Incidental Mutation 'R1332:Vmn2r86'
ID 156746
Institutional Source Beutler Lab
Gene Symbol Vmn2r86
Ensembl Gene ENSMUSG00000092162
Gene Name vomeronasal 2, receptor 86
Synonyms EG625109
MMRRC Submission 039397-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.080) question?
Stock # R1332 (G1)
Quality Score 225
Status Validated
Chromosome 10
Chromosomal Location 130282068-130291763 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 130282739 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Phenylalanine at position 626 (L626F)
Ref Sequence ENSEMBL: ENSMUSP00000126596 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000170257]
AlphaFold G5E8Y4
Predicted Effect probably damaging
Transcript: ENSMUST00000170257
AA Change: L626F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000126596
Gene: ENSMUSG00000092162
AA Change: L626F

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
Pfam:ANF_receptor 77 425 1.1e-25 PFAM
Pfam:NCD3G 508 562 2.4e-19 PFAM
Pfam:7tm_3 595 829 6.4e-55 PFAM
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.2%
  • 10x: 96.1%
  • 20x: 93.0%
Validation Efficiency 100% (35/35)
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933415A04Rik T TNNNNNNNNNNNNNNNNNN 11: 43,478,256 (GRCm39) probably benign Het
Abhd14b A T 9: 106,329,195 (GRCm39) I42F probably damaging Het
Apbb1 A T 7: 105,214,750 (GRCm39) I498N possibly damaging Het
Asah2 A G 19: 32,022,341 (GRCm39) I231T probably damaging Het
Bid C T 6: 120,874,216 (GRCm39) A110T possibly damaging Het
Caskin2 C T 11: 115,694,171 (GRCm39) probably benign Het
Ccdc141 T C 2: 76,844,784 (GRCm39) T1428A probably damaging Het
Cd22 A C 7: 30,569,912 (GRCm39) W477G possibly damaging Het
Cox16 T C 12: 81,519,064 (GRCm39) D89G probably damaging Het
Dnah17 A G 11: 117,934,041 (GRCm39) I3511T possibly damaging Het
Dpy19l4 A T 4: 11,276,901 (GRCm39) Y333N probably damaging Het
Eya2 T C 2: 165,529,528 (GRCm39) probably benign Het
Fras1 A G 5: 96,855,167 (GRCm39) D1892G probably benign Het
Hlf G T 11: 90,231,679 (GRCm39) S265* probably null Het
Immt T C 6: 71,823,256 (GRCm39) probably benign Het
Lair1 T C 7: 4,013,595 (GRCm39) E36G possibly damaging Het
Lrfn5 T C 12: 61,904,314 (GRCm39) probably benign Het
Nos1ap T C 1: 170,177,001 (GRCm39) N134S probably damaging Het
Ogfod1 T C 8: 94,784,727 (GRCm39) C344R probably damaging Het
Or6c212 A G 10: 129,559,116 (GRCm39) L99S probably damaging Het
Pkhd1l1 G A 15: 44,368,943 (GRCm39) V863I probably damaging Het
Pmfbp1 T G 8: 110,256,898 (GRCm39) I534S probably damaging Het
Prex2 A G 1: 11,274,315 (GRCm39) D1329G probably damaging Het
Rasal2 T C 1: 157,003,391 (GRCm39) T423A probably benign Het
Rif1 T A 2: 51,968,326 (GRCm39) W170R probably benign Het
Scarb2 C T 5: 92,599,205 (GRCm39) probably null Het
Stard9 C A 2: 120,504,117 (GRCm39) S221R probably damaging Het
Tlr3 A C 8: 45,851,774 (GRCm39) N374K probably damaging Het
Uck1 T C 2: 32,149,666 (GRCm39) D71G probably damaging Het
Vcan C T 13: 89,841,174 (GRCm39) E497K probably damaging Het
Vmn2r89 A G 14: 51,692,559 (GRCm39) T121A probably benign Het
Wdr64 T C 1: 175,622,706 (GRCm39) S828P possibly damaging Het
Zfp334 A T 2: 165,222,776 (GRCm39) H422Q probably damaging Het
Other mutations in Vmn2r86
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01295:Vmn2r86 APN 10 130,288,895 (GRCm39) missense probably damaging 0.99
IGL01328:Vmn2r86 APN 10 130,288,365 (GRCm39) missense possibly damaging 0.78
IGL01377:Vmn2r86 APN 10 130,288,855 (GRCm39) missense probably damaging 0.99
IGL01548:Vmn2r86 APN 10 130,282,151 (GRCm39) missense probably benign 0.22
IGL01804:Vmn2r86 APN 10 130,288,858 (GRCm39) missense probably damaging 0.99
IGL01921:Vmn2r86 APN 10 130,291,610 (GRCm39) missense probably benign 0.00
IGL02406:Vmn2r86 APN 10 130,284,508 (GRCm39) missense possibly damaging 0.81
IGL02625:Vmn2r86 APN 10 130,288,781 (GRCm39) missense probably damaging 1.00
IGL02960:Vmn2r86 APN 10 130,289,636 (GRCm39) missense possibly damaging 0.74
