Incidental Mutation 'R1471:Igf1r'
| ID |
164892 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Igf1r
|
| Ensembl Gene |
ENSMUSG00000005533 |
| Gene Name |
insulin-like growth factor I receptor |
| Synonyms |
IGF-1R, line 186, A330103N21Rik, hyft, CD221 |
| MMRRC Submission |
039524-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R1471 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
67602575-67883416 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 67653585 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Serine
at position 41
(N41S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000005671
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000005671]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000005671
AA Change: N41S
PolyPhen 2
Score 0.980 (Sensitivity: 0.75; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000005671
Gene: ENSMUSG00000005533
AA Change: N41S
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Recep_L_domain
|
51 |
161 |
1.6e-29 |
PFAM |
|
FU
|
227 |
270 |
2.98e-12 |
SMART |
|
Pfam:Recep_L_domain
|
353 |
467 |
3.8e-32 |
PFAM |
|
FN3
|
490 |
593 |
4.67e-2 |
SMART |
|
FN3
|
612 |
815 |
1.95e-4 |
SMART |
|
FN3
|
833 |
915 |
7.4e-5 |
SMART |
|
low complexity region
|
937 |
954 |
N/A |
INTRINSIC |
|
TyrKc
|
1000 |
1268 |
8.51e-141 |
SMART |
|
low complexity region
|
1285 |
1303 |
N/A |
INTRINSIC |
|
low complexity region
|
1306 |
1319 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.6%
- 10x: 96.8%
- 20x: 94.4%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]
PHENOTYPE: Targeted null mutants die at birth of respiratory failure; fetuses exhibit retarded growth, organ hypoplasia, ossification delay and nervous system and epidermal abnormalities. hyft homozygous fetuses are growth retarded and exhibit hydrops fetalis and focal hepatic ischemia. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 96 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930486L24Rik |
C |
A |
13: 61,001,336 (GRCm39) |
K130N |
probably damaging |
Het |
| Adam6a |
T |
A |
12: 113,508,013 (GRCm39) |
S129T |
probably damaging |
Het |
| Adamts10 |
T |
A |
17: 33,772,112 (GRCm39) |
F1087I |
probably damaging |
Het |
| Afp |
T |
A |
5: 90,651,541 (GRCm39) |
N385K |
possibly damaging |
Het |
| Ahnak |
T |
G |
19: 8,990,296 (GRCm39) |
|
probably benign |
Het |
| Akap6 |
A |
G |
12: 53,188,279 (GRCm39) |
T1898A |
probably benign |
Het |
| Antxr2 |
C |
A |
5: 98,123,199 (GRCm39) |
V283F |
possibly damaging |
Het |
| Asgr1 |
T |
C |
11: 69,946,919 (GRCm39) |
V55A |
possibly damaging |
Het |
| Asxl3 |
A |
G |
18: 22,649,411 (GRCm39) |
K467E |
probably damaging |
Het |
| Atp5f1a |
C |
A |
18: 77,868,969 (GRCm39) |
Q398K |
probably damaging |
Het |
| Atxn2 |
T |
A |
5: 121,924,437 (GRCm39) |
D455E |
probably damaging |
Het |
| B4galt6 |
C |
T |
18: 20,878,410 (GRCm39) |
A39T |
possibly damaging |
Het |
| C130073F10Rik |
C |
T |
4: 101,747,535 (GRCm39) |
E165K |
probably benign |
Het |
| Cabin1 |
A |
G |
10: 75,530,626 (GRCm39) |
C1519R |
probably damaging |
Het |
| Casp8ap2 |
C |
T |
4: 32,639,386 (GRCm39) |
R147* |
probably null |
Het |
| Ccdc88b |
