Mutagenetix > Incidental Mutation

Incidental Mutation 'R1445:Lyst'

158815

Institutional Source

Beutler Lab

Gene Symbol

Lyst

Ensembl Gene

ENSMUSG00000019726

Gene Name

lysosomal trafficking regulator

Synonyms

D13Sfk13

MMRRC Submission

039500-MU

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.395) question?

Stock #

R1445 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

13764982-13953388 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 13814639 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Methionine at position 1131 (I1131M)

Ref Sequence

ENSEMBL: ENSMUSP00000106188 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000110559]

AlphaFold

no structure available at present

Predicted Effect

possibly damaging
Transcript: ENSMUST00000110559
AA Change: I1131M

PolyPhen 2 Score 0.941 (Sensitivity: 0.80; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000106188
Gene: ENSMUSG00000019726
AA Change: I1131M

Domain	Start	End	E-Value	Type
low complexity region	26	36	N/A	INTRINSIC
low complexity region	72	82	N/A	INTRINSIC
low complexity region	399	412	N/A	INTRINSIC
low complexity region	1333	1344	N/A	INTRINSIC
low complexity region	2295	2307	N/A	INTRINSIC
low complexity region	2427	2445	N/A	INTRINSIC
low complexity region	2534	2546	N/A	INTRINSIC
Pfam:PH_BEACH	3006	3101	5.8e-25	PFAM
Beach	3118	3408	1.25e-193	SMART
Blast:Beach	3441	3478	9e-13	BLAST
WD40	3539	3579	5.75e-1	SMART
WD40	3591	3630	2.89e-5	SMART
WD40	3633	3676	1.38e0	SMART
WD40	3724	3765	1.27e-1	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000220937

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000223053

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000223527

Meta Mutation Damage Score

0.0824

Coding Region Coverage

1x: 98.8%
3x: 97.7%
10x: 93.9%
20x: 84.0%

Validation Efficiency

96% (101/105)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that regulates intracellular protein trafficking in endosomes, and may be involved in pigmentation. Mutations in this gene are associated with Chediak-Higashi syndrome, a lysosomal storage disorder. Alternative splicing results in multiple transcript variants, though the full-length nature of some of these variants has not been determined. [provided by RefSeq, Apr 2013]
PHENOTYPE: Homozygous mice have a phenotype similar to human Chediak-Higashi syndrome patients, exhibiting lysosomal dysfunction with resultant protein storage; diluted coat color; abnormal melanogenesis; immune cell dysfunction resulting in increased susceptibility to bacterial, viral, and parasitic infections and decreased cytotoxic activity against tumor cells. [provided by MGI curators]

Allele List at MGI

All alleles(52) : Targeted(3) Gene trapped(34) Spontaneous(8) Chemically induced(6) Radiation induced(1)

