Incidental Mutation 'IGL00813:Lrrc37'
ID 12640
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Lrrc37
Ensembl Gene ENSMUSG00000034239
Gene Name leucine rich repeat containing 37
Synonyms LOC380730, Gm884
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.266) question?
Stock # IGL00813
Quality Score
Status
Chromosome 11
Chromosomal Location 103425403-103511966 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 103505324 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Valine at position 2215 (F2215V)
Ref Sequence ENSEMBL: ENSMUSP00000058511 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000059279] [ENSMUST00000167262]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000059279
AA Change: F2215V

PolyPhen 2 Score 0.053 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000058511
Gene: ENSMUSG00000034239
AA Change: F2215V

DomainStartEndE-ValueType
Pfam:LRRC37 149 223 5.4e-10 PFAM
low complexity region 244 264 N/A INTRINSIC
low complexity region 298 308 N/A INTRINSIC
Pfam:LRRC37 335 403 1.9e-14 PFAM
Pfam:LRRC37 419 514 1.2e-8 PFAM
Pfam:LRRC37 565 620 2e-10 PFAM
Pfam:LRRC37 669 739 7.6e-18 PFAM
Pfam:LRRC37 741 792 1.6e-9 PFAM
Pfam:LRRC37 789 860 1.4e-23 PFAM
Pfam:LRRC37 861 914 2.8e-9 PFAM
Pfam:LRRC37 911 983 1.9e-23 PFAM
Pfam:LRRC37 979 1038 1e-8 PFAM
Pfam:LRRC37 1034 1105 2.7e-24 PFAM
Pfam:LRRC37 1105 1158 2.3e-9 PFAM
Pfam:LRRC37 1155 1219 2.4e-17 PFAM
Pfam:LRRC37 1222 1265 9.2e-7 PFAM
Pfam:LRRC37 1263 1330 4.9e-24 PFAM
Pfam:LRRC37 1331 1384 1.4e-10 PFAM
Pfam:LRRC37 1380 1451 4.3e-15 PFAM
Pfam:LRRC37 1487 1558 1.9e-15 PFAM
Pfam:LRRC37 1594 1665 2.9e-18 PFAM
Pfam:LRRC37 1701 1772 5.6e-23 PFAM
Pfam:LRRC37 1808 1910 2.8e-18 PFAM
Pfam:LRRC37 1915 1986 7.2e-17 PFAM
Pfam:LRRC37 2022 2093 4.9e-22 PFAM
Pfam:LRRC37 2129 2200 4.4e-22 PFAM
Pfam:LRRC37 2236 2307 2.1e-21 PFAM
Pfam:LRRC37 2343 2414 3.8e-17 PFAM
Pfam:LRRC37 2449 2519 1.6e-19 PFAM
LRR 2777 2796 3.09e1 SMART
LRR_TYP 2797 2820 2.09e-3 SMART
LRR 2821 2844 4.44e0 SMART
LRR 2848 2872 8.26e1 SMART
low complexity region 2991 3002 N/A INTRINSIC
low complexity region 3220 3230 N/A INTRINSIC
low complexity region 3382 3393 N/A INTRINSIC
Pfam:LRRC37AB_C 3424 3570 7.7e-76 PFAM
low complexity region 3571 3589 N/A INTRINSIC
low complexity region 3622 3640 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000167262
AA Change: F39V
SMART Domains Protein: ENSMUSP00000129662
Gene: ENSMUSG00000034239
AA Change: F39V

DomainStartEndE-ValueType
internal_repeat_1 1 70 1.46e-11 PROSPERO
internal_repeat_1 108 290 1.46e-11 PROSPERO
LRR 601 620 3.09e1 SMART
LRR_TYP 621 644 2.09e-3 SMART
LRR 645 668 4.44e0 SMART
LRR 672 696 8.26e1 SMART
low complexity region 815 826 N/A INTRINSIC
