Incidental Mutation 'IGL01837:Naa15'
ID 155005
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Naa15
Ensembl Gene ENSMUSG00000063273
Gene Name N(alpha)-acetyltransferase 15, NatA auxiliary subunit
Synonyms Narg1, 5730450D16Rik, ASTBDN, Tbdn-1, tubedown, mNAT1
Accession Numbers
Essential gene? Probably essential (E-score: 0.964) question?
Stock # IGL01837
Quality Score
Status
Chromosome 3
Chromosomal Location 51323437-51383406 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 51351369 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Stop codon at position 180 (K180*)
Ref Sequence ENSEMBL: ENSMUSP00000141433 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000029303] [ENSMUST00000192419] [ENSMUST00000193266]
AlphaFold no structure available at present
Predicted Effect probably null
Transcript: ENSMUST00000029303
AA Change: K230*
SMART Domains Protein: ENSMUSP00000029303
Gene: ENSMUSG00000063273
AA Change: K230*

DomainStartEndE-ValueType
TPR 46 79 6.24e1 SMART
TPR 80 113 1.01e0 SMART
Blast:TPR 224 257 3e-12 BLAST
TPR 374 407 1.87e1 SMART
TPR 408 441 5.06e1 SMART
low complexity region 603 641 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000192197
AA Change: K148*
Predicted Effect probably benign
Transcript: ENSMUST00000192419
SMART Domains Protein: ENSMUSP00000141965
Gene: ENSMUSG00000063273

DomainStartEndE-ValueType
Blast:TPR 1 29 8e-12 BLAST
Pfam:TPR_2 30 63 3.4e-5 PFAM
Pfam:TPR_8 30 63 2.6e-4 PFAM
Pfam:TPR_11 31 95 4.8e-7 PFAM
Pfam:TPR_7 32 65 1.5e-2 PFAM
Pfam:TPR_1 37 63 1.6e-4 PFAM
Pfam:TPR_9 38 85 1e-2 PFAM
Pfam:TPR_9 88 126 1.2e0 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000192523
Predicted Effect probably null
Transcript: ENSMUST00000193266
AA Change: K180*
SMART Domains Protein: ENSMUSP00000141433
Gene: ENSMUSG00000063273
AA Change: K180*