A |
G |
19: 6,831,391 (GRCm39) |
L517P |
probably benign |
Het |
| Cd109 |
G |
A |
9: 78,561,869 (GRCm39) |
V220I |
probably damaging |
Het |
| Cd2ap |
T |
C |
17: 43,131,488 (GRCm39) |
K369R |
probably benign |
Het |
| Cd300c |
A |
G |
11: 114,850,614 (GRCm39) |
V63A |
probably benign |
Het |
| Cnot10 |
A |
G |
9: 114,420,619 (GRCm39) |
V741A |
probably benign |
Het |
| Col18a1 |
G |
T |
10: 76,932,040 (GRCm39) |
Q350K |
unknown |
Het |
| Crnkl1 |
T |
C |
2: 145,774,236 (GRCm39) |
K76E |
possibly damaging |
Het |
| Cryzl2 |
A |
G |
1: 157,298,291 (GRCm39) |
K227E |
probably benign |
Het |
| Cts6 |
G |
A |
13: 61,344,194 (GRCm39) |
T286I |
probably benign |
Het |
| Cul1 |
T |
C |
6: 47,491,820 (GRCm39) |
V392A |
probably damaging |
Het |
| Dcaf7 |
T |
A |
11: 105,937,573 (GRCm39) |
F65L |
probably benign |
Het |
| Dgke |
A |
C |
11: 88,946,320 (GRCm39) |
V160G |
possibly damaging |
Het |
| Dock8 |
C |
A |
19: 25,178,400 (GRCm39) |
Q2098K |
possibly damaging |
Het |
| Efhb |
T |
A |
17: 53,706,140 (GRCm39) |
D799V |
possibly damaging |
Het |
| Ephb2 |
T |
C |
4: 136,386,262 (GRCm39) |
D829G |
probably benign |
Het |
| Exosc1 |
A |
T |
19: 41,913,157 (GRCm39) |
S117R |
probably damaging |
Het |
| Fga |
T |
C |
3: 82,935,925 (GRCm39) |
S51P |
probably benign |
Het |
| Fmn1 |
T |
C |
2: 113,523,439 (GRCm39) |
F1141L |
possibly damaging |
Het |
| Foxm1 |
C |
T |
6: 128,350,837 (GRCm39) |
L713F |
probably damaging |
Het |
| Galnt4 |
A |
G |
10: 98,944,536 (GRCm39) |
E87G |
probably benign |
Het |
| Gamt |
T |
C |
10: 80,096,692 (GRCm39) |
D15G |
probably benign |
Het |
| Gm15557 |
C |
A |
2: 155,784,174 (GRCm39) |
D154E |
possibly damaging |
Het |
| Gnptab |
A |
G |
10: 88,281,625 (GRCm39) |
I1211V |
probably benign |
Het |
| Greb1 |
A |
T |
12: 16,761,775 (GRCm39) |
M535K |
probably damaging |
Het |
| Grm8 |
C |
A |
6: 27,363,308 (GRCm39) |
A736S |
possibly damaging |
Het |
| Hspa14 |
T |
C |
2: 3,492,645 (GRCm39) |
I373M |
probably benign |
Het |
| Ifi207 |
T |
A |
1: 173,557,629 (GRCm39) |
T370S |
unknown |
Het |
| Ikzf5 |
A |
T |
7: 130,993,496 (GRCm39) |
V224D |
probably damaging |
Het |
| Il10 |
C |
A |
1: 130,949,110 (GRCm39) |
Y90* |
probably null |
Het |
| Itga4 |
A |
G |
2: 79,117,376 (GRCm39) |
D394G |
probably benign |
Het |
| Kif21a |
A |
T |
15: 90,840,622 (GRCm39) |
S1165T |
probably benign |
Het |
| Krtap14 |
A |
G |
16: 88,622,515 (GRCm39) |
S155P |
probably damaging |
Het |
| Loxl2 |
A |
G |
14: 69,930,546 (GRCm39) |
N770S |
probably benign |
Het |
| Man2b1 |
A |
G |
8: 85,813,474 (GRCm39) |
D222G |
probably damaging |
Het |
| Mcub |
T |
A |
3: 129,709,464 (GRCm39) |
Y283F |
probably damaging |
Het |
| Meis3 |
T |
A |
7: 15,911,496 (GRCm39) |
Y64* |
probably null |
Het |
| Mfsd6 |
T |
A |
1: 52,748,716 (GRCm39) |
I50F |
probably benign |
Het |
| Micu2 |
T |
C |
14: 58,182,854 (GRCm39) |
T165A |
probably damaging |
Het |
| Mtcl1 |
T |
C |
17: 66,686,143 (GRCm39) |
E921G |
probably damaging |
Het |
| Muc5b |
A |
T |
7: 141,396,971 (GRCm39) |
N215Y |
unknown |
Het |
| Muc6 |
A |
G |
7: 141,234,176 (GRCm39) |
F772L |
possibly damaging |
Het |
| Myt1 |
A |
G |
