Incidental Mutation 'IGL01650:Eif3a'
ID 102814
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Eif3a
Ensembl Gene ENSMUSG00000024991
Gene Name eukaryotic translation initiation factor 3, subunit A
Synonyms Eif3, Csma, Eif3s10, A830012B05Rik
Accession Numbers
Essential gene? Probably essential (E-score: 0.971) question?
Stock # IGL01650
Quality Score
Status
Chromosome 19
Chromosomal Location 60749555-60779096 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 60762434 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 450 (I450F)
Ref Sequence ENSEMBL: ENSMUSP00000025955 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000025955]
AlphaFold P23116
Predicted Effect probably damaging
Transcript: ENSMUST00000025955
AA Change: I450F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000025955
Gene: ENSMUSG00000024991
AA Change: I450F

DomainStartEndE-ValueType
coiled coil region 82 120 N/A INTRINSIC
PINT 426 506 5.69e-18 SMART
SCOP:d1f5aa2 563 711 5e-3 SMART
coiled coil region 772 880 N/A INTRINSIC
low complexity region 919 947 N/A INTRINSIC
low complexity region 951 976 N/A INTRINSIC
internal_repeat_2 978 991 1.01e-8 PROSPERO
low complexity region 993 1007 N/A INTRINSIC
low complexity region 1013 1027 N/A INTRINSIC
low complexity region 1033 1057 N/A INTRINSIC
low complexity region 1064 1089 N/A INTRINSIC
internal_repeat_1 1090 1111 6.2e-12 PROSPERO
internal_repeat_2 1099 1112 1.01e-8 PROSPERO
internal_repeat_1 1110 1131 6.2e-12 PROSPERO
low complexity region 1146 1173 N/A INTRINSIC
low complexity region 1176 1206 N/A INTRINSIC
low complexity region 1221 1260 N/A INTRINSIC
low complexity region 1265 1297 N/A INTRINSIC
low complexity region 1301 1314 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000082962
Predicted Effect noncoding transcript
Transcript: ENSMUST00000158973
Predicted Effect noncoding transcript
Transcript: ENSMUST00000199618
Coding Region Coverage
Validation Efficiency
Allele List at MGI

All alleles(36) : Targeted, other(2) Gene trapped(34)

Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agbl1 A G 7: 76,070,067 (GRCm39) D281G probably damaging Het
Arhgap28 T C 17: 68,180,127 (GRCm39) E236G probably damaging Het
Bltp1 G A 3: 37,046,822 (GRCm39) probably benign Het
Btbd3 A T 2: 138,126,025 (GRCm39) D334V probably damaging Het
Cabp4 T C 19: 4,189,323 (GRCm39) E78G probably benign Het
Clcn4 T C 7: 7,287,280 (GRCm39) probably benign Het
Col14a1 A G 15: 55,270,089 (GRCm39) Y600C unknown Het
Cpne4 A G 9: 104,778,710 (GRCm39) D167G probably damaging Het
Enpp2 T A 15: 54,783,329 (GRCm39) Y10F probably benign Het
Fam227a A T 15: 79,518,274 (GRCm39) H339Q possibly damaging Het
Far2 C A 6: 148,074,985 (GRCm39) T406K possibly damaging Het
Fmo1 A G 1: 162,661,153 (GRCm39) S377P probably benign Het
Fsip2 G A 2: 82,821,430 (GRCm39) S5721N probably benign Het
Gatb T C 3: 85,520,791 (GRCm39) I300T possibly damaging Het
Gpam T C 19: 55,070,132 (GRCm39) N375D probably benign Het
Gsdma G T 11: 98,564,513 (GRCm39) D331Y probably damaging Het
Kif13b T C 14: 65,002,594 (GRCm39) V1073A probably benign Het
Mfsd4b1 T A 10: 39,879,115 (GRCm39) M261L probably benign Het
Nav1 A T 1: 135,382,498 (GRCm39) D1321E probably damaging Het
Or4f59 A G 2: 111,872,720 (GRCm39) I219T possibly damaging Het
Or52j3 A G 7: 102,836,286 (GRCm39) I159M probably benign Het
Or6c69 A G 10: 129,747,550 (GRCm39) V199A probably benign Het
Or6c76b T A 10: 129,692,936 (GRCm39) L183Q probably damaging Het
Or8g32 G T 9: 39,305,252 (GRCm39) S55I probably damaging Het
Ppp1r10 G T 17: 36,242,053 (GRCm39) R857L unknown Het
Prune2 T A 19: 17,145,656 (GRCm39) I2752N possibly damaging Het
Pxdn T C 12: 30,052,400 (GRCm39) I859T probably benign Het
Ros1 T C 10: 52,031,075 (GRCm39) D510G probably damaging Het
Sema3g C A 14: 30,943,744 (GRCm39) P208H probably benign Het
Smcr8 T C 11: 60,669,010 (GRCm39) F53L probably damaging Het
Tnfsf13b A T 8: 10,081,411 (GRCm39) I219F probably damaging Het
Vmn1r62 T C 7: 5,679,024 (GRCm39) V235A probably damaging Het
Vmn2r44 C A 7: 8,383,103 (GRCm39) probably null Het
Zkscan7 A G 9: 122,723,892 (GRCm39) D287G probably benign Het
Other mutations in Eif3a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00485:Eif3a APN 19 60,758,328 (GRCm39) missense unknown
IGL00981:Eif3a APN 19 60,755,049 (GRCm39) missense unknown
IGL01926:Eif3a APN 19 60,758,399 (GRCm39) missense unknown
IGL02100:Eif3a APN 19 60,755,442 (GRCm39) splice site probably benign
IGL02316:Eif3a APN 19 60,760,076 (GRCm39) splice site probably benign
IGL02444:Eif3a APN 19 60,762,045 (GRCm39) missense possibly damaging 0.89
IGL02552:Eif3a APN 19 60,751,664 (GRCm39) unclassified probably benign
IGL02797:Eif3a APN 19 60,761,164 (GRCm39) missense probably damaging 1.00
IGL03108:Eif3a APN 19 60,770,747 (GRCm39) missense possibly damaging 0.85
FR4304:Eif3a UTSW 19 60,763,728 (GRCm39) critical splice donor site probably benign
FR4548:Eif3a UTSW 19 60,763,729 (GRCm39) critical splice donor site probably benign
FR4737:Eif3a UTSW 19 60,763,727 (GRCm39) critical splice donor site probably benign
FR4976:Eif3a UTSW 19 60,763,729 (GRCm39) critical splice donor site probably benign
G5538:Eif3a UTSW 19 60,770,340 (GRCm39) missense probably damaging 0.97
R0054:Eif3a UTSW 19 60,755,264 (GRCm39) missense unknown
R0054:Eif3a UTSW 19 60,755,264 (GRCm39) missense unknown
R1483:Eif3a UTSW 19 60,757,164 (GRCm39) missense unknown
R1636:Eif3a UTSW 19 60,770,343 (GRCm39) missense possibly damaging 0.93
R1748:Eif3a UTSW 19 60,755,236 (GRCm39) missense unknown
R1857:Eif3a UTSW 19 60,770,635 (GRCm39) missense probably damaging 1.00
R1858:Eif3a UTSW 19 60,770,635 (GRCm39) missense probably damaging 1.00
R1993:Eif3a UTSW 19 60,769,954 (GRCm39) missense probably benign 0.19
R2034:Eif3a UTSW 19 60,750,568 (GRCm39) unclassified probably benign
R2099:Eif3a UTSW 19 60,752,551 (GRCm39) unclassified probably benign
R2140:Eif3a UTSW 19 60,763,832 (GRCm39) splice site probably benign
R2434:Eif3a UTSW 19 60,752,488 (GRCm39) unclassified probably benign
R2940:Eif3a UTSW 19 60,762,115 (GRCm39) missense probably benign 0.22
R4630:Eif3a UTSW 19 60,766,424 (GRCm39) missense probably benign 0.41
R4630:Eif3a UTSW 19 60,758,366 (GRCm39) missense unknown
R4926:Eif3a UTSW 19 60,751,656 (GRCm39) unclassified probably benign
R5366:Eif3a UTSW 19 60,767,971 (GRCm39) missense probably benign 0.12
R6003:Eif3a UTSW 19 60,755,319 (GRCm39) missense unknown
R6082:Eif3a UTSW 19 60,760,568 (GRCm39) missense possibly damaging 0.82
R6256:Eif3a UTSW 19 60,759,464 (GRCm39) missense possibly damaging 0.72
R7056:Eif3a UTSW 19 60,751,500 (GRCm39) splice site probably null
R7365:Eif3a UTSW 19 60,755,082 (GRCm39) missense unknown
R7922:Eif3a UTSW 19 60,764,280 (GRCm39) missense probably damaging 1.00
R8076:Eif3a UTSW 19 60,762,363 (GRCm39) missense probably damaging 0.97
R8169:Eif3a UTSW 19 60,750,628 (GRCm39) missense unknown
R8246:Eif3a UTSW 19 60,767,806 (GRCm39) missense probably damaging 1.00
R8474:Eif3a UTSW 19 60,767,929 (GRCm39) missense possibly damaging 0.63
R8546:Eif3a UTSW 19 60,755,208 (GRCm39) missense unknown
R8964:Eif3a UTSW 19 60,751,630 (GRCm39) missense unknown
R9071:Eif3a UTSW 19 60,751,634 (GRCm39) missense unknown
R9290:Eif3a UTSW 19 60,765,221 (GRCm39) missense probably damaging 1.00
R9484:Eif3a UTSW 19 60,755,006 (GRCm39) missense unknown
R9780:Eif3a UTSW 19 60,766,398 (GRCm39) missense probably damaging 1.00
X0028:Eif3a UTSW 19 60,770,340 (GRCm39) missense probably damaging 0.97
X0066:Eif3a UTSW 19 60,750,731 (GRCm39) unclassified probably benign
Posted On 2014-01-21