854 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
IGL02188:Myo7a
|
APN |
7 |
97,740,234 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02304:Myo7a
|
APN |
7 |
97,726,943 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL02305:Myo7a
|
APN |
7 |
97,700,836 (GRCm39) |
makesense |
probably null |
|
|
IGL02331:Myo7a
|
APN |
7 |
97,702,389 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL02386:Myo7a
|
APN |
7 |
97,724,319 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02389:Myo7a
|
APN |
7 |
97,756,198 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02832:Myo7a
|
APN |
7 |
97,740,227 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02839:Myo7a
|
APN |
7 |
97,740,329 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03193:Myo7a
|
APN |
7 |
97,740,264 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03237:Myo7a
|
APN |
7 |
97,751,800 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03384:Myo7a
|
APN |
7 |
97,742,800 (GRCm39) |
missense |
probably damaging |
1.00 |
|
coward
|
UTSW |
7 |
97,734,673 (GRCm39) |
missense |
probably damaging |
1.00 |
|
H8786:Myo7a
|
UTSW |
7 |
97,744,985 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
IGL03046:Myo7a
|
UTSW |
7 |
97,728,534 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03134:Myo7a
|
UTSW |
7 |
97,705,974 (GRCm39) |
missense |
probably damaging |
0.96 |
|
PIT4696001:Myo7a
|
UTSW |
7 |
97,712,806 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0054:Myo7a
|
UTSW |
7 |
97,714,905 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0054:Myo7a
|
UTSW |
7 |
97,714,905 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0071:Myo7a
|
UTSW |
7 |
97,706,037 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0071:Myo7a
|
UTSW |
7 |
97,706,037 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0267:Myo7a
|
UTSW |
7 |
97,703,831 (GRCm39) |
missense |
probably benign |
0.08 |
|
R0408:Myo7a
|
UTSW |
7 |
97,705,988 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0411:Myo7a
|
UTSW |
7 |
97,721,144 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0540:Myo7a
|
UTSW |
7 |
97,721,153 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0607:Myo7a
|
UTSW |
7 |
97,721,153 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0629:Myo7a
|
UTSW |
7 |
97,734,673 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0632:Myo7a
|
UTSW |
7 |
97,761,357 (GRCm39) |
intron |
probably benign |
|
|
R0659:Myo7a
|
UTSW |
7 |
97,703,545 (GRCm39) |
splice site |
probably benign |
|
|
R0735:Myo7a
|
UTSW |
7 |
97,730,387 (GRCm39) |
splice site |
probably benign |
|
|
R0924:Myo7a
|
UTSW |
7 |
97,747,463 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0930:Myo7a
|
UTSW |
7 |
97,747,463 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1018:Myo7a
|
UTSW |
7 |
97,756,212 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1196:Myo7a
|
UTSW |
7 |
97,746,880 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R1331:Myo7a
|
UTSW |
7 |
97,756,215 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1487:Myo7a
|
UTSW |
7 |
97,703,017 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1695:Myo7a
|
UTSW |
7 |
97,741,703 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1770:Myo7a
|
UTSW |
7 |
97,761,813 (GRCm39) |
intron |
probably benign |
|
|
R1781:Myo7a
|
UTSW |
7 |
97,722,331 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1789:Myo7a
|
UTSW |
7 |
97,756,302 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1827:Myo7a
|
UTSW |
7 |
97,725,938 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1864:Myo7a
|
UTSW |
7 |
97,701,463 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1955:Myo7a
|
UTSW |
7 |
97,704,128 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2011:Myo7a
|
UTSW |
7 |
97,703,915 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R2229:Myo7a
|
UTSW |
7 |
97,704,117 (GRCm39) |
missense |
probably benign |
0.12 |
|
R2259:Myo7a
|
UTSW |
7 |
97,718,706 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2443:Myo7a
|
UTSW |
7 |
97,744,976 (GRCm39) |
missense |
probably benign |
0.07 |
|
R2898:Myo7a
|
UTSW |
7 |
97,746,413 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2898:Myo7a
|
UTSW |
7 |
97,703,631 (GRCm39) |
nonsense |
probably null |
|
|
R3158:Myo7a
|
UTSW |
7 |
97,701,499 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3408:Myo7a
|
UTSW |
7 |
97,730,294 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4222:Myo7a
|
UTSW |
7 |
97,722,436 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R4255:Myo7a
|
UTSW |
7 |
97,721,171 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4374:Myo7a
|
UTSW |
7 |
97,751,881 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4429:Myo7a
|
UTSW |
7 |
97,702,395 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4445:Myo7a
|
UTSW |
7 |
97,715,611 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4579:Myo7a
|
UTSW |
7 |
97,722,400 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4659:Myo7a
