Incidental Mutation 'IGL01830:Lpar5'
| ID |
154751 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Lpar5
|
| Ensembl Gene |
ENSMUSG00000067714 |
| Gene Name |
lysophosphatidic acid receptor 5 |
| Synonyms |
Gpr92, LOC381810, GPR93, LPA5 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.074)
|
| Stock # |
IGL01830
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
6 |
| Chromosomal Location |
125044883-125059435 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 125058785 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Alanine to Threonine
at position 169
(A169T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000132511
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000088292]
[ENSMUST00000140346]
[ENSMUST00000171989]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000088292
AA Change: A169T
PolyPhen 2
Score 0.010 (Sensitivity: 0.96; Specificity: 0.77)
|
| SMART Domains |
Protein: ENSMUSP00000085630
Gene: ENSMUSG00000067714
AA Change: A169T
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
15 |
27 |
N/A |
INTRINSIC |
|
Pfam:7tm_1
|
55 |
313 |
7.4e-40 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000140346
|
| SMART Domains |
Protein: ENSMUSP00000119904
Gene: ENSMUSG00000067714
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
15 |
27 |
N/A |
INTRINSIC |
|
Pfam:7tm_1
|
55 |
164 |
1.5e-30 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000171989
AA Change: A169T
PolyPhen 2
Score 0.010 (Sensitivity: 0.96; Specificity: 0.77)
|
| SMART Domains |
Protein: ENSMUSP00000132511
Gene: ENSMUSG00000067714
AA Change: A169T
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
15 |
27 |
N/A |
INTRINSIC |
|
Pfam:7tm_1
|
55 |
313 |
1.1e-48 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000203956
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the rhodopsin class of G protein-coupled transmembrane receptors. This protein transmits extracellular signals from lysophosphatidic acid to cells through heterotrimeric G proteins and mediates numerous cellular processes. Many G protein receptors serve as targets for pharmaceutical drugs. Transcript variants of this gene have been described.[provided by RefSeq, Dec 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit resistance to neuropathic pain and myelin sheath alterations. Mice homozygous for a different targeted allele exhibit decreased nociception sensitivity, decreased anxiety-related response and enhanced coordination and spatial learning. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 39 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Ahsg |
C |
A |
16: 22,717,779 (GRCm39) |
P252Q |
probably damaging |
Het |
| Anks4b |
T |
A |
7: 119,773,219 (GRCm39) |
N26K |
probably damaging |
Het |
| Arrdc5 |
C |
T |
17: 56,601,652 (GRCm39) |
V158I |
probably damaging |
Het |
| Catsper2 |
T |
C |
2: 121,237,843 (GRCm39) |
D179G |
probably damaging |
Het |
| Cd44 |
T |
C |
2: 102,672,603 (GRCm39) |
|
probably benign |
Het |
| Ceacam3 |
T |
A |
7: 16,888,925 (GRCm39) |
D231E |
possibly damaging |
Het |
| Cep57l1 |
C |
T |
10: 41,604,649 (GRCm39) |
C160Y |
probably benign |
Het |
| Chek2 |
T |
A |
5: 111,021,374 (GRCm39) |
L528Q |
probably benign |
Het |
| Ciita |
T |
C |
16: 10,338,915 (GRCm39) |
L973P |
probably damaging |
Het |
| Dock2 |
A |
T |
11: 34,582,744 (GRCm39) |
L637* |
probably null |
Het |
| Fsip2 |
A |
C |
2: 82,815,273 (GRCm39) |
I3669L |
probably benign |
Het |
| Gapvd1 |
A |
G |
2: 34,578,968 (GRCm39) |
V1218A |
probably benign |
Het |
| Gip |
T |
C |
11: 95,919,550 (GRCm39) |
L91S |
possibly damaging |
Het |
| Gp2 |
T |
C |
7: 119,050,765 (GRCm39) |
D322G |
probably damaging |
Het |
| Ift172 |
A |
G |
5: 31,442,636 (GRCm39) |
V177A |
probably damaging |
Het |
| Kng2 |
T |
C |
16: 22,806,801 (GRCm39) |
D466G |
probably damaging |
Het |
| Med13 |
C |
T |
11: 86,179,754 (GRCm39) |
|
probably benign |
Het |
| Meiob |
T |
A |
17: 25,054,105 (GRCm39) |
C391S |
probably benign |
Het |
| Mgat5 |
A |
G |
1: 127,339,869 (GRCm39) |
T417A |
probably damaging |
Het |
| Myo1b |
A |
T |
1: 51,836,624 (GRCm39) |
L279* |
probably null |
Het |