2: 181,438,904 (GRCm39) |
D142G |
probably benign |
Het |
| Nol6 |
C |
T |
4: 41,120,281 (GRCm39) |
V479I |
probably benign |
Het |
| Nsun7 |
A |
G |
5: 66,441,572 (GRCm39) |
K414E |
probably benign |
Het |
| Nup210l |
A |
C |
3: 90,077,869 (GRCm39) |
I914L |
probably benign |
Het |
| Obox3 |
G |
A |
7: 15,360,875 (GRCm39) |
P88L |
probably benign |
Het |
| Or10ag57 |
A |
G |
2: 87,218,862 (GRCm39) |
Y271C |
probably damaging |
Het |
| Or4f4b |
T |
C |
2: 111,314,351 (GRCm39) |
L192P |
probably damaging |
Het |
| Or8h8 |
C |
T |
2: 86,752,922 (GRCm39) |
|
probably null |
Het |
| Or8w1 |
T |
C |
2: 87,466,014 (GRCm39) |
T26A |
probably benign |
Het |
| Pclo |
T |
C |
5: 14,730,441 (GRCm39) |
|
probably benign |
Het |
| Pcsk5 |
T |
C |
19: 17,545,688 (GRCm39) |
N745D |
probably damaging |
Het |
| Pdzrn3 |
T |
A |
6: 101,128,473 (GRCm39) |
N731I |
possibly damaging |
Het |
| Pkdrej |
T |
A |
15: 85,701,334 (GRCm39) |
Q1534L |
probably benign |
Het |
| Pramel28 |
T |
C |
4: 143,691,523 (GRCm39) |
N400S |
probably benign |
Het |
| Rell1 |
T |
A |
5: 64,093,428 (GRCm39) |
D109V |
probably damaging |
Het |
| Rplp0 |
C |
T |
5: 115,701,403 (GRCm39) |
T285I |
probably damaging |
Het |
| Sanbr |
A |
T |
11: 23,565,222 (GRCm39) |
M255K |
probably damaging |
Het |
| Sema3g |
C |
T |
14: 30,950,002 (GRCm39) |
R728C |
probably damaging |
Het |
| Slc15a2 |
A |
G |
16: 36,574,153 (GRCm39) |
Y536H |
probably damaging |
Het |
| Slc26a5 |
T |
A |
5: 22,021,962 (GRCm39) |
Y488F |
probably benign |
Het |
| Slc5a4a |
A |
T |
10: 76,022,362 (GRCm39) |
S566C |
probably damaging |
Het |
| Spink7 |
C |
T |
18: 62,729,275 (GRCm39) |
E21K |
possibly damaging |
Het |
| Src |
C |
T |
2: 157,299,107 (GRCm39) |
Q35* |
probably null |
Het |
| Srrm2 |
T |
A |
17: 24,039,770 (GRCm39) |
V2234E |
probably damaging |
Het |
| Stk36 |
A |
T |
1: 74,650,314 (GRCm39) |
Q282L |
probably benign |
Het |
| Tas2r118 |
T |
G |
6: 23,969,170 (GRCm39) |
E297A |
probably damaging |
Het |
| Terf1 |
A |
G |
1: 15,913,194 (GRCm39) |
Y385C |
probably damaging |
Het |
| Tmc3 |
T |
C |
7: 83,247,498 (GRCm39) |
S198P |
probably damaging |
Het |
| Tmprss11b |
C |
T |
5: 86,808,355 (GRCm39) |
R407H |
possibly damaging |
Het |
| Tspyl4 |
G |
A |
10: 34,174,107 (GRCm39) |
E200K |
probably damaging |
Het |
| Ttc21a |
T |
C |
9: 119,771,707 (GRCm39) |
Y169H |
probably damaging |
Het |
| Ugt2b36 |
C |
T |
5: 87,239,930 (GRCm39) |
D152N |
probably damaging |
Het |
| Unk |
T |
C |
11: 115,940,235 (GRCm39) |
I196T |
probably benign |
Het |
| Uroc1 |
T |
G |
6: 90,321,153 (GRCm39) |
V243G |
probably damaging |
Het |
| Usp34 |
C |
A |
11: 23,438,862 (GRCm39) |
Q3475K |
probably benign |
Het |
| Vmn2r117 |
T |
A |
17: 23,697,447 (GRCm39) |
I82L |
probably benign |
Het |
| Vmn2r44 |
A |
T |
7: 8,380,882 (GRCm39) |
V337E |
probably damaging |
Het |
| Zbtb14 |
C |
A |
17: 69,695,497 (GRCm39) |
F398L |
probably damaging |
Het |
| Zfp362 |
T |
C |
4: 128,680,993 (GRCm39) |
T111A |
probably benign |
Het |
| Zfp598 |
T |
C |
17: 24,899,046 (GRCm39) |
V615A |
probably benign |
Het |
|
| Other mutations in Igf1r |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00742:Igf1r
