Mutagenetix > Incidental Mutation

Incidental Mutation 'R1494:Dock2'

163825

Institutional Source

Beutler Lab

Gene Symbol

Dock2

Ensembl Gene

ENSMUSG00000020143

Gene Name

dedicator of cyto-kinesis 2

Synonyms

CED-5, Hch, MBC

MMRRC Submission

039545-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R1494 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

34176815-34674719 bp(-) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

T to A at 34232761 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Lysine to Stop codon at position 1080 (K1080*)

Ref Sequence

ENSEMBL: ENSMUSP00000098916 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000093193] [ENSMUST00000101365]

AlphaFold

Q8C3J5

Predicted Effect

probably null
Transcript: ENSMUST00000093193
AA Change: K1080*

SMART Domains

Protein: ENSMUSP00000090884
Gene: ENSMUSG00000020143
AA Change: K1080*

Domain	Start	End	E-Value	Type
SH3	11	68	1.22e-11	SMART
Pfam:DOCK_N	71	414	2e-113	PFAM
Pfam:DOCK-C2	419	616	1e-60	PFAM
Pfam:DHR-2	1114	1614	6.3e-96	PFAM
low complexity region	1691	1706	N/A	INTRINSIC
low complexity region	1793	1800	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000101365
AA Change: K1080*

SMART Domains

Protein: ENSMUSP00000098916
Gene: ENSMUSG00000020143
AA Change: K1080*

Domain	Start	End	E-Value	Type
SH3	11	68	1.22e-11	SMART
Pfam:DOCK_N	71	414	1.4e-113	PFAM
Pfam:DOCK-C2	419	616	5.5e-61	PFAM
low complexity region	1163	1171	N/A	INTRINSIC