low complexity region 1044 1054 N/A INTRINSIC
low complexity region 1206 1217 N/A INTRINSIC
Pfam:LRRC37AB_C 1243 1396 1.2e-92 PFAM
low complexity region 1446 1464 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 25 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca12 C A 1: 71,392,921 (GRCm39) probably null Het
Aco1 T C 4: 40,180,290 (GRCm39) probably null Het
Bloc1s5 T C 13: 38,803,158 (GRCm39) N76S probably damaging Het
Cyp3a44 A T 5: 145,711,157 (GRCm39) *505R probably null Het
Epor T C 9: 21,871,887 (GRCm39) T253A possibly damaging Het
Faim G A 9: 98,874,218 (GRCm39) G15R probably damaging Het
Hecw1 T A 13: 14,452,961 (GRCm39) probably null Het
Hhla1 A T 15: 65,813,810 (GRCm39) V209E probably damaging Het
Ino80d G A 1: 63,132,462 (GRCm39) P67L probably damaging Het
Lysmd3 C A 13: 81,813,361 (GRCm39) N76K probably damaging Het
Map10 G A 8: 126,398,671 (GRCm39) R688Q probably benign Het
Mars1 A T 10: 127,135,916 (GRCm39) M554K probably damaging Het
Mgat5 G A 1: 127,312,543 (GRCm39) M227I probably benign Het
Nup210l A G 3: 90,039,725 (GRCm39) I389V probably benign Het
Ppp1r16b A G 2: 158,598,885 (GRCm39) K315R probably damaging Het
Rae1 A G 2: 172,848,726 (GRCm39) D114G probably damaging Het
Rbms1 T C 2: 60,628,049 (GRCm39) K64E probably damaging Het
Shox2 C A 3: 66,882,777 (GRCm39) Q105H probably damaging Het
Simc1 C A 13: 54,694,799 (GRCm39) F293L probably damaging Het
Slc11a1 A G 1: 74,422,639 (GRCm39) I289V probably benign Het
Slit2 G A 5: 48,146,493 (GRCm39) E95K possibly damaging Het
Stk32a T A 18: 43,443,585 (GRCm39) V254E probably benign Het
Them5 A G 3: 94,250,595 (GRCm39) K53E probably damaging Het
Tmem67 T C 4: 12,058,587 (GRCm39) probably benign Het
Wdr7 T A 18: 63,868,675 (GRCm39) L248Q possibly damaging Het
Other mutations in Lrrc37
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00572:Lrrc37 APN 11 103,506,236 (GRCm39) missense probably benign 0.01
IGL00576:Lrrc37 APN 11 103,508,212 (GRCm39) unclassified probably benign
IGL01311:Lrrc37 APN 11 103,425,502 (GRCm39) missense unknown
IGL01946:Lrrc37 APN 11 103,503,759 (GRCm39) missense probably benign 0.28
IGL02217:Lrrc37 APN 11 103,503,697 (GRCm39) splice site probably benign
IGL02556:Lrrc37 APN 11 103,504,109 (GRCm39) missense probably benign 0.01
IGL02825:Lrrc37 APN 11 103,507,894 (GRCm39) unclassified probably benign
IGL02868:Lrrc37 APN 11 103,505,965 (GRCm39) missense probably benign 0.10
IGL02904:Lrrc37 APN 11 103,507,187 (GRCm39) unclassified probably benign
IGL03008:Lrrc37 APN 11 103,511,293 (GRCm39) missense unknown
IGL03120:Lrrc37 APN 11 103,507,801 (GRCm39) unclassified probably benign
IGL03159:Lrrc37 APN 11 103,495,328 (GRCm39) splice site probably benign
