Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01986:Trak1'

181926

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Trak1

Ensembl Gene

ENSMUSG00000032536

Gene Name

trafficking protein, kinesin binding 1

Synonyms

hyrt, 2310001H13Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.227) question?

Stock #

IGL01986

Quality Score

Status

Chromosome

Chromosomal Location

121126568-121303984 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 121302033 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Alanine to Threonine at position 930 (A930T)

Ref Sequence

ENSEMBL: ENSMUSP00000044482 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000045903] [ENSMUST00000210798] [ENSMUST00000211301]

AlphaFold

Q6PD31

Predicted Effect

probably benign
Transcript: ENSMUST00000045903
AA Change: A930T

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

SMART Domains

Protein: ENSMUSP00000044482
Gene: ENSMUSG00000032536
AA Change: A930T

Domain	Start	End	E-Value	Type
Pfam:HAP1_N	47	352	8.1e-139	PFAM
Pfam:Milton	411	580	5e-72	PFAM
low complexity region	882	897	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000209446

Predicted Effect

probably benign
Transcript: ENSMUST00000210798

Predicted Effect

probably benign
Transcript: ENSMUST00000211301

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice with a spontaneous mutation in this allele have various behavioral abnormalities consistent with hypertonia. Inclusions can be found in neuronal processes of the gray matter of the brainstem and spinal cord. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 39 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
6820408C15Rik	A	T	2: 152,282,956 (GRCm39)	I245F	possibly damaging	Het
Abca3	G	A	17: 24,627,088 (GRCm39)	G1263D	probably damaging	Het
Arap2	A	T	5: 62,779,265 (GRCm39)	S1442T	probably damaging	Het
Arl15	C	A	13: 114,058,902 (GRCm39)	S56R	possibly damaging	Het
Ccdc38	A	T	10: 93,415,705 (GRCm39)	N415Y	probably damaging	Het
Ccny	G	A	18: 9,377,817 (GRCm39)	R81C	probably damaging	Het
Cracd	T	A	5: 77,006,457 (GRCm39)	S939R	unknown	Het
Csmd3	T	C	15: 47,522,591 (GRCm39)	T2693A	possibly damaging	Het
Fancm	C	T	12: 65,173,429 (GRCm39)	Q1914*	probably null	Het
Fcsk	T	C	8: 111,609,889 (GRCm39)	T1042A	probably benign	Het
Gm18856	G	A	13: 14,139,413 (GRCm39)		probably benign	Het
Gramd1a	A	T	7: 30,833,434 (GRCm39)	L610Q	possibly damaging	Het
Hsd17b4	C	A	18: 50,293,193 (GRCm39)		probably benign	Het
Hspa12a	A	G	19: 58,787,834 (GRCm39)	S663P	probably benign	Het
Insr	C	T	8: 3,208,817 (GRCm39)	V1215I	probably damaging	Het
Kdr	A	G	5: 76,113,519 (GRCm39)	V783A	probably benign	Het
Klhl9	T	C	4: 88,640,016 (GRCm39)	D75G	probably damaging	Het
Lmntd1	A	G	6: 145,365,533 (GRCm39)	S53P	probably damaging	Het
Lrrc41	T	A	4: 115,946,519 (GRCm39)	F411L	probably benign	Het
Lyst	G	A	13: 13,950,212 (GRCm39)		probably null	Het
Mmp17	A	G	5: 129,673,692 (GRCm39)	H257R	probably damaging	Het
Nkiras1	G	A	14: 18,280,071 (GRCm38)	R154Q	probably damaging	Het
Or10ag2	A	G	2: 87,248,880 (GRCm39)	I163V	probably benign	Het
Or2b4	A	G	17: 38,116,957 (GRCm39)	K307R	probably damaging	Het
Or4p21	C	T	2: 88,276,839 (GRCm39)	V148I	probably benign	Het
Or8s16	T	C	15: 98,210,660 (GRCm39)	Y257C	probably damaging	Het
Pcsk6	G	A	7: 65,577,625 (GRCm39)	R60H	probably damaging	Het
Polk	T	C	13: 96,620,331 (GRCm39)	D623G	probably benign	Het
Rlf	A	T	4: 121,005,303 (GRCm39)	C1226S	probably damaging	Het
Rpa2	C	T	4: 132,499,191 (GRCm39)	P87S	probably benign	Het
Rpa2	C	T	4: 132,499,192 (GRCm39)	P87L	probably benign	Het
Sema5a	T	C	15: 32,682,506 (GRCm39)		probably benign	Het
Sis	A	T	3: 72,852,545 (GRCm39)	M529K	probably damaging	Het
Sspo	T	C	6: 48,460,237 (GRCm39)	M3375T	probably benign	Het
Syne3	A	T	12: 104,934,259 (GRCm39)	L83Q	probably damaging	Het
Tec	A	T	5: 72,939,348 (GRCm39)	Y222*	probably null	Het
Tfap2d	C	T	1: 19,189,383 (GRCm39)		probably benign	Het
Ugt2b34	G	T	5: 87,049,111 (GRCm39)	H305N	probably benign	Het
Vmn2r95	A	G	17: 18,660,473 (GRCm39)	N295S	probably benign	Het

