Incidental Mutation 'R1471:Ephb2'
| ID |
164868 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Ephb2
|
| Ensembl Gene |
ENSMUSG00000028664 |
| Gene Name |
Eph receptor B2 |
| Synonyms |
eteck, Cek5, Qek5, Sek3, Hek5, Drt, Prkm5, Nuk, Erk, Tyro5 |
| MMRRC Submission |
039524-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.740)
|
| Stock # |
R1471 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
4 |
| Chromosomal Location |
136374850-136563299 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 136386262 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glycine
at position 829
(D829G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000101471
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000059287]
[ENSMUST00000105845]
[ENSMUST00000105846]
|
| AlphaFold |
P54763 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000059287
AA Change: D830G
PolyPhen 2
Score 0.028 (Sensitivity: 0.95; Specificity: 0.81)
|
| SMART Domains |
Protein: ENSMUSP00000058135
Gene: ENSMUSG00000028664
AA Change: D830G
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
EPH_lbd
|
20 |
197 |
7.37e-130 |
SMART |
|
Pfam:GCC2_GCC3
|
261 |
304 |
8.1e-10 |
PFAM |
|
FN3
|
325 |
417 |
1.75e-6 |
SMART |
|
FN3
|
436 |
518 |
1.23e-10 |
SMART |
|
Pfam:EphA2_TM
|
545 |
619 |
6e-25 |
PFAM |
|
TyrKc
|
622 |
881 |
1.34e-138 |
SMART |
|
SAM
|
911 |
978 |
1.18e-23 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000105845
AA Change: D829G
PolyPhen 2
Score 0.035 (Sensitivity: 0.94; Specificity: 0.82)
|
| SMART Domains |
Protein: ENSMUSP00000101471
Gene: ENSMUSG00000028664
AA Change: D829G
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
EPH_lbd
|
20 |
197 |
7.37e-130 |
SMART |
|
Pfam:GCC2_GCC3
|
259 |
305 |
2.2e-10 |
PFAM |
|
FN3
|
325 |
417 |
1.75e-6 |
SMART |
|
FN3
|
436 |
517 |
1.41e-10 |
SMART |
|
Pfam:EphA2_TM
|
543 |
618 |
2.1e-30 |
PFAM |
|
TyrKc
|
621 |
880 |
1.34e-138 |
SMART |
|
SAM
|
910 |
977 |
1.18e-23 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000105846
AA Change: D830G
PolyPhen 2
Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
|
| SMART Domains |
Protein: ENSMUSP00000101472
Gene: ENSMUSG00000028664
AA Change: D830G
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
EPH_lbd
|
20 |
197 |
7.37e-130 |
SMART |
|
Pfam:GCC2_GCC3
|
259 |
305 |
2.2e-10 |
PFAM |
|
FN3
|
325 |
417 |
1.75e-6 |
SMART |
|
FN3
|
436 |
517 |
1.41e-10 |
SMART |
|
Pfam:EphA2_TM
|
543 |
619 |
1e-30 |
PFAM |
|
TyrKc
|
622 |
881 |
1.34e-138 |
SMART |
|
SAM
|
911 |
978 |
1.18e-23 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000151502
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000156558
|
| SMART Domains |
Protein: ENSMUSP00000116350
Gene: ENSMUSG00000028664
| Domain | Start | End | E-Value | Type |
|---|
|
FN3
|
1 |
85 |
6.48e1 |
SMART |
|
FN3
|
104 |
186 |
1.23e-10 |
SMART |
|
Pfam:EphA2_TM
|
213 |
276 |
2.5e-16 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.6%
- 10x: 96.8%
- 20x: 94.4%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: This gene encodes a member of the Eph receptor family of receptor tyrosine kinase transmembrane glycoproteins. These receptors consist of an N-terminal glycosylated ligand-binding domain, a transmembrane region and an intracellular kinase domain. The encoded receptor preferentially binds membrane-bound ephrin-B ligands and is involved in nervous system and vascular development. This gene is used as a marker of intestinal stem cells. Homozygous knockout mice for this gene exhibit impaired axon guidance and vestibular function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