Other mutations in this stock

Total: 94 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700061I17Rik	G	T	3: 116,861,385 (GRCm39)		noncoding transcript	Het
2300003K06Rik	G	T	11: 99,728,793 (GRCm39)	Q17K	probably benign	Het
Abca16	T	C	7: 120,119,256 (GRCm39)	V999A	probably benign	Het
Actn3	C	T	19: 4,915,483 (GRCm39)		probably benign	Het
Agap2	T	A	10: 126,926,981 (GRCm39)		probably benign	Het
Ago3	C	A	4: 126,265,580 (GRCm39)	R278L	probably benign	Het
Aldh1a2	T	C	9: 71,192,492 (GRCm39)	V449A	possibly damaging	Het
Alkbh2	C	T	5: 114,262,287 (GRCm39)	E148K	probably damaging	Het
Aplnr	A	G	2: 84,967,353 (GRCm39)	Y126C	probably damaging	Het
Apob	T	C	12: 8,066,084 (GRCm39)	I4351T	possibly damaging	Het
Ash1l	T	C	3: 88,914,659 (GRCm39)	L1763P	probably benign	Het
Aspn	T	C	13: 49,710,849 (GRCm39)	S165P	possibly damaging	Het
Atg13	A	T	2: 91,510,335 (GRCm39)	V349E	probably damaging	Het
Atp1b2	T	A	11: 69,493,309 (GRCm39)		probably null	Het
B3glct	A	T	5: 149,677,604 (GRCm39)	D411V	probably damaging	Het
Bcar3	A	T	3: 122,316,840 (GRCm39)	I255F	probably damaging	Het
Cacna1b	G	A	2: 24,608,148 (GRCm39)		probably benign	Het
Cep164	T	G	9: 45,690,198 (GRCm39)	E675A	possibly damaging	Het
Chd1l	C	T	3: 97,490,047 (GRCm39)	E503K	probably benign	Het
Chst8	C	A	7: 34,447,593 (GRCm39)	M8I	possibly damaging	Het
Clec4n	A	G	6: 123,212,475 (GRCm39)	E67G	probably benign	Het
Cobll1	A	T	2: 64,929,480 (GRCm39)	D653E	probably damaging	Het
Col9a1	T	C	1: 24,276,579 (GRCm39)		probably null	Het
Crip2	T	C	12: 113,107,124 (GRCm39)	L30P	probably damaging	Het
Ctbp1	C	T	5: 33,418,407 (GRCm39)	V22I	probably benign	Het
Cwc22	T	C	2: 77,747,521 (GRCm39)		probably benign	Het
Cyp4a32	C	A	4: 115,460,147 (GRCm39)	Y119*	probably null	Het
Dido1	G	T	2: 180,313,263 (GRCm39)	A463E	possibly damaging	Het
Dnah7a	G	A	1: 53,567,956 (GRCm39)	P1880L	probably benign	Het
Dock2	T	A	11: 34,189,705 (GRCm39)	T1489S	probably benign	Het
Dsp	A	G	13: 38,375,907 (GRCm39)	T1231A	probably damaging	Het
Eif2ak1	G	T	5: 143,810,717 (GRCm39)		probably benign	Het
Entrep1	G	A	19: 23,998,998 (GRCm39)	T140M	probably damaging	Het
Epc1	A	T	18: 6,452,360 (GRCm39)	M233K	probably damaging	Het
Gigyf2	A	G	1: 87,371,360 (GRCm39)		probably benign	Het
Greb1	T	G	12: 16,757,852 (GRCm39)	H58P	probably damaging	Het
Gtpbp1	T	C	15: 79,597,649 (GRCm39)	I348T	possibly damaging	Het
Hck	A	T	2: 152,970,192 (GRCm39)	N64Y	probably benign	Het
Herc2	T	C	7: 55,818,744 (GRCm39)	S2812P	probably damaging	Het
Inpp4b	T	A	8: 82,679,463 (GRCm39)		probably null	Het
Kcnq5	A	C	1: 21,475,248 (GRCm39)	S473A	probably benign	Het
Lrat	T	G	3: 82,810,676 (GRCm39)	D115A	probably damaging	Het
Man2a2	T	C	7: 80,018,310 (GRCm39)	D160G	probably benign	Het
Marf1	C	T	16: 13,933,688 (GRCm39)	D1567N	probably benign	Het
Mars1	T	C	10: 127,133,857 (GRCm39)	D680G	possibly damaging	Het
Mat1a	T	C	14: 40,843,797 (GRCm39)	S339P	probably damaging	Het
Megf8	T	C	7: 25,042,081 (GRCm39)	S1300P	probably damaging	Het
