Incidental Mutation 'R1166:Lrrc37'
ID 101034
Institutional Source Beutler Lab
Gene Symbol Lrrc37
Ensembl Gene ENSMUSG00000034239
Gene Name leucine rich repeat containing 37
Synonyms LOC380730, Gm884
MMRRC Submission 039239-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.266) question?
Stock # R1166 (G1)
Quality Score 225
Status Validated
Chromosome 11
Chromosomal Location 103425403-103511966 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 103506209 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 1920 (S1920P)
Ref Sequence ENSEMBL: ENSMUSP00000058511 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000059279] [ENSMUST00000167262]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000059279
AA Change: S1920P

PolyPhen 2 Score 0.214 (Sensitivity: 0.92; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000058511
Gene: ENSMUSG00000034239
AA Change: S1920P

DomainStartEndE-ValueType
Pfam:LRRC37 149 223 5.4e-10 PFAM
low complexity region 244 264 N/A INTRINSIC
low complexity region 298 308 N/A INTRINSIC
Pfam:LRRC37 335 403 1.9e-14 PFAM
Pfam:LRRC37 419 514 1.2e-8 PFAM
Pfam:LRRC37 565 620 2e-10 PFAM
Pfam:LRRC37 669 739 7.6e-18 PFAM
Pfam:LRRC37 741 792 1.6e-9 PFAM
Pfam:LRRC37 789 860 1.4e-23 PFAM
Pfam:LRRC37 861 914 2.8e-9 PFAM
Pfam:LRRC37 911 983 1.9e-23 PFAM
Pfam:LRRC37 979 1038 1e-8 PFAM
Pfam:LRRC37 1034 1105 2.7e-24 PFAM
Pfam:LRRC37 1105 1158 2.3e-9 PFAM
Pfam:LRRC37 1155 1219 2.4e-17 PFAM
Pfam:LRRC37 1222 1265 9.2e-7 PFAM
Pfam:LRRC37 1263 1330 4.9e-24 PFAM
Pfam:LRRC37 1331 1384 1.4e-10 PFAM
Pfam:LRRC37 1380 1451 4.3e-15 PFAM
Pfam:LRRC37 1487 1558 1.9e-15 PFAM
Pfam:LRRC37 1594 1665 2.9e-18 PFAM
Pfam:LRRC37 1701 1772 5.6e-23 PFAM
Pfam:LRRC37 1808 1910 2.8e-18 PFAM
Pfam:LRRC37 1915 1986 7.2e-17 PFAM
Pfam:LRRC37 2022 2093 4.9e-22 PFAM
Pfam:LRRC37 2129 2200 4.4e-22 PFAM
Pfam:LRRC37 2236 2307 2.1e-21 PFAM
Pfam:LRRC37 2343 2414 3.8e-17 PFAM
Pfam:LRRC37 2449 2519 1.6e-19 PFAM
LRR 2777 2796 3.09e1 SMART
LRR_TYP 2797 2820 2.09e-3 SMART
LRR 2821 2844 4.44e0 SMART
LRR 2848 2872 8.26e1 SMART
low complexity region 2991 3002 N/A INTRINSIC
low complexity region 3220 3230 N/A INTRINSIC
low complexity region 3382 3393 N/A INTRINSIC
Pfam:LRRC37AB_C 3424 3570 7.7e-76 PFAM
low complexity region 3571 3589 N/A INTRINSIC
low complexity region 3622 3640 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000167262
SMART Domains Protein: ENSMUSP00000129662
Gene: ENSMUSG00000034239

DomainStartEndE-ValueType
internal_repeat_1 1 70 1.46e-11 PROSPERO
internal_repeat_1 108 290 1.46e-11 PROSPERO
LRR 601 620 3.09e1 SMART
LRR_TYP 621 644 2.09e-3 SMART
LRR 645 668 4.44e0 SMART
LRR 672 696 8.26e1 SMART
low complexity region 815 826 N/A INTRINSIC
low complexity region 1044 1054 N/A INTRINSIC
low complexity region 1206 1217 N/A INTRINSIC
Pfam:LRRC37AB_C 1243 1396 1.2e-92 PFAM
low complexity region 1446 1464 N/A INTRINSIC