PHENOTYPE: Mice homozygous for a null allele exhibit abnormal axon guidance, circling, head bobbing, and hyperactivity. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 96 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930486L24Rik |
C |
A |
13: 61,001,336 (GRCm39) |
K130N |
probably damaging |
Het |
| Adam6a |
T |
A |
12: 113,508,013 (GRCm39) |
S129T |
probably damaging |
Het |
| Adamts10 |
T |
A |
17: 33,772,112 (GRCm39) |
F1087I |
probably damaging |
Het |
| Afp |
T |
A |
5: 90,651,541 (GRCm39) |
N385K |
possibly damaging |
Het |
| Ahnak |
T |
G |
19: 8,990,296 (GRCm39) |
|
probably benign |
Het |
| Akap6 |
A |
G |
12: 53,188,279 (GRCm39) |
T1898A |
probably benign |
Het |
| Antxr2 |
C |
A |
5: 98,123,199 (GRCm39) |
V283F |
possibly damaging |
Het |
| Asgr1 |
T |
C |
11: 69,946,919 (GRCm39) |
V55A |
possibly damaging |
Het |
| Asxl3 |
A |
G |
18: 22,649,411 (GRCm39) |
K467E |
probably damaging |
Het |
| Atp5f1a |
C |
A |
18: 77,868,969 (GRCm39) |
Q398K |
probably damaging |
Het |
| Atxn2 |
T |
A |
5: 121,924,437 (GRCm39) |
D455E |
probably damaging |
Het |
| B4galt6 |
C |
T |
18: 20,878,410 (GRCm39) |
A39T |
possibly damaging |
Het |
| C130073F10Rik |
C |
T |
4: 101,747,535 (GRCm39) |
E165K |
probably benign |
Het |
| Cabin1 |
A |
G |
10: 75,530,626 (GRCm39) |
C1519R |
probably damaging |
Het |
| Casp8ap2 |
C |
T |
4: 32,639,386 (GRCm39) |
R147* |
probably null |
Het |
| Ccdc88b |
A |
G |
19: 6,831,391 (GRCm39) |
L517P |
probably benign |
Het |
| Cd109 |
G |
A |
9: 78,561,869 (GRCm39) |
V220I |
probably damaging |
Het |
| Cd2ap |
T |
C |
17: 43,131,488 (GRCm39) |
K369R |
probably benign |
Het |
| Cd300c |
A |
G |
11: 114,850,614 (GRCm39) |
V63A |
probably benign |
Het |
| Cnot10 |
A |
G |
9: 114,420,619 (GRCm39) |
V741A |
probably benign |
Het |
| Col18a1 |
G |
T |
10: 76,932,040 (GRCm39) |
Q350K |
unknown |
Het |
| Crnkl1 |
T |
C |
2: 145,774,236 (GRCm39) |
K76E |
possibly damaging |
Het |
| Cryzl2 |
A |
G |
1: 157,298,291 (GRCm39) |
K227E |
probably benign |
Het |
| Cts6 |
G |
A |
13: 61,344,194 (GRCm39) |
T286I |
probably benign |
Het |
| Cul1 |
T |
C |
6: 47,491,820 (GRCm39) |
V392A |
probably damaging |
Het |
| Dcaf7 |
T |
A |
11: 105,937,573 (GRCm39) |
F65L |
probably benign |
Het |
| Dgke |
A |
C |
11: 88,946,320 (GRCm39) |
V160G |
possibly damaging |
Het |
| Dock8 |
C |
A |
19: 25,178,400 (GRCm39) |
Q2098K |
possibly damaging |
Het |
| Efhb |
T |
A |
17: 53,706,140 (GRCm39) |
D799V |
possibly damaging |
Het |
| Exosc1 |
A |
T |
19: 41,913,157 (GRCm39) |
S117R |
probably damaging |
Het |
| Fga |
T |
C |
3: 82,935,925 (GRCm39) |
S51P |
probably benign |
Het |
| Fmn1 |
T |
C |
2: 113,523,439 (GRCm39) |
F1141L |
possibly damaging |
Het |
| Foxm1 |
C |
T |
6: 128,350,837 (GRCm39) |
L713F |
probably damaging |
Het |
| Galnt4 |
A |
G |
10: 98,944,536 (GRCm39) |
E87G |
probably benign |
Het |
| Gamt |
T |
C |
10: 80,096,692 (GRCm39) |
D15G |
probably benign |
Het |
| Gm15557 |
C |
A |
2: 155,784,174 (GRCm39) |
D154E |
possibly damaging |
Het |
| Gnptab |
A |
G |
10: 88,281,625 (GRCm39) |
I1211V |
probably benign |
Het |
| Greb1 |
A |
T |
12: 16,761,775 (GRCm39) |
M535K |
probably damaging |
Het |
| Grm8 |
C |
A |
6: 27,363,308 (GRCm39) |
A736S |
possibly damaging |
Het |
| Hspa14 |
T |
C |
2: 3,492,645 (GRCm39) |
I373M |
probably benign |
Het |
| Ifi207 |
T |
A |
1: 173,557,629 (GRCm39) |
T370S |
unknown |
Het |
| Igf1r |
A |
G |
