Incidental Mutation 'IGL01833:Or7a35'
ID 154831
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or7a35
Ensembl Gene ENSMUSG00000063216
Gene Name olfactory receptor family 7 subfamily A member 35
Synonyms Olfr1351, GA_x6K02T2QGN0-2794907-2793948, MOR139-4
Accession Numbers
Essential gene? Probably non essential (E-score: 0.145) question?
Stock # IGL01833
Quality Score
Status
Chromosome 10
Chromosomal Location 78853158-78854117 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 78853770 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Leucine at position 205 (M205L)
Ref Sequence ENSEMBL: ENSMUSP00000149241 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080730] [ENSMUST00000203906] [ENSMUST00000216030]
AlphaFold Q8VGU6
Predicted Effect probably benign
Transcript: ENSMUST00000080730
AA Change: M205L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000079555
Gene: ENSMUSG00000063216
AA Change: M205L

DomainStartEndE-ValueType
low complexity region 9 19 N/A INTRINSIC
Pfam:7tm_4 32 308 2e-49 PFAM
Pfam:7tm_1 42 291 1.9e-23 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000203906
AA Change: M205L
SMART Domains Protein: ENSMUSP00000144814
Gene: ENSMUSG00000060205
AA Change: M205L

DomainStartEndE-ValueType
low complexity region 9 19 N/A INTRINSIC
Pfam:7tm_4 32 308 2e-49 PFAM
Pfam:7tm_1 42 291 1.9e-23 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000216030
AA Change: M205L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acsbg3 A G 17: 57,188,062 (GRCm39) N190S probably benign Het
Adamts18 T A 8: 114,469,728 (GRCm39) Y658F probably benign Het
Camsap3 T A 8: 3,658,508 (GRCm39) L1151Q probably damaging Het
Casp14 T A 10: 78,551,237 (GRCm39) Y16F probably damaging Het
Clip2 A T 5: 134,526,938 (GRCm39) probably benign Het
Clip4 G A 17: 72,134,785 (GRCm39) probably benign Het
Cyb5r4 G A 9: 86,941,505 (GRCm39) probably null Het
Ep400 A T 5: 110,827,874 (GRCm39) N2329K unknown Het
Fam163a T A 1: 155,955,742 (GRCm39) I17F probably damaging Het
Galnt1 T A 18: 24,400,617 (GRCm39) I241N probably damaging Het
Galnt14 T G 17: 73,811,899 (GRCm39) I441L probably benign Het
Gpr45 T C 1: 43,071,402 (GRCm39) L15P probably benign Het
Hivep1 A T 13: 42,308,464 (GRCm39) K235* probably null Het
Kcnip2 T C 19: 45,782,746 (GRCm39) probably null Het
Kpna3 T C 14: 61,607,894 (GRCm39) N437S possibly damaging Het
Lmtk2 A T 5: 144,112,753 (GRCm39) R1158* probably null Het
Lpo A G 11: 87,698,159 (GRCm39) V612A possibly damaging Het
Myh15 T C 16: 48,934,421 (GRCm39) C663R probably damaging Het
Nacad G A 11: 6,555,700 (GRCm39) R17C unknown Het
Pcsk2 A G 2: 143,529,500 (GRCm39) Q99R possibly damaging Het
Pkd1l2 T C 8: 117,787,264 (GRCm39) N593S probably benign Het
Plce1 G A 19: 38,709,425 (GRCm39) S1093N probably damaging Het
Prxl2b G T 4: 154,981,059 (GRCm39) probably benign Het
Rhpn2 T A 7: 35,075,596 (GRCm39) Y258N probably benign Het
Serpinb9d T C 13: 33,384,688 (GRCm39) Y222H probably damaging Het
Shprh T C 10: 11,066,806 (GRCm39) L1401P probably damaging Het
Slc5a7 A G 17: 54,588,861 (GRCm39) L262P probably damaging Het
Stat2 T G 10: 128,117,045 (GRCm39) F293V probably benign Het
Stpg4 T A 17: 87,702,585 (GRCm39) probably null Het
Styk1 G T 6: 131,279,329 (GRCm39) probably benign Het
Sult2a2 T A 7: 13,468,721 (GRCm39) D62E probably damaging Het
Sytl2 G A 7: 90,045,745 (GRCm39) V632M probably damaging Het
Themis C T 10: 28,658,307 (GRCm39) Q445* probably null Het
Tmem225 A T 9: 40,059,725 (GRCm39) E35V probably damaging Het
Vmn1r48 T A 6: 90,013,265 (GRCm39) T187S probably damaging Het
Xpnpep1 A G 19: 52,988,824 (GRCm39) Y463H probably damaging Het
Other mutations in Or7a35
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00913:Or7a35 APN 10 78,854,085 (GRCm39) missense probably benign 0.00
IGL02141:Or7a35 APN 10 78,853,555 (GRCm39) missense probably damaging 1.00
IGL02178:Or7a35 APN 10 78,853,554 (GRCm39) missense possibly damaging 0.59
R1070:Or7a35 UTSW 10 78,853,684 (GRCm39) missense probably damaging 0.99
R1631:Or7a35 UTSW 10 78,853,239 (GRCm39) missense probably benign 0.00
R1646:Or7a35 UTSW 10 78,853,340 (GRCm39) nonsense probably null
R1781:Or7a35 UTSW 10 78,853,159 (GRCm39) start codon destroyed probably null 0.89
R2358:Or7a35 UTSW 10 78,854,022 (GRCm39) missense probably damaging 1.00
R3161:Or7a35 UTSW 10 78,853,438 (GRCm39) missense probably benign
R3162:Or7a35 UTSW 10 78,853,438 (GRCm39) missense probably benign
R3162:Or7a35 UTSW 10 78,853,438 (GRCm39) missense probably benign
R5874:Or7a35 UTSW 10 78,853,191 (GRCm39) missense possibly damaging 0.95
R6382:Or7a35 UTSW 10 78,853,351 (GRCm39) missense probably damaging 1.00
R7108:Or7a35 UTSW 10 78,853,483 (GRCm39) nonsense probably null
R7567:Or7a35 UTSW 10 78,853,379 (GRCm39) missense probably benign 0.04
R7568:Or7a35 UTSW 10 78,853,341 (GRCm39) missense probably benign
R7915:Or7a35 UTSW 10 78,853,264 (GRCm39) missense probably damaging 1.00
R7936:Or7a35 UTSW 10 78,853,872 (GRCm39) missense probably damaging 1.00
R9687:Or7a35 UTSW 10 78,853,843 (GRCm39) missense probably damaging 1.00
Z1176:Or7a35 UTSW 10 78,854,039 (GRCm39) missense probably damaging 1.00
Posted On 2014-02-04