Mutagenetix > Incidental Mutation

Incidental Mutation 'I2505:Zfp738'

16417

Institutional Source

Beutler Lab

Gene Symbol

Zfp738

Ensembl Gene

ENSMUSG00000048280

Gene Name

zinc finger protein 738

Synonyms

6720487G11Rik, 3830402I07Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.077) question?

Stock #

I2505 (G3) of strain dew

Quality Score

Status

Validated

Chromosome

Chromosomal Location

67815560-67831631 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 67821186 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Isoleucine at position 64 (V64I)

Ref Sequence

ENSEMBL: ENSMUSP00000134865 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000110973] [ENSMUST00000125495] [ENSMUST00000137496] [ENSMUST00000175678] [ENSMUST00000175821]

AlphaFold

B8JJX8

Predicted Effect

probably benign
Transcript: ENSMUST00000110973
AA Change: V51I

PolyPhen 2 Score 0.038 (Sensitivity: 0.94; Specificity: 0.82)

SMART Domains

Protein: ENSMUSP00000106600
Gene: ENSMUSG00000048280
AA Change: V51I

Domain	Start	End	E-Value	Type
KRAB	2	62	1.97e-31	SMART
SCOP:d1fgja_	76	119	1e-7	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000125495
AA Change: V54I

PolyPhen 2 Score 0.200 (Sensitivity: 0.92; Specificity: 0.88)

SMART Domains

Protein: ENSMUSP00000135683
Gene: ENSMUSG00000048280
AA Change: V54I

Domain	Start	End	E-Value	Type
KRAB	5	65	1.97e-31	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000137496
AA Change: V64I

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000121275
Gene: ENSMUSG00000048280
AA Change: V64I

Domain	Start	End	E-Value	Type
KRAB	15	75	1.97e-31	SMART
ZnF_C2H2	91	111	3.13e1	SMART
ZnF_C2H2	119	141	9.56e1	SMART
ZnF_C2H2	147	169	3.58e-2	SMART
ZnF_C2H2	175	197	3.21e-4	SMART
ZnF_C2H2	203	225	6.78e-3	SMART
ZnF_C2H2	231	253	8.34e-3	SMART
ZnF_C2H2	259	281	6.67e-2	SMART
ZnF_C2H2	287	309	1.12e-3	SMART
ZnF_C2H2	315	337	3.83e-2	SMART
ZnF_C2H2	343	365	8.34e-3	SMART
ZnF_C2H2	371	393	4.87e-4	SMART
ZnF_C2H2	427	449	9.58e-3	SMART
ZnF_C2H2	455	477	1.38e-3	SMART
ZnF_C2H2	483	505	3.89e-3	SMART
ZnF_C2H2	511	533	7.49e-5	SMART
ZnF_C2H2	539	561	5.5e-3	SMART
ZnF_C2H2	567	589	5.42e-2	SMART
ZnF_C2H2	595	617	7.78e-3	SMART
ZnF_C2H2	623	645	2.05e-2	SMART
ZnF_C2H2	651	673	2.57e-3	SMART
ZnF_C2H2	679	701	7.26e-3	SMART
ZnF_C2H2	735	757	5.42e-2	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000175678
AA Change: V64I

PolyPhen 2 Score 0.358 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000134865
Gene: ENSMUSG00000048280
AA Change: V64I

Domain	Start	End	E-Value	Type
KRAB	15	75	1.97e-31	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000175821
AA Change: V54I

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)

SMART Domains

Protein: ENSMUSP00000135050
Gene: ENSMUSG00000048280
AA Change: V54I

Domain	Start	End	E-Value	Type
KRAB	5	65	1.97e-31	SMART
ZnF_C2H2	81	101	3.13e1	SMART
ZnF_C2H2	109	131	9.56e1	SMART
ZnF_C2H2	137	159	3.58e-2	SMART
ZnF_C2H2	165	187	3.21e-4	SMART

Meta Mutation Damage Score

0.0898

Coding Region Coverage

Validation Efficiency

98% (113/115)

Allele List at MGI

Other mutations in this stock

Total: 2 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Obi1	T	A	14: 104,740,885 (GRCm39)		probably benign	Het
Rxrb	T	C	17: 34,252,523 (GRCm39)		probably benign	Het