|
UTSW |
7 |
97,734,673 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5073:Myo7a
|
UTSW |
7 |
97,722,425 (GRCm39) |
nonsense |
probably null |
|
|
R5138:Myo7a
|
UTSW |
7 |
97,732,806 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5566:Myo7a
|
UTSW |
7 |
97,714,023 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5580:Myo7a
|
UTSW |
7 |
97,722,367 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6079:Myo7a
|
UTSW |
7 |
97,714,997 (GRCm39) |
nonsense |
probably null |
|
|
R6138:Myo7a
|
UTSW |
7 |
97,714,997 (GRCm39) |
nonsense |
probably null |
|
|
R6451:Myo7a
|
UTSW |
7 |
97,722,374 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6452:Myo7a
|
UTSW |
7 |
97,722,374 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6453:Myo7a
|
UTSW |
7 |
97,722,374 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6454:Myo7a
|
UTSW |
7 |
97,722,374 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6455:Myo7a
|
UTSW |
7 |
97,722,374 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6465:Myo7a
|
UTSW |
7 |
97,711,887 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6653:Myo7a
|
UTSW |
7 |
97,703,710 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6709:Myo7a
|
UTSW |
7 |
97,703,906 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6917:Myo7a
|
UTSW |
7 |
97,744,970 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R7313:Myo7a
|
UTSW |
7 |
97,713,402 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7334:Myo7a
|
UTSW |
7 |
97,728,573 (GRCm39) |
missense |
probably benign |
|
|
R7356:Myo7a
|
UTSW |
7 |
97,751,890 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7393:Myo7a
|
UTSW |
7 |
97,712,906 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R7422:Myo7a
|
UTSW |
7 |
97,700,833 (GRCm39) |
splice site |
probably null |
|
|
R7472:Myo7a
|
UTSW |
7 |
97,714,000 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7483:Myo7a
|
UTSW |
7 |
97,712,881 (GRCm39) |
missense |
probably benign |
0.07 |
|
R7526:Myo7a
|
UTSW |
7 |
97,734,655 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R7948:Myo7a
|
UTSW |
7 |
97,724,236 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8069:Myo7a
|
UTSW |
7 |
97,732,833 (GRCm39) |
nonsense |
probably null |
|
|
R8115:Myo7a
|
UTSW |
7 |
97,715,653 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8150:Myo7a
|
UTSW |
7 |
97,712,846 (GRCm39) |
missense |
probably benign |
0.19 |
|
R8265:Myo7a
|
UTSW |
7 |
97,734,604 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8289:Myo7a
|
UTSW |
7 |
97,726,376 (GRCm39) |
missense |
probably benign |
|
|
R8298:Myo7a
|
UTSW |
7 |
97,747,541 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8518:Myo7a
|
UTSW |
7 |
97,740,270 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R8539:Myo7a
|
UTSW |
7 |
97,721,668 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8557:Myo7a
|
UTSW |
7 |
97,703,081 (GRCm39) |
missense |
probably benign |
0.08 |
|
R8685:Myo7a
|
UTSW |
7 |
97,746,334 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8902:Myo7a
|
UTSW |
7 |
97,741,820 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9034:Myo7a
|
UTSW |
7 |
97,728,465 (GRCm39) |
missense |
probably benign |
0.40 |
|
R9090:Myo7a
|
UTSW |
7 |
97,740,281 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9172:Myo7a
|
UTSW |
7 |
97,732,369 (GRCm39) |
missense |
probably benign |
|
|
R9271:Myo7a
|
UTSW |
7 |
97,740,281 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9334:Myo7a
|
UTSW |
7 |
97,716,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9356:Myo7a
|
UTSW |
7 |
97,725,873 (GRCm39) |
missense |
probably benign |
0.11 |
|
R9444:Myo7a
|
UTSW |
7 |
97,742,698 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R9459:Myo7a
|
UTSW |
7 |
97,722,380 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R9513:Myo7a
|
UTSW |
7 |
97,746,818 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9517:Myo7a
|
UTSW |
7 |
97,721,166 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9629:Myo7a
|
UTSW |
7 |
97,712,937 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9662:Myo7a
|
UTSW |
7 |
97,747,499 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R9709:Myo7a
|
UTSW |
7 |
97,743,536 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
RF005:Myo7a
|
UTSW |
7 |
97,742,824 (GRCm39) |
missense |
probably benign |
0.42 |
|
U15987:Myo7a
|
UTSW |
7 |
97,714,997 (GRCm39) |
nonsense |
probably null |
|
|
X0028:Myo7a
|
UTSW |
7 |
97,714,932 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0058:Myo7a
|
UTSW |
7 |
97,711,855 (GRCm39) |
missense |
probably benign |
0.02 |
|
Z1176:Myo7a
|
UTSW |
7 |
97,744,934 (GRCm39) |
missense |
probably damaging |
0.98 |
|
Z1177:Myo7a
|
UTSW |
7 |
97,734,730 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
Z1177:Myo7a
|
UTSW |
7 |
97,701,433 (GRCm39) |
missense |
probably damaging |
0.98 |
|
| Predicted Primers |
|
| Posted On |
2014-05-09 |
Incidental Mutation