Mga	T	C	2: 119,733,179 (GRCm39)	L9S	probably damaging	Het
Mllt6	T	C	11: 97,563,277 (GRCm39)		probably benign	Het
Mrpl37	A	G	4: 106,921,692 (GRCm39)	L179P	probably benign	Het
Mtnr1a	G	T	8: 45,540,782 (GRCm39)	V248L	probably benign	Het
Mylk	T	C	16: 34,635,835 (GRCm39)	S19P	possibly damaging	Het
Or11g1	A	G	14: 50,651,858 (GRCm39)	T286A	probably damaging	Het
Pacc1	A	G	1: 191,080,559 (GRCm39)		probably benign	Het
Parp8	A	T	13: 117,161,886 (GRCm39)		probably null	Het
Pcnx2	T	C	8: 126,479,023 (GRCm39)	D2075G	probably damaging	Het
Pigo	A	T	4: 43,021,460 (GRCm39)	I494K	probably benign	Het
Pkd1l1	A	T	11: 8,820,313 (GRCm39)	D1217E	probably benign	Het
Pkhd1l1	T	C	15: 44,369,040 (GRCm39)	V895A	probably benign	Het
Plcb4	A	T	2: 135,842,109 (GRCm39)	H1031L	possibly damaging	Het
Plxnb1	A	G	9: 108,937,989 (GRCm39)	K1245R	probably null	Het
Pold1	C	T	7: 44,192,181 (GRCm39)		probably benign	Het
Ptprq	T	C	10: 107,498,423 (GRCm39)	I885V	probably damaging	Het
Ptprz1	A	G	6: 23,050,473 (GRCm39)	D1398G	probably damaging	Het
Pygm	G	A	19: 6,439,917 (GRCm39)	A364T	probably benign	Het
Rbl1	T	C	2: 157,035,018 (GRCm39)	N354S	probably benign	Het
Scgb2b19	C	T	7: 32,979,037 (GRCm39)		probably null	Het
Slc26a8	C	T	17: 28,867,187 (GRCm39)	V545M	possibly damaging	Het
Slc27a1	T	A	8: 72,036,757 (GRCm39)		probably null	Het
Smpd1	A	G	7: 105,205,881 (GRCm39)	D416G	possibly damaging	Het
Sorbs3	A	G	14: 70,431,095 (GRCm39)	V284A	probably benign	Het
Stfa2l1	T	C	16: 35,982,154 (GRCm39)	V75A	probably damaging	Het
Syndig1	A	G	2: 149,772,841 (GRCm39)	D166G	probably damaging	Het
Tcp10a	G	A	17: 7,593,406 (GRCm39)		probably null	Het
Themis2	T	A	4: 132,510,212 (GRCm39)	I663F	possibly damaging	Het
Thrap3	T	C	4: 126,070,129 (GRCm39)	Q586R	probably damaging	Het
Tinag	C	A	9: 76,952,798 (GRCm39)	C62F	probably damaging	Het
Tmod1	T	C	4: 46,090,884 (GRCm39)	Y146H	probably damaging	Het
Tmprss4	T	A	9: 45,095,683 (GRCm39)	I54F	possibly damaging	Het
Tnks	A	C	8: 35,301,757 (GRCm39)		probably benign	Het
Trim43a	GATTTATTTATTTATTTATTTATTTATTTATTTATTTATT	GATTTATTTATTTATTTATTTATTTATTTATTTATTTATTTATT	9: 88,465,042 (GRCm39)		probably benign	Het
Trpc6	A	G	9: 8,680,538 (GRCm39)	E844G	probably benign	Het
Ubtd2	C	T	11: 32,466,125 (GRCm39)	R115W	probably damaging	Het
Ubxn6	T	C	17: 56,376,042 (GRCm39)	D373G	probably benign	Het
Upf1	T	A	8: 70,794,174 (GRCm39)	Q244L	probably benign	Het
Usp33	A	G	3: 152,074,271 (GRCm39)	I372M	probably damaging	Het
Usp34	A	G	11: 23,301,629 (GRCm39)	E351G	probably damaging	Het
Utrn	A	G	10: 12,554,318 (GRCm39)		probably benign	Het
Vmn1r78	A	G	7: 11,886,508 (GRCm39)	K40E	possibly damaging	Het
Vmn2r7	T	A	3: 64,632,223 (GRCm39)	M80L	probably benign	Het
Vps13a	G	T	19: 16,678,602 (GRCm39)	Y1126*	probably null	Het
Wfdc11	T	C	2: 164,506,366 (GRCm39)	N60S	probably benign	Het
Wnk2	C	T	13: 49,224,586 (GRCm39)	D992N	probably damaging	Het
Zpbp2	C	A	11: 98,444,670 (GRCm39)	T66K	probably damaging	Het