DomainStartEndE-ValueType
Blast:TPR 1 29 3e-10 BLAST
TPR 30 63 4.9e-3 SMART
Blast:TPR 174 207 3e-12 BLAST
TPR 324 357 8.9e-2 SMART
TPR 358 391 2.4e-1 SMART
coiled coil region 533 585 N/A INTRINSIC
Blast:TPR 622 655 7e-10 BLAST
Predicted Effect noncoding transcript
Transcript: ENSMUST00000195430
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] N-alpha-acetylation is among the most common post-translational protein modifications in eukaryotic cells. This process involves the transfer of an acetyl group from acetyl-coenzyme A to the alpha-amino group on a nascent polypeptide and is essential for normal cell function. This gene encodes the auxillary subunit of the N-terminal acetyltransferase A (NatA) complex. [provided by RefSeq, Jan 2017]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca3 T C 17: 24,627,671 (GRCm39) F1372L probably damaging Het
Alcam T A 16: 52,073,531 (GRCm39) N339I probably benign Het
Ankrd35 A C 3: 96,587,982 (GRCm39) D141A probably damaging Het
Apc2 A G 10: 80,150,492 (GRCm39) I1820V probably benign Het
Ccp110 T A 7: 118,324,684 (GRCm39) probably null Het
Copa T A 1: 171,946,419 (GRCm39) D954E probably benign Het
Csmd2 A T 4: 128,313,363 (GRCm39) I1347F possibly damaging Het
Ddx10 A G 9: 53,140,498 (GRCm39) I301T probably benign Het
Defb23 T A 2: 152,301,294 (GRCm39) M93L probably benign Het
Dnah8 T C 17: 30,970,565 (GRCm39) probably null Het
Dok3 T C 13: 55,671,383 (GRCm39) E396G probably damaging Het
Eml6 T A 11: 29,727,055 (GRCm39) M1318L probably benign Het
Foxm1 T A 6: 128,343,167 (GRCm39) probably benign Het
Gm11992 A T 11: 9,011,266 (GRCm39) R236W probably damaging Het
Greb1 T C 12: 16,734,452 (GRCm39) I1513V probably benign Het
Hivep3 A G 4: 119,951,759 (GRCm39) E25G possibly damaging Het
Ighg2b C T 12: 113,270,065 (GRCm39) E318K unknown Het
Itga4 T C 2: 79,145,349 (GRCm39) S722P probably damaging Het
Kirrel3 G A 9: 34,946,224 (GRCm39) R617H probably damaging Het
Mboat1 A T 13: 30,425,166 (GRCm39) H409L possibly damaging Het
Nccrp1 A G 7: 28,246,191 (GRCm39) S124P probably damaging Het
Nphp4 T C 4: 152,573,338 (GRCm39) I92T probably damaging Het
Or13a28 G A 7: 140,218,124 (GRCm39) C170Y probably damaging Het
Or6d14 C A 6: 116,533,807 (GRCm39) Y140* probably null Het
Pkd1l3 A G 8: 110,356,798 (GRCm39) D741G possibly damaging Het
Plcb2 C T 2: 118,542,407 (GRCm39) probably null Het
Pramel19 A G 4: 101,798,650 (GRCm39) E207G probably damaging Het
Prm2 G A 16: 10,609,775 (GRCm39) probably null Het
R3hdm1 C T 1: 128,114,497 (GRCm39) Q184* probably null Het
Rgl1 A T 1: 152,424,901 (GRCm39) N359K probably damaging Het
Rnf44 A G 13: 54,829,966 (GRCm39) Y366H probably damaging Het
Rpap2 G A 5: 107,773,835 (GRCm39) probably null Het
Ryr3 T C 2: 112,631,665 (GRCm39) N2120S probably damaging Het
Samd8 A G 14: 21,825,027 (GRCm39) probably benign Het
Sipa1 G T 19: 5,702,099 (GRCm39) T937K probably damaging Het
Sos1 A T 17: 80,730,157 (GRCm39) D707E probably damaging Het
Tas2r109 T C 6: 132,957,477 (GRCm39) N151S probably benign Het
Try5 T C 6: 41,290,358 (GRCm39) N42S probably benign Het
Ttn G T 2: 76,732,338 (GRCm39) probably benign Het
Utp14b A G 1: 78,642,636 (GRCm39) E178G probably damaging Het
Other mutations in Naa15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00088:Naa15 APN 3 51,345,826 (GRCm39) missense probably damaging 1.00
IGL01753:Naa15 APN 3 51,350,274 (GRCm39) missense probably damaging 1.00
IGL02619:Naa15 APN 3 51,367,552 (GRCm39) missense probably benign 0.03
IGL02691:Naa15 APN 3 51,358,747 (GRCm39) missense probably damaging 0.97
IGL02974:Naa15 APN 3 51,368,628 (GRCm39) missense possibly damaging 0.95
R0009:Naa15 UTSW 3 51,377,640 (GRCm39) missense probably damaging 1.00
R0010:Naa15 UTSW 3 51,343,634 (GRCm39) critical splice acceptor site probably null
R0114:Naa15 UTSW 3 51,355,859 (GRCm39) critical splice donor site probably null
R0411:Naa15 UTSW 3 51,373,060 (GRCm39) missense possibly damaging 0.81
R1348:Naa15 UTSW 3 51,373,091 (GRCm39) missense probably damaging 1.00
R1941:Naa15 UTSW 3 51,363,355 (GRCm39) nonsense probably null
R3082:Naa15 UTSW 3 51,367,471 (GRCm39) missense probably damaging 1.00
R4377:Naa15 UTSW 3 51,355,786 (GRCm39) missense possibly damaging 0.91
R4591:Naa15 UTSW 3 51,349,345 (GRCm39) missense probably damaging 1.00
R4980:Naa15 UTSW 3 51,366,173 (GRCm39) critical splice donor site probably null
R5087:Naa15 UTSW 3 51,364,706 (GRCm39) splice site probably null
R5139:Naa15 UTSW 3 51,351,261 (GRCm39) missense probably damaging 1.00
R5289:Naa15 UTSW 3 51,363,315 (GRCm39) missense probably damaging 1.00
R5527:Naa15 UTSW 3 51,349,368 (GRCm39) missense probably damaging 1.00
R5776:Naa15 UTSW 3 51,367,447 (GRCm39) missense probably damaging 0.96
R5909:Naa15 UTSW 3 51,367,485 (GRCm39) missense probably damaging 1.00
R6034:Naa15 UTSW 3 51,350,242 (GRCm39) missense probably damaging 0.98
R6034:Naa15 UTSW 3 51,350,242 (GRCm39) missense probably damaging 0.98
R6194:Naa15 UTSW 3 51,370,721 (GRCm39) missense probably benign 0.00
R6291:Naa15 UTSW 3 51,350,212 (GRCm39) missense probably damaging 1.00
R6522:Naa15 UTSW 3 51,378,935 (GRCm39) missense probably damaging 1.00
R6731:Naa15 UTSW 3 51,363,294 (GRCm39) missense probably damaging 1.00
R6984:Naa15 UTSW 3 51,380,021 (GRCm39) missense probably benign 0.10
R7040:Naa15 UTSW 3 51,380,205 (GRCm39) missense possibly damaging 0.89
R7091:Naa15 UTSW 3 51,366,177 (GRCm39) splice site probably null
R7380:Naa15 UTSW 3 51,367,268 (GRCm39) splice site probably null
R7685:Naa15 UTSW 3 51,377,395 (GRCm39) splice site probably null
R7781:Naa15 UTSW 3 51,378,904 (GRCm39) critical splice acceptor site probably null
R7797:Naa15 UTSW 3 51,356,031 (GRCm39) missense probably damaging 0.99
R7836:Naa15 UTSW 3 51,370,688 (GRCm39) nonsense probably null
R7981:Naa15 UTSW 3 51,366,092 (GRCm39) missense probably damaging 0.96
R8513:Naa15 UTSW 3 51,367,444 (GRCm39) missense probably damaging 0.99
R8923:Naa15 UTSW 3 51,367,443 (GRCm39) missense probably damaging 1.00
R9159:Naa15 UTSW 3 51,358,802 (GRCm39) missense probably benign 0.01
R9701:Naa15 UTSW 3 51,349,370 (GRCm39) nonsense probably null
R9802:Naa15 UTSW 3 51,349,370 (GRCm39) nonsense probably null
X0020:Naa15 UTSW 3 51,377,553 (GRCm39) missense probably benign 0.00
X0061:Naa15 UTSW 3 51,356,022 (GRCm39) missense probably benign 0.11
X0061:Naa15 UTSW 3 51,356,021 (GRCm39) missense probably damaging 1.00
Posted On 2014-02-04