IGL03181:Lrrc37 APN 11 103,507,242 (GRCm39) unclassified probably benign
IGL03202:Lrrc37 APN 11 103,506,199 (GRCm39) missense probably benign 0.03
IGL03263:Lrrc37 APN 11 103,504,525 (GRCm39) missense possibly damaging 0.86
esteemed UTSW 11 103,509,656 (GRCm39) missense unknown
lauded UTSW 11 103,503,929 (GRCm39) missense possibly damaging 0.62
PIT4486001:Lrrc37 UTSW 11 103,509,027 (GRCm39) missense unknown
R0040:Lrrc37 UTSW 11 103,433,816 (GRCm39) missense probably damaging 0.99
R0135:Lrrc37 UTSW 11 103,508,873 (GRCm39) unclassified probably benign
R0141:Lrrc37 UTSW 11 103,504,512 (GRCm39) missense probably damaging 1.00
R0226:Lrrc37 UTSW 11 103,494,067 (GRCm39) missense probably benign 0.08
R0547:Lrrc37 UTSW 11 103,510,990 (GRCm39) missense unknown
R0646:Lrrc37 UTSW 11 103,503,986 (GRCm39) nonsense probably null
R0685:Lrrc37 UTSW 11 103,507,714 (GRCm39) unclassified probably benign
R0732:Lrrc37 UTSW 11 103,510,664 (GRCm39) missense unknown
R1015:Lrrc37 UTSW 11 103,436,622 (GRCm39) missense probably benign 0.01
R1166:Lrrc37 UTSW 11 103,506,209 (GRCm39) missense probably benign 0.21
R1168:Lrrc37 UTSW 11 103,509,776 (GRCm39) unclassified probably benign
R1257:Lrrc37 UTSW 11 103,425,467 (GRCm39) missense unknown
R1545:Lrrc37 UTSW 11 103,499,745 (GRCm39) missense probably benign 0.16
R1570:Lrrc37 UTSW 11 103,500,764 (GRCm39) missense possibly damaging 0.76
R1677:Lrrc37 UTSW 11 103,505,768 (GRCm39) missense probably benign 0.19
R1703:Lrrc37 UTSW 11 103,431,700 (GRCm39) missense probably benign 0.39
R1719:Lrrc37 UTSW 11 103,507,897 (GRCm39) unclassified probably benign
R1752:Lrrc37 UTSW 11 103,505,381 (GRCm39) missense possibly damaging 0.67
R1870:Lrrc37 UTSW 11 103,511,431 (GRCm39) missense unknown
R2155:Lrrc37 UTSW 11 103,511,285 (GRCm39) missense unknown
R2191:Lrrc37 UTSW 11 103,509,793 (GRCm39) unclassified probably benign
R2271:Lrrc37 UTSW 11 103,505,033 (GRCm39) missense possibly damaging 0.53
R2378:Lrrc37 UTSW 11 103,510,537 (GRCm39) unclassified probably benign
R2405:Lrrc37 UTSW 11 103,511,810 (GRCm39) missense unknown
R2864:Lrrc37 UTSW 11 103,431,744 (GRCm39) missense probably benign 0.34
R3011:Lrrc37 UTSW 11 103,503,929 (GRCm39) missense possibly damaging 0.62
R3415:Lrrc37 UTSW 11 103,505,435 (GRCm39) missense possibly damaging 0.82
R3417:Lrrc37 UTSW 11 103,505,435 (GRCm39) missense possibly damaging 0.82
R3835:Lrrc37 UTSW 11 103,510,836 (GRCm39) missense unknown
R3974:Lrrc37 UTSW 11 103,509,927 (GRCm39) unclassified probably benign
R4019:Lrrc37 UTSW 11 103,506,119 (GRCm39) missense probably benign 0.19
R4020:Lrrc37 UTSW 11 103,506,119 (GRCm39) missense probably benign 0.19
R4176:Lrrc37 UTSW 11 103,427,426 (GRCm39) missense unknown