Other mutations in Lyst

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00156:Lyst	APN	13	13,823,463 (GRCm39)	missense	probably benign
IGL00474:Lyst	APN	13	13,818,121 (GRCm39)	missense	possibly damaging	0.48
IGL00484:Lyst	APN	13	13,884,188 (GRCm39)	missense	probably benign	0.02
IGL00492:Lyst	APN	13	13,852,760 (GRCm39)	missense	possibly damaging	0.54
IGL00807:Lyst	APN	13	13,825,008 (GRCm39)	missense	possibly damaging	0.91
IGL00949:Lyst	APN	13	13,810,070 (GRCm39)	missense	possibly damaging	0.87
IGL00952:Lyst	APN	13	13,852,692 (GRCm39)	missense	probably benign	0.05
IGL01305:Lyst	APN	13	13,852,641 (GRCm39)	missense	probably benign	0.01
IGL01317:Lyst	APN	13	13,845,455 (GRCm39)	missense	probably benign
IGL01419:Lyst	APN	13	13,810,423 (GRCm39)	missense	probably benign	0.00
IGL01445:Lyst	APN	13	13,826,299 (GRCm39)	missense	probably benign	0.00
IGL01690:Lyst	APN	13	13,917,831 (GRCm39)	missense	probably damaging	1.00
IGL01791:Lyst	APN	13	13,809,887 (GRCm39)	missense	probably damaging	1.00
IGL01809:Lyst	APN	13	13,812,388 (GRCm39)	missense	probably damaging	1.00
IGL01896:Lyst	APN	13	13,810,162 (GRCm39)	missense	probably benign	0.04
IGL01938:Lyst	APN	13	13,812,009 (GRCm39)	missense	possibly damaging	0.93
IGL01986:Lyst	APN	13	13,950,212 (GRCm39)	critical splice donor site	probably null
IGL02022:Lyst	APN	13	13,838,629 (GRCm39)	nonsense	probably null
IGL02044:Lyst	APN	13	13,887,431 (GRCm39)	missense	probably damaging	1.00
IGL02157:Lyst	APN	13	13,835,541 (GRCm39)	missense	probably benign
IGL02185:Lyst	APN	13	13,835,678 (GRCm39)	nonsense	probably null
IGL02215:Lyst	APN	13	13,835,541 (GRCm39)	missense	probably benign
IGL02245:Lyst	APN	13	13,835,541 (GRCm39)	missense	probably benign
IGL02246:Lyst	APN	13	13,835,541 (GRCm39)	missense	probably benign
IGL02247:Lyst	APN	13	13,835,541 (GRCm39)	missense	probably benign
IGL02297:Lyst	APN	13	13,812,677 (GRCm39)	nonsense	probably null
IGL02411:Lyst	APN	13	13,835,541 (GRCm39)	missense	probably benign
IGL02415:Lyst	APN	13	13,835,541 (GRCm39)	missense	probably benign
IGL02419:Lyst	APN	13	13,835,541 (GRCm39)	missense	probably benign
IGL02420:Lyst	APN	13	13,835,541 (GRCm39)	missense	probably benign
IGL02429:Lyst	APN	13	13,835,541 (GRCm39)	missense	probably benign
IGL02501:Lyst	APN	13	13,886,230 (GRCm39)	missense	probably benign	0.02
IGL02522:Lyst	APN	13	13,809,290 (GRCm39)	missense	possibly damaging	0.81
IGL02535:Lyst	APN	13	13,824,927 (GRCm39)	missense	probably benign	0.00
IGL02596:Lyst	APN	13	13,835,541 (GRCm39)	missense	probably benign
IGL02601:Lyst	APN	13	13,835,541 (GRCm39)	missense	probably benign
IGL02603:Lyst	APN	13	13,835,541 (GRCm39)	missense	probably benign
IGL02608:Lyst	APN	13	13,887,339 (GRCm39)	missense	probably damaging	0.98
IGL02622:Lyst	APN	13	13,855,975 (GRCm39)	missense	probably damaging	1.00
IGL02690:Lyst	APN	13	13,815,710 (GRCm39)	missense	possibly damaging	0.58
IGL02715:Lyst	APN	13	13,848,905 (GRCm39)	splice site	probably null
IGL02725:Lyst	APN	13	13,935,412 (GRCm39)	missense	probably damaging	1.00
IGL02729:Lyst	APN	13	13,921,194 (GRCm39)	missense	possibly damaging	0.95
IGL02729:Lyst	APN	13	13,848,924 (GRCm39)	missense	possibly damaging	0.81
IGL02820:Lyst	APN	13	13,812,643 (GRCm39)	missense	probably benign	0.03
IGL02945:Lyst	APN	13	13,935,783 (GRCm39)	missense	possibly damaging	0.48
IGL02981:Lyst	APN	13	13,809,496 (GRCm39)	missense	probably damaging	0.99
IGL03087:Lyst	APN	13	13,809,641 (GRCm39)	missense	probably damaging	1.00
IGL03149:Lyst	APN	13	13,856,029 (GRCm39)	missense	probably benign	0.14
IGL03158:Lyst	APN	13	13,826,337 (GRCm39)	critical splice donor site	probably null
