Incidental Mutation 'R0041:Prss59'
ID 15633
Institutional Source Beutler Lab
Gene Symbol Prss59
Ensembl Gene ENSMUSG00000029883
Gene Name serine protease 59
Synonyms Tryx5, 1700074P13Rik
MMRRC Submission 038335-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.051) question?
Stock # R0041 (G1)
Quality Score
Status Validated
Chromosome 6
Chromosomal Location 40897371-40917491 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 40903042 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Stop codon at position 110 (L110*)
Ref Sequence ENSEMBL: ENSMUSP00000116538 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000031935] [ENSMUST00000122181] [ENSMUST00000136499]
AlphaFold Q9D9G7
Predicted Effect probably null
Transcript: ENSMUST00000031935
AA Change: L110*
SMART Domains Protein: ENSMUSP00000031935
Gene: ENSMUSG00000029883
AA Change: L110*

DomainStartEndE-ValueType
Tryp_SPc 24 244 4.27e-19 SMART
Predicted Effect probably null
Transcript: ENSMUST00000122181
AA Change: L110*
SMART Domains Protein: ENSMUSP00000112987
Gene: ENSMUSG00000029883
AA Change: L110*

DomainStartEndE-ValueType
Tryp_SPc 24 244 4.27e-19 SMART
Predicted Effect probably null
Transcript: ENSMUST00000136499
AA Change: L110*
SMART Domains Protein: ENSMUSP00000116538
Gene: ENSMUSG00000029883
AA Change: L110*

DomainStartEndE-ValueType
Tryp_SPc 24 174 6.08e-5 SMART
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 77.6%
  • 3x: 65.6%
  • 10x: 37.8%
  • 20x: 19.1%
Validation Efficiency 90% (47/52)
Allele List at MGI

All alleles(1) : Targeted(1)

Other mutations in this stock
Total: 24 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgra3 A G 5: 50,117,901 (GRCm39) Y1216H probably benign Het
Avpi1 C A 19: 42,112,223 (GRCm39) E112* probably null Het
Braf C T 6: 39,617,413 (GRCm39) A534T probably damaging Het
Cntnap5c C A 17: 58,183,464 (GRCm39) Q57K probably benign Het
Dlk1 G C 12: 109,421,439 (GRCm39) G50A probably damaging Het
Dtna C T 18: 23,779,932 (GRCm39) probably benign Het
Fancm T A 12: 65,153,217 (GRCm39) C1224* probably null Het
Gigyf2 A C 1: 87,306,698 (GRCm39) R129S probably damaging Het
Kcnk2 G T 1: 189,027,888 (GRCm39) N122K probably benign Het
Lrrc7 G A 3: 157,869,897 (GRCm39) probably benign Het
Msto1 A G 3: 88,817,542 (GRCm39) S464P probably damaging Het
Myh1 A C 11: 67,099,904 (GRCm39) N605H possibly damaging Het
Olfml1 A T 7: 107,189,393 (GRCm39) I153L possibly damaging Het
Plekhg1 T A 10: 3,914,074 (GRCm39) N1265K probably benign Het
Rlf T A 4: 121,007,126 (GRCm39) H618L probably damaging Het
Rock1 T C 18: 10,140,240 (GRCm39) D117G probably damaging Het
Serpinb6d A G 13: 33,851,615 (GRCm39) D124G probably damaging Het
Slco1a1 A G 6: 141,864,185 (GRCm39) probably benign Het
Swap70 A G 7: 109,878,562 (GRCm39) K511E probably benign Het
Synb T C 14: 69,747,926 (GRCm39) T193A probably damaging Het
Syt11 A G 3: 88,655,210 (GRCm39) Y364H probably damaging Het
Vcan T A 13: 89,810,104 (GRCm39) H3229L probably damaging Het
Wdr64 G A 1: 175,554,037 (GRCm39) W189* probably null Het
Zfp1001 A G 2: 150,165,745 (GRCm39) I42V possibly damaging Het
Other mutations in Prss59
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03151:Prss59 APN 6 40,902,946 (GRCm39) missense probably damaging 1.00
R0041:Prss59 UTSW 6 40,903,042 (GRCm39) nonsense probably null
R0686:Prss59 UTSW 6 40,905,452 (GRCm39) missense probably damaging 0.99
R0799:Prss59 UTSW 6 40,905,533 (GRCm39) missense probably damaging 0.97
R1250:Prss59 UTSW 6 40,902,909 (GRCm39) critical splice donor site probably null
R1499:Prss59 UTSW 6 40,898,652 (GRCm39) missense probably benign 0.26
R1678:Prss59 UTSW 6 40,906,453 (GRCm39) start gained probably benign
R1755:Prss59 UTSW 6 40,903,096 (GRCm39) missense probably damaging 0.99
R1891:Prss59 UTSW 6 40,902,967 (GRCm39) missense possibly damaging 0.73
R3160:Prss59 UTSW 6 40,903,003 (GRCm39) missense probably benign 0.05
R3162:Prss59 UTSW 6 40,903,003 (GRCm39) missense probably benign 0.05
R4194:Prss59 UTSW 6 40,898,005 (GRCm39) missense probably damaging 1.00
R4750:Prss59 UTSW 6 40,897,955 (GRCm39) missense probably damaging 1.00
R6197:Prss59 UTSW 6 40,897,939 (GRCm39) missense probably benign 0.05
R6217:Prss59 UTSW 6 40,903,019 (GRCm39) missense possibly damaging 0.88
R6394:Prss59 UTSW 6 40,898,726 (GRCm39) nonsense probably null
R7966:Prss59 UTSW 6 40,903,022 (GRCm39) missense probably benign 0.02
R7991:Prss59 UTSW 6 40,905,444 (GRCm39) critical splice donor site probably null
R8937:Prss59 UTSW 6 40,902,999 (GRCm39) nonsense probably null
R8983:Prss59 UTSW 6 40,897,934 (GRCm39) missense possibly damaging 0.87
R9354:Prss59 UTSW 6 40,905,473 (GRCm39) missense probably damaging 1.00
Posted On 2012-12-21