| Myo1g |
T |
A |
11: 6,464,522 (GRCm39) |
K513* |
probably null |
Het |
| Nxpe2 |
A |
T |
9: 48,237,794 (GRCm39) |
S154T |
probably damaging |
Het |
| Ogn |
C |
T |
13: 49,762,723 (GRCm39) |
Q22* |
probably null |
Het |
| Or4c12 |
A |
G |
2: 89,773,775 (GRCm39) |
L228S |
probably benign |
Het |
| Pacs2 |
A |
T |
12: 113,020,574 (GRCm39) |
K316* |
probably null |
Het |
| Pelo |
T |
A |
13: 115,225,131 (GRCm39) |
I365F |
probably damaging |
Het |
| Phf3 |
G |
A |
1: 30,853,148 (GRCm39) |
Q1021* |
probably null |
Het |
| Pik3r4 |
A |
G |
9: 105,522,154 (GRCm39) |
D240G |
probably damaging |
Het |
| Pknox1 |
T |
C |
17: 31,814,284 (GRCm39) |
M203T |
probably benign |
Het |
| Pld1 |
T |
C |
3: 28,102,153 (GRCm39) |
|
probably benign |
Het |
| Rabgef1 |
G |
T |
5: 130,240,907 (GRCm39) |
C342F |
possibly damaging |
Het |
| Rbm19 |
A |
C |
5: 120,262,760 (GRCm39) |
K307T |
possibly damaging |
Het |
| Sdcbp2 |
T |
A |
2: 151,431,494 (GRCm39) |
I289N |
probably damaging |
Het |
| Slc5a12 |
G |
A |
2: 110,428,151 (GRCm39) |
G69R |
probably damaging |
Het |
| Spag1 |
C |
A |
15: 36,221,705 (GRCm39) |
S599R |
probably benign |
Het |
| Ubr4 |
A |
T |
4: 139,199,811 (GRCm39) |
D4565V |
probably damaging |
Het |
| Usp34 |
G |
A |
11: 23,386,020 (GRCm39) |
R2149H |
probably damaging |
Het |
| Vmn1r225 |
T |
C |
17: 20,722,717 (GRCm39) |
S53P |
probably damaging |
Het |
| Xrcc1 |
T |
A |
7: 24,272,767 (GRCm39) |
|
probably benign |
Het |
|
| Other mutations in Lpar5 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01719:Lpar5
|
APN |
6 |
125,058,969 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL01975:Lpar5
|
APN |
6 |
125,058,750 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02021:Lpar5
|
APN |
6 |
125,058,955 (GRCm39) |
nonsense |
probably null |
|
|
IGL02718:Lpar5
|
APN |
6 |
125,059,207 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03027:Lpar5
|
APN |
6 |
125,059,203 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03300:Lpar5
|
APN |
6 |
125,059,203 (GRCm39) |
missense |
probably damaging |
1.00 |
|
F5770:Lpar5
|
UTSW |
6 |
125,058,690 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R0633:Lpar5
|
UTSW |
6 |
125,058,954 (GRCm39) |
missense |
probably benign |
0.25 |
|
R1639:Lpar5
|
UTSW |
6 |
125,058,564 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1822:Lpar5
|
UTSW |
6 |
125,058,378 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R2227:Lpar5
|
UTSW |
6 |
125,058,098 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R4019:Lpar5
|
UTSW |
6 |
125,058,638 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4288:Lpar5
|
UTSW |
6 |
125,058,827 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4705:Lpar5
|
UTSW |
6 |
125,059,170 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R4787:Lpar5
|
UTSW |
6 |
125,059,461 (GRCm39) |
splice site |
probably null |
|
|
R5027:Lpar5
|
UTSW |
6 |
125,059,110 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R6114:Lpar5
|
UTSW |
6 |
125,058,639 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7197:Lpar5
|
UTSW |
6 |
125,059,347 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7779:Lpar5
|
UTSW |
6 |
125,059,207 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8193:Lpar5
|
UTSW |
6 |
125,058,302 (GRCm39) |
missense |
probably benign |
|
|
R8264:Lpar5
|
UTSW |
6 |
125,058,465 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9460:Lpar5
|
UTSW |
6 |
125,058,234 (GRCm39) |
start gained |
probably benign |
|
|
R9628:Lpar5
|
UTSW |
6 |
125,058,948 (GRCm39) |
missense |
probably damaging |
0.96 |
|
V7580:Lpar5
|
UTSW |
6 |
125,058,690 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
V7581:Lpar5
|
UTSW |
6 |
125,058,690 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
V7582:Lpar5
|
UTSW |
6 |
125,058,690 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
Z1176:Lpar5
|
UTSW |
6 |
125,059,035 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Lpar5
|
UTSW |
6 |
125,058,342 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
Z1177:Lpar5
|
UTSW |
6 |
125,058,981 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2014-02-04 |
Incidental Mutation