7: 67,653,585 (GRCm39) |
N41S |
probably damaging |
Het |
| Ikzf5 |
A |
T |
7: 130,993,496 (GRCm39) |
V224D |
probably damaging |
Het |
| Il10 |
C |
A |
1: 130,949,110 (GRCm39) |
Y90* |
probably null |
Het |
| Itga4 |
A |
G |
2: 79,117,376 (GRCm39) |
D394G |
probably benign |
Het |
| Kif21a |
A |
T |
15: 90,840,622 (GRCm39) |
S1165T |
probably benign |
Het |
| Krtap14 |
A |
G |
16: 88,622,515 (GRCm39) |
S155P |
probably damaging |
Het |
| Loxl2 |
A |
G |
14: 69,930,546 (GRCm39) |
N770S |
probably benign |
Het |
| Man2b1 |
A |
G |
8: 85,813,474 (GRCm39) |
D222G |
probably damaging |
Het |
| Mcub |
T |
A |
3: 129,709,464 (GRCm39) |
Y283F |
probably damaging |
Het |
| Meis3 |
T |
A |
7: 15,911,496 (GRCm39) |
Y64* |
probably null |
Het |
| Mfsd6 |
T |
A |
1: 52,748,716 (GRCm39) |
I50F |
probably benign |
Het |
| Micu2 |
T |
C |
14: 58,182,854 (GRCm39) |
T165A |
probably damaging |
Het |
| Mtcl1 |
T |
C |
17: 66,686,143 (GRCm39) |
E921G |
probably damaging |
Het |
| Muc5b |
A |
T |
7: 141,396,971 (GRCm39) |
N215Y |
unknown |
Het |
| Muc6 |
A |
G |
7: 141,234,176 (GRCm39) |
F772L |
possibly damaging |
Het |
| Myt1 |
A |
G |
2: 181,438,904 (GRCm39) |
D142G |
probably benign |
Het |
| Nol6 |
C |
T |
4: 41,120,281 (GRCm39) |
V479I |
probably benign |
Het |
| Nsun7 |
A |
G |
5: 66,441,572 (GRCm39) |
K414E |
probably benign |
Het |
| Nup210l |
A |
C |
3: 90,077,869 (GRCm39) |
I914L |
probably benign |
Het |
| Obox3 |
G |
A |
7: 15,360,875 (GRCm39) |
P88L |
probably benign |
Het |
| Or10ag57 |
A |
G |
2: 87,218,862 (GRCm39) |
Y271C |
probably damaging |
Het |
| Or4f4b |
T |
C |
2: 111,314,351 (GRCm39) |
L192P |
probably damaging |
Het |
| Or8h8 |
C |
T |
2: 86,752,922 (GRCm39) |
|
probably null |
Het |
| Or8w1 |
T |
C |
2: 87,466,014 (GRCm39) |
T26A |
probably benign |
Het |
| Pclo |
T |
C |
5: 14,730,441 (GRCm39) |
|
probably benign |
Het |
| Pcsk5 |
T |
C |
19: 17,545,688 (GRCm39) |
N745D |
probably damaging |
Het |
| Pdzrn3 |
T |
A |
6: 101,128,473 (GRCm39) |
N731I |
possibly damaging |
Het |
| Pkdrej |
T |
A |
15: 85,701,334 (GRCm39) |
Q1534L |
probably benign |
Het |
| Pramel28 |
T |
C |
4: 143,691,523 (GRCm39) |
N400S |
probably benign |
Het |
| Rell1 |
T |
A |
5: 64,093,428 (GRCm39) |
D109V |
probably damaging |
Het |
| Rplp0 |
C |
T |
5: 115,701,403 (GRCm39) |
T285I |
probably damaging |
Het |
| Sanbr |
A |
T |
11: 23,565,222 (GRCm39) |
M255K |
probably damaging |
Het |
| Sema3g |
C |
T |
14: 30,950,002 (GRCm39) |
R728C |
probably damaging |
Het |
| Slc15a2 |
A |
G |
16: 36,574,153 (GRCm39) |
Y536H |
probably damaging |
Het |
| Slc26a5 |
T |
A |
5: 22,021,962 (GRCm39) |
Y488F |
probably benign |
Het |
| Slc5a4a |
A |
T |
10: 76,022,362 (GRCm39) |
S566C |
probably damaging |
Het |
| Spink7 |
C |
T |
18: 62,729,275 (GRCm39) |
E21K |
possibly damaging |
Het |
| Src |
C |
T |
2: 157,299,107 (GRCm39) |
Q35* |
probably null |
Het |
| Srrm2 |
T |
A |
17: 24,039,770 (GRCm39) |
V2234E |
probably damaging |
Het |
| Stk36 |
A |
T |
1: 74,650,314 (GRCm39) |
Q282L |
probably benign |
Het |
| Tas2r118 |
T |
G |
6: 23,969,170 (GRCm39) |
E297A |
probably damaging |
Het |
| Terf1 |
A |
G |
1: 15,913,194 (GRCm39) |
Y385C |
probably damaging |
Het |
| Tmc3 |
T |
C |
7: 83,247,498 (GRCm39) |
S198P |
probably damaging |
Het |
| Tmprss11b |
C |
T |
5: 86,808,355 (GRCm39) |
R407H |
possibly damaging |
Het |
| Tspyl4 |
G |
A |
10: 34,174,107 (GRCm39) |
E200K |
probably damaging |
Het |
| Ttc21a |
T |
C |
9: 119,771,707 (GRCm39) |
Y169H |
probably damaging |
Het |