Meta Mutation Damage Score

0.9755

Coding Region Coverage

1x: 99.0%
3x: 98.1%
10x: 95.8%
20x: 91.3%

Validation Efficiency

97% (57/59)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells and is predominantly expressed in peripheral blood leukocytes. The protein is involved in remodeling of the actin cytoskeleton required for lymphocyte migration in response to chemokine signaling. It activates members of the Rho family of GTPases, for example RAC1 and RAC2, by acting as a guanine nucleotide exchange factor (GEF) to exchange bound GDP for free GTP. [provided by RefSeq, Oct 2016]
PHENOTYPE: Homozygous mutants are defective in the migration of T and B lympohcytes in response to chemokines, and thus display immune defects such as lymphocytopenia, atrophy of lymphoid follicles and loss of marginal-zone B cells. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 55 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700067P10Rik	A	G	17: 48,400,991 (GRCm39)	E92G	probably benign	Het
Abca13	C	T	11: 9,416,429 (GRCm39)	Q4064*	probably null	Het
Abca14	G	A	7: 119,815,524 (GRCm39)	M257I	probably benign	Het
Acsm2	T	A	7: 119,174,855 (GRCm39)	C207S	probably damaging	Het
Actr3	A	G	1: 125,344,018 (GRCm39)	I67T	probably benign	Het
Adcy7	T	C	8: 89,046,835 (GRCm39)	V606A	probably benign	Het
Ahnak2	G	A	12: 112,751,570 (GRCm39)	S54F	probably damaging	Het
Ano6	T	C	15: 95,870,388 (GRCm39)	S848P	probably damaging	Het
Atg3	C	T	16: 44,992,123 (GRCm39)		probably benign	Het
Atp8b1	T	A	18: 64,697,597 (GRCm39)	S416C	probably damaging	Het
C2cd5	A	G	6: 142,987,072 (GRCm39)		probably benign	Het
Capn11	A	T	17: 45,954,735 (GRCm39)	V134E	probably damaging	Het
Ccnd3	A	G	17: 47,909,033 (GRCm39)		probably null	Het
Chaf1b	T	A	16: 93,684,998 (GRCm39)	V149E	probably damaging	Het
Col5a2	T	A	1: 45,542,074 (GRCm39)	M1L	unknown	Het
Copa	T	C	1: 171,931,694 (GRCm39)	I315T	probably benign	Het
Cyp3a57	A	G	5: 145,318,077 (GRCm39)	M353V	probably damaging	Het
Dcaf6	T	C	1: 165,160,942 (GRCm39)	M828V	probably damaging	Het
Dock6	A	G	9: 21,726,038 (GRCm39)	V1424A	probably benign	Het
Foxa1	T	C	12: 57,588,984 (GRCm39)	D412G	probably damaging	Het
Foxp4	G	C	17: 48,191,278 (GRCm39)		probably benign	Het
Galnt9	T	A	5: 110,736,196 (GRCm39)	S171T	probably damaging	Het
Glt6d1	A	G	2: 25,684,260 (GRCm39)	Y249H	probably damaging	Het
Gm37240	A	T	3: 84,434,998 (GRCm39)	Y104N	probably damaging	Het
Gpx8	C	T	13: 113,182,149 (GRCm39)	E95K	possibly damaging	Het
Grm1	T	C	10: 10,565,450 (GRCm39)	T953A	probably benign	Het
Helz	T	C	11: 107,494,889 (GRCm39)		probably benign	Het
Hif3a	T	C	7: 16,788,647 (GRCm39)	Y108C	probably damaging	Het
Kcnj13	A	T	1: 87,316,939 (GRCm39)	L58Q	probably damaging	Het
Mfsd14b	A	T	13: 65,243,485 (GRCm39)	V53D	probably damaging	Het
Mrps7	G	C	11: 115,494,952 (GRCm39)		probably benign	Het
Mug1	G	A	6: 121,856,259 (GRCm39)	G1013D	probably damaging	Het
Or52h7	T	A	7: 104,214,038 (GRCm39)	Y203*	probably null	Het
Or6c8	A	T	10: 128,915,484 (GRCm39)	M116K	probably damaging	Het
Pax6	T	C	2: 105,521,955 (GRCm39)	I19T	probably benign	Het
Pde8b	G	A	13: 95,184,304 (GRCm39)	R416C	probably damaging	Het
Prl2c2	G	C	13: 13,176,786 (GRCm39)	T47R	probably damaging	Het
Pygl	G	A	12: 70,246,504 (GRCm39)	R348W	probably damaging	Het
Ralgapa1	T	A	12: 55,731,309 (GRCm39)	D1874V	probably damaging	Het
Shf	G	A	2: 122,199,163 (GRCm39)	P51S	probably damaging	Het
Sncaip	T	C	18: 53,001,958 (GRCm39)	S160P	probably damaging	Het
Sptbn4	A	G	7: 27,133,719 (GRCm39)	V79A	probably damaging	Het
Sptlc3	A	T	2: 139,431,480 (GRCm39)	Y334F	possibly damaging	Het
Supt16	A	G	14: 52,409,916 (GRCm39)	Y764H	probably benign	Het
Syne3	A	T	12: 104,921,841 (GRCm39)	V438E	possibly damaging	Het
Tagap1	T	C	17: 7,224,210 (GRCm39)	D162G	probably damaging	Het
Terb1	T	C	8: 105,225,122 (GRCm39)		probably benign	Het
Themis3	C	A	17: 66,866,949 (GRCm39)	R97L	probably benign	Het
Tnk1	T	A	11: 69,747,372 (GRCm39)	E86D	possibly damaging	Het
Tnpo3	A	G	6: 29,557,043 (GRCm39)	L53P	probably damaging	Het
Trpc6	G	A	9: 8,658,305 (GRCm39)	R725K	probably benign	Het
Ttll11	T	G	2: 35,685,391 (GRCm39)	T566P	probably damaging	Het
Unc5c	A	T	3: 141,533,310 (GRCm39)	T779S	possibly damaging	Het
Zfp42	A	G	8: 43,748,638 (GRCm39)	C288R	possibly damaging	Het
Zfp763	G	A	17: 33,240,477 (GRCm39)	T52I	probably damaging	Het