Other mutations in Zfp738

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01511:Zfp738	APN	13	67,831,520 (GRCm39)	critical splice donor site	probably null
IGL01734:Zfp738	APN	13	67,831,563 (GRCm39)	utr 5 prime	probably benign
IGL01980:Zfp738	APN	13	67,818,096 (GRCm39)	missense	possibly damaging	0.80
IGL02052:Zfp738	APN	13	67,819,600 (GRCm39)	missense	possibly damaging	0.87
IGL02330:Zfp738	APN	13	67,819,550 (GRCm39)	missense	probably damaging	0.99
IGL02686:Zfp738	APN	13	67,821,771 (GRCm39)	missense	probably damaging	1.00
R0219:Zfp738	UTSW	13	67,831,508 (GRCm39)	intron	probably benign
R0491:Zfp738	UTSW	13	67,818,140 (GRCm39)	missense	possibly damaging	0.87
R0722:Zfp738	UTSW	13	67,819,643 (GRCm39)	missense	probably benign	0.09
R1116:Zfp738	UTSW	13	67,818,362 (GRCm39)	splice site	probably null
R1425:Zfp738	UTSW	13	67,818,894 (GRCm39)	missense	possibly damaging	0.77
R1854:Zfp738	UTSW	13	67,818,476 (GRCm39)	missense	probably damaging	1.00
R2095:Zfp738	UTSW	13	67,819,422 (GRCm39)	missense	probably damaging	1.00
R2171:Zfp738	UTSW	13	67,819,096 (GRCm39)	nonsense	probably null
R2180:Zfp738	UTSW	13	67,819,313 (GRCm39)	missense	probably damaging	1.00
R2225:Zfp738	UTSW	13	67,818,431 (GRCm39)	missense	probably damaging	1.00
R2226:Zfp738	UTSW	13	67,818,431 (GRCm39)	missense	probably damaging	1.00
R2907:Zfp738	UTSW	13	67,818,231 (GRCm39)	missense	probably benign	0.33
R3605:Zfp738	UTSW	13	67,819,508 (GRCm39)	nonsense	probably null
R4731:Zfp738	UTSW	13	67,818,033 (GRCm39)	missense	probably damaging	1.00
R5037:Zfp738	UTSW	13	67,818,320 (GRCm39)	missense	probably damaging	1.00
R5223:Zfp738	UTSW	13	67,821,182 (GRCm39)	missense	probably damaging	0.99
R5259:Zfp738	UTSW	13	67,817,805 (GRCm39)	missense	probably benign
R5358:Zfp738	UTSW	13	67,819,131 (GRCm39)	missense	probably damaging	0.98
R6404:Zfp738	UTSW	13	67,819,179 (GRCm39)	missense	possibly damaging	0.89
R6874:Zfp738	UTSW	13	67,818,382 (GRCm39)	missense	possibly damaging	0.93
R7041:Zfp738	UTSW	13	67,818,420 (GRCm39)	missense	probably damaging	1.00
R7172:Zfp738	UTSW	13	67,818,527 (GRCm39)	missense	probably damaging	1.00
R7178:Zfp738	UTSW	13	67,821,147 (GRCm39)	missense	probably damaging	1.00
R7308:Zfp738	UTSW	13	67,817,672 (GRCm39)	missense	probably benign	0.00
R7386:Zfp738	UTSW	13	67,818,369 (GRCm39)	missense	probably damaging	1.00
R7453:Zfp738	UTSW	13	67,818,474 (GRCm39)	missense	probably benign	0.42
R7456:Zfp738	UTSW	13	67,817,619 (GRCm39)	missense	probably damaging	1.00
R7467:Zfp738	UTSW	13	67,821,080 (GRCm39)	missense	probably benign	0.03
R7615:Zfp738	UTSW	13	67,818,322 (GRCm39)	missense	probably damaging	0.96
R7663:Zfp738	UTSW	13	67,831,520 (GRCm39)	critical splice donor site	probably null
R7752:Zfp738	UTSW	13	67,821,110 (GRCm39)	nonsense	probably null
R7901:Zfp738	UTSW	13	67,821,110 (GRCm39)	nonsense	probably null
R8042:Zfp738	UTSW	13	67,819,010 (GRCm39)	missense	probably damaging	0.98
R8288:Zfp738	UTSW	13	67,818,908 (GRCm39)	missense	possibly damaging	0.88
R8340:Zfp738	UTSW	13	67,819,231 (GRCm39)	missense	probably damaging	0.98
R8735:Zfp738	UTSW	13	67,819,550 (GRCm39)	missense	probably damaging	0.99
R8846:Zfp738	UTSW	13	67,818,155 (GRCm39)	missense	probably benign	0.00
R8896:Zfp738	UTSW	13	67,817,910 (GRCm39)	missense
R9124:Zfp738	UTSW	13	67,819,457 (GRCm39)	missense	possibly damaging	0.94
R9233:Zfp738	UTSW	13	67,819,017 (GRCm39)	missense	possibly damaging	0.88
R9513:Zfp738	UTSW	13	67,817,635 (GRCm39)	nonsense	probably null

Posted On

2013-01-20