| Ugt2b36 |
C |
T |
5: 87,239,930 (GRCm39) |
D152N |
probably damaging |
Het |
| Unk |
T |
C |
11: 115,940,235 (GRCm39) |
I196T |
probably benign |
Het |
| Uroc1 |
T |
G |
6: 90,321,153 (GRCm39) |
V243G |
probably damaging |
Het |
| Usp34 |
C |
A |
11: 23,438,862 (GRCm39) |
Q3475K |
probably benign |
Het |
| Vmn2r117 |
T |
A |
17: 23,697,447 (GRCm39) |
I82L |
probably benign |
Het |
| Vmn2r44 |
A |
T |
7: 8,380,882 (GRCm39) |
V337E |
probably damaging |
Het |
| Zbtb14 |
C |
A |
17: 69,695,497 (GRCm39) |
F398L |
probably damaging |
Het |
| Zfp362 |
T |
C |
4: 128,680,993 (GRCm39) |
T111A |
probably benign |
Het |
| Zfp598 |
T |
C |
17: 24,899,046 (GRCm39) |
V615A |
probably benign |
Het |
|
| Other mutations in Ephb2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00336:Ephb2
|
APN |
4 |
136,384,795 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL00963:Ephb2
|
APN |
4 |
136,386,262 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL01111:Ephb2
|
APN |
4 |
136,384,721 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01462:Ephb2
|
APN |
4 |
136,498,681 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
IGL01863:Ephb2
|
APN |
4 |
136,387,088 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02149:Ephb2
|
APN |
4 |
136,421,225 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02232:Ephb2
|
APN |
4 |
136,384,762 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02269:Ephb2
|
APN |
4 |
136,498,360 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
IGL02828:Ephb2
|
APN |
4 |
136,498,461 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL03109:Ephb2
|
APN |
4 |
136,498,855 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03284:Ephb2
|
APN |
4 |
136,388,827 (GRCm39) |
missense |
probably damaging |
0.96 |
|
Zimbalist
|
UTSW |
4 |
136,387,020 (GRCm39) |
missense |
probably damaging |
1.00 |
|
BB006:Ephb2
|
UTSW |
4 |
136,388,195 (GRCm39) |
missense |
probably damaging |
1.00 |
|
BB016:Ephb2
|
UTSW |
4 |
136,388,195 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4453001:Ephb2
|
UTSW |
4 |
136,388,121 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0004:Ephb2
|
UTSW |
4 |
136,384,835 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0121:Ephb2
|
UTSW |
4 |
136,498,368 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0539:Ephb2
|
UTSW |
4 |
136,383,287 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0614:Ephb2
|
UTSW |
4 |
136,400,676 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0988:Ephb2
|
UTSW |
4 |
136,387,019 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R1473:Ephb2
|
UTSW |
4 |
136,421,369 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R1546:Ephb2
|
UTSW |
4 |
136,498,320 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1639:Ephb2
|
UTSW |
4 |
136,421,216 (GRCm39) |
missense |
probably benign |
0.10 |
|
R1725:Ephb2
|
UTSW |
4 |
136,387,089 (GRCm39) |
nonsense |
probably null |
|
|
R1779:Ephb2
|
UTSW |
4 |
136,421,136 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R1818:Ephb2
|
UTSW |
4 |
136,382,647 (GRCm39) |
missense |
probably benign |
0.02 |
|
R2099:Ephb2
|
UTSW |
4 |
136,388,066 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2916:Ephb2
|
UTSW |
4 |
136,411,256 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3885:Ephb2
|
UTSW |
4 |
136,498,345 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4572:Ephb2
|
UTSW |
4 |
136,383,251 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4709:Ephb2
|
UTSW |
4 |