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.3%
  • 10x: 95.0%
  • 20x: 86.3%
Validation Efficiency 96% (43/45)
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2ml1 T C 6: 128,547,880 (GRCm39) K286R probably benign Het
Arhgef10l T C 4: 140,302,581 (GRCm39) probably benign Het
Ccdc175 T G 12: 72,152,706 (GRCm39) K733T probably damaging Het
Cenpn T G 8: 117,652,946 (GRCm39) I39R probably damaging Het
Cfap53 A T 18: 74,433,251 (GRCm39) Y112F possibly damaging Het
Cngb1 C A 8: 95,986,809 (GRCm39) C361F probably damaging Het
Ctf2 T C 7: 127,318,685 (GRCm39) T105A probably benign Het
Dnah7b A T 1: 46,364,970 (GRCm39) T3584S probably damaging Het
Ebf3 C T 7: 136,914,896 (GRCm39) probably benign Het
Ep300 A G 15: 81,514,265 (GRCm39) probably benign Het
Fbxo17 T A 7: 28,432,953 (GRCm39) V158E probably damaging Het
Fbxw24 T C 9: 109,436,066 (GRCm39) E322G probably benign Het
Gm5698 G T 1: 31,016,366 (GRCm39) D228E probably damaging Het
Hfm1 A T 5: 107,059,277 (GRCm39) D248E probably benign Het
Insm2 T C 12: 55,647,281 (GRCm39) S342P probably benign Het
Krt36 G A 11: 99,993,654 (GRCm39) R395C probably benign Het
Lsm14b T A 2: 179,673,334 (GRCm39) probably benign Het
Map1a A G 2: 121,130,741 (GRCm39) E519G probably damaging Het
Mfsd14a T C 3: 116,427,543 (GRCm39) probably benign Het
Mfsd4b5 T C 10: 39,846,419 (GRCm39) Y387C probably damaging Het
Mybpc2 T C 7: 44,154,449 (GRCm39) N1063D possibly damaging Het
Nlrp10 T A 7: 108,524,217 (GRCm39) H421L probably damaging Het
Nup155 A T 15: 8,187,244 (GRCm39) H1391L probably damaging Het
Or4a81 A G 2: 89,619,675 (GRCm39) V7A possibly damaging Het
Pacrg A T 17: 10,622,268 (GRCm39) Y235* probably null Het
Pde4dip T A 3: 97,620,512 (GRCm39) D1629V possibly damaging Het
Prl8a2 G T 13: 27,537,935 (GRCm39) S204I possibly damaging Het
Sec24a A T 11: 51,624,294 (GRCm39) M356K possibly damaging Het
Sh3tc2 A C 18: 62,124,247 (GRCm39) S972R probably damaging Het
Shc2 C T 10: 79,456,946 (GRCm39) V557M probably damaging Het
Slc2a9 A G 5: 38,539,384 (GRCm39) probably null Het
Tcaf1 T C 6: 42,655,612 (GRCm39) I455V probably benign Het
Umodl1 T G 17: 31,221,772 (GRCm39) probably benign Het
Wdr27 T C 17: 15,112,733 (GRCm39) T658A probably damaging Het
Zfp318 T C 17: 46,720,618 (GRCm39) Y1119H possibly damaging Het
Zfp939 C A 7: 39,122,763 (GRCm39) noncoding transcript Het
Other mutations in Lrrc37
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00572:Lrrc37 APN 11 103,506,236 (GRCm39) missense probably benign 0.01
IGL00576:Lrrc37 APN 11 103,508,212 (GRCm39) unclassified probably benign
IGL00813:Lrrc37 APN 11 103,505,324 (GRCm39) missense probably benign 0.05
IGL01311:Lrrc37 APN 11 103,425,502 (GRCm39) missense unknown
IGL01946:Lrrc37 APN 11 103,503,759 (GRCm39) missense probably benign 0.28
IGL02217:Lrrc37 APN 11 103,503,697 (GRCm39) splice site probably benign