R4361:Lrrc37 UTSW 11 103,508,327 (GRCm39) frame shift probably null
R4418:Lrrc37 UTSW 11 103,509,140 (GRCm39) unclassified probably benign
R4633:Lrrc37 UTSW 11 103,509,957 (GRCm39) unclassified probably benign
R4693:Lrrc37 UTSW 11 103,510,686 (GRCm39) missense unknown
R4758:Lrrc37 UTSW 11 103,505,290 (GRCm39) missense possibly damaging 0.48
R4878:Lrrc37 UTSW 11 103,508,717 (GRCm39) unclassified probably benign
R4887:Lrrc37 UTSW 11 103,505,698 (GRCm39) missense probably benign 0.03
R4944:Lrrc37 UTSW 11 103,504,286 (GRCm39) missense possibly damaging 0.68
R4952:Lrrc37 UTSW 11 103,505,033 (GRCm39) missense possibly damaging 0.53
R5030:Lrrc37 UTSW 11 103,425,675 (GRCm39) missense unknown
R5183:Lrrc37 UTSW 11 103,433,947 (GRCm39) missense probably damaging 0.99
R5294:Lrrc37 UTSW 11 103,507,057 (GRCm39) unclassified probably benign
R5317:Lrrc37 UTSW 11 103,504,971 (GRCm39) missense possibly damaging 0.73
R5334:Lrrc37 UTSW 11 103,504,699 (GRCm39) missense probably benign 0.18
R5426:Lrrc37 UTSW 11 103,511,586 (GRCm39) missense unknown
R5467:Lrrc37 UTSW 11 103,494,091 (GRCm39) nonsense probably null
R5518:Lrrc37 UTSW 11 103,506,079 (GRCm39) missense probably benign 0.03
R5634:Lrrc37 UTSW 11 103,432,840 (GRCm39) missense possibly damaging 0.95
R5647:Lrrc37 UTSW 11 103,508,300 (GRCm39) unclassified probably benign
R5663:Lrrc37 UTSW 11 103,503,949 (GRCm39) missense probably benign 0.01
R5668:Lrrc37 UTSW 11 103,507,880 (GRCm39) unclassified probably benign
R5763:Lrrc37 UTSW 11 103,504,469 (GRCm39) missense probably damaging 0.97
R5829:Lrrc37 UTSW 11 103,432,712 (GRCm39) missense possibly damaging 0.95
R5871:Lrrc37 UTSW 11 103,507,280 (GRCm39) unclassified probably benign
R5905:Lrrc37 UTSW 11 103,505,081 (GRCm39) missense probably damaging 0.98
R5940:Lrrc37 UTSW 11 103,504,712 (GRCm39) missense probably benign 0.18
R5964:Lrrc37 UTSW 11 103,432,946 (GRCm39) missense possibly damaging 0.92
R5988:Lrrc37 UTSW 11 103,506,722 (GRCm39) unclassified probably benign
R5992:Lrrc37 UTSW 11 103,504,618 (GRCm39) missense possibly damaging 0.81
R6114:Lrrc37 UTSW 11 103,508,617 (GRCm39) unclassified probably benign
R6154:Lrrc37 UTSW 11 103,504,969 (GRCm39) missense probably benign 0.33
R6233:Lrrc37 UTSW 11 103,504,214 (GRCm39) missense probably damaging 0.98
R6301:Lrrc37 UTSW 11 103,509,756 (GRCm39) unclassified probably benign
R6362:Lrrc37 UTSW 11 103,511,478 (GRCm39) missense unknown
R6471:Lrrc37 UTSW 11 103,510,448 (GRCm39) unclassified probably benign
R6806:Lrrc37 UTSW 11 103,511,950 (GRCm39) missense unknown
R6962:Lrrc37 UTSW 11 103,505,126 (GRCm39) missense possibly damaging 0.67
R6996:Lrrc37 UTSW 11 103,509,583 (GRCm39) nonsense probably null
R7028:Lrrc37 UTSW 11 103,505,363 (GRCm39) missense probably benign 0.28