IGL03226:Lyst	APN	13	13,884,144 (GRCm39)	missense	probably benign	0.01
IGL03242:Lyst	APN	13	13,831,466 (GRCm39)	nonsense	probably null
IGL03385:Lyst	APN	13	13,831,565 (GRCm39)	nonsense	probably null
50-cal	UTSW	13	13,882,797 (GRCm39)	critical splice donor site	probably null
charcoal	UTSW	13	13,871,346 (GRCm39)	nonsense	probably null
charlotte_gray	UTSW	13	13,602,026 (GRCm38)	intron	probably benign
charzard	UTSW	13	13,821,668 (GRCm39)	nonsense	probably null
grey_wolf	UTSW	13	0 ()	unclassified
lightspeed	UTSW	13	13,915,121 (GRCm39)	missense	possibly damaging	0.91
pardon	UTSW	13	13,852,537 (GRCm39)	missense	probably benign	0.00
robin	UTSW	13	13,823,387 (GRCm39)	nonsense	probably null
sooty	UTSW	13	0 ()	unclassified
souris	UTSW	13	13,857,808 (GRCm39)	unclassified	probably benign
Swallow	UTSW	13	13,932,007 (GRCm39)	missense	probably benign	0.00
vulpix	UTSW	13	13,871,379 (GRCm39)	splice site	probably null
ANU22:Lyst	UTSW	13	13,852,641 (GRCm39)	missense	probably benign	0.01
IGL02835:Lyst	UTSW	13	13,835,685 (GRCm39)	missense	possibly damaging	0.82
P0031:Lyst	UTSW	13	13,838,616 (GRCm39)	missense	probably damaging	1.00
R0012:Lyst	UTSW	13	13,862,279 (GRCm39)	missense	probably benign	0.10
R0012:Lyst	UTSW	13	13,862,279 (GRCm39)	missense	probably benign	0.10
R0031:Lyst	UTSW	13	13,882,741 (GRCm39)	missense	probably benign	0.14
R0115:Lyst	UTSW	13	13,852,537 (GRCm39)	missense	probably benign	0.00
R0212:Lyst	UTSW	13	13,810,570 (GRCm39)	missense	possibly damaging	0.93
R0386:Lyst	UTSW	13	13,882,799 (GRCm39)	splice site	probably benign
R0393:Lyst	UTSW	13	13,821,664 (GRCm39)	missense	probably benign	0.01
R0415:Lyst	UTSW	13	13,886,195 (GRCm39)	splice site	probably benign
R0446:Lyst	UTSW	13	13,812,633 (GRCm39)	missense	probably benign	0.00
R0481:Lyst	UTSW	13	13,852,537 (GRCm39)	missense	probably benign	0.00
R0499:Lyst	UTSW	13	13,791,298 (GRCm39)	missense	probably damaging	1.00
R0506:Lyst	UTSW	13	13,812,600 (GRCm39)	missense	probably benign
R0530:Lyst	UTSW	13	13,931,891 (GRCm39)	splice site	probably benign
R0541:Lyst	UTSW	13	13,855,878 (GRCm39)	missense	probably benign	0.00
R0570:Lyst	UTSW	13	13,883,971 (GRCm39)	missense	probably benign	0.26
R0680:Lyst	UTSW	13	13,824,926 (GRCm39)	missense	probably benign	0.01
R0842:Lyst	UTSW	13	13,852,826 (GRCm39)	nonsense	probably null
R0848:Lyst	UTSW	13	13,809,515 (GRCm39)	missense	probably benign	0.00
R1014:Lyst	UTSW	13	13,808,645 (GRCm39)	missense	possibly damaging	0.49
R1205:Lyst	UTSW	13	13,854,787 (GRCm39)	missense	probably benign
R1251:Lyst	UTSW	13	13,809,068 (GRCm39)	missense	probably benign	0.00
R1304:Lyst	UTSW	13	13,926,569 (GRCm39)	nonsense	probably null
R1398:Lyst	UTSW	13	13,915,121 (GRCm39)	missense	possibly damaging	0.91
R1475:Lyst	UTSW	13	13,882,797 (GRCm39)	critical splice donor site	probably null
R1479:Lyst	UTSW	13	13,809,067 (GRCm39)	missense	probably benign	0.00
R1484:Lyst	UTSW	13	13,852,775 (GRCm39)	missense	probably benign	0.01
R1498:Lyst	UTSW	13	13,824,960 (GRCm39)	missense	possibly damaging	0.49
R1540:Lyst	UTSW	13	13,809,686 (GRCm39)	missense	possibly damaging	0.81
R1611:Lyst	UTSW	13	13,809,482 (GRCm39)	missense	probably damaging	0.97
R1653:Lyst	UTSW	13	13,809,811 (GRCm39)	missense	probably damaging	1.00
R1669:Lyst	UTSW	13	13,818,672 (GRCm39)	missense	possibly damaging	0.90
R1686:Lyst	UTSW	13	13,809,290 (GRCm39)	missense	possibly damaging	0.81
R1694:Lyst	UTSW	13	13,835,746 (GRCm39)	missense	probably damaging	0.98
R1747:Lyst	UTSW	13	13,932,007 (GRCm39)	missense	probably benign	0.00
R1793:Lyst	UTSW	13	13,821,668 (GRCm39)	nonsense	probably null
R1871:Lyst	UTSW	13	13,826,297 (GRCm39)	missense	probably benign	0.00