IGL02556:Lrrc37 APN 11 103,504,109 (GRCm39) missense probably benign 0.01
IGL02825:Lrrc37 APN 11 103,507,894 (GRCm39) unclassified probably benign
IGL02868:Lrrc37 APN 11 103,505,965 (GRCm39) missense probably benign 0.10
IGL02904:Lrrc37 APN 11 103,507,187 (GRCm39) unclassified probably benign
IGL03008:Lrrc37 APN 11 103,511,293 (GRCm39) missense unknown
IGL03120:Lrrc37 APN 11 103,507,801 (GRCm39) unclassified probably benign
IGL03159:Lrrc37 APN 11 103,495,328 (GRCm39) splice site probably benign
IGL03181:Lrrc37 APN 11 103,507,242 (GRCm39) unclassified probably benign
IGL03202:Lrrc37 APN 11 103,506,199 (GRCm39) missense probably benign 0.03
IGL03263:Lrrc37 APN 11 103,504,525 (GRCm39) missense possibly damaging 0.86
esteemed UTSW 11 103,509,656 (GRCm39) missense unknown
lauded UTSW 11 103,503,929 (GRCm39) missense possibly damaging 0.62
PIT4486001:Lrrc37 UTSW 11 103,509,027 (GRCm39) missense unknown
R0040:Lrrc37 UTSW 11 103,433,816 (GRCm39) missense probably damaging 0.99
R0135:Lrrc37 UTSW 11 103,508,873 (GRCm39) unclassified probably benign
R0141:Lrrc37 UTSW 11 103,504,512 (GRCm39) missense probably damaging 1.00
R0226:Lrrc37 UTSW 11 103,494,067 (GRCm39) missense probably benign 0.08
R0547:Lrrc37 UTSW 11 103,510,990 (GRCm39) missense unknown
R0646:Lrrc37 UTSW 11 103,503,986 (GRCm39) nonsense probably null
R0685:Lrrc37 UTSW 11 103,507,714 (GRCm39) unclassified probably benign
R0732:Lrrc37 UTSW 11 103,510,664 (GRCm39) missense unknown
R1015:Lrrc37 UTSW 11 103,436,622 (GRCm39) missense probably benign 0.01
R1168:Lrrc37 UTSW 11 103,509,776 (GRCm39) unclassified probably benign
R1257:Lrrc37 UTSW 11 103,425,467 (GRCm39) missense unknown
R1545:Lrrc37 UTSW 11 103,499,745 (GRCm39) missense probably benign 0.16
R1570:Lrrc37 UTSW 11 103,500,764 (GRCm39) missense possibly damaging 0.76
R1677:Lrrc37 UTSW 11 103,505,768 (GRCm39) missense probably benign 0.19
R1703:Lrrc37 UTSW 11 103,431,700 (GRCm39) missense probably benign 0.39
R1719:Lrrc37 UTSW 11 103,507,897 (GRCm39) unclassified probably benign
R1752:Lrrc37 UTSW 11 103,505,381 (GRCm39) missense possibly damaging 0.67
R1870:Lrrc37 UTSW 11 103,511,431 (GRCm39) missense unknown
R2155:Lrrc37 UTSW 11 103,511,285 (GRCm39) missense unknown
R2191:Lrrc37 UTSW 11 103,509,793 (GRCm39) unclassified probably benign
R2271:Lrrc37 UTSW 11 103,505,033 (GRCm39) missense possibly damaging 0.53
R2378:Lrrc37 UTSW 11 103,510,537 (GRCm39) unclassified probably benign
R2405:Lrrc37 UTSW 11 103,511,810 (GRCm39) missense unknown
R2864:Lrrc37 UTSW 11 103,431,744 (GRCm39) missense probably benign 0.34
R3011:Lrrc37 UTSW 11 103,503,929 (GRCm39) missense possibly damaging 0.62
R3415:Lrrc37 UTSW 11 103,505,435 (GRCm39) missense possibly damaging 0.82
R3417:Lrrc37 UTSW 11 103,505,435 (GRCm39) missense possibly damaging 0.82
R3835:Lrrc37 UTSW 11 103,510,836 (GRCm39) missense unknown
