Mutagenetix > Incidental Mutation

Incidental Mutation 'R1153:Gpr6'

101632

Institutional Source

Beutler Lab

Gene Symbol

Gpr6

Ensembl Gene

ENSMUSG00000046922

Gene Name

G protein-coupled receptor 6

Synonyms

MMRRC Submission

039226-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R1153 (G1)

Quality Score

219

Status

Not validated

Chromosome

Chromosomal Location

40945973-40948281 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to C at 40946833 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Glycine at position 250 (C250G)

Ref Sequence

ENSEMBL: ENSMUSP00000057323 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000061796]

AlphaFold

Q6YNI2

Predicted Effect

probably damaging
Transcript: ENSMUST00000061796
AA Change: C250G

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000057323
Gene: ENSMUSG00000046922
AA Change: C250G

Domain	Start	End	E-Value	Type
low complexity region	13	30	N/A	INTRINSIC
low complexity region	37	59	N/A	INTRINSIC
Pfam:7tm_1	90	330	2.5e-32	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000213704

Coding Region Coverage

1x: 98.9%
3x: 97.9%
10x: 95.2%
20x: 89.7%

Validation Efficiency

MGI Phenotype

PHENOTYPE: Homozygous mutation of this gene does not appear to result in a phenotype. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 1 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Parp14	C	A	16: 35,678,041 (GRCm39)	K642N	possibly damaging	Het

Other mutations in Gpr6

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00309:Gpr6	APN	10	40,946,812 (GRCm39)	missense	probably damaging	0.99
IGL01010:Gpr6	APN	10	40,947,147 (GRCm39)	missense	probably benign
IGL01098:Gpr6	APN	10	40,946,739 (GRCm39)	missense	probably damaging	1.00
IGL01323:Gpr6	APN	10	40,947,555 (GRCm39)	missense	possibly damaging	0.96
R1154:Gpr6	UTSW	10	40,946,833 (GRCm39)	missense	probably damaging	1.00
R1622:Gpr6	UTSW	10	40,947,288 (GRCm39)	missense	probably damaging	1.00
R1628:Gpr6	UTSW	10	40,947,544 (GRCm39)	missense	possibly damaging	0.96
R1638:Gpr6	UTSW	10	40,946,530 (GRCm39)	missense	probably benign	0.02
R1935:Gpr6	UTSW	10	40,947,477 (GRCm39)	missense	probably benign	0.02
R1936:Gpr6	UTSW	10	40,947,477 (GRCm39)	missense	probably benign	0.02
R2108:Gpr6	UTSW	10	40,946,649 (GRCm39)	missense	possibly damaging	0.79
R2129:Gpr6	UTSW	10	40,947,168 (GRCm39)	missense	possibly damaging	0.50
R4024:Gpr6	UTSW	10	40,947,264 (GRCm39)	missense	probably damaging	1.00
R4237:Gpr6	UTSW	10	40,946,604 (GRCm39)	missense	probably damaging	1.00
R4418:Gpr6	UTSW	10	40,946,604 (GRCm39)	missense	probably damaging	1.00
R4703:Gpr6	UTSW	10	40,947,037 (GRCm39)	missense	probably damaging	1.00
R4814:Gpr6	UTSW	10	40,947,258 (GRCm39)	missense	possibly damaging	0.94
R6821:Gpr6	UTSW	10	40,947,004 (GRCm39)	missense	probably benign	0.04
R7190:Gpr6	UTSW	10	40,946,956 (GRCm39)	missense	probably damaging	1.00
R7573:Gpr6	UTSW	10	40,946,868 (GRCm39)	missense	probably damaging	0.99
R7574:Gpr6	UTSW	10	40,946,652 (GRCm39)	missense	possibly damaging	0.47
R7611:Gpr6	UTSW	10	40,946,875 (GRCm39)	missense	probably benign	0.02
R8011:Gpr6	UTSW	10	40,946,911 (GRCm39)	missense	probably benign	0.01
R9416:Gpr6	UTSW	10	40,946,944 (GRCm39)	missense	possibly damaging	0.86

Predicted Primers

Posted On

2014-01-15