|
APN |
7 |
67,839,771 (GRCm39) |
missense |
probably benign |
|
|
IGL00837:Igf1r
|
APN |
7 |
67,851,100 (GRCm39) |
splice site |
probably benign |
|
|
IGL01515:Igf1r
|
APN |
7 |
67,857,200 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01572:Igf1r
|
APN |
7 |
67,843,189 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02100:Igf1r
|
APN |
7 |
67,839,706 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02506:Igf1r
|
APN |
7 |
67,843,144 (GRCm39) |
missense |
probably benign |
|
|
IGL02672:Igf1r
|
APN |
7 |
67,839,781 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02701:Igf1r
|
APN |
7 |
67,850,997 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL02742:Igf1r
|
APN |
7 |
67,839,739 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL03073:Igf1r
|
APN |
7 |
67,864,791 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03257:Igf1r
|
APN |
7 |
67,864,688 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Frufru
|
UTSW |
7 |
67,653,911 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Hungarian
|
UTSW |
7 |
67,864,745 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Mimi
|
UTSW |
7 |
67,844,774 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
Piroshka
|
UTSW |
7 |
67,857,084 (GRCm39) |
nonsense |
probably null |
|
|
Romanian
|
UTSW |
7 |
67,653,885 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
Sublime
|
UTSW |
7 |
67,653,927 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Toy
|
UTSW |
7 |
67,653,720 (GRCm39) |
missense |
probably damaging |
1.00 |
|
BB009:Igf1r
|
UTSW |
7 |
67,861,802 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
BB019:Igf1r
|
UTSW |
7 |
67,861,802 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
FR4548:Igf1r
|
UTSW |
7 |
67,875,934 (GRCm39) |
small insertion |
probably benign |
|
|
FR4737:Igf1r
|
UTSW |
7 |
67,875,929 (GRCm39) |
small insertion |
probably benign |
|
|
FR4976:Igf1r
|
UTSW |
7 |
67,875,934 (GRCm39) |
small insertion |
probably benign |
|
|
FR4976:Igf1r
|
UTSW |
7 |
67,875,929 (GRCm39) |
small insertion |
probably benign |
|
|
PIT4445001:Igf1r
|
UTSW |
7 |
67,857,211 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0003:Igf1r
|
UTSW |
7 |
67,814,990 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0184:Igf1r
|
UTSW |
7 |
67,875,941 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R0538:Igf1r
|
UTSW |
7 |
67,857,574 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0632:Igf1r
|
UTSW |
7 |
67,814,903 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0727:Igf1r
|
UTSW |
7 |
67,861,906 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0750:Igf1r
|
UTSW |
7 |
67,861,839 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1104:Igf1r
|
UTSW |
7 |
67,844,774 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R1169:Igf1r
|
UTSW |
7 |
67,814,875 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1348:Igf1r
|
UTSW |
7 |
67,868,216 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1580:Igf1r
|
UTSW |
7 |
67,857,617 (GRCm39) |
missense |
probably benign |
|
|
R1745:Igf1r
|
UTSW |
7 |
67,819,661 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1772:Igf1r
|