R3974:Lrrc37 UTSW 11 103,509,927 (GRCm39) unclassified probably benign
R4019:Lrrc37 UTSW 11 103,506,119 (GRCm39) missense probably benign 0.19
R4020:Lrrc37 UTSW 11 103,506,119 (GRCm39) missense probably benign 0.19
R4176:Lrrc37 UTSW 11 103,427,426 (GRCm39) missense unknown
R4361:Lrrc37 UTSW 11 103,508,327 (GRCm39) frame shift probably null
R4418:Lrrc37 UTSW 11 103,509,140 (GRCm39) unclassified probably benign
R4633:Lrrc37 UTSW 11 103,509,957 (GRCm39) unclassified probably benign
R4693:Lrrc37 UTSW 11 103,510,686 (GRCm39) missense unknown
R4758:Lrrc37 UTSW 11 103,505,290 (GRCm39) missense possibly damaging 0.48
R4878:Lrrc37 UTSW 11 103,508,717 (GRCm39) unclassified probably benign
R4887:Lrrc37 UTSW 11 103,505,698 (GRCm39) missense probably benign 0.03
R4944:Lrrc37 UTSW 11 103,504,286 (GRCm39) missense possibly damaging 0.68
R4952:Lrrc37 UTSW 11 103,505,033 (GRCm39) missense possibly damaging 0.53
R5030:Lrrc37 UTSW 11 103,425,675 (GRCm39) missense unknown
R5183:Lrrc37 UTSW 11 103,433,947 (GRCm39) missense probably damaging 0.99
R5294:Lrrc37 UTSW 11 103,507,057 (GRCm39) unclassified probably benign
R5317:Lrrc37 UTSW 11 103,504,971 (GRCm39) missense possibly damaging 0.73
R5334:Lrrc37 UTSW 11 103,504,699 (GRCm39) missense probably benign 0.18
R5426:Lrrc37 UTSW 11 103,511,586 (GRCm39) missense unknown
R5467:Lrrc37 UTSW 11 103,494,091 (GRCm39) nonsense probably null
R5518:Lrrc37 UTSW 11 103,506,079 (GRCm39) missense probably benign 0.03
R5634:Lrrc37 UTSW 11 103,432,840 (GRCm39) missense possibly damaging 0.95
R5647:Lrrc37 UTSW 11 103,508,300 (GRCm39) unclassified probably benign
R5663:Lrrc37 UTSW 11 103,503,949 (GRCm39) missense probably benign 0.01
R5668:Lrrc37 UTSW 11 103,507,880 (GRCm39) unclassified probably benign
R5763:Lrrc37 UTSW 11 103,504,469 (GRCm39) missense probably damaging 0.97
R5829:Lrrc37 UTSW 11 103,432,712 (GRCm39) missense possibly damaging 0.95
R5871:Lrrc37 UTSW 11 103,507,280 (GRCm39) unclassified probably benign
R5905:Lrrc37 UTSW 11 103,505,081 (GRCm39) missense probably damaging 0.98
R5940:Lrrc37 UTSW 11 103,504,712 (GRCm39) missense probably benign 0.18
R5964:Lrrc37 UTSW 11 103,432,946 (GRCm39) missense possibly damaging 0.92
R5988:Lrrc37 UTSW 11 103,506,722 (GRCm39) unclassified probably benign
R5992:Lrrc37 UTSW 11 103,504,618 (GRCm39) missense possibly damaging 0.81
R6114:Lrrc37 UTSW 11 103,508,617 (GRCm39) unclassified probably benign
R6154:Lrrc37 UTSW 11 103,504,969 (GRCm39) missense probably benign 0.33
R6233:Lrrc37 UTSW 11 103,504,214 (GRCm39) missense probably damaging 0.98
R6301:Lrrc37 UTSW 11 103,509,756 (GRCm39) unclassified probably benign
R6362:Lrrc37 UTSW 11 103,511,478 (GRCm39) missense unknown
R6471:Lrrc37 UTSW 11 103,510,448 (GRCm39) unclassified probably benign
R6806:Lrrc37 UTSW 11 103,511,950 (GRCm39) missense unknown
R6962:Lrrc37 UTSW 11 103,505,126 (GRCm39) missense possibly damaging 0.67