136,423,363 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4893:Ephb2
|
UTSW |
4 |
136,387,064 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4981:Ephb2
|
UTSW |
4 |
136,423,321 (GRCm39) |
missense |
probably benign |
0.09 |
|
R4992:Ephb2
|
UTSW |
4 |
136,388,150 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5004:Ephb2
|
UTSW |
4 |
136,387,010 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R5307:Ephb2
|
UTSW |
4 |
136,421,098 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R5370:Ephb2
|
UTSW |
4 |
136,498,881 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5561:Ephb2
|
UTSW |
4 |
136,388,717 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5643:Ephb2
|
UTSW |
4 |
136,498,923 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5826:Ephb2
|
UTSW |
4 |
136,388,048 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5858:Ephb2
|
UTSW |
4 |
136,399,756 (GRCm39) |
missense |
probably benign |
|
|
R5867:Ephb2
|
UTSW |
4 |
136,402,733 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R5990:Ephb2
|
UTSW |
4 |
136,423,366 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6000:Ephb2
|
UTSW |
4 |
136,411,341 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R6156:Ephb2
|
UTSW |
4 |
136,388,816 (GRCm39) |
missense |
probably benign |
0.44 |
|
R6413:Ephb2
|
UTSW |
4 |
136,498,433 (GRCm39) |
missense |
probably benign |
0.08 |
|
R6577:Ephb2
|
UTSW |
4 |
136,384,861 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6633:Ephb2
|
UTSW |
4 |
136,411,307 (GRCm39) |
missense |
probably benign |
0.07 |
|
R6720:Ephb2
|
UTSW |
4 |
136,384,813 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6795:Ephb2
|
UTSW |
4 |
136,400,646 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R7235:Ephb2
|
UTSW |
4 |
136,421,139 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7260:Ephb2
|
UTSW |
4 |
136,498,885 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7328:Ephb2
|
UTSW |
4 |
136,386,245 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7404:Ephb2
|
UTSW |
4 |
136,498,524 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7466:Ephb2
|
UTSW |
4 |
136,386,376 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7524:Ephb2
|
UTSW |
4 |
136,387,020 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7605:Ephb2
|
UTSW |
4 |
136,498,419 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7611:Ephb2
|
UTSW |
4 |
136,388,212 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R7777:Ephb2
|
UTSW |
4 |
136,498,947 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R7889:Ephb2
|
UTSW |
4 |
136,498,353 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7929:Ephb2
|
UTSW |
4 |
136,388,195 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8191:Ephb2
|
UTSW |
4 |
136,386,256 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8370:Ephb2
|
UTSW |
4 |
136,383,302 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8444:Ephb2
|
UTSW |
4 |
136,388,711 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8724:Ephb2
|
UTSW |
4 |
136,498,368 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8988:Ephb2
|
UTSW |
4 |
136,402,769 (GRCm39) |
missense |
probably benign |
0.42 |
|
R9410:Ephb2
|
UTSW |
4 |
136,386,948 (GRCm39) |
missense |
probably null |
1.00 |
|
R9722:Ephb2
|
UTSW |
4 |
136,384,768 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- ACAAAGCTCGCTACCTGCCTTC -3'
(R):5'- TGTGGAATCCAGATGGCAGTGC -3'
Sequencing Primer
(F):5'- CTCCGATCTAGTGCCTGAC -3'
(R):5'- ggggtatggggaggcac -3'
|
| Posted On |
2014-03-28 |
Incidental Mutation