R1905:Lyst	UTSW	13	13,808,719 (GRCm39)	missense	probably benign
R1958:Lyst	UTSW	13	13,791,203 (GRCm39)	missense	probably damaging	1.00
R1969:Lyst	UTSW	13	13,904,929 (GRCm39)	missense	probably damaging	0.99
R2040:Lyst	UTSW	13	13,815,807 (GRCm39)	missense	probably benign	0.00
R2109:Lyst	UTSW	13	13,887,405 (GRCm39)	missense	possibly damaging	0.46
R2116:Lyst	UTSW	13	13,810,286 (GRCm39)	missense	probably damaging	0.99
R2121:Lyst	UTSW	13	13,835,556 (GRCm39)	missense	probably damaging	1.00
R2127:Lyst	UTSW	13	13,809,847 (GRCm39)	missense	probably damaging	1.00
R2187:Lyst	UTSW	13	13,883,926 (GRCm39)	missense	possibly damaging	0.61
R2238:Lyst	UTSW	13	13,917,848 (GRCm39)	missense	probably benign	0.41
R2258:Lyst	UTSW	13	13,812,243 (GRCm39)	missense	probably benign	0.00
R2292:Lyst	UTSW	13	13,915,080 (GRCm39)	missense	probably damaging	1.00
R2368:Lyst	UTSW	13	13,871,248 (GRCm39)	missense	probably damaging	0.96
R2908:Lyst	UTSW	13	13,844,458 (GRCm39)	missense	probably benign	0.03
R3001:Lyst	UTSW	13	13,871,290 (GRCm39)	missense	probably benign
R3002:Lyst	UTSW	13	13,871,290 (GRCm39)	missense	probably benign
R3024:Lyst	UTSW	13	13,833,272 (GRCm39)	missense	probably benign
R3113:Lyst	UTSW	13	13,844,512 (GRCm39)	missense	probably benign	0.12
R3406:Lyst	UTSW	13	13,809,815 (GRCm39)	missense	possibly damaging	0.56
R3972:Lyst	UTSW	13	13,881,210 (GRCm39)	missense	possibly damaging	0.67
R3978:Lyst	UTSW	13	13,808,753 (GRCm39)	missense	possibly damaging	0.82
R4032:Lyst	UTSW	13	13,791,250 (GRCm39)	missense	probably damaging	1.00
R4192:Lyst	UTSW	13	13,915,098 (GRCm39)	missense	probably damaging	1.00
R4206:Lyst	UTSW	13	13,810,574 (GRCm39)	missense	probably benign	0.03
R4298:Lyst	UTSW	13	13,809,472 (GRCm39)	missense	probably damaging	1.00
R4344:Lyst	UTSW	13	13,873,051 (GRCm39)	missense	probably benign	0.06
R4441:Lyst	UTSW	13	13,809,968 (GRCm39)	missense	probably damaging	1.00
R4445:Lyst	UTSW	13	13,884,149 (GRCm39)	missense	probably benign	0.42
R4477:Lyst	UTSW	13	13,809,968 (GRCm39)	missense	probably damaging	1.00
R4493:Lyst	UTSW	13	13,809,968 (GRCm39)	missense	probably damaging	1.00
R4494:Lyst	UTSW	13	13,809,968 (GRCm39)	missense	probably damaging	1.00
R4495:Lyst	UTSW	13	13,809,968 (GRCm39)	missense	probably damaging	1.00
R4622:Lyst	UTSW	13	13,848,983 (GRCm39)	missense	probably benign	0.01
R4638:Lyst	UTSW	13	13,871,379 (GRCm39)	splice site	probably null
R4658:Lyst	UTSW	13	13,809,968 (GRCm39)	missense	probably damaging	1.00
R4675:Lyst	UTSW	13	13,809,968 (GRCm39)	missense	probably damaging	1.00
R4719:Lyst	UTSW	13	13,824,935 (GRCm39)	missense	probably benign
R4729:Lyst	UTSW	13	13,812,486 (GRCm39)	missense	probably damaging	1.00
R4774:Lyst	UTSW	13	13,915,182 (GRCm39)	missense	probably damaging	1.00
R4811:Lyst	UTSW	13	13,951,685 (GRCm39)	missense	probably benign	0.33
R4877:Lyst	UTSW	13	13,857,734 (GRCm39)	missense	probably damaging	1.00
R4920:Lyst	UTSW	13	13,821,645 (GRCm39)	missense	possibly damaging	0.79
R4933:Lyst	UTSW	13	13,933,963 (GRCm39)	missense	probably benign	0.12
R4933:Lyst	UTSW	13	13,812,349 (GRCm39)	missense	probably damaging	0.98
R4958:Lyst	UTSW	13	13,810,048 (GRCm39)	missense	probably benign	0.00
R4982:Lyst	UTSW	13	13,900,539 (GRCm39)	missense	probably damaging	1.00
R4992:Lyst	UTSW	13	13,835,748 (GRCm39)	missense	probably damaging	1.00
R5024:Lyst	UTSW	13	13,808,989 (GRCm39)	missense	probably benign
R5049:Lyst	UTSW	13	13,810,649 (GRCm39)	missense	probably damaging	1.00
R5079:Lyst	UTSW	13	13,931,938 (GRCm39)	missense	probably benign	0.08
R5254:Lyst	UTSW	13	13,857,655 (GRCm39)	missense	probably benign	0.00
R5266:Lyst	UTSW	13	13,835,555 (GRCm39)	missense	probably damaging	1.00
