Incidental Mutation 'R1363:Cdc14a'
ID 156352
Institutional Source Beutler Lab
Gene Symbol Cdc14a
Ensembl Gene ENSMUSG00000033502
Gene Name CDC14 cell division cycle 14A
Synonyms A830059A17Rik, CDC14a1, CDC14A2, Cdc14
MMRRC Submission 039428-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.229) question?
Stock # R1363 (G1)
Quality Score 101
Status Not validated
Chromosome 3
Chromosomal Location 116066202-116222390 bp(-) (GRCm39)
Type of Mutation small deletion (1 aa in frame mutation)
DNA Base Change (assembly) CGCTGCTGCTGCTGCTGCTG to CGCTGCTGCTGCTGCTG at 116087509 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000102100 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000090464] [ENSMUST00000106491]
AlphaFold Q6GQT0
Predicted Effect probably benign
Transcript: ENSMUST00000090464
SMART Domains Protein: ENSMUSP00000087950
Gene: ENSMUSG00000033502

DomainStartEndE-ValueType
Pfam:DSPn 13 153 1.6e-66 PFAM
Pfam:Y_phosphatase 210 324 1.1e-7 PFAM
Pfam:DSPc 214 328 1.8e-14 PFAM
low complexity region 539 558 N/A INTRINSIC
low complexity region 573 595 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000106491
SMART Domains Protein: ENSMUSP00000102100
Gene: ENSMUSG00000033502

DomainStartEndE-ValueType
Pfam:DSPn 12 121 9.5e-44 PFAM
Pfam:Y_phosphatase 160 274 6.4e-8 PFAM
Pfam:DSPc 160 280 2.8e-14 PFAM
low complexity region 490 509 N/A INTRINSIC
low complexity region 524 546 N/A INTRINSIC
Coding Region Coverage
  • 1x: 98.6%
  • 3x: 97.1%
  • 10x: 92.3%
  • 20x: 80.9%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. It is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, suggesting a role in cell cycle control. This protein has been shown to interact with, and dephosphorylate tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splicing of this gene results in several transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 18 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ccdc88b T A 19: 6,827,739 (GRCm39) Y921F possibly damaging Het
Cct7 G T 6: 85,443,017 (GRCm39) D265Y probably damaging Het
Csf1r A G 18: 61,257,917 (GRCm39) M629V possibly damaging Het
Dlk1 G T 12: 109,421,430 (GRCm39) G48V probably damaging Het
Fancc T C 13: 63,509,412 (GRCm39) Y60C probably damaging Het
Ifi204 C T 1: 173,576,862 (GRCm39) V580I probably benign Het
Irs1 A G 1: 82,265,009 (GRCm39) V1069A probably benign Het
Plxna2 C T 1: 194,487,247 (GRCm39) Q1601* probably null Het
Psmg2 CTTCAGTT CTTCAGTTCAGTT 18: 67,779,095 (GRCm39) probably null Het
Ptpn14 C A 1: 189,530,825 (GRCm39) F97L probably damaging Het
Rasl10b G A 11: 83,308,665 (GRCm39) probably null Het
Rnf6 A T 5: 146,148,369 (GRCm39) F216L probably benign Het
Rps24 A G 14: 24,541,830 (GRCm39) T6A probably damaging Het
Scyl3 A G 1: 163,778,259 (GRCm39) I466V probably benign Het
Slc7a11 T C 3: 50,378,500 (GRCm39) Y246C probably damaging Het
Stk33 A T 7: 108,879,028 (GRCm39) S440R probably benign Het
Ttbk2 T C 2: 120,637,389 (GRCm39) probably null Het
Vmn2r105 T A 17: 20,428,932 (GRCm39) T715S probably benign Het
Other mutations in Cdc14a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00801:Cdc14a APN 3 116,088,493 (GRCm39) nonsense probably null
IGL01062:Cdc14a APN 3 116,068,361 (GRCm39) splice site probably benign
IGL01584:Cdc14a APN 3 116,186,474 (GRCm39) nonsense probably null
IGL03084:Cdc14a APN 3 116,142,101 (GRCm39) critical splice donor site probably null
IGL03237:Cdc14a APN 3 116,198,275 (GRCm39) intron probably benign
IGL03296:Cdc14a APN 3 116,090,807 (GRCm39) missense probably benign 0.02
PIT4131001:Cdc14a UTSW 3 116,122,310 (GRCm39) missense possibly damaging 0.66
R0707:Cdc14a UTSW 3 116,087,362 (GRCm39) splice site probably benign
R0782:Cdc14a UTSW 3 116,115,785 (GRCm39) missense probably damaging 1.00
R0835:Cdc14a UTSW 3 116,122,171 (GRCm39) missense probably benign 0.12
R1507:Cdc14a UTSW 3 116,087,646 (GRCm39) missense possibly damaging 0.47
R1545:Cdc14a UTSW 3 116,087,373 (GRCm39) critical splice donor site probably null
R1795:Cdc14a UTSW 3 116,092,122 (GRCm39) missense possibly damaging 0.81
R1797:Cdc14a UTSW 3 116,115,843 (GRCm39) missense probably damaging 1.00
R1830:Cdc14a UTSW 3 116,216,296 (GRCm39) nonsense probably null
R4229:Cdc14a UTSW 3 116,087,413 (GRCm39) missense probably damaging 0.99
R4655:Cdc14a UTSW 3 116,122,136 (GRCm39) missense probably damaging 1.00
R4769:Cdc14a UTSW 3 116,088,399 (GRCm39) critical splice donor site probably null
R4870:Cdc14a UTSW 3 116,217,109 (GRCm39) missense probably benign 0.30
R4980:Cdc14a UTSW 3 116,186,506 (GRCm39) nonsense probably null
R6228:Cdc14a UTSW 3 116,144,862 (GRCm39) missense probably damaging 1.00
R6248:Cdc14a UTSW 3 116,101,843 (GRCm39) missense probably benign 0.01
R6402:Cdc14a UTSW 3 116,142,108 (GRCm39) missense probably damaging 1.00
R6749:Cdc14a UTSW 3 116,090,807 (GRCm39) missense possibly damaging 0.68
R6852:Cdc14a UTSW 3 116,122,325 (GRCm39) missense possibly damaging 0.94
R6996:Cdc14a UTSW 3 116,122,355 (GRCm39) missense probably damaging 1.00
R7185:Cdc14a UTSW 3 116,087,676 (GRCm39) missense probably benign
R7783:Cdc14a UTSW 3 116,198,236 (GRCm39) missense probably damaging 1.00
R7896:Cdc14a UTSW 3 116,088,482 (GRCm39) missense probably benign 0.00
R7991:Cdc14a UTSW 3 116,101,887 (GRCm39) missense probably benign 0.01
R8049:Cdc14a UTSW 3 116,087,577 (GRCm39) missense probably benign 0.33
R9163:Cdc14a UTSW 3 116,122,213 (GRCm39) missense possibly damaging 0.95
R9434:Cdc14a UTSW 3 116,217,092 (GRCm39) missense probably benign
R9526:Cdc14a UTSW 3 116,087,509 (GRCm39) small deletion probably benign
R9662:Cdc14a UTSW 3 116,088,484 (GRCm39) missense probably damaging 0.99
R9781:Cdc14a UTSW 3 116,122,274 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- CCAGAGGTGGTGTCTGTGAACTTAC -3'
(R):5'- ACGACCAGTCAGTGTTCAAGCC -3'

Sequencing Primer
(F):5'- ACTTACAGGTATAGAACGGCTC -3'
(R):5'- TCTAGGGAACTTGAACGCC -3'
Posted On 2014-02-11