Other mutations in Dock2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00334:Dock2	APN	11	34,595,488 (GRCm39)	missense	probably damaging	1.00
IGL00469:Dock2	APN	11	34,179,603 (GRCm39)	splice site	probably benign
IGL01061:Dock2	APN	11	34,596,653 (GRCm39)	missense	probably damaging	1.00
IGL01319:Dock2	APN	11	34,589,617 (GRCm39)	missense	possibly damaging	0.61
IGL01451:Dock2	APN	11	34,260,390 (GRCm39)	missense	probably damaging	1.00
IGL01490:Dock2	APN	11	34,596,608 (GRCm39)	missense	probably damaging	0.97
IGL01601:Dock2	APN	11	34,189,528 (GRCm39)	critical splice donor site	probably null
IGL01800:Dock2	APN	11	34,647,100 (GRCm39)	missense	probably damaging	1.00
IGL01804:Dock2	APN	11	34,212,433 (GRCm39)	missense	probably benign	0.01
IGL01823:Dock2	APN	11	34,212,391 (GRCm39)	missense	probably damaging	1.00
IGL01829:Dock2	APN	11	34,596,668 (GRCm39)	missense	probably damaging	0.98
IGL01830:Dock2	APN	11	34,582,744 (GRCm39)	nonsense	probably null
IGL01835:Dock2	APN	11	34,260,435 (GRCm39)	missense	possibly damaging	0.51
IGL01845:Dock2	APN	11	34,599,692 (GRCm39)	missense	probably benign	0.02
IGL01953:Dock2	APN	11	34,623,183 (GRCm39)	missense	probably benign	0.28
IGL01989:Dock2	APN	11	34,218,053 (GRCm39)	missense	probably benign
IGL02081:Dock2	APN	11	34,204,355 (GRCm39)	missense	probably benign
IGL02105:Dock2	APN	11	34,605,352 (GRCm39)	missense	probably damaging	1.00
IGL02153:Dock2	APN	11	34,180,670 (GRCm39)	missense	probably benign	0.01
IGL02170:Dock2	APN	11	34,217,949 (GRCm39)	missense	probably damaging	1.00
IGL02344:Dock2	APN	11	34,622,337 (GRCm39)	missense	probably damaging	0.98
IGL02389:Dock2	APN	11	34,589,567 (GRCm39)	splice site	probably benign
IGL02409:Dock2	APN	11	34,451,204 (GRCm39)	missense	probably benign	0.00
IGL02472:Dock2	APN	11	34,199,801 (GRCm39)	missense	probably benign	0.00
IGL02625:Dock2	APN	11	34,451,168 (GRCm39)	critical splice donor site	probably null
IGL02929:Dock2	APN	11	34,218,048 (GRCm39)	missense	probably damaging	1.00
IGL02951:Dock2	APN	11	34,260,448 (GRCm39)	unclassified	probably benign
IGL02999:Dock2	APN	11	34,583,086 (GRCm39)	missense	probably damaging	0.99
IGL03165:Dock2	APN	11	34,578,360 (GRCm39)	missense	probably damaging	0.99
Arches	UTSW	11	34,580,587 (GRCm39)	missense	probably damaging	1.00
capitol_reef	UTSW	11	34,244,170 (GRCm39)	critical splice acceptor site	probably null
Croesus	UTSW	11	34,611,854 (GRCm39)	missense	probably damaging	1.00
denali	UTSW	11	34,179,472 (GRCm39)	critical splice donor site	probably null
dew	UTSW	11	34,198,636 (GRCm39)	nonsense	probably null
Dinghy	UTSW	11	34,212,460 (GRCm39)	missense	possibly damaging	0.70
Dry	UTSW	11	34,181,652 (GRCm39)	missense	possibly damaging	0.79
frazz	UTSW	11	34,198,572 (GRCm39)	critical splice donor site	probably benign
frizz	UTSW	11	34,208,184 (GRCm39)	splice site	probably benign
gildenstern	UTSW	11	34,623,166 (GRCm39)	critical splice donor site	probably null