R5279:Lyst	UTSW	13	13,823,387 (GRCm39)	nonsense	probably null
R5285:Lyst	UTSW	13	13,809,011 (GRCm39)	missense	probably benign	0.01
R5364:Lyst	UTSW	13	13,831,439 (GRCm39)	missense	probably benign	0.35
R5435:Lyst	UTSW	13	13,951,649 (GRCm39)	missense	possibly damaging	0.64
R5516:Lyst	UTSW	13	13,818,707 (GRCm39)	missense	probably benign	0.10
R5524:Lyst	UTSW	13	13,921,364 (GRCm39)	missense	probably benign	0.03
R5591:Lyst	UTSW	13	13,917,918 (GRCm39)	missense	probably damaging	0.99
R5592:Lyst	UTSW	13	13,917,918 (GRCm39)	missense	probably damaging	0.99
R5593:Lyst	UTSW	13	13,917,918 (GRCm39)	missense	probably damaging	0.99
R5594:Lyst	UTSW	13	13,917,918 (GRCm39)	missense	probably damaging	0.99
R5594:Lyst	UTSW	13	13,933,982 (GRCm39)	missense	probably benign	0.00
R5644:Lyst	UTSW	13	13,812,081 (GRCm39)	missense	possibly damaging	0.58
R5659:Lyst	UTSW	13	13,809,212 (GRCm39)	missense	possibly damaging	0.58
R5741:Lyst	UTSW	13	13,808,615 (GRCm39)	missense	probably benign	0.44
R5908:Lyst	UTSW	13	13,871,346 (GRCm39)	nonsense	probably null
R5969:Lyst	UTSW	13	13,862,398 (GRCm39)	splice site	probably null
R6128:Lyst	UTSW	13	13,933,964 (GRCm39)	missense	possibly damaging	0.67
R6271:Lyst	UTSW	13	13,833,339 (GRCm39)	missense	probably benign	0.30
R6315:Lyst	UTSW	13	13,818,089 (GRCm39)	missense	probably benign
R6318:Lyst	UTSW	13	13,917,896 (GRCm39)	missense	possibly damaging	0.88
R6555:Lyst	UTSW	13	13,823,510 (GRCm39)	missense	probably benign	0.01
R6663:Lyst	UTSW	13	13,838,701 (GRCm39)	splice site	probably null
R6701:Lyst	UTSW	13	13,856,070 (GRCm39)	missense	probably benign	0.06
R6711:Lyst	UTSW	13	13,809,820 (GRCm39)	missense	possibly damaging	0.80
R6909:Lyst	UTSW	13	13,917,960 (GRCm39)	missense	probably damaging	1.00
R6915:Lyst	UTSW	13	13,900,629 (GRCm39)	missense	probably benign	0.01
R6929:Lyst	UTSW	13	13,917,909 (GRCm39)	missense	probably damaging	1.00
R6960:Lyst	UTSW	13	13,808,663 (GRCm39)	missense	probably benign	0.12
R7018:Lyst	UTSW	13	13,918,044 (GRCm39)	critical splice donor site	probably null
R7037:Lyst	UTSW	13	13,791,251 (GRCm39)	missense	probably damaging	1.00
R7045:Lyst	UTSW	13	13,812,293 (GRCm39)	missense	probably damaging	1.00
R7045:Lyst	UTSW	13	13,809,485 (GRCm39)	missense	probably benign	0.34
R7070:Lyst	UTSW	13	13,932,029 (GRCm39)	missense	probably benign	0.23
R7188:Lyst	UTSW	13	13,926,675 (GRCm39)	missense	possibly damaging	0.66
R7201:Lyst	UTSW	13	13,883,885 (GRCm39)	nonsense	probably null
R7210:Lyst	UTSW	13	13,831,568 (GRCm39)	missense	probably damaging	1.00
R7229:Lyst	UTSW	13	13,818,094 (GRCm39)	missense	probably benign	0.00
R7293:Lyst	UTSW	13	13,854,822 (GRCm39)	missense	probably benign	0.01
R7318:Lyst	UTSW	13	13,932,028 (GRCm39)	missense	probably benign	0.13
R7344:Lyst	UTSW	13	13,881,140 (GRCm39)	missense	probably benign
R7426:Lyst	UTSW	13	13,812,109 (GRCm39)	missense	probably benign
R7522:Lyst	UTSW	13	13,821,668 (GRCm39)	nonsense	probably null
R7583:Lyst	UTSW	13	13,810,472 (GRCm39)	missense	probably damaging	1.00
R7606:Lyst	UTSW	13	13,812,060 (GRCm39)	missense	probably damaging	1.00
R7636:Lyst	UTSW	13	13,791,332 (GRCm39)	critical splice donor site	probably null
R7658:Lyst	UTSW	13	13,905,061 (GRCm39)	missense	possibly damaging	0.63
R7685:Lyst	UTSW	13	13,844,450 (GRCm39)	missense	probably benign	0.00
R7689:Lyst	UTSW	13	13,857,808 (GRCm39)	critical splice donor site	probably null
R7765:Lyst	UTSW	13	13,884,117 (GRCm39)	missense	possibly damaging	0.75
R7779:Lyst	UTSW	13	13,809,128 (GRCm39)	missense	probably damaging	1.00
R7871:Lyst	UTSW	13	13,810,637 (GRCm39)	nonsense	probably null
R7872:Lyst	UTSW	13	13,810,450 (GRCm39)	missense	probably benign	0.14