UTSW |
7 |
67,844,822 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1789:Igf1r
|
UTSW |
7 |
67,864,681 (GRCm39) |
nonsense |
probably null |
|
|
R1823:Igf1r
|
UTSW |
7 |
67,844,729 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R1902:Igf1r
|
UTSW |
7 |
67,850,997 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R1962:Igf1r
|
UTSW |
7 |
67,857,023 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2179:Igf1r
|
UTSW |
7 |
67,653,698 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2215:Igf1r
|
UTSW |
7 |
67,814,982 (GRCm39) |
missense |
probably benign |
|
|
R2221:Igf1r
|
UTSW |
7 |
67,851,710 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2233:Igf1r
|
UTSW |
7 |
67,861,828 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2234:Igf1r
|
UTSW |
7 |
67,861,828 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2235:Igf1r
|
UTSW |
7 |
67,861,828 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3023:Igf1r
|
UTSW |
7 |
67,833,147 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4044:Igf1r
|
UTSW |
7 |
67,839,810 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R4226:Igf1r
|
UTSW |
7 |
67,844,826 (GRCm39) |
nonsense |
probably null |
|
|
R4387:Igf1r
|
UTSW |
7 |
67,819,757 (GRCm39) |
missense |
probably benign |
|
|
R4388:Igf1r
|
UTSW |
7 |
67,819,757 (GRCm39) |
missense |
probably benign |
|
|
R4728:Igf1r
|
UTSW |
7 |
67,839,372 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4781:Igf1r
|
UTSW |
7 |
67,814,947 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R5254:Igf1r
|
UTSW |
7 |
67,857,067 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5278:Igf1r
|
UTSW |
7 |
67,843,166 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R5510:Igf1r
|
UTSW |
7 |
67,843,107 (GRCm39) |
missense |
probably benign |
0.19 |
|
R5522:Igf1r
|
UTSW |
7 |
67,833,258 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5527:Igf1r
|
UTSW |
7 |
67,857,569 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5761:Igf1r
|
UTSW |
7 |
67,857,001 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5849:Igf1r
|
UTSW |
7 |
67,839,781 (GRCm39) |
missense |
probably benign |
|
|
R6189:Igf1r
|
UTSW |
7 |
67,857,084 (GRCm39) |
nonsense |
probably null |
|
|
R6262:Igf1r
|
UTSW |
7 |
67,653,720 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6285:Igf1r
|
UTSW |
7 |
67,653,885 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6318:Igf1r
|
UTSW |
7 |
67,814,981 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6365:Igf1r
|
UTSW |
7 |
67,839,798 (GRCm39) |
missense |
probably benign |
0.26 |
|
R6377:Igf1r
|
UTSW |
7 |
67,850,998 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6831:Igf1r
|
UTSW |
7 |
67,857,067 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R6848:Igf1r
|
UTSW |
7 |
67,653,927 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6902:Igf1r
|
UTSW |
7 |
67,653,911 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7193:Igf1r
|
UTSW |
7 |
67,836,905 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7373:Igf1r
|
UTSW |
7 |
67,844,826 (GRCm39) |
nonsense |
probably null |
|
|
R7442:Igf1r
|
UTSW |
7 |