godsgrace	UTSW	11	34,586,280 (GRCm39)	missense	probably damaging	1.00
Harborside	UTSW	11	34,212,445 (GRCm39)	missense	probably benign
Landing	UTSW	11	34,605,328 (GRCm39)	missense	possibly damaging	0.83
latest	UTSW	11	34,647,049 (GRCm39)	missense	probably damaging	1.00
Launch	UTSW	11	34,206,562 (GRCm39)	missense	probably damaging	1.00
liaoning	UTSW	11	34,599,620 (GRCm39)	missense	probably damaging	1.00
lucre	UTSW	11	34,595,436 (GRCm39)	frame shift	probably null
midas	UTSW	11	34,244,323 (GRCm39)	missense	probably damaging	0.99
muelle	UTSW	11	34,578,365 (GRCm39)	missense	probably damaging	1.00
narrowest	UTSW	11	34,232,652 (GRCm39)	missense	probably damaging	0.98
pier	UTSW	11	34,580,593 (GRCm39)	missense	probably damaging	1.00
Plank	UTSW	11	34,674,622 (GRCm39)	missense	possibly damaging	0.51
resplendent	UTSW	11	34,618,287 (GRCm39)	nonsense	probably null
riches	UTSW	11	34,579,279 (GRCm39)	critical splice donor site	probably null
skiff	UTSW	11	34,212,388 (GRCm39)	missense	probably null	0.80
Slip	UTSW	11	34,244,286 (GRCm39)	missense	probably benign	0.25
toothskin	UTSW	11	34,414,922 (GRCm39)	missense	probably damaging	1.00
Touch	UTSW	11	34,223,750 (GRCm39)	missense	possibly damaging	0.95
wassup	UTSW	11	34,453,413 (GRCm39)	missense	probably damaging	1.00
Wharf	UTSW	11	34,623,198 (GRCm39)	missense	possibly damaging	0.81
BB009:Dock2	UTSW	11	34,217,998 (GRCm39)	missense	probably benign	0.00
BB019:Dock2	UTSW	11	34,217,998 (GRCm39)	missense	probably benign	0.00
IGL03052:Dock2	UTSW	11	34,182,853 (GRCm39)	missense	probably benign	0.01
PIT4377001:Dock2	UTSW	11	34,611,835 (GRCm39)	missense	probably benign	0.02
R0006:Dock2	UTSW	11	34,262,453 (GRCm39)	unclassified	probably benign
R0012:Dock2	UTSW	11	34,674,622 (GRCm39)	missense	possibly damaging	0.51
R0063:Dock2	UTSW	11	34,647,111 (GRCm39)	critical splice acceptor site	probably null
R0063:Dock2	UTSW	11	34,647,111 (GRCm39)	critical splice acceptor site	probably null
R0116:Dock2	UTSW	11	34,579,392 (GRCm39)	intron	probably benign
R0149:Dock2	UTSW	11	34,388,327 (GRCm39)	missense	probably damaging	1.00
R0361:Dock2	UTSW	11	34,388,327 (GRCm39)	missense	probably damaging	1.00
R0462:Dock2	UTSW	11	34,218,052 (GRCm39)	missense	possibly damaging	0.74
R0471:Dock2	UTSW	11	34,579,380 (GRCm39)	missense	probably benign	0.30
R0538:Dock2	UTSW	11	34,595,545 (GRCm39)	splice site	probably benign
R0543:Dock2	UTSW	11	34,244,325 (GRCm39)	missense	probably damaging	1.00
R0660:Dock2	UTSW	11	34,198,621 (GRCm39)	missense	probably damaging	1.00
R0676:Dock2	UTSW	11	34,586,063 (GRCm39)	missense	probably damaging	0.99
R0722:Dock2	UTSW	11	34,414,970 (GRCm39)	splice site	probably benign
R0801:Dock2	UTSW	11	34,599,620 (GRCm39)	missense	probably damaging	1.00
R1110:Dock2	UTSW	11	34,206,535 (GRCm39)	missense	possibly damaging	0.78
R1171:Dock2	UTSW	11	34,586,068 (GRCm39)	missense	probably damaging	1.00