R7884:Lyst	UTSW	13	13,882,268 (GRCm39)	missense	probably benign	0.09
R7890:Lyst	UTSW	13	13,915,154 (GRCm39)	missense	probably damaging	0.99
R7916:Lyst	UTSW	13	13,821,657 (GRCm39)	missense	possibly damaging	0.64
R7948:Lyst	UTSW	13	13,921,174 (GRCm39)	missense	possibly damaging	0.59
R7956:Lyst	UTSW	13	13,815,788 (GRCm39)	missense	possibly damaging	0.80
R8048:Lyst	UTSW	13	13,862,230 (GRCm39)	missense	probably benign	0.12
R8085:Lyst	UTSW	13	13,808,894 (GRCm39)	missense	probably damaging	0.98
R8165:Lyst	UTSW	13	13,872,945 (GRCm39)	missense	probably damaging	0.99
R8235:Lyst	UTSW	13	13,935,323 (GRCm39)	missense	possibly damaging	0.69
R8237:Lyst	UTSW	13	13,826,317 (GRCm39)	missense	probably benign	0.00
R8275:Lyst	UTSW	13	13,950,667 (GRCm39)	missense	probably benign	0.02
R8300:Lyst	UTSW	13	13,838,643 (GRCm39)	missense	possibly damaging	0.79
R8350:Lyst	UTSW	13	13,824,973 (GRCm39)	nonsense	probably null
R8526:Lyst	UTSW	13	13,935,391 (GRCm39)	missense	probably damaging	0.99
R8551:Lyst	UTSW	13	13,808,645 (GRCm39)	missense	possibly damaging	0.77
R8723:Lyst	UTSW	13	13,887,342 (GRCm39)	missense	possibly damaging	0.89
R8772:Lyst	UTSW	13	13,812,077 (GRCm39)	nonsense	probably null
R8778:Lyst	UTSW	13	13,903,152 (GRCm39)	missense	possibly damaging	0.89
R8778:Lyst	UTSW	13	13,810,361 (GRCm39)	missense	possibly damaging	0.89
R8801:Lyst	UTSW	13	13,835,595 (GRCm39)	missense	probably benign	0.10
R8837:Lyst	UTSW	13	13,852,548 (GRCm39)	missense	probably benign
R8874:Lyst	UTSW	13	13,812,147 (GRCm39)	missense	probably benign
R8878:Lyst	UTSW	13	13,815,661 (GRCm39)	missense	probably benign	0.00
R8891:Lyst	UTSW	13	13,887,435 (GRCm39)	missense	possibly damaging	0.67
R9077:Lyst	UTSW	13	13,857,693 (GRCm39)	missense	probably benign	0.02
R9127:Lyst	UTSW	13	13,808,827 (GRCm39)	missense	probably damaging	1.00
R9143:Lyst	UTSW	13	13,835,750 (GRCm39)	missense	probably damaging	0.98
R9216:Lyst	UTSW	13	13,823,188 (GRCm39)	missense	probably benign
R9217:Lyst	UTSW	13	13,871,245 (GRCm39)	missense	probably benign	0.01
R9291:Lyst	UTSW	13	13,883,938 (GRCm39)	missense	probably benign	0.01
R9302:Lyst	UTSW	13	13,904,947 (GRCm39)	missense	possibly damaging	0.46
R9370:Lyst	UTSW	13	13,935,333 (GRCm39)	missense	probably damaging	1.00
R9402:Lyst	UTSW	13	13,812,463 (GRCm39)	missense	probably benign
R9457:Lyst	UTSW	13	13,862,330 (GRCm39)	missense	possibly damaging	0.83
R9481:Lyst	UTSW	13	13,857,653 (GRCm39)	missense	possibly damaging	0.68
R9563:Lyst	UTSW	13	13,812,408 (GRCm39)	missense	probably benign	0.36
R9623:Lyst	UTSW	13	13,852,587 (GRCm39)	missense	probably benign
R9661:Lyst	UTSW	13	13,808,779 (GRCm39)	missense	probably benign	0.01
R9682:Lyst	UTSW	13	13,831,526 (GRCm39)	missense	probably benign	0.21
R9743:Lyst	UTSW	13	13,809,323 (GRCm39)	missense	possibly damaging	0.67
R9801:Lyst	UTSW	13	13,809,290 (GRCm39)	missense	probably damaging	0.97
RF001:Lyst	UTSW	13	13,810,426 (GRCm39)	missense	probably benign
RF002:Lyst	UTSW	13	13,808,948 (GRCm39)	missense	probably benign	0.05
X0024:Lyst	UTSW	13	13,809,033 (GRCm39)	missense	probably benign	0.00
X0026:Lyst	UTSW	13	13,926,555 (GRCm39)	missense	probably damaging	0.99
Z1088:Lyst	UTSW	13	13,918,018 (GRCm39)	missense	probably benign	0.09
Z1176:Lyst	UTSW	13	13,951,664 (GRCm39)	missense	probably benign	0.27
Z1176:Lyst	UTSW	13	13,814,692 (GRCm39)	missense	probably damaging	1.00
Z1177:Lyst	UTSW	13	13,854,719 (GRCm39)	missense	possibly damaging	0.73

Predicted Primers

PCR Primer
(F):5'- GCTAGGCAAGCGTAATAGCTTCATTCA -3'
(R):5'- ATTCATACCTTCTCAGTCACAGCATCAC -3'

Sequencing Primer
(F):5'- gccatctccccagcctc -3'
(R):5'- GTCACAGCATCACCAGGG -3'

Posted On

2014-03-14