Mutagenetix > Incidental Mutation

Incidental Mutation 'I2505:Obi1'

16380

Institutional Source

Beutler Lab

Gene Symbol

Obi1

Ensembl Gene

ENSMUSG00000022120

Gene Name

ORC ubiquitin ligase 1

Synonyms

2610206B13Rik, 2810449K13Rik, Rnf219

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.074) question?

Stock #

I2505 (G3) of strain dew

Quality Score

Status

Validated

Chromosome

Chromosomal Location

104714972-104760081 bp(-) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

T to A at 104740885 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000154655 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000022716] [ENSMUST00000227640] [ENSMUST00000228210] [ENSMUST00000228448]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000022716

SMART Domains

Protein: ENSMUSP00000022716
Gene: ENSMUSG00000022120

Domain	Start	End	E-Value	Type
RING	18	55	2.78e-3	SMART
coiled coil region	87	129	N/A	INTRINSIC
coiled coil region	157	263	N/A	INTRINSIC
low complexity region	302	319	N/A	INTRINSIC
low complexity region	647	658	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000227640

Predicted Effect

probably benign
Transcript: ENSMUST00000228210

Predicted Effect

probably benign
Transcript: ENSMUST00000228448

Coding Region Coverage

Validation Efficiency

98% (113/115)

Allele List at MGI

Other mutations in this stock

Total: 2 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Rxrb	T	C	17: 34,252,523 (GRCm39)		probably benign	Het
Zfp738	C	T	13: 67,821,186 (GRCm39)	V64I	probably benign	Het

Other mutations in Obi1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01727:Obi1	APN	14	104,716,823 (GRCm39)	nonsense	probably null
IGL01731:Obi1	APN	14	104,716,738 (GRCm39)	missense	probably damaging	1.00
IGL03098:Obi1	UTSW	14	104,716,253 (GRCm39)	missense	possibly damaging	0.93
PIT4651001:Obi1	UTSW	14	104,743,692 (GRCm39)	missense	probably damaging	0.99
R0047:Obi1	UTSW	14	104,740,780 (GRCm39)	splice site	probably null
R0047:Obi1	UTSW	14	104,740,780 (GRCm39)	splice site	probably null
R0394:Obi1	UTSW	14	104,716,289 (GRCm39)	missense	possibly damaging	0.74
R0608:Obi1	UTSW	14	104,716,963 (GRCm39)	missense	probably damaging	1.00
R0727:Obi1	UTSW	14	104,717,624 (GRCm39)	missense	probably damaging	1.00
R1109:Obi1	UTSW	14	104,717,200 (GRCm39)	nonsense	probably null
R1774:Obi1	UTSW	14	104,717,098 (GRCm39)	missense	possibly damaging	0.68
R1922:Obi1	UTSW	14	104,716,622 (GRCm39)	missense	probably benign	0.02
R2018:Obi1	UTSW	14	104,759,978 (GRCm39)	missense	probably damaging	1.00
R2061:Obi1	UTSW	14	104,759,968 (GRCm39)	splice site	probably benign
R2182:Obi1	UTSW	14	104,743,612 (GRCm39)	missense	possibly damaging	0.55
R2336:Obi1	UTSW	14	104,716,318 (GRCm39)	missense	probably damaging	1.00
R4308:Obi1	UTSW	14	104,717,029 (GRCm39)	missense	probably damaging	0.97
R4355:Obi1	UTSW	14	104,716,693 (GRCm39)	missense	probably benign	0.01
R4703:Obi1	UTSW	14	104,743,644 (GRCm39)	missense	probably benign	0.03
R4738:Obi1	UTSW	14	104,747,819 (GRCm39)	missense	probably damaging	1.00
R4739:Obi1	UTSW	14	104,747,819 (GRCm39)	missense	probably damaging	1.00
R4869:Obi1	UTSW	14	104,716,252 (GRCm39)	missense	probably damaging	0.99
R5025:Obi1	UTSW	14	104,745,466 (GRCm39)	missense	probably damaging	1.00
R5054:Obi1	UTSW	14	104,745,466 (GRCm39)	missense	probably damaging	1.00
R5167:Obi1	UTSW	14	104,716,223 (GRCm39)	missense	probably damaging	1.00
R6356:Obi1	UTSW	14	104,716,313 (GRCm39)	missense	probably damaging	0.99
R6427:Obi1	UTSW	14	104,717,662 (GRCm39)	missense	possibly damaging	0.70
R6482:Obi1	UTSW	14	104,717,253 (GRCm39)	nonsense	probably null
R6518:Obi1	UTSW	14	104,716,501 (GRCm39)	missense	probably damaging	1.00
R6619:Obi1	UTSW	14	104,759,993 (GRCm39)	missense	possibly damaging	0.88
R6731:Obi1	UTSW	14	104,716,910 (GRCm39)	missense	probably benign	0.06
R6754:Obi1	UTSW	14	104,740,850 (GRCm39)	missense	probably damaging	1.00
R6812:Obi1	UTSW	14	104,747,868 (GRCm39)	missense	unknown
R7225:Obi1	UTSW	14	104,717,294 (GRCm39)	missense	probably benign	0.00
R7567:Obi1	UTSW	14	104,716,814 (GRCm39)	missense	probably damaging	1.00
R8133:Obi1	UTSW	14	104,716,681 (GRCm39)	nonsense	probably null
R8322:Obi1	UTSW	14	104,717,091 (GRCm39)	missense	probably damaging	1.00
R8682:Obi1	UTSW	14	104,717,669 (GRCm39)	missense	probably damaging	0.99
R8780:Obi1	UTSW	14	104,717,082 (GRCm39)	nonsense	probably null
R8986:Obi1	UTSW	14	104,745,418 (GRCm39)	missense	probably damaging	1.00
X0002:Obi1	UTSW	14	104,745,413 (GRCm39)	missense	probably damaging	1.00

Posted On

2013-01-20