R1387:Dock2	UTSW	11	34,223,309 (GRCm39)	splice site	probably benign
R1445:Dock2	UTSW	11	34,189,705 (GRCm39)	missense	probably benign
R1589:Dock2	UTSW	11	34,597,288 (GRCm39)	missense	probably damaging	0.99
R1597:Dock2	UTSW	11	34,595,474 (GRCm39)	missense	probably benign	0.00
R1629:Dock2	UTSW	11	34,212,480 (GRCm39)	splice site	probably null
R1749:Dock2	UTSW	11	34,182,767 (GRCm39)	critical splice donor site	probably null
R1888:Dock2	UTSW	11	34,598,169 (GRCm39)	missense	probably damaging	1.00
R1888:Dock2	UTSW	11	34,598,169 (GRCm39)	missense	probably damaging	1.00
R1899:Dock2	UTSW	11	34,244,286 (GRCm39)	missense	probably benign	0.25
R1924:Dock2	UTSW	11	34,414,934 (GRCm39)	missense	possibly damaging	0.69
R2031:Dock2	UTSW	11	34,618,297 (GRCm39)	splice site	probably benign
R2045:Dock2	UTSW	11	34,244,106 (GRCm39)	splice site	probably null
R2098:Dock2	UTSW	11	34,609,832 (GRCm39)	missense	probably damaging	0.99
R2098:Dock2	UTSW	11	34,216,279 (GRCm39)	missense	probably benign	0.16
R2129:Dock2	UTSW	11	34,618,242 (GRCm39)	missense	probably damaging	1.00
R2147:Dock2	UTSW	11	34,179,472 (GRCm39)	critical splice donor site	probably null
R2149:Dock2	UTSW	11	34,179,472 (GRCm39)	critical splice donor site	probably null
R2150:Dock2	UTSW	11	34,179,472 (GRCm39)	critical splice donor site	probably null
R2176:Dock2	UTSW	11	34,586,044 (GRCm39)	missense	probably benign	0.00
R2230:Dock2	UTSW	11	34,244,323 (GRCm39)	missense	probably damaging	0.99
R2508:Dock2	UTSW	11	34,262,485 (GRCm39)	missense	probably benign	0.04
R2875:Dock2	UTSW	11	34,609,712 (GRCm39)	missense	probably damaging	1.00
R2885:Dock2	UTSW	11	34,580,593 (GRCm39)	missense	probably damaging	1.00
R2910:Dock2	UTSW	11	34,182,910 (GRCm39)	splice site	probably benign
R3081:Dock2	UTSW	11	34,181,610 (GRCm39)	missense	probably benign
R3418:Dock2	UTSW	11	34,580,587 (GRCm39)	missense	probably damaging	1.00
R3552:Dock2	UTSW	11	34,611,787 (GRCm39)	missense	probably benign	0.22
R3731:Dock2	UTSW	11	34,599,722 (GRCm39)	missense	probably damaging	1.00
R3846:Dock2	UTSW	11	34,623,198 (GRCm39)	missense	possibly damaging	0.81
R4135:Dock2	UTSW	11	34,605,328 (GRCm39)	missense	possibly damaging	0.83
R4598:Dock2	UTSW	11	34,189,536 (GRCm39)	missense	probably damaging	1.00
R4599:Dock2	UTSW	11	34,189,536 (GRCm39)	missense	probably damaging	1.00
R4715:Dock2	UTSW	11	34,244,118 (GRCm39)	missense	probably damaging	1.00
R4722:Dock2	UTSW	11	34,586,298 (GRCm39)	missense	probably damaging	1.00
R4742:Dock2	UTSW	11	34,244,170 (GRCm39)	critical splice acceptor site	probably null
R4830:Dock2	UTSW	11	34,223,767 (GRCm39)	splice site	probably null
R4884:Dock2	UTSW	11	34,216,248 (GRCm39)	missense	probably damaging	1.00
R4990:Dock2	UTSW	11	34,586,078 (GRCm39)	missense	probably damaging	1.00
R5334:Dock2	UTSW	11	34,178,643 (GRCm39)	missense	probably benign	0.00
R5570:Dock2	UTSW	11	34,618,233 (GRCm39)	missense	probably damaging	1.00