Other mutations in Trak1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01308:Trak1	APN	9	121,272,802 (GRCm39)	critical splice donor site	probably null
IGL01335:Trak1	APN	9	121,283,382 (GRCm39)	missense	possibly damaging	0.58
IGL01777:Trak1	APN	9	121,260,626 (GRCm39)	splice site	probably null
IGL01804:Trak1	APN	9	121,271,751 (GRCm39)	splice site	probably benign
IGL02248:Trak1	APN	9	121,275,860 (GRCm39)	missense	probably damaging	1.00
IGL02276:Trak1	APN	9	121,280,734 (GRCm39)	missense	probably damaging	1.00
IGL02556:Trak1	APN	9	121,277,967 (GRCm39)	missense	probably damaging	1.00
IGL03368:Trak1	APN	9	121,196,188 (GRCm39)	missense	possibly damaging	0.66
PIT4468001:Trak1	UTSW	9	121,282,398 (GRCm39)	missense	probably benign	0.18
R0067:Trak1	UTSW	9	121,301,973 (GRCm39)	missense	probably damaging	1.00
R0276:Trak1	UTSW	9	121,283,404 (GRCm39)	missense	probably damaging	0.97
R0535:Trak1	UTSW	9	121,272,778 (GRCm39)	missense	probably null	1.00
R0629:Trak1	UTSW	9	121,196,233 (GRCm39)	missense	probably benign	0.37
R0671:Trak1	UTSW	9	121,278,021 (GRCm39)	critical splice donor site	probably null
R0883:Trak1	UTSW	9	121,282,351 (GRCm39)	missense	possibly damaging	0.90
R1160:Trak1	UTSW	9	121,221,073 (GRCm39)	missense	probably benign	0.01
R1162:Trak1	UTSW	9	121,282,407 (GRCm39)	missense	possibly damaging	0.93
R1168:Trak1	UTSW	9	121,269,745 (GRCm39)	missense	probably damaging	1.00
R1398:Trak1	UTSW	9	121,283,425 (GRCm39)	missense	probably damaging	1.00
R2118:Trak1	UTSW	9	121,302,063 (GRCm39)	makesense	probably null
R2119:Trak1	UTSW	9	121,302,063 (GRCm39)	makesense	probably null
R2120:Trak1	UTSW	9	121,302,063 (GRCm39)	makesense	probably null
R2137:Trak1	UTSW	9	121,302,028 (GRCm39)	missense	possibly damaging	0.83
R3162:Trak1	UTSW	9	121,280,800 (GRCm39)	splice site	probably benign
R3888:Trak1	UTSW	9	121,271,863 (GRCm39)	splice site	probably null
R3889:Trak1	UTSW	9	121,274,939 (GRCm39)	missense	probably null	0.40
R4031:Trak1	UTSW	9	121,280,736 (GRCm39)	missense	probably damaging	1.00
R4116:Trak1	UTSW	9	121,277,909 (GRCm39)	missense	probably damaging	1.00
R4406:Trak1	UTSW	9	121,260,602 (GRCm39)	missense	probably damaging	1.00
R4630:Trak1	UTSW	9	121,283,491 (GRCm39)	missense	probably benign	0.02
R4631:Trak1	UTSW	9	121,283,491 (GRCm39)	missense	probably benign	0.02
R4632:Trak1	UTSW	9	121,283,491 (GRCm39)	missense	probably benign	0.02
R4786:Trak1	UTSW	9	121,301,560 (GRCm39)	missense	probably benign	0.25