IGL03104:Vmn2r86 APN 10 130,282,501 (GRCm39) missense probably damaging 1.00
R0408:Vmn2r86 UTSW 10 130,282,723 (GRCm39) missense probably damaging 1.00
R0437:Vmn2r86 UTSW 10 130,282,412 (GRCm39) missense probably damaging 1.00
R0577:Vmn2r86 UTSW 10 130,288,444 (GRCm39) missense probably benign 0.04
R0726:Vmn2r86 UTSW 10 130,282,265 (GRCm39) missense probably damaging 1.00
R0811:Vmn2r86 UTSW 10 130,289,497 (GRCm39) missense probably benign 0.00
R0812:Vmn2r86 UTSW 10 130,289,497 (GRCm39) missense probably benign 0.00
R1055:Vmn2r86 UTSW 10 130,282,226 (GRCm39) missense probably damaging 1.00
R1066:Vmn2r86 UTSW 10 130,282,145 (GRCm39) missense probably benign 0.01
R1199:Vmn2r86 UTSW 10 130,284,443 (GRCm39) splice site probably benign
R1568:Vmn2r86 UTSW 10 130,289,010 (GRCm39) missense probably benign 0.09
R1866:Vmn2r86 UTSW 10 130,282,255 (GRCm39) missense probably damaging 1.00
R1897:Vmn2r86 UTSW 10 130,288,314 (GRCm39) missense probably damaging 1.00
R2017:Vmn2r86 UTSW 10 130,282,582 (GRCm39) missense probably benign 0.39
R3162:Vmn2r86 UTSW 10 130,291,673 (GRCm39) missense probably damaging 0.99
R3162:Vmn2r86 UTSW 10 130,291,673 (GRCm39) missense probably damaging 0.99
R3858:Vmn2r86 UTSW 10 130,291,594 (GRCm39) missense probably benign
R4049:Vmn2r86 UTSW 10 130,282,966 (GRCm39) missense probably damaging 0.98
R4378:Vmn2r86 UTSW 10 130,288,469 (GRCm39) missense possibly damaging 0.67
R4411:Vmn2r86 UTSW 10 130,288,469 (GRCm39) missense possibly damaging 0.67
R4413:Vmn2r86 UTSW 10 130,288,469 (GRCm39) missense possibly damaging 0.67
R4422:Vmn2r86 UTSW 10 130,288,845 (GRCm39) missense possibly damaging 0.87
R4738:Vmn2r86 UTSW 10 130,282,939 (GRCm39) missense probably damaging 0.99
R4767:Vmn2r86 UTSW 10 130,291,606 (GRCm39) missense probably benign 0.00
R4872:Vmn2r86 UTSW 10 130,289,460 (GRCm39) missense probably damaging 0.98
R4880:Vmn2r86 UTSW 10 130,289,484 (GRCm39) missense probably benign 0.33
R5092:Vmn2r86 UTSW 10 130,282,456 (GRCm39) missense probably damaging 1.00
R5421:Vmn2r86 UTSW 10 130,282,805 (GRCm39) missense probably benign 0.41
R6007:Vmn2r86 UTSW 10 130,289,535 (GRCm39) missense probably damaging 1.00
R6330:Vmn2r86 UTSW 10 130,282,396 (GRCm39) missense probably benign 0.05
R6355:Vmn2r86 UTSW 10 130,291,763 (GRCm39) start codon destroyed probably damaging 0.98
R6397:Vmn2r86 UTSW 10 130,282,131 (GRCm39) nonsense probably null
R6419:Vmn2r86 UTSW 10 130,282,795 (GRCm39) missense probably damaging 1.00
R6933:Vmn2r86 UTSW 10 130,282,126 (GRCm39) missense probably damaging 1.00
R6937:Vmn2r86 UTSW 10 130,284,523 (GRCm39) missense probably damaging 1.00
R6959:Vmn2r86 UTSW 10 130,282,400 (GRCm39) missense probably damaging 1.00
R7010:Vmn2r86 UTSW 10 130,291,726 (GRCm39) missense probably benign
R7549:Vmn2r86 UTSW 10 130,282,697 (GRCm39) missense probably damaging 1.00
R8179:Vmn2r86 UTSW 10 130,288,953 (GRCm39) missense probably benign 0.00
R8257:Vmn2r86 UTSW 10 130,288,279 (GRCm39) missense possibly damaging 0.87
R8286:Vmn2r86 UTSW 10 130,285,855 (GRCm39) missense probably benign 0.03
R8479:Vmn2r86 UTSW 10 130,282,735 (GRCm39) missense probably damaging 1.00
R8805:Vmn2r86 UTSW 10 130,282,396 (GRCm39) missense probably benign 0.05
R8960:Vmn2r86 UTSW 10 130,289,672 (GRCm39) missense probably benign 0.27
R9021:Vmn2r86 UTSW 10 130,282,934 (GRCm39) missense probably damaging 1.00
R9120:Vmn2r86 UTSW 10 130,289,677 (GRCm39) missense probably benign 0.00
R9137:Vmn2r86 UTSW 10 130,282,409 (GRCm39) missense probably damaging 1.00
R9311:Vmn2r86 UTSW 10 130,288,440 (GRCm39) missense probably damaging 1.00
R9312:Vmn2r86 UTSW 10 130,288,406 (GRCm39) missense probably benign 0.02
R9433:Vmn2r86 UTSW 10 130,282,567 (GRCm39) missense possibly damaging 0.88
R9696:Vmn2r86 UTSW 10 130,285,702 (GRCm39) missense possibly damaging 0.49
Predicted Primers PCR Primer
(F):5'- TTCCTAGCCAGGAAAGCCACAATG -3'
(R):5'- GCCAATTTAGAGCAAATGCACTGCC -3'

Sequencing Primer
(F):5'- AAGGACAGAGCCTTTGTTGC -3'
(R):5'- ACTGCCTCCAAAGAGCTGTG -3'
Posted On 2014-02-11