R5602:Dock2	UTSW	11	34,204,391 (GRCm39)	missense	probably benign	0.16
R5681:Dock2	UTSW	11	34,199,836 (GRCm39)	missense	probably benign	0.06
R5809:Dock2	UTSW	11	34,212,445 (GRCm39)	missense	probably benign
R5860:Dock2	UTSW	11	34,206,562 (GRCm39)	missense	probably damaging	1.00
R6111:Dock2	UTSW	11	34,599,614 (GRCm39)	missense	probably damaging	0.99
R6155:Dock2	UTSW	11	34,244,123 (GRCm39)	missense	probably benign	0.06
R6156:Dock2	UTSW	11	34,197,789 (GRCm39)	missense	possibly damaging	0.51
R6173:Dock2	UTSW	11	34,212,388 (GRCm39)	missense	probably null	0.80
R6182:Dock2	UTSW	11	34,179,476 (GRCm39)	missense	probably damaging	0.97
R6188:Dock2	UTSW	11	34,453,396 (GRCm39)	missense	probably damaging	0.98
R6191:Dock2	UTSW	11	34,181,652 (GRCm39)	missense	possibly damaging	0.79
R6283:Dock2	UTSW	11	34,598,152 (GRCm39)	missense	probably damaging	0.99
R6395:Dock2	UTSW	11	34,182,874 (GRCm39)	missense	probably damaging	1.00
R6465:Dock2	UTSW	11	34,453,413 (GRCm39)	missense	probably damaging	1.00
R6500:Dock2	UTSW	11	34,312,822 (GRCm39)	missense	possibly damaging	0.76
R6561:Dock2	UTSW	11	34,578,365 (GRCm39)	missense	probably damaging	1.00
R6745:Dock2	UTSW	11	34,596,670 (GRCm39)	missense	probably damaging	1.00
R6745:Dock2	UTSW	11	34,596,669 (GRCm39)	missense	probably damaging	1.00
R6880:Dock2	UTSW	11	34,579,279 (GRCm39)	critical splice donor site	probably null
R6913:Dock2	UTSW	11	34,647,049 (GRCm39)	missense	probably damaging	1.00
R6997:Dock2	UTSW	11	34,414,922 (GRCm39)	missense	probably damaging	1.00
R7057:Dock2	UTSW	11	34,586,044 (GRCm39)	missense	probably benign	0.00
R7057:Dock2	UTSW	11	34,177,684 (GRCm39)	missense	probably benign	0.10
R7134:Dock2	UTSW	11	34,260,363 (GRCm39)	missense	probably benign	0.03
R7188:Dock2	UTSW	11	34,189,675 (GRCm39)	missense	possibly damaging	0.87
R7239:Dock2	UTSW	11	34,181,677 (GRCm39)	missense	probably benign	0.00
R7247:Dock2	UTSW	11	34,605,340 (GRCm39)	nonsense	probably null
R7250:Dock2	UTSW	11	34,586,120 (GRCm39)	missense	probably damaging	1.00
R7250:Dock2	UTSW	11	34,586,032 (GRCm39)	missense	probably benign	0.01
R7271:Dock2	UTSW	11	34,223,750 (GRCm39)	missense	possibly damaging	0.95
R7284:Dock2	UTSW	11	34,180,672 (GRCm39)	missense	probably benign	0.01
R7397:Dock2	UTSW	11	34,609,816 (GRCm39)	missense	probably benign	0.00
R7464:Dock2	UTSW	11	34,586,105 (GRCm39)	missense	probably damaging	0.99
R7512:Dock2	UTSW	11	34,262,542 (GRCm39)	missense	possibly damaging	0.95
R7556:Dock2	UTSW	11	34,611,778 (GRCm39)	missense	probably benign	0.43
R7663:Dock2	UTSW	11	34,611,854 (GRCm39)	missense	probably damaging	1.00
R7779:Dock2	UTSW	11	34,605,282 (GRCm39)	missense	probably benign	0.38
R7797:Dock2	UTSW	11	34,232,652 (GRCm39)	missense	probably damaging	0.98
R7855:Dock2	UTSW	11	34,223,698 (GRCm39)	missense	probably damaging	1.00
R7922:Dock2	UTSW	11	34,598,154 (GRCm39)	missense	probably benign	0.29