R6996:Lrrc37 UTSW 11 103,509,583 (GRCm39) nonsense probably null
R7028:Lrrc37 UTSW 11 103,505,363 (GRCm39) missense probably benign 0.28
R7034:Lrrc37 UTSW 11 103,506,638 (GRCm39) unclassified probably benign
R7036:Lrrc37 UTSW 11 103,506,638 (GRCm39) unclassified probably benign
R7113:Lrrc37 UTSW 11 103,509,625 (GRCm39) missense unknown
R7405:Lrrc37 UTSW 11 103,505,987 (GRCm39) missense probably benign 0.02
R7420:Lrrc37 UTSW 11 103,504,451 (GRCm39) missense probably benign 0.11
R7461:Lrrc37 UTSW 11 103,507,116 (GRCm39) missense unknown
R7544:Lrrc37 UTSW 11 103,506,274 (GRCm39) missense probably benign 0.01
R7613:Lrrc37 UTSW 11 103,507,116 (GRCm39) missense unknown
R7711:Lrrc37 UTSW 11 103,505,738 (GRCm39) missense probably benign 0.02
R7714:Lrrc37 UTSW 11 103,507,719 (GRCm39) missense unknown
R7747:Lrrc37 UTSW 11 103,505,081 (GRCm39) missense probably damaging 0.98
R7814:Lrrc37 UTSW 11 103,504,999 (GRCm39) missense possibly damaging 0.53
R8053:Lrrc37 UTSW 11 103,495,392 (GRCm39) missense unknown
R8063:Lrrc37 UTSW 11 103,433,087 (GRCm39) missense unknown
R8116:Lrrc37 UTSW 11 103,434,115 (GRCm39) missense unknown
R8124:Lrrc37 UTSW 11 103,511,257 (GRCm39) missense unknown
R8141:Lrrc37 UTSW 11 103,511,855 (GRCm39) missense unknown
R8163:Lrrc37 UTSW 11 103,506,688 (GRCm39) missense unknown
R8270:Lrrc37 UTSW 11 103,434,141 (GRCm39) missense unknown
R8348:Lrrc37 UTSW 11 103,511,726 (GRCm39) missense unknown
R8362:Lrrc37 UTSW 11 103,506,163 (GRCm39) missense probably benign 0.34
R8448:Lrrc37 UTSW 11 103,511,726 (GRCm39) missense unknown
R8465:Lrrc37 UTSW 11 103,506,947 (GRCm39) unclassified probably benign
R8473:Lrrc37 UTSW 11 103,434,266 (GRCm39) missense unknown
R8781:Lrrc37 UTSW 11 103,508,958 (GRCm39) missense unknown
R8821:Lrrc37 UTSW 11 103,510,470 (GRCm39) missense unknown
R8859:Lrrc37 UTSW 11 103,506,370 (GRCm39) missense unknown
R8888:Lrrc37 UTSW 11 103,509,656 (GRCm39) missense unknown
R8895:Lrrc37 UTSW 11 103,509,656 (GRCm39) missense unknown
R9083:Lrrc37 UTSW 11 103,509,830 (GRCm39) missense unknown
R9085:Lrrc37 UTSW 11 103,507,565 (GRCm39) missense unknown
R9088:Lrrc37 UTSW 11 103,511,762 (GRCm39) missense unknown
R9124:Lrrc37 UTSW 11 103,509,721 (GRCm39) missense unknown
R9177:Lrrc37 UTSW 11 103,508,263 (GRCm39) missense unknown
R9238:Lrrc37 UTSW 11 103,509,859 (GRCm39) missense unknown
R9267:Lrrc37 UTSW 11 103,495,406 (GRCm39) missense unknown
R9444:Lrrc37 UTSW 11 103,508,846 (GRCm39) nonsense probably null
R9517:Lrrc37 UTSW 11 103,433,416 (GRCm39) missense unknown
R9564:Lrrc37 UTSW 11 103,503,822 (GRCm39) missense unknown
R9632:Lrrc37 UTSW 11 103,433,252 (GRCm39) missense unknown
R9741:Lrrc37 UTSW 11 103,504,255 (GRCm39) missense possibly damaging 0.68
Z1176:Lrrc37 UTSW 11 103,504,507 (GRCm39) missense probably benign 0.45
Predicted Primers
Posted On 2014-01-15