R7034:Lrrc37 UTSW 11 103,506,638 (GRCm39) unclassified probably benign
R7036:Lrrc37 UTSW 11 103,506,638 (GRCm39) unclassified probably benign
R7113:Lrrc37 UTSW 11 103,509,625 (GRCm39) missense unknown
R7405:Lrrc37 UTSW 11 103,505,987 (GRCm39) missense probably benign 0.02
R7420:Lrrc37 UTSW 11 103,504,451 (GRCm39) missense probably benign 0.11
R7461:Lrrc37 UTSW 11 103,507,116 (GRCm39) missense unknown
R7544:Lrrc37 UTSW 11 103,506,274 (GRCm39) missense probably benign 0.01
R7613:Lrrc37 UTSW 11 103,507,116 (GRCm39) missense unknown
R7711:Lrrc37 UTSW 11 103,505,738 (GRCm39) missense probably benign 0.02
R7714:Lrrc37 UTSW 11 103,507,719 (GRCm39) missense unknown
R7747:Lrrc37 UTSW 11 103,505,081 (GRCm39) missense probably damaging 0.98
R7814:Lrrc37 UTSW 11 103,504,999 (GRCm39) missense possibly damaging 0.53
R8053:Lrrc37 UTSW 11 103,495,392 (GRCm39) missense unknown
R8063:Lrrc37 UTSW 11 103,433,087 (GRCm39) missense unknown
R8116:Lrrc37 UTSW 11 103,434,115 (GRCm39) missense unknown
R8124:Lrrc37 UTSW 11 103,511,257 (GRCm39) missense unknown
R8141:Lrrc37 UTSW 11 103,511,855 (GRCm39) missense unknown
R8163:Lrrc37 UTSW 11 103,506,688 (GRCm39) missense unknown
R8270:Lrrc37 UTSW 11 103,434,141 (GRCm39) missense unknown
R8348:Lrrc37 UTSW 11 103,511,726 (GRCm39) missense unknown
R8362:Lrrc37 UTSW 11 103,506,163 (GRCm39) missense probably benign 0.34
R8448:Lrrc37 UTSW 11 103,511,726 (GRCm39) missense unknown
R8465:Lrrc37 UTSW 11 103,506,947 (GRCm39) unclassified probably benign
R8473:Lrrc37 UTSW 11 103,434,266 (GRCm39) missense unknown
R8781:Lrrc37 UTSW 11 103,508,958 (GRCm39) missense unknown
R8821:Lrrc37 UTSW 11 103,510,470 (GRCm39) missense unknown
R8859:Lrrc37 UTSW 11 103,506,370 (GRCm39) missense unknown
R8888:Lrrc37 UTSW 11 103,509,656 (GRCm39) missense unknown
R8895:Lrrc37 UTSW 11 103,509,656 (GRCm39) missense unknown
R9083:Lrrc37 UTSW 11 103,509,830 (GRCm39) missense unknown
R9085:Lrrc37 UTSW 11 103,507,565 (GRCm39) missense unknown
R9088:Lrrc37 UTSW 11 103,511,762 (GRCm39) missense unknown
R9124:Lrrc37 UTSW 11 103,509,721 (GRCm39) missense unknown
R9177:Lrrc37 UTSW 11 103,508,263 (GRCm39) missense unknown
R9238:Lrrc37 UTSW 11 103,509,859 (GRCm39) missense unknown
R9267:Lrrc37 UTSW 11 103,495,406 (GRCm39) missense unknown
R9444:Lrrc37 UTSW 11 103,508,846 (GRCm39) nonsense probably null
R9517:Lrrc37 UTSW 11 103,433,416 (GRCm39) missense unknown
R9564:Lrrc37 UTSW 11 103,503,822 (GRCm39) missense unknown
R9632:Lrrc37 UTSW 11 103,433,252 (GRCm39) missense unknown
R9741:Lrrc37 UTSW 11 103,504,255 (GRCm39) missense possibly damaging 0.68
Z1176:Lrrc37 UTSW 11 103,504,507 (GRCm39) missense probably benign 0.45
Posted On 2012-12-06