R7932:Dock2	UTSW	11	34,217,998 (GRCm39)	missense	probably benign	0.00
R8013:Dock2	UTSW	11	34,596,677 (GRCm39)	missense	probably damaging	0.96
R8192:Dock2	UTSW	11	34,623,166 (GRCm39)	critical splice donor site	probably null
R8244:Dock2	UTSW	11	34,586,280 (GRCm39)	missense	probably damaging	1.00
R8307:Dock2	UTSW	11	34,260,362 (GRCm39)	missense	possibly damaging	0.95
R8418:Dock2	UTSW	11	34,609,795 (GRCm39)	missense	probably benign	0.01
R8460:Dock2	UTSW	11	34,180,825 (GRCm39)	critical splice acceptor site	probably null
R8495:Dock2	UTSW	11	34,181,622 (GRCm39)	missense	probably benign	0.14
R8556:Dock2	UTSW	11	34,212,457 (GRCm39)	missense	possibly damaging	0.84
R8690:Dock2	UTSW	11	34,618,287 (GRCm39)	nonsense	probably null
R8743:Dock2	UTSW	11	34,223,252 (GRCm39)	nonsense	probably null
R8757:Dock2	UTSW	11	34,586,067 (GRCm39)	missense	probably benign	0.13
R8759:Dock2	UTSW	11	34,586,067 (GRCm39)	missense	probably benign	0.13
R8793:Dock2	UTSW	11	34,451,215 (GRCm39)	missense	probably benign	0.00
R8882:Dock2	UTSW	11	34,595,436 (GRCm39)	frame shift	probably null
R8885:Dock2	UTSW	11	34,260,396 (GRCm39)	missense	probably benign	0.01
R8943:Dock2	UTSW	11	34,599,646 (GRCm39)	missense	possibly damaging	0.63
R9171:Dock2	UTSW	11	34,589,670 (GRCm39)	missense	probably benign	0.12
R9182:Dock2	UTSW	11	34,260,398 (GRCm39)	missense	possibly damaging	0.51
R9203:Dock2	UTSW	11	34,622,366 (GRCm39)	missense	possibly damaging	0.92
R9310:Dock2	UTSW	11	34,244,139 (GRCm39)	missense	possibly damaging	0.71
R9388:Dock2	UTSW	11	34,212,460 (GRCm39)	missense	possibly damaging	0.70
R9490:Dock2	UTSW	11	34,589,582 (GRCm39)	missense	possibly damaging	0.90
R9568:Dock2	UTSW	11	34,599,638 (GRCm39)	missense	possibly damaging	0.83
R9593:Dock2	UTSW	11	34,178,607 (GRCm39)	missense	probably benign	0.34
R9694:Dock2	UTSW	11	34,218,054 (GRCm39)	missense	probably benign
R9697:Dock2	UTSW	11	34,204,417 (GRCm39)	missense	probably benign
R9753:Dock2	UTSW	11	34,223,673 (GRCm39)	missense	possibly damaging	0.68
R9783:Dock2	UTSW	11	34,208,128 (GRCm39)	missense	possibly damaging	0.83
X0017:Dock2	UTSW	11	34,216,271 (GRCm39)	missense	probably benign	0.08
X0018:Dock2	UTSW	11	34,182,833 (GRCm39)	missense	possibly damaging	0.65
X0058:Dock2	UTSW	11	34,206,564 (GRCm39)	missense	probably damaging	1.00
X0066:Dock2	UTSW	11	34,260,357 (GRCm39)	missense	possibly damaging	0.95
Z1088:Dock2	UTSW	11	34,583,209 (GRCm39)	missense	probably damaging	1.00
Z1088:Dock2	UTSW	11	34,388,300 (GRCm39)	missense	probably benign	0.14
Z1088:Dock2	UTSW	11	34,586,039 (GRCm39)	nonsense	probably null
Z1176:Dock2	UTSW	11	34,609,751 (GRCm39)	missense	probably benign	0.04
Z1177:Dock2	UTSW	11	34,262,553 (GRCm39)	missense	possibly damaging	0.68

Predicted Primers

PCR Primer
(F):5'- TAATGTCCCTATCCCGCAGAAGCC -3'
(R):5'- GATCCATGCTCATCCCTCAGCAAG -3'

Sequencing Primer
(F):5'- TCTCAGTGAAGCACAGGC -3'
(R):5'- GCTAACCTATACATAATGATCAGAGC -3'

Posted On

2014-03-28