R5137:Trak1	UTSW	9	121,196,121 (GRCm39)	intron	probably benign
R5159:Trak1	UTSW	9	121,289,478 (GRCm39)	missense	probably damaging	0.99
R5467:Trak1	UTSW	9	121,275,864 (GRCm39)	missense	probably damaging	1.00
R5661:Trak1	UTSW	9	121,272,703 (GRCm39)	missense	possibly damaging	0.46
R5664:Trak1	UTSW	9	121,301,373 (GRCm39)	missense	possibly damaging	0.47
R5769:Trak1	UTSW	9	121,277,904 (GRCm39)	missense	probably damaging	1.00
R6041:Trak1	UTSW	9	121,289,478 (GRCm39)	missense	probably damaging	0.99
R6257:Trak1	UTSW	9	121,196,290 (GRCm39)	missense	possibly damaging	0.92
R6257:Trak1	UTSW	9	121,275,821 (GRCm39)	missense	probably damaging	1.00
R6354:Trak1	UTSW	9	121,280,792 (GRCm39)	missense	probably null	0.03
R6399:Trak1	UTSW	9	121,282,562 (GRCm39)	splice site	probably null
R6513:Trak1	UTSW	9	121,272,822 (GRCm39)	missense	probably benign
R6579:Trak1	UTSW	9	121,272,704 (GRCm39)	missense	probably benign	0.29
R6940:Trak1	UTSW	9	121,272,784 (GRCm39)	missense	possibly damaging	0.78
R7120:Trak1	UTSW	9	121,289,564 (GRCm39)	missense	probably benign
R7299:Trak1	UTSW	9	121,280,929 (GRCm39)	splice site	probably null
R7304:Trak1	UTSW	9	121,245,278 (GRCm39)	missense	probably benign
R7396:Trak1	UTSW	9	121,277,973 (GRCm39)	missense	possibly damaging	0.71
R7522:Trak1	UTSW	9	121,271,777 (GRCm39)	missense	probably damaging	0.99
R7657:Trak1	UTSW	9	121,301,652 (GRCm39)	missense	probably damaging	1.00
R7733:Trak1	UTSW	9	121,196,291 (GRCm39)	missense	possibly damaging	0.92
R7793:Trak1	UTSW	9	121,245,264 (GRCm39)	nonsense	probably null
R7999:Trak1	UTSW	9	121,289,491 (GRCm39)	missense	probably damaging	1.00
R8209:Trak1	UTSW	9	121,280,793 (GRCm39)	missense	probably benign
R8215:Trak1	UTSW	9	121,298,096 (GRCm39)	missense	probably damaging	1.00
R8226:Trak1	UTSW	9	121,280,793 (GRCm39)	missense	probably benign
R8261:Trak1	UTSW	9	121,280,733 (GRCm39)	missense	probably damaging	1.00
R8300:Trak1	UTSW	9	121,289,565 (GRCm39)	nonsense	probably null
R8914:Trak1	UTSW	9	121,272,847 (GRCm39)	missense	unknown
R9072:Trak1	UTSW	9	121,289,554 (GRCm39)	missense	probably damaging	1.00
R9073:Trak1	UTSW	9	121,289,554 (GRCm39)	missense	probably damaging	1.00
R9312:Trak1	UTSW	9	121,280,757 (GRCm39)	missense	probably benign	0.01
R9366:Trak1	UTSW	9	121,301,578 (GRCm39)	missense	probably damaging	1.00
R9663:Trak1	UTSW	9	121,220,924 (GRCm39)	missense	probably benign	0.18

Posted On

2014-05-07