67,823,026 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7903:Igf1r
|
UTSW |
7 |
67,834,500 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7923:Igf1r
|
UTSW |
7 |
67,839,849 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7932:Igf1r
|
UTSW |
7 |
67,861,802 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R8368:Igf1r
|
UTSW |
7 |
67,836,796 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8458:Igf1r
|
UTSW |
7 |
67,845,377 (GRCm39) |
missense |
probably benign |
|
|
R8539:Igf1r
|
UTSW |
7 |
67,653,596 (GRCm39) |
missense |
probably benign |
0.06 |
|
R8704:Igf1r
|
UTSW |
7 |
67,819,802 (GRCm39) |
splice site |
probably benign |
|
|
R8746:Igf1r
|
UTSW |
7 |
67,864,745 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8829:Igf1r
|
UTSW |
7 |
67,875,769 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8832:Igf1r
|
UTSW |
7 |
67,875,769 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8859:Igf1r
|
UTSW |
7 |
67,833,211 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R9057:Igf1r
|
UTSW |
7 |
67,833,186 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9243:Igf1r
|
UTSW |
7 |
67,861,775 (GRCm39) |
missense |
probably benign |
0.11 |
|
R9342:Igf1r
|
UTSW |
7 |
67,844,746 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9412:Igf1r
|
UTSW |
7 |
67,857,001 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9525:Igf1r
|
UTSW |
7 |
67,864,682 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9727:Igf1r
|
UTSW |
7 |
67,857,554 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9730:Igf1r
|
UTSW |
7 |
67,839,423 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9779:Igf1r
|
UTSW |
7 |
67,654,065 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF025:Igf1r
|
UTSW |
7 |
67,875,927 (GRCm39) |
small insertion |
probably benign |
|
|
RF032:Igf1r
|
UTSW |
7 |
67,875,927 (GRCm39) |
small insertion |
probably benign |
|
|
RF034:Igf1r
|
UTSW |
7 |
67,875,924 (GRCm39) |
small insertion |
probably benign |
|
|
RF037:Igf1r
|
UTSW |
7 |
67,875,924 (GRCm39) |
small insertion |
probably benign |
|
|
RF039:Igf1r
|
UTSW |
7 |
67,875,924 (GRCm39) |
small insertion |
probably benign |
|
|
RF044:Igf1r
|
UTSW |
7 |
67,875,927 (GRCm39) |
small insertion |
probably benign |
|
|
Z1186:Igf1r
|
UTSW |
7 |
67,875,916 (GRCm39) |
small insertion |
probably benign |
|
|
Z1186:Igf1r
|
UTSW |
7 |
67,875,930 (GRCm39) |
small insertion |
probably benign |
|
|
Z1186:Igf1r
|
UTSW |
7 |
67,875,928 (GRCm39) |
small insertion |
probably benign |
|
|
Z1186:Igf1r
|
UTSW |
7 |
67,875,922 (GRCm39) |
small insertion |
probably benign |
|
|
Z1186:Igf1r
|
UTSW |
7 |
67,875,917 (GRCm39) |
small insertion |
probably benign |
|
|
Z1191:Igf1r
|
UTSW |
7 |
67,875,918 (GRCm39) |
small insertion |
probably benign |
|
|
Z1191:Igf1r
|
UTSW |
7 |
67,875,917 (GRCm39) |
small insertion |
probably benign |
|
|
Z1191:Igf1r
|
UTSW |
7 |
67,875,921 (GRCm39) |
small insertion |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TCTCCCACAGGTCAGTGAGTATGTC -3'
(R):5'- GTAGAAGAGTTTCCAGCCACGGATG -3'
Sequencing Primer
(F):5'- CTGAGTGACAGTAACCAGGTAGC -3'
(R):5'- GCCACGGATGACTGTGAG -3'
|
| Posted On |
2014-